AU2007293187A1 - A method for detecting nucleic acids - Google Patents

A method for detecting nucleic acids Download PDF

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Publication number
AU2007293187A1
AU2007293187A1 AU2007293187A AU2007293187A AU2007293187A1 AU 2007293187 A1 AU2007293187 A1 AU 2007293187A1 AU 2007293187 A AU2007293187 A AU 2007293187A AU 2007293187 A AU2007293187 A AU 2007293187A AU 2007293187 A1 AU2007293187 A1 AU 2007293187A1
Authority
AU
Australia
Prior art keywords
nucleic acid
target nucleic
probe
target
mirna
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2007293187A
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English (en)
Inventor
Esther Meiri
Gilad Shlomit
Noga Yerushalmi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rosetta Genomics Ltd
Original Assignee
Rosetta Genomics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rosetta Genomics Ltd filed Critical Rosetta Genomics Ltd
Publication of AU2007293187A1 publication Critical patent/AU2007293187A1/en
Abandoned legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6832—Enhancement of hybridisation reaction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6853—Nucleic acid amplification reactions using modified primers or templates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pathology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
AU2007293187A 2006-06-30 2007-06-29 A method for detecting nucleic acids Abandoned AU2007293187A1 (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US80640406P 2006-06-30 2006-06-30
US60/806,404 2006-06-30
US82237106P 2006-08-14 2006-08-14
US60/822,371 2006-08-14
US85045506P 2006-10-10 2006-10-10
US60/850,455 2006-10-10
US87109506P 2006-12-20 2006-12-20
US60/871,095 2006-12-20
PCT/IB2007/003732 WO2008029295A2 (en) 2006-06-30 2007-06-29 A method for detecting nucleic acids

Publications (1)

Publication Number Publication Date
AU2007293187A1 true AU2007293187A1 (en) 2008-03-13

Family

ID=39157641

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2007293187A Abandoned AU2007293187A1 (en) 2006-06-30 2007-06-29 A method for detecting nucleic acids

Country Status (8)

