AU2007250213B2 - Phenylamino-benzoxazole substituted carboxylic acids, method for their production and use thereof as medicaments - Google Patents

Phenylamino-benzoxazole substituted carboxylic acids, method for their production and use thereof as medicaments Download PDF

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Publication number
AU2007250213B2
AU2007250213B2 AU2007250213A AU2007250213A AU2007250213B2 AU 2007250213 B2 AU2007250213 B2 AU 2007250213B2 AU 2007250213 A AU2007250213 A AU 2007250213A AU 2007250213 A AU2007250213 A AU 2007250213A AU 2007250213 B2 AU2007250213 B2 AU 2007250213B2
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AU
Australia
Prior art keywords
inhibitors
agonists
compound
formula
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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AU2007250213A
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English (en)
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AU2007250213A1 (en
Inventor
Stefan Bartoschek
Elisabeth Defossa
Viktoria Drosou
Markus Follmann
Guido Haschke
Andreas Herling
Gerhard Hessler
Thomas Klabunde
Siegfried Stengelin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
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Sanofi Aventis France
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Filing date
Publication date
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Publication of AU2007250213A1 publication Critical patent/AU2007250213A1/en
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Publication of AU2007250213B2 publication Critical patent/AU2007250213B2/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/423—Oxazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU2007250213A 2006-05-11 2007-04-30 Phenylamino-benzoxazole substituted carboxylic acids, method for their production and use thereof as medicaments Expired - Fee Related AU2007250213B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102006021878A DE102006021878A1 (de) 2006-05-11 2006-05-11 Phenylamino-benzoxazol substituierte Carbonsäuren, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE102006021878.7 2006-05-11
PCT/EP2007/003806 WO2007131622A1 (de) 2006-05-11 2007-04-30 Phenylamino-benzoxazol substituierte carbonsäuren, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Publications (2)

Publication Number Publication Date
AU2007250213A1 AU2007250213A1 (en) 2007-11-22
AU2007250213B2 true AU2007250213B2 (en) 2013-04-11

Family

ID=38371048

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2007250213A Expired - Fee Related AU2007250213B2 (en) 2006-05-11 2007-04-30 Phenylamino-benzoxazole substituted carboxylic acids, method for their production and use thereof as medicaments

Country Status (30)

Country Link
US (2) US20090149519A1 (OSRAM)
EP (1) EP2024347B1 (OSRAM)
JP (1) JP2009536629A (OSRAM)
KR (1) KR20090006846A (OSRAM)
CN (1) CN101437805B (OSRAM)
AR (1) AR060990A1 (OSRAM)
AU (1) AU2007250213B2 (OSRAM)
BR (1) BRPI0711448A2 (OSRAM)
CA (1) CA2651660A1 (OSRAM)
CO (1) CO6241107A2 (OSRAM)
CY (1) CY1113177T1 (OSRAM)
DE (1) DE102006021878A1 (OSRAM)
DK (1) DK2024347T3 (OSRAM)
ES (1) ES2391203T3 (OSRAM)
HR (1) HRP20120829T1 (OSRAM)
IL (1) IL195179A0 (OSRAM)
MA (1) MA30402B1 (OSRAM)
MX (1) MX2008014102A (OSRAM)
MY (1) MY148258A (OSRAM)
NO (1) NO20085068L (OSRAM)
NZ (1) NZ572692A (OSRAM)
PL (1) PL2024347T3 (OSRAM)
PT (1) PT2024347E (OSRAM)
RS (1) RS52450B (OSRAM)
RU (1) RU2434003C2 (OSRAM)
SI (1) SI2024347T1 (OSRAM)
TW (1) TW200812987A (OSRAM)
UY (1) UY30338A1 (OSRAM)
WO (1) WO2007131622A1 (OSRAM)
ZA (1) ZA200808490B (OSRAM)

