AU2007248950B2 - 2-pyridone derivatives for the treatment of disease or condition in which inhibition of neutrophil elastase activity is beneficial. - Google Patents
2-pyridone derivatives for the treatment of disease or condition in which inhibition of neutrophil elastase activity is beneficial. Download PDFInfo
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- AU2007248950B2 AU2007248950B2 AU2007248950A AU2007248950A AU2007248950B2 AU 2007248950 B2 AU2007248950 B2 AU 2007248950B2 AU 2007248950 A AU2007248950 A AU 2007248950A AU 2007248950 A AU2007248950 A AU 2007248950A AU 2007248950 B2 AU2007248950 B2 AU 2007248950B2
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- Prior art keywords
- alkyl
- compound
- ring
- phenyl
- formula
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Classifications
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
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- General Health & Medical Sciences (AREA)
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- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Otolaryngology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US79878606P | 2006-05-08 | 2006-05-08 | |
| US60/798,786 | 2006-05-08 | ||
| PCT/SE2007/000441 WO2007129962A1 (en) | 2006-05-08 | 2007-05-07 | 2-pyridone derivatives for the treatment of disease or condition in which inhibition of neutrophil elastase activity is beneficial. |
Publications (2)
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| AU2007248950A1 AU2007248950A1 (en) | 2007-11-15 |
| AU2007248950B2 true AU2007248950B2 (en) | 2010-11-18 |
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| Application Number | Title | Priority Date | Filing Date |
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| AU2007248950A Ceased AU2007248950B2 (en) | 2006-05-08 | 2007-05-07 | 2-pyridone derivatives for the treatment of disease or condition in which inhibition of neutrophil elastase activity is beneficial. |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US7998984B2 (OSRAM) |
| EP (1) | EP2018375B1 (OSRAM) |
| JP (1) | JP2009536196A (OSRAM) |
| KR (1) | KR20090017573A (OSRAM) |
| CN (1) | CN101490033A (OSRAM) |
| AR (1) | AR060875A1 (OSRAM) |
| AT (1) | ATE459615T1 (OSRAM) |
| AU (1) | AU2007248950B2 (OSRAM) |
| BR (1) | BRPI0711357A2 (OSRAM) |
| CA (1) | CA2649813A1 (OSRAM) |
| CL (1) | CL2007001282A1 (OSRAM) |
| DE (1) | DE602007005120D1 (OSRAM) |
| ES (1) | ES2339607T3 (OSRAM) |
| IL (1) | IL194948A0 (OSRAM) |
| MX (1) | MX2008013836A (OSRAM) |
| NO (1) | NO20084872L (OSRAM) |
| TW (1) | TW200808763A (OSRAM) |
| UY (1) | UY30328A1 (OSRAM) |
| WO (1) | WO2007129962A1 (OSRAM) |
| ZA (1) | ZA200809024B (OSRAM) |
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| SE0302486D0 (sv) * | 2003-09-18 | 2003-09-18 | Astrazeneca Ab | Novel compounds |
| TW200808771A (en) | 2006-05-08 | 2008-02-16 | Astrazeneca Ab | Novel compounds II |
| TW200808763A (en) | 2006-05-08 | 2008-02-16 | Astrazeneca Ab | Novel compounds I |
| WO2008036379A2 (en) * | 2006-09-21 | 2008-03-27 | Activx Biosciences, Inc. | Serine hydrolase inhibitors |
| DE102007031397A1 (de) * | 2007-07-05 | 2009-01-08 | D2O Bioscience Group Ltd. | Verwendung von Deuteriumoxid zur Behandlung von Virus-basierten Erkrankungen der Haut |
| JP2011502982A (ja) | 2007-11-06 | 2011-01-27 | アストラゼネカ・アクチエボラーグ | 好中球エラスターゼの阻害剤としてのある種の２−ピラジノン誘導体およびその使用 |
| DK2110132T3 (da) | 2008-04-20 | 2014-04-28 | D2 Bioscience Group Ltd | Anvendelse af deuteriumoxid som elastasehæmmer |
| DE102009003942A1 (de) * | 2009-01-07 | 2010-07-08 | D2O Biosience Group Ltd., Hamilton | Verwendung von Deuteriumoxid zur Behandlung Virus-basierter Erkrankungen des Auges |
| TW201036957A (en) | 2009-02-20 | 2010-10-16 | Astrazeneca Ab | Novel salt 628 |
| EP2433124B1 (en) * | 2009-05-19 | 2017-03-01 | Vivia Biotech S.L. | Methods for providing personalized medicine tests ex vivo for hematological neoplasms |
| MX2012003644A (es) | 2009-10-02 | 2012-04-30 | Astrazeneca Ab | Compuestos de 2-piridona empleados como inhibidores de la elastasa neutrofila. |
| DE102010030187A1 (de) | 2010-06-16 | 2011-12-22 | Bayer Schering Pharma Aktiengesellschaft | 4-Cyan-2-sulfonylphenyl)pyrazolyl-substituierte Pyridinone und Pyrazinone und ihre Verwendung |