Country Link
US (2) US9115389B2 (cg-RX-API-DMAC7.html)
EP (1) EP2038432B1 (cg-RX-API-DMAC7.html)
JP (1) JP2010500867A (cg-RX-API-DMAC7.html)
AU (1) AU2007293187A1 (cg-RX-API-DMAC7.html)
CA (1) CA2672246A1 (cg-RX-API-DMAC7.html)
DK (1) DK2038432T3 (cg-RX-API-DMAC7.html)
IL (1) IL196241A0 (cg-RX-API-DMAC7.html)
WO (1) WO2008029295A2 (cg-RX-API-DMAC7.html)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2479286B1 (en) 2006-01-05 2013-11-13 The Ohio State University Research Foundation MicroRNA-based methods and compositions for the diagnosis and treatment of solid cancers
CA2646051A1 (en) 2006-03-20 2007-09-27 Carlo M. Croce Microrna fingerprints during human megakaryocytopoiesis
US20100273172A1 (en) 2007-03-27 2010-10-28 Rosetta Genomics Ltd. Micrornas expression signature for determination of tumors origin
US8802599B2 (en) * 2007-03-27 2014-08-12 Rosetta Genomics, Ltd. Gene expression signature for classification of tissue of origin of tumor samples
US9096906B2 (en) 2007-03-27 2015-08-04 Rosetta Genomics Ltd. Gene expression signature for classification of tissue of origin of tumor samples
WO2009018303A2 (en) 2007-07-31 2009-02-05 The Ohio State University Research Foundation Methods for reverting methylation by targeting dnmt3a and dnmt3b
CA2695514A1 (en) 2007-08-03 2009-02-12 The Ohio State University Research Foundation Ultraconserved regions encoding ncrnas
AU2008288806B2 (en) 2007-08-22 2014-11-27 The Ohio State University Research Foundation Methods and compositions for inducing deregulation of EphA7 and Erk phosphorylation in human acute leukemias
EP2315852B1 (en) 2008-07-18 2015-01-28 Qiagen GmbH Method for determining the origin of a sample
EP2853601B1 (en) 2008-07-18 2016-09-21 TrovaGene, Inc. Methods for PCR-based detection of "ultra short" nucleic acid sequences
US20110143959A1 (en) * 2008-08-13 2011-06-16 Rosetta Genomics Ltd. Compositions and methods for determining the prognosis of bladder urothelial cancer
WO2010058393A2 (en) * 2008-11-20 2010-05-27 Rosetta Genomics Ltd. Compositions and methods for the prognosis of colon cancer
CN102292456A (zh) * 2008-12-05 2011-12-21 俄亥俄州立大学研究基金会 用于诊断和治疗卵巢癌的基于microRNA 的方法和组合物
WO2010103522A1 (en) * 2009-03-10 2010-09-16 Rosetta Genomics Ltd. Method for detection of nucleic acid sequences
WO2010133562A1 (en) * 2009-05-18 2010-11-25 INSERM (Institut National de la Santé et de la Recherche Médicale) A method for predicting the responsiveness of a patient to a treatment with an anti-cd20 antibody and a method for diagnosing rheumatoid arthritis
EP2504452A4 (en) 2009-11-23 2014-06-11 Univ Ohio State Res Found MATERIALS AND METHODS FOR INFLUENCING GROWTH, MIGRATION AND INVASION OF TUMOR CELLS
WO2011156434A2 (en) * 2010-06-07 2011-12-15 Firefly Bioworks, Inc. Nucleic acid detection and quantification by post-hybridization labeling and universal encoding
US9163329B2 (en) 2010-11-12 2015-10-20 Agilent Technologies, Inc. RNA labeling method
CA2816603A1 (en) 2010-11-12 2012-05-18 The Ohio State University Research Foundation Materials and methods related to microrna-21, mismatch repair, and colorectal cancer
