AU2007297012B2 - Tartrate derivatives for use as coagulation factor IXa inhibitors - Google Patents
Tartrate derivatives for use as coagulation factor IXa inhibitors Download PDFInfo
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- AU2007297012B2 AU2007297012B2 AU2007297012A AU2007297012A AU2007297012B2 AU 2007297012 B2 AU2007297012 B2 AU 2007297012B2 AU 2007297012 A AU2007297012 A AU 2007297012A AU 2007297012 A AU2007297012 A AU 2007297012A AU 2007297012 B2 AU2007297012 B2 AU 2007297012B2
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- formula
- compound
- amino
- dihydroxy
- phenyl
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- 108010048049 Factor IXa Proteins 0.000 title description 13
- 229940123849 Factor IXa inhibitor Drugs 0.000 title description 2
- 150000003892 tartrate salts Chemical class 0.000 title description 2
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Classifications
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/60—Two oxygen atoms, e.g. succinic anhydride
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C235/16—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
- C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
- C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/58—One oxygen atom, e.g. butenolide
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Vascular Medicine (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Ophthalmology & Optometry (AREA)
- Emergency Medicine (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102006042927 | 2006-09-13 | ||
| DE102006042927.3 | 2006-09-13 | ||
| PCT/EP2007/007612 WO2008031508A1 (de) | 2006-09-13 | 2007-08-31 | Tartratderivate als inhibitoren des koagulationsfaktors ixa |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2007297012A1 AU2007297012A1 (en) | 2008-03-20 |
| AU2007297012B2 true AU2007297012B2 (en) | 2011-12-22 |
Family
ID=38720737
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2007297012A Ceased AU2007297012B2 (en) | 2006-09-13 | 2007-08-31 | Tartrate derivatives for use as coagulation factor IXa inhibitors |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US8263621B2 (enExample) |
| EP (1) | EP2069288B1 (enExample) |
| JP (1) | JP5249225B2 (enExample) |
| KR (1) | KR20090053813A (enExample) |
| CN (1) | CN101516833B (enExample) |
| AR (1) | AR062744A1 (enExample) |
| AU (1) | AU2007297012B2 (enExample) |
| BR (1) | BRPI0716778A2 (enExample) |
| CA (1) | CA2663543A1 (enExample) |
| CL (1) | CL2007002651A1 (enExample) |
| CO (1) | CO6220943A2 (enExample) |
| IL (1) | IL197505A0 (enExample) |
| MA (1) | MA30706B1 (enExample) |
| MX (1) | MX2009001990A (enExample) |
| MY (1) | MY148254A (enExample) |
| NO (1) | NO20091106L (enExample) |
| NZ (1) | NZ575604A (enExample) |
| RU (1) | RU2446160C2 (enExample) |
| TW (1) | TWI406852B (enExample) |
| UY (1) | UY30586A1 (enExample) |
| WO (1) | WO2008031508A1 (enExample) |
| ZA (1) | ZA200900806B (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101209976B (zh) * | 2006-12-29 | 2012-01-11 | 中国人民解放军军事医学科学院毒物药物研究所 | 取代的酒石酸衍生物及其用于制备β-分泌酶抑制剂的用途 |
| US8987242B2 (en) | 2008-12-05 | 2015-03-24 | Merck Sharp & Dohme Corp. | Morpholinone compounds as factor IXA inhibitors |
| TW201033184A (en) * | 2008-12-05 | 2010-09-16 | Mochida Pharm Co Ltd | Morpholinone compounds as factor IXa inhibitors |
| WO2011100401A1 (en) * | 2010-02-11 | 2011-08-18 | Bristol-Myers Squibb Company | Macrocycles as factor xia inhibitors |
| EP3131897B8 (en) | 2014-04-16 | 2022-08-03 | Merck Sharp & Dohme LLC | Factor ixa inhibitors |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3731542A1 (de) * | 1987-09-17 | 1989-03-30 | Schering Ag | Neue dicarbonsaeure-bis(3,5-dicarbamoyl-2,4,6-triiod-anilide), verfahren zu deren herstellung sowie diese enthaltende roentgenkontrastmittel |
| RU2043344C1 (ru) * | 1991-05-20 | 1995-09-10 | Курский Государственный Медицинский Институт | N-2-(1- r1-5-r2-6-r3- бензимидазолил)сукцинаминовые кислоты, проявляющие нейролептическую, антигипоксическую и антиаритмическую активность |
