CO6220943A2 - Derivados de tartrato para uso como inhibidores del factor de coagulacion ixa - Google Patents

Derivados de tartrato para uso como inhibidores del factor de coagulacion ixa

Info

Publication number
CO6220943A2
CO6220943A2 CO09022192A CO09022192A CO6220943A2 CO 6220943 A2 CO6220943 A2 CO 6220943A2 CO 09022192 A CO09022192 A CO 09022192A CO 09022192 A CO09022192 A CO 09022192A CO 6220943 A2 CO6220943 A2 CO 6220943A2
Authority
CO
Colombia
Prior art keywords
aryl
trisubstituted
mono
het
alkylene
Prior art date
Application number
CO09022192A
Other languages
English (en)
Inventor
Henning Steinhagen
Markus Follmann
Jochen Goerlitzer
Herman Schreuder
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of CO6220943A2 publication Critical patent/CO6220943A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/60—Two oxygen atoms, e.g. succinic anhydride
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/16—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/58—One oxygen atom, e.g. butenolide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Oncology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

1.- Un compuesto de la fórmula Iy/o todas las formas estereoisómeras del compuesto de la fórmula I y/o las mezclas de estas formas en cualquier relación, y/o una sal fisiológicamente tolerable del compuesto de la fórmula I, en la que R1 es 1) -aril(C6-C14)-Z, donde Z es un grupo que contiene nitrógeno básico, donde el ácido conjugado de este grupo tiene un pKa de 5 a 15 y donde el arilo no está sustituido o está mono-, di- o trisustituido con T, 2) un Het-Z de cuatro a quince miembros, donde Z es un grupo que contiene nitrógeno básico donde el ácido conjugado de este grupo tiene un pKa de 5 a 15 y donde Het no está sustituido o está adicionalmente mono-, di- o trisustituido con T, R2 y R4 son idénticos o diferentes y cada uno es un átomo de hidrógeno, R3 es 1) -alquilen (C0-C4)-arilo (C6-C14), donde el arilo no está sustituido o está mono-, di- o trisustituido con T, 2) -alquilen (C0-C4)-aril (C6-C14)-Q-arilo (C6-C14), donde los dos arilos, en cada caso independientemente uno del otro, no están sustituidos o están mono-, di- o trisustituidos con T,3) -alquilen (C0-C4)-aril (C6-C14)-Q-Het, donde arilo y Het, donde arilo y Het, en cada caso independientemente uno del otro, no están sustituidos o están mono-, di- o trisustituidos con T,Q es un enlace covalente, -alquileno (C1-C4), -NH-, -N(alquilo (C1-C4))-, -O-, -SO2- o -S-,T es 1) halógeno,2) -alquilo (C1-C6), donde el alquilo no está sustituido o está mono,di- o trisustituido con -?uoroalquilo (C1-C3), -N-C(O)-OH o -N-C(O)-alquilo (C1-C4), 3) -cicloalquilo (C3-C8), o4) -NO2,R5 y R6 son idénticos y en cada caso son un átomo de hidrógeno.
CO09022192A 2006-09-13 2009-03-04 Derivados de tartrato para uso como inhibidores del factor de coagulacion ixa CO6220943A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102006042927 2006-09-13

Publications (1)

Publication Number Publication Date
CO6220943A2 true CO6220943A2 (es) 2010-11-19

Family

ID=38720737

Family Applications (1)

Application Number Title Priority Date Filing Date
CO09022192A CO6220943A2 (es) 2006-09-13 2009-03-04 Derivados de tartrato para uso como inhibidores del factor de coagulacion ixa

Country Status (23)

Country Link
US (1) US8263621B2 (es)
EP (1) EP2069288B1 (es)
JP (1) JP5249225B2 (es)
KR (1) KR20090053813A (es)
CN (1) CN101516833B (es)
AR (1) AR062744A1 (es)
AU (1) AU2007297012B2 (es)
BR (1) BRPI0716778A2 (es)
CA (1) CA2663543A1 (es)
CL (1) CL2007002651A1 (es)
CO (1) CO6220943A2 (es)
HK (1) HK1137419A1 (es)
IL (1) IL197505A0 (es)
MA (1) MA30706B1 (es)
MX (1) MX2009001990A (es)
MY (1) MY148254A (es)
NO (1) NO20091106L (es)
NZ (1) NZ575604A (es)
RU (1) RU2446160C2 (es)
TW (1) TWI406852B (es)
UY (1) UY30586A1 (es)
WO (1) WO2008031508A1 (es)
ZA (1) ZA200900806B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101209976B (zh) * 2006-12-29 2012-01-11 中国人民解放军军事医学科学院毒物药物研究所 取代的酒石酸衍生物及其用于制备β-分泌酶抑制剂的用途
TW201033184A (en) 2008-12-05 2010-09-16 Mochida Pharm Co Ltd Morpholinone compounds as factor IXa inhibitors
US8987242B2 (en) 2008-12-05 2015-03-24 Merck Sharp & Dohme Corp. Morpholinone compounds as factor IXA inhibitors
JP5841547B2 (ja) * 2010-02-11 2016-01-13 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ 第ｘｉａ因子阻害剤としてのマクロ環
EP3131897B8 (en) 2014-04-16 2022-08-03 Merck Sharp & Dohme LLC Factor ixa inhibitors