BR112013011942A2 (pt) 2010-11-15 2016-11-01 Univ Michigan formulação, forma de dosagem de droga para administração transmucosa oral, sistema transmucoso de fornecimento de droga, método de tratamento e profilaxia de uma doença ou distúrbio, método de tratamento, formulação, método para tratamento ou prevenção de carcinoma de célula escamosa de cabeça e pescoço (hnscc), método para quimioprevenção de um câncer oral ou condição pré-cancerosa, método para aumentar a concentração de uma composição de retinida, método de tratamento e profilaxia de uma doença ou condição, método de ratamento de um sujeito apresentando uma condição médica sintomática, método de tratamento de um câncer oral ou condição pré-cancerosa num paciente, método para fazer um sistema de fornecimento de droga bucal, método para aumentar a liberação e permeação de uma composição de retinida.
US8703653B2 (en) 2011-02-18 2014-04-22 NVS Technologies, Inc. Quantitative, highly multiplexed detection of nucleic acids
US9631236B2 (en) 2011-05-24 2017-04-25 Rosetta Genomics Ltd. Methods and compositions for determining heart failure or a risk of heart failure
HK1197273A1 (en) 2011-10-14 2015-01-09 The Ohio State University Methods and materials related to ovarian cancer
SG11201402341QA (en) * 2011-11-17 2014-06-27 Nvs Technologies Inc Quantitative, highly multiplexed detection of nucleic acids
US9481885B2 (en) 2011-12-13 2016-11-01 Ohio State Innovation Foundation Methods and compositions related to miR-21 and miR-29a, exosome inhibition, and cancer metastasis
US8859202B2 (en) 2012-01-20 2014-10-14 The Ohio State University Breast cancer biomarker signatures for invasiveness and prognosis
CA2867144C (en) 2012-03-27 2019-07-02 Ventana Medical Systems, Inc. Signaling conjugates and methods of use
JP2015530113A (ja) * 2012-09-28 2015-10-15 セファイド マイクロｒｎａ多重アッセイのための２プライマーｐｃｒ
ES2749463T3 (es) 2012-11-02 2020-03-20 Life Technologies Corp Captura, detección y cuantificación de ARN pequeño
KR101922125B1 (ko) 2012-11-29 2018-11-26 삼성전자주식회사 표적 핵산을 표지하는 방법
US10434174B2 (en) 2014-06-09 2019-10-08 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Combination therapies using platinum agents and agents that target tumor-associated stroma or tumor cells
US11034757B2 (en) 2014-06-09 2021-06-15 Biomed Valley Discoveries, Inc. Combination therapies using agents that target tumor-associated stroma or tumor cells and tumor vasculature
WO2015191610A2 (en) 2014-06-09 2015-12-17 Biomed Valley Discoveries, Inc. Combination therapies using agents that target tumor-associated stroma or tumor cells and other pathways
WO2015191590A2 (en) 2014-06-09 2015-12-17 Biomed Valley Discoveries, Inc. Combination therapies targeting tumor-associated stroma or tumor cells and microtubules
WO2015191615A2 (en) 2014-06-09 2015-12-17 Biomed Valley Discoveries, Inc. Combination therapies using agents that target tumor-associated stroma or tumor cells and alkylating agents
US10758614B2 (en) 2014-06-09 2020-09-01 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services National Institutes Of Health Combination therapies targeting tumor-associated stroma or tumor cells and topoisomerase
US10758613B2 (en) 2014-06-09 2020-09-01 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services National Intstitutes Of Health Combination therapies using anti-metabolites and agents that target tumor-associated stroma or tumor cells
CN107250382A (zh) * 2015-02-17 2017-10-13 生物辐射实验室股份有限公司 使用分裂循环扩增的小核酸定量
US10563250B2 (en) 2015-03-13 2020-02-18 Life Technologies Corporation Methods, compositions and kits for small RNA capture, detection and quantification
EP3070178B1 (en) 2015-03-20 2020-02-12 Albert-Ludwigs-Universität Freiburg Method for diagnosing breast cancer
CN113005181B (zh) * 2020-12-22 2022-01-18 广州血康陆道培生物技术有限公司 一种基于茎环法的多重荧光定量pcr检测非编码小rna的引物组
JP7743246B2 (ja) * 2021-09-29 2025-09-24 栄研化学株式会社 標的ｒｎａ検出方法及びプローブキット