| CA2159649A1 (en) | 1993-03-29 | 1994-10-13 | Queen's University At Kingston | Anticoagulant compounds |
| AU2002227269A1 (en) | 2000-11-07 | 2002-06-03 | Bristol-Myers Squibb Company | Acid derivatives useful as serine protease inhibitors |
| US20020151595A1 (en) | 2001-02-02 | 2002-10-17 | Ries Uwe Joerg | Carboxylic acid amides having antithrombotic activity |
| DE10104598A1 (de) * | 2001-02-02 | 2002-08-08 | Boehringer Ingelheim Pharma | Carbonsäureamide, deren Herstellung und deren Verwendung als Arzneimittel |
| EP1594505A4 (en) | 2003-02-11 | 2008-08-13 | Bristol Myers Squibb Co | PHENYLGLYCIN DERIVATIVES USEFUL AS SERINE PROTEASE INHIBITORS |
| US7638513B2 (en) * | 2004-06-02 | 2009-12-29 | Schering Corporation | Compounds for the treatment of inflammatory disorders |
-
2007
- 2007-08-31 JP JP2009527719A patent/JP5249225B2/ja not_active Expired - Fee Related
- 2007-08-31 KR KR1020097005182A patent/KR20090053813A/ko not_active Ceased
- 2007-08-31 CN CN2007800339733A patent/CN101516833B/zh not_active Expired - Fee Related
- 2007-08-31 NZ NZ575604A patent/NZ575604A/en not_active IP Right Cessation
- 2007-08-31 BR BRPI0716778-4A2A patent/BRPI0716778A2/pt not_active IP Right Cessation
- 2007-08-31 MX MX2009001990A patent/MX2009001990A/es active IP Right Grant
- 2007-08-31 EP EP07802030.2A patent/EP2069288B1/de active Active
- 2007-08-31 WO PCT/EP2007/007612 patent/WO2008031508A1/de not_active Ceased
- 2007-08-31 AU AU2007297012A patent/AU2007297012B2/en not_active Ceased
- 2007-08-31 RU RU2009113616/04A patent/RU2446160C2/ru not_active IP Right Cessation
- 2007-08-31 MY MYPI20090508A patent/MY148254A/en unknown
- 2007-08-31 CA CA002663543A patent/CA2663543A1/en not_active Abandoned
- 2007-09-11 AR ARP070104011A patent/AR062744A1/es not_active Application Discontinuation
- 2007-09-11 TW TW096133789A patent/TWI406852B/zh not_active IP Right Cessation
- 2007-09-11 UY UY30586A patent/UY30586A1/es not_active Application Discontinuation
- 2007-09-12 CL CL200702651A patent/CL2007002651A1/es unknown
-
2009
- 2009-02-03 ZA ZA2009/00806A patent/ZA200900806B/en unknown
- 2009-03-04 CO CO09022192A patent/CO6220943A2/es not_active Application Discontinuation
- 2009-03-06 MA MA31699A patent/MA30706B1/fr unknown
- 2009-03-09 IL IL197505A patent/IL197505A0/en unknown
- 2009-03-09 US US12/400,187 patent/US8263621B2/en not_active Expired - Fee Related
- 2009-03-16 NO NO20091106A patent/NO20091106L/no not_active Application Discontinuation
Non-Patent Citations (1)
| Title |
|---|
| Tingle, J. B. and Burke, C. E., J. Am. Chem. Soc., 1909, vol. 31, pages 1312-1319 * |
Also Published As
| Publication number | Publication date |
|---|---|
| RU2446160C2 (ru) | 2012-03-27 |
| KR20090053813A (ko) | 2009-05-27 |
| RU2009113616A (ru) | 2010-10-20 |
| MA30706B1 (fr) | 2009-09-01 |
| EP2069288B1 (de) | 2014-03-26 |
| NZ575604A (en) | 2011-12-22 |
| NO20091106L (no) | 2009-06-09 |
| CN101516833B (zh) | 2013-04-03 |
| AU2007297012A1 (en) | 2008-03-20 |
| CL2007002651A1 (es) | 2008-02-08 |
| HK1137419A1 (en) | 2010-07-30 |
| BRPI0716778A2 (pt) | 2014-04-22 |
| CO6220943A2 (es) | 2010-11-19 |
| JP5249225B2 (ja) | 2013-07-31 |
| CN101516833A (zh) | 2009-08-26 |
| AR062744A1 (es) | 2008-12-03 |
| US20090233961A1 (en) | 2009-09-17 |
| US8263621B2 (en) | 2012-09-11 |
| EP2069288A1 (de) | 2009-06-17 |
| WO2008031508A1 (de) | 2008-03-20 |
| UY30586A1 (es) | 2008-05-02 |
| CA2663543A1 (en) | 2008-03-20 |
| TWI406852B (zh) | 2013-09-01 |
| TW200829557A (en) | 2008-07-16 |
| ZA200900806B (en) | 2009-12-30 |
| JP2010503624A (ja) | 2010-02-04 |
| MX2009001990A (es) | 2009-03-06 |
| MY148254A (en) | 2013-03-29 |
| IL197505A0 (en) | 2009-12-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FGA | Letters patent sealed or granted (standard patent) | ||
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |