AU2007248172B2 - Method for treatment of diarrhea-predominant irritable bowel syndrome - Google Patents

Method for treatment of diarrhea-predominant irritable bowel syndrome Download PDF

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Publication number
AU2007248172B2
AU2007248172B2 AU2007248172A AU2007248172A AU2007248172B2 AU 2007248172 B2 AU2007248172 B2 AU 2007248172B2 AU 2007248172 A AU2007248172 A AU 2007248172A AU 2007248172 A AU2007248172 A AU 2007248172A AU 2007248172 B2 AU2007248172 B2 AU 2007248172B2
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AU
Australia
Prior art keywords
crofelemer
ibs
inhibitor
per day
amount
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Active
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AU2007248172A
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English (en)
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AU2007248172A1 (en
Inventor
Robert Blanks
Thomas Neenan
Barry Quart
David Rosenbaum
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Napo Pharmaceuticals Inc
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Napo Pharmaceuticals Inc
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Application filed by Napo Pharmaceuticals Inc filed Critical Napo Pharmaceuticals Inc
Publication of AU2007248172A1 publication Critical patent/AU2007248172A1/en
Application granted granted Critical
Publication of AU2007248172B2 publication Critical patent/AU2007248172B2/en
Priority to AU2013205344A priority Critical patent/AU2013205344B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/38—Clusiaceae, Hypericaceae or Guttiferae (Hypericum or Mangosteen family), e.g. common St. Johnswort
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AU2007248172A 2006-05-01 2007-04-30 Method for treatment of diarrhea-predominant irritable bowel syndrome Active AU2007248172B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2013205344A AU2013205344B2 (en) 2006-05-01 2013-04-11 Method for treatment of diarrhea-predominant irritable bowel syndrome

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US79707406P 2006-05-01 2006-05-01
US60/797,074 2006-05-01
US11/510,152 2006-08-24
US11/510,152 US20070254050A1 (en) 2006-05-01 2006-08-24 Method for treatment of diarrhea-predominant irritable bowel syndrome
PCT/US2007/067725 WO2007130882A2 (en) 2006-05-01 2007-04-30 Method for treatment of diarrhea-predominant irritable bowel syndrome

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2013205344A Division AU2013205344B2 (en) 2006-05-01 2013-04-11 Method for treatment of diarrhea-predominant irritable bowel syndrome

Publications (2)

Publication Number Publication Date
AU2007248172A1 AU2007248172A1 (en) 2007-11-15
AU2007248172B2 true AU2007248172B2 (en) 2013-03-21

Family

ID=38648619

Family Applications (1)

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AU2007248172A Active AU2007248172B2 (en) 2006-05-01 2007-04-30 Method for treatment of diarrhea-predominant irritable bowel syndrome

Country Status (18)

Country Link
US (3) US20070254050A1 (enExample)
EP (1) EP2034844B1 (enExample)
JP (2) JP5384329B2 (enExample)
KR (2) KR101487919B1 (enExample)
AR (1) AR060829A1 (enExample)
AU (1) AU2007248172B2 (enExample)
CA (1) CA2650294C (enExample)
DK (1) DK2034844T3 (enExample)
ES (1) ES2628290T3 (enExample)
MX (2) MX2008013871A (enExample)
NZ (2) NZ595749A (enExample)
PE (1) PE20081569A1 (enExample)
PL (1) PL2034844T3 (enExample)
PT (1) PT2034844T (enExample)
SG (1) SG174025A1 (enExample)
TR (1) TR201708043T4 (enExample)
TW (2) TWI481410B (enExample)
WO (1) WO2007130882A2 (enExample)