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4766064A (en) * 1984-05-07 1988-08-23 Allied Corporation Displacement polynucleotide assay employing polyether and diagnostic kit
US5430136A (en) * 1984-10-16 1995-07-04 Chiron Corporation Oligonucleotides having selectably cleavable and/or abasic sites
US5034506A (en) * 1985-03-15 1991-07-23 Anti-Gene Development Group Uncharged morpholino-based polymers having achiral intersubunit linkages
US5235033A (en) 1985-03-15 1993-08-10 Anti-Gene Development Group Alpha-morpholino ribonucleoside derivatives and polymers thereof
ATE88761T1 (de) 1986-01-10 1993-05-15 Amoco Corp Kompetitiver homogener test.
US5124246A (en) 1987-10-15 1992-06-23 Chiron Corporation Nucleic acid multimers and amplified nucleic acid hybridization assays using same
US5359100A (en) 1987-10-15 1994-10-25 Chiron Corporation Bifunctional blocked phosphoramidites useful in making nucleic acid mutimers
US5681697A (en) * 1993-12-08 1997-10-28 Chiron Corporation Solution phase nucleic acid sandwich assays having reduced background noise and kits therefor
US5597909A (en) 1994-08-25 1997-01-28 Chiron Corporation Polynucleotide reagents containing modified deoxyribose moieties, and associated methods of synthesis and use
US5580731A (en) * 1994-08-25 1996-12-03 Chiron Corporation N-4 modified pyrimidine deoxynucleotides and oligonucleotide probes synthesized therewith
US5681702A (en) 1994-08-30 1997-10-28 Chiron Corporation Reduction of nonspecific hybridization by using novel base-pairing schemes
US5780233A (en) * 1996-06-06 1998-07-14 Wisconsin Alumni Research Foundation Artificial mismatch hybridization
US6506559B1 (en) 1997-12-23 2003-01-14 Carnegie Institute Of Washington Genetic inhibition by double-stranded RNA
US6080868A (en) 1998-01-23 2000-06-27 The Perkin-Elmer Corporation Nitro-substituted non-fluorescent asymmetric cyanine dye compounds
US6270973B1 (en) * 1998-03-13 2001-08-07 Promega Corporation Multiplex method for nucleic acid detection
US6235480B1 (en) * 1998-03-13 2001-05-22 Promega Corporation Detection of nucleic acid hybrids
AUPP249298A0 (en) 1998-03-20 1998-04-23 Ag-Gene Australia Limited Synthetic genes and genetic constructs comprising same I
GB9817078D0 (en) * 1998-08-05 1998-10-07 Habib Nagy A Device for liver surgery
AU3274500A (en) 1999-03-18 2000-10-09 Exiqon A/S Detection of mutations in genes by specific lna primers
EP1130113A1 (en) * 2000-02-15 2001-09-05 Johannes Petrus Schouten Multiplex ligation dependent amplification assay
EP1130119A1 (en) 2000-02-17 2001-09-05 Amsterdam Support Diagnostics B.V. Reducing background in hybridisation reactions
US6653081B2 (en) * 2000-06-12 2003-11-25 Virologic, Inc. Methods for monitoring antiretroviral therapy and guiding therapeutic decision in the treatment of HIV/AIDS
US20020102557A1 (en) * 2001-01-31 2002-08-01 Gentile-Davey Maria C. Self -complementary molecular probe
EP1280090A1 (de) 2001-07-27 2003-01-29 iSenseIt AG Verfahren zur Konfiguration paralleler Nukleinsäureanalyseverfahren
ATE354370T1 (de) * 2001-09-27 2007-03-15 Gangagen Inc Inaktivierte immunogene bakterielle ganzzell- zusammensetzungen
KR20030042581A (ko) 2001-11-23 2003-06-02 삼성전자주식회사 대립유전자－특이적 프라이머 연장반응에서 프라이머간의 식별을 증가시키는 방법
WO2003078450A2 (en) 2002-03-11 2003-09-25 Epoch Biosciences, Inc. Negatively charged minor groove binders
JP2004024247A (ja) * 2002-04-30 2004-01-29 Internatl Reagents Corp 遺伝子変異検出用プローブ及び遺伝子変異検出方法
US6797464B2 (en) * 2002-07-10 2004-09-28 University Of Massachusetts Detection of drug-resistant human immunodeficiency virus
DK1620544T3 (en) * 2003-04-17 2019-01-14 Alnylam Pharmaceuticals Inc MODIFIED iRNA AGENTS
US7745117B2 (en) * 2003-06-06 2010-06-29 The Regents Of The University Of Michigan Methods for incorporating non-perfectly matched oligonucleotides into target-specific hybridization sequences
EP1649053A4 (en) * 2003-06-18 2006-10-18 Chinese Nat Human Genome Ct Sh CHARACTERIZATION OF THE EARLY LEVELS OF THE VIRUS OF HEAVY ACUTE RESPIRATORY SYNDROME (SARS) AND USES THEREOF
EP1636337A4 (en) * 2003-06-20 2007-07-04 Illumina Inc METHODS AND COMPOSITIONS USEFUL FOR THE AMPLIFICATION AND GENOTYPING OF THE GENOME
KR100936908B1 (ko) 2003-07-18 2010-01-18 삼성전자주식회사 전계발광 디바이스의 박막 트랜지스터, 이를 이용한전계발광 디바이스 및 이의 제조 방법
US7888497B2 (en) * 2003-08-13 2011-02-15 Rosetta Genomics Ltd. Bioinformatically detectable group of novel regulatory oligonucleotides and uses thereof
EP1687451A2 (en) * 2003-09-30 2006-08-09 Applera Corporation Methods and kits for hybridizing multiple probe panels to nucleic acid samples
US20050182005A1 (en) 2004-02-13 2005-08-18 Tuschl Thomas H. Anti-microRNA oligonucleotide molecules
US7127355B2 (en) 2004-03-05 2006-10-24 Perlegen Sciences, Inc. Methods for genetic analysis
US8192937B2 (en) * 2004-04-07 2012-06-05 Exiqon A/S Methods for quantification of microRNAs and small interfering RNAs
AU2005248149A1 (en) * 2004-05-26 2005-12-08 Rosetta Genomics Ltd. Viral and viral associated miRNAs and uses thereof
US7825229B2 (en) * 2005-03-25 2010-11-02 Rosetta Genomics Ltd. Lung cancer-related nucleic acids
US7642348B2 (en) * 2004-10-04 2010-01-05 Rosetta Genomics Ltd Prostate cancer-related nucleic acids
KR100682923B1 (ko) 2005-01-22 2007-02-15 삼성전자주식회사 허들 ｄｎａ와 인공적인 미스매치가 도입된 프로브를이용한 단일 염기 미스매치에 대한 구별 향상 방법
WO2006126040A1 (en) 2005-05-25 2006-11-30 Rosetta Genomics Ltd. Bacterial and bacterial associated mirnas and uses thereof
CN100510105C (zh) 2006-02-08 2009-07-08 博奥生物有限公司 一种序列特异性寡核苷酸探针及其应用
KR100813263B1 (ko) 2006-08-17 2008-03-13 삼성전자주식회사 표적 서열 검출용 프로브 설계 방법 및 상기 프로브를이용한 표적 서열 검출 방법

Also Published As

Publication number Publication date
US20150376695A1 (en) 2015-12-31
EP2038432A4 (en) 2012-05-30
DK2038432T3 (en) 2017-04-03
EP2038432A2 (en) 2009-03-25
WO2008029295A2 (en) 2008-03-13
CA2672246A1 (en) 2008-03-13
EP2038432B1 (en) 2017-02-08
JP2010500867A (ja) 2010-01-14
US20100047784A1 (en) 2010-02-25
WO2008029295A3 (en) 2011-05-12
US9115389B2 (en) 2015-08-25
IL196241A0 (en) 2009-09-22

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