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US7465804B2 (en) 2005-05-20 2008-12-16 Amgen Inc. Compounds, pharmaceutical compositions and methods for their use in treating metabolic disorders
EP1924546A1 (en) 2005-09-14 2008-05-28 Amgen, Inc Conformationally constrained 3- (4-hydroxy-phenyl) - substituted-propanoic acids useful for treating metabolic disorders
EP2061760A1 (en) 2006-09-07 2009-05-27 Amgen, Inc Benzo-fused compounds for use in treating metabolic disorders
WO2008030520A1 (en) 2006-09-07 2008-03-13 Amgen Inc. Heterocyclic gpr40 modulators
JP2010524932A (ja) 2007-04-16 2010-07-22 アムジエン・インコーポレーテツド 置換ビフェニルフェノキシ−、チオフェニル−及びアミノフェニルプロパン酸ｇｐｒ４０調節物質
EP2025674A1 (de) 2007-08-15 2009-02-18 sanofi-aventis Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
KR20100090249A (ko) 2007-10-10 2010-08-13 암젠 인크 치환된 비페닐 ｇｒｐ４０ 조절제
WO2009145829A1 (en) * 2008-04-01 2009-12-03 University Of Massachusetts Type iii secretion inhibitors, analogs and uses thereof
US8450522B2 (en) 2008-03-06 2013-05-28 Amgen Inc. Conformationally constrained carboxylic acid derivatives useful for treating metabolic disorders
ES2450567T3 (es) 2008-10-15 2014-03-25 Amgen, Inc Moduladores de GPR40 espirocíclicos
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
US8450350B2 (en) 2010-05-05 2013-05-28 Infinity Pharmaceuticals, Inc. Triazoles as inhibitors of fatty acid synthase
EP3159331A1 (en) 2010-05-05 2017-04-26 Infinity Pharmaceuticals, Inc. Tetrazolones as inhibitors of fatty acid synthase
EP2582709B1 (de) 2010-06-18 2018-01-24 Sanofi Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
WO2012030165A2 (ko) 2010-08-31 2012-03-08 서울대학교산학협력단 P P A R δ 활성물질의 태자재프로그래밍용도
EP2683704B1 (de) 2011-03-08 2014-12-17 Sanofi Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
US8710050B2 (en) 2011-03-08 2014-04-29 Sanofi Di and tri- substituted oxathiazine derivatives, method for the production, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
WO2012120052A1 (de) 2011-03-08 2012-09-13 Sanofi Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
US8871758B2 (en) 2011-03-08 2014-10-28 Sanofi Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof
EP2683705B1 (de) 2011-03-08 2015-04-22 Sanofi Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013039140A1 (ja) * 2011-09-14 2013-03-21 第一三共株式会社 縮合へテロ環誘導体
EP2760862B1 (en) 2011-09-27 2015-10-21 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
CN105142621A (zh) 2012-10-24 2015-12-09 国家健康科学研究所 用于预防或治疗糖尿病和促进β-细胞存活的TPL2激酶抑制剂
US9957219B2 (en) 2013-12-04 2018-05-01 Merck Sharp & Dohme Corp. Antidiabetic bicyclic compounds
US10059667B2 (en) 2014-02-06 2018-08-28 Merck Sharp & Dohme Corp. Antidiabetic compounds
WO2016151018A1 (en) 2015-03-24 2016-09-29 INSERM (Institut National de la Santé et de la Recherche Médicale) Method and pharmaceutical composition for use in the treatment of diabetes
CN111712494A (zh) 2018-02-13 2020-09-25 吉利德科学公司 Pd-1/pd-l1抑制剂
EP4600247A3 (en) 2018-04-19 2025-11-19 Gilead Sciences, Inc. Pd-1/pd-l1 inhibitors
KR20230159715A (ko) 2018-07-13 2023-11-21 길리애드 사이언시즈, 인코포레이티드 Pd-1/pd-l1 억제제
AU2019366355B2 (en) 2018-10-24 2022-10-13 Gilead Sciences, Inc. PD-1/PD-L1 inhibitors
SG11202107080VA (en) 2019-01-11 2021-07-29 Naegis Pharmaceuticals Inc Leukotriene synthesis inhibitors

Citations (4)

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DE2450042A1 (de) * 1973-10-23 1975-04-24 Lilly Industries Ltd Neue benzoxazolderivate und verfahren zu ihrer herstellung
US4025637A (en) * 1973-10-23 1977-05-24 Lilly Industries, Ltd. 2,5 OR 2,6 Disubstituted benzoxazoles
WO2000049005A1 (en) * 1999-02-16 2000-08-24 Aventis Pharma Limited Bicyclic compounds and their use as integrin receptor ligands
WO2005070906A1 (en) * 2004-01-21 2005-08-04 Novartis Ag Organic compounds

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US5296486A (en) * 1991-09-24 1994-03-22 Boehringer Ingelheim Pharmaceuticals, Inc. Leukotriene biosynthesis inhibitors
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WO2000005223A2 (en) * 1998-07-23 2000-02-03 Astrazeneca Ab Heterocyclic derivatives and their use as integrin inhibitors
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Patent Citations (4)

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Publication number Priority date Publication date Assignee Title
DE2450042A1 (de) * 1973-10-23 1975-04-24 Lilly Industries Ltd Neue benzoxazolderivate und verfahren zu ihrer herstellung
US4025637A (en) * 1973-10-23 1977-05-24 Lilly Industries, Ltd. 2,5 OR 2,6 Disubstituted benzoxazoles
WO2000049005A1 (en) * 1999-02-16 2000-08-24 Aventis Pharma Limited Bicyclic compounds and their use as integrin receptor ligands
WO2005070906A1 (en) * 2004-01-21 2005-08-04 Novartis Ag Organic compounds

Also Published As

Publication number Publication date
MY148258A (en) 2013-03-29
EP2024347A1 (de) 2009-02-18
MX2008014102A (es) 2008-11-14
NO20085068L (no) 2009-02-04
RS52450B (sr) 2013-02-28
US20090149519A1 (en) 2009-06-11
CA2651660A1 (en) 2007-11-22
CN101437805A (zh) 2009-05-20
JP2009536629A (ja) 2009-10-15
RU2434003C2 (ru) 2011-11-20
RU2008148838A (ru) 2010-06-20
KR20090006846A (ko) 2009-01-15
WO2007131622A1 (de) 2007-11-22
CY1113177T1 (el) 2016-04-13
MA30402B1 (fr) 2009-05-04
DE102006021878A1 (de) 2007-11-15
BRPI0711448A2 (pt) 2011-11-08
PT2024347E (pt) 2012-10-09
NZ572692A (en) 2011-03-31
ZA200808490B (en) 2009-10-28
TW200812987A (en) 2008-03-16
HRP20120829T1 (hr) 2012-11-30
AU2007250213A1 (en) 2007-11-22
CN101437805B (zh) 2012-05-30
PL2024347T3 (pl) 2013-01-31
DK2024347T3 (da) 2012-10-29
US20130303578A1 (en) 2013-11-14
US8748465B2 (en) 2014-06-10
IL195179A0 (en) 2009-08-03
HK1131978A1 (en) 2010-02-12
SI2024347T1 (sl) 2012-11-30
ES2391203T3 (es) 2012-11-22
CO6241107A2 (es) 2011-01-20
UY30338A1 (es) 2008-01-02
AR060990A1 (es) 2008-07-30
EP2024347B1 (de) 2012-08-01

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MK25 Application lapsed reg. 22.2i(2) - failure to pay acceptance fee