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US20070254050A1 (en) 2006-05-01 2007-11-01 Quart Barry D Method for treatment of diarrhea-predominant irritable bowel syndrome
PT2529626T (pt) 2006-05-01 2018-02-27 Napo Pharmaceuticals Inc Composições e métodos para tratamento ou prevenção do cancro do cólon
FR2900823B1 (fr) * 2006-05-15 2009-02-13 Bioprojet Soc Civ Ile Nouvelle forme d'administration du racecadotril.
US8436051B2 (en) 2007-06-08 2013-05-07 Aptalis Pharma Canada Inc. Mesalamine suppository
US8217083B2 (en) * 2007-06-08 2012-07-10 Aptalis Pharma Canada Inc. Mesalamine suppository
US7541384B2 (en) 2007-06-08 2009-06-02 Axcan Pharma Inc. Mesalamine suppository
US20110263478A1 (en) * 2008-09-16 2011-10-27 Simard J Marc Sur1 inhibitors for therapy
JP4565219B2 (ja) * 2008-12-26 2010-10-20 アサヒビール株式会社 ポリフェノール含有顆粒またはポリフェノール含有チュアブル錠剤およびその製造方法
AU2010303577B2 (en) * 2009-10-06 2015-10-22 Napo Pharmaceuticals, Inc. Methods of treating diseases with proanthocyanidin oligomers such as crofelemer
WO2011073950A1 (en) * 2009-12-17 2011-06-23 National University Of Singapore Method of preparing derivatives/oligomers of epicatechin and applications thereof
WO2012058664A1 (en) * 2010-10-31 2012-05-03 Salix Pharmaceuticals, Ltd. Methods and compositions for treating hiv-associated diarrhea
WO2012135702A1 (en) 2011-04-01 2012-10-04 Ocean Spray Cranberries, Inc. Inflammation and immunity treatments
US20140057993A1 (en) * 2011-04-27 2014-02-27 Northshore University Healthsystem Prophylaxis and Treatment of Enteropathogenic Bacterial Infection
WO2013161973A1 (en) * 2012-04-23 2013-10-31 Sucampo Ag Method for treating irritable bowel syndrome with diarrhea
EP2922557B1 (en) 2012-11-21 2017-10-04 KBS Research, LLC Herbal supplements and methods of use thereof
US9717726B2 (en) 2013-03-14 2017-08-01 Maregade Rx, LLC Product and method for treating diarrhea
KR101579688B1 (ko) 2014-07-08 2015-12-24 재단법인 전남생물산업진흥원 좁쌀풀 추출물을 유효성분으로 함유하는 과민성 대장증후군에 의한 내장 통증 억제예방 또는 치료용 약학 조성물
CN104873485B (zh) * 2015-05-08 2019-02-19 中国药科大学 槲皮素治疗与胃肠道应激失调相关疾病的用途
CN107125440A (zh) * 2016-02-29 2017-09-05 湖南晶天科技实业有限公司 一种饲料添加剂肠溶包衣单宁酸及其制备方法以及一种饲料
IT201600122310A1 (it) 2016-12-01 2018-06-01 Sofar Spa Composizione per uso nella terapia di alterazioni dell'intestino
US20180185356A1 (en) 2016-12-23 2018-07-05 Maregade Rx, LLC Low dose product and method for treating diarrhea
EP3592333B1 (en) * 2017-03-06 2024-04-03 Athena Pharmaceutiques SAS A pharmaceutical composition comprising racecadotril and process for preparing the same
AU2018275685B2 (en) 2017-05-31 2025-04-17 Napo Pharmaceuticals, Inc. Methods and compositions for treating bile acid diarrhea, diarrhea associated with small intestine resection or gallbladder removal, and short bowel syndrome
JP2020525407A (ja) * 2017-05-31 2020-08-27 ナポ ファーマシューティカルズ インク．Ｎａｐｏ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． 先天性下痢障害を治療するための方法及び組成物
KR20220046544A (ko) * 2019-06-12 2022-04-14 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 답즙산 설사를 치료하는 방법
CN113975412B (zh) * 2021-12-30 2022-04-05 北京赛尔富森生物科技有限公司 一种评价轮状病毒疫苗有效性的方法

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Also Published As

Publication number Publication date
DK2034844T3 (en) 2017-06-06
TWI481410B (zh) 2015-04-21
TW200810772A (en) 2008-03-01
TWI574694B (zh) 2017-03-21
AU2007248172A1 (en) 2007-11-15
NZ595749A (en) 2013-11-29
PE20081569A1 (es) 2009-01-14
EP2034844A2 (en) 2009-03-18
PT2034844T (pt) 2017-06-26
WO2007130882A2 (en) 2007-11-15
TW201434475A (zh) 2014-09-16
US9980938B2 (en) 2018-05-29
PL2034844T3 (pl) 2017-09-29
EP2034844B1 (en) 2017-03-22
AR060829A1 (es) 2008-07-16
MX2008013871A (es) 2009-01-07
SG174025A1 (en) 2011-09-29
WO2007130882A3 (en) 2008-02-07
TR201708043T4 (tr) 2018-11-21
JP5820440B2 (ja) 2015-11-24
US20070254050A1 (en) 2007-11-01
KR101537361B1 (ko) 2015-07-17
KR101487919B1 (ko) 2015-02-03
CA2650294C (en) 2019-01-22
MX382400B (es) 2025-03-13
KR20090009291A (ko) 2009-01-22
JP2014012695A (ja) 2014-01-23
KR20130063552A (ko) 2013-06-14
US20120189720A1 (en) 2012-07-26
JP2009535417A (ja) 2009-10-01
US8846113B2 (en) 2014-09-30
NZ609344A (en) 2014-08-29
US20150050338A1 (en) 2015-02-19
CA2650294A1 (en) 2007-11-15
ES2628290T3 (es) 2017-08-02
EP2034844A4 (en) 2010-11-17
JP5384329B2 (ja) 2014-01-08

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