AU2007224229B2 - Dosage forms for administering combinations of drugs - Google Patents
Dosage forms for administering combinations of drugs Download