| JP2013177318A (ja) * | 2010-06-30 | 2013-09-09 | Dainippon Sumitomo Pharma Co Ltd | ジヒドロピリミジノン誘導体およびその医薬用途 |
| EP2740728A4 (en) | 2011-08-01 | 2015-04-01 | Sumitomo Dainippon Pharma Co Ltd | URACIL DERIVATIVE AND ITS USE FOR MEDICAL PURPOSES |
| US20140057926A1 (en) | 2012-08-23 | 2014-02-27 | Boehringer Ingelheim International Gmbh | Substituted 4-pyridones and their use as inhibitors of neutrophil elastase activity |
| US9102624B2 (en) | 2012-08-23 | 2015-08-11 | Boehringer Ingelheim International Gmbh | Substituted 4-pyridones and their use as inhibitors of neutrophil elastase activity |
| US20140057920A1 (en) | 2012-08-23 | 2014-02-27 | Boehringer Ingelheim International Gmbh | Substituted 4-pyridones and their use as inhibitors of neutrophil elastase activity |
| US9409870B2 (en) | 2014-12-15 | 2016-08-09 | Chiesi Farmaceutici S.P.A. | Compounds |
| AU2016315360B2 (en) | 2015-09-02 | 2019-09-12 | Glaxosmithkline Intellectual Property (No.2) Limited | Pyridinone dicarboxamide for use as bromodomain inhibitors |
| CN106674098B (zh) * | 2016-12-23 | 2019-07-02 | 中国医科大学 | N-(3-氰基-4-烷氧基苯基)吡啶甲酰胺类化合物及其用途 |
| US11666888B2 (en) | 2018-02-05 | 2023-06-06 | Bio-Rad Laboratories, Inc. | Chromatography resin having an anionic exchange-hydrophobic mixed mode ligand |
| US20220354833A1 (en) | 2019-09-17 | 2022-11-10 | Mereo Biopharma 4 Limited | Alvelestat for use in the treatment of graft rejection, bronchiolitis obliterans syndrome and graft versus host disease |
| DK4106757T3 (da) | 2020-04-16 | 2023-10-23 | Mereo Biopharma 4 Ltd | Fremgangsmåder der involverer neutrofil elastase-inhibitor alvelestat til behandling af luftvejssygdom medieret af alpha-1-antitrypsin-mangel |
| CN118265527A (zh) | 2021-10-20 | 2024-06-28 | 美莱奥生物制药第四有限公司 | 用于治疗纤维化的中性粒细胞弹性蛋白酶抑制剂 |
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- 2007-05-07 US US12/299,879 patent/US7998984B2/en not_active Expired - Fee Related
- 2007-05-07 CL CL2007001282A patent/CL2007001282A1/es unknown
- 2007-05-07 ES ES07748105T patent/ES2339607T3/es active Active
- 2007-05-07 MX MX2008013836A patent/MX2008013836A/es active IP Right Grant
- 2007-05-07 BR BRPI0711357-9A patent/BRPI0711357A2/pt not_active IP Right Cessation
- 2007-05-07 CA CA002649813A patent/CA2649813A1/en not_active Abandoned
- 2007-05-07 WO PCT/SE2007/000441 patent/WO2007129962A1/en not_active Ceased
- 2007-05-07 CN CNA2007800259071A patent/CN101490033A/zh active Pending
- 2007-05-07 UY UY30328A patent/UY30328A1/es not_active Application Discontinuation
- 2007-05-07 KR KR1020087029811A patent/KR20090017573A/ko not_active Ceased
- 2007-05-07 JP JP2009509485A patent/JP2009536196A/ja not_active Withdrawn
- 2007-05-07 AT AT07748105T patent/ATE459615T1/de not_active IP Right Cessation
- 2007-05-07 AU AU2007248950A patent/AU2007248950B2/en not_active Ceased
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- 2007-05-07 DE DE602007005120T patent/DE602007005120D1/de active Active
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- 2008-10-27 IL IL194948A patent/IL194948A0/en unknown
- 2008-11-19 NO NO20084872A patent/NO20084872L/no not_active Application Discontinuation
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Also Published As
| Publication number | Publication date |
|---|---|
| ATE459615T1 (de) | 2010-03-15 |
| WO2007129962A1 (en) | 2007-11-15 |
| CL2007001282A1 (es) | 2008-01-18 |
| DE602007005120D1 (de) | 2010-04-15 |
| EP2018375B1 (en) | 2010-03-03 |
| US20090131486A1 (en) | 2009-05-21 |
| AU2007248950A1 (en) | 2007-11-15 |
| CA2649813A1 (en) | 2007-11-15 |
| IL194948A0 (en) | 2009-08-03 |
| AR060875A1 (es) | 2008-07-16 |
| KR20090017573A (ko) | 2009-02-18 |
| UY30328A1 (es) | 2008-01-02 |
| JP2009536196A (ja) | 2009-10-08 |
| CN101490033A (zh) | 2009-07-22 |
| ZA200809024B (en) | 2010-03-31 |
| ES2339607T3 (es) | 2010-05-21 |
| HK1127599A1 (en) | 2009-10-02 |
| MX2008013836A (es) | 2008-11-10 |
| BRPI0711357A2 (pt) | 2011-09-27 |
| US7998984B2 (en) | 2011-08-16 |
| EP2018375A1 (en) | 2009-01-28 |
| NO20084872L (no) | 2009-02-03 |
| TW200808763A (en) | 2008-02-16 |
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