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3731542A1 (de) 1987-09-17 1989-03-30 Schering Ag Neue dicarbonsaeure-bis(3,5-dicarbamoyl-2,4,6-triiod-anilide), verfahren zu deren herstellung sowie diese enthaltende roentgenkontrastmittel
RU2043344C1 (ru) * 1991-05-20 1995-09-10 Курский Государственный Медицинский Институт N-2-(1- r1-5-r2-6-r3- бензимидазолил)сукцинаминовые кислоты, проявляющие нейролептическую, антигипоксическую и антиаритмическую активность
WO1994022885A1 (en) 1993-03-29 1994-10-13 Queen's University At Kingston Anticoagulant compounds
EP1332131A2 (en) 2000-11-07 2003-08-06 Bristol-Myers Squibb Company Acid derivatives useful as serine protease inhibitors
DE10104598A1 (de) 2001-02-02 2002-08-08 Boehringer Ingelheim Pharma Carbonsäureamide, deren Herstellung und deren Verwendung als Arzneimittel
US20020151595A1 (en) 2001-02-02 2002-10-17 Ries Uwe Joerg Carboxylic acid amides having antithrombotic activity
US7122559B2 (en) 2003-02-11 2006-10-17 Bristol-Myers Squibb Company Phenylglycine derivatives useful as serine protease inhibitors
US7638513B2 (en) * 2004-06-02 2009-12-29 Schering Corporation Compounds for the treatment of inflammatory disorders

Also Published As

Publication number Publication date
JP5249225B2 (ja) 2013-07-31
TWI406852B (zh) 2013-09-01
BRPI0716778A2 (pt) 2014-04-22
AU2007297012B2 (en) 2011-12-22
NO20091106L (no) 2009-06-09
ZA200900806B (en) 2009-12-30
KR20090053813A (ko) 2009-05-27
TW200829557A (en) 2008-07-16
AR062744A1 (es) 2008-12-03
EP2069288A1 (de) 2009-06-17
CA2663543A1 (en) 2008-03-20
JP2010503624A (ja) 2010-02-04
MA30706B1 (fr) 2009-09-01
CL2007002651A1 (es) 2008-02-08
RU2446160C2 (ru) 2012-03-27
EP2069288B1 (de) 2014-03-26
RU2009113616A (ru) 2010-10-20
HK1137419A1 (en) 2010-07-30
US8263621B2 (en) 2012-09-11
US20090233961A1 (en) 2009-09-17
UY30586A1 (es) 2008-05-02
NZ575604A (en) 2011-12-22
MY148254A (en) 2013-03-29
WO2008031508A1 (de) 2008-03-20
CN101516833A (zh) 2009-08-26
MX2009001990A (es) 2009-03-06
AU2007297012A1 (en) 2008-03-20
IL197505A0 (en) 2009-12-24
CN101516833B (zh) 2013-04-03

Similar Documents

Publication Publication Date Title
CY1121961T1 (el) Προφαρμακο που περιεχει εναν αυτο-διασπωμενο συνδετη
CY1121867T1 (el) Αναστολεις jak2 και alk2 και μεθοδοι για τη χρηση τους
CO6220943A2 (es) Derivados de tartrato para uso como inhibidores del factor de coagulacion ixa
NI200900037A (es) Derivados de 2-aril-6-fenil-imidazo[1,2-alfa] piridinas, su preparación y su aplicación en terapéutica.
CY1123308T1 (el) Αναστολεας ινωσης
CY1117113T1 (el) Αναστολεις πρωτεασης σερινης hcv λαμβανομενοι απο μακροκυκλικη προλινη
SV2009003281A (es) Inhibidores espiro cetona de acetil-coa carboxilasa.0
CR8595A (es) Inhibidor del dipeptidil-peptidasa
AR091023A1 (es) Inhibidores del nampt
ECSP12012161A (es) Compuestos en calidad de antagonistas de Bradiquinina-b1
AR066348A1 (es) Inhibidores de las iap
CO6220972A2 (es) Derivados de 6-amino dihidropurin -8-ona utiles como agentes terapeuticos y/o preventivos para el tratamiento de enfermedades alergicas, virales o cancer
NO20021399L (no) Kazolinderivater og deres anvendelse som farmasöyter
AR119010A1 (es) Compuestos, composiciones y métodos de uso
UY29963A1 (es) Compuestos terapéuticos: piridinas y pirazinas como andamios
UY28855A1 (es) Derivados de la 1-amino-ftalazina su preparación y su uso en terapia
AR074648A1 (es) Derivados de isoxazolina que poseen un anillo de cuatro miembros como grupo terminal, intermediarios de sintesis, composiciones biocidas que los contienen y metodos para combatir y controlar dichas plagas
ECSP10010359A (es) Derivados bicíclicos de carboxamidas aza-bicíclicas, su preparación y su aplicación terapéutica
AR092147A1 (es) Composiciones liquidas mejoradas que contienen inhibidores de ureasa y alcoholes aril alquilicos y metodos de elaboracion y uso de las mismas
BR112014010813A2 (pt) n-(tetrazol-5-il)-aril-carboxamidas e n-(triazol-5-il)-aril-carboxamidas substituídas em 5-fenilo e sua utilização como herbicidas
CY1109247T1 (el) Αναστολεις πρωτεασης hiv σουλφοναμιδιου 2-αμινο-βενζοξαζολης ευρεως φασματος
CY1108073T1 (el) Αναστολεις της hiv πρωτεασης ευρεως φασματος σουλφοναμιδιου 2-(υποκατεστημενο-αμινο) βενζοθειαζολης
AR070273A1 (es) Derivados de heteroarilamida diazepinopirimidinona sustituidos utiles en el tratamiento y/o prevencion de enfermedades neurodegenerativas y otras, provocadas por la actividad anormal de quinasas gsk3beta, medicamentos que los contienen y proceso de preparacion e intermediarios.
BR112015013485A2 (pt) derivados de benzilsulfonamida como moduladores de rorc
AR066605A1 (es) Derivados de heteroarilamida pirimidona

Legal Events

Date Code Title Description
FC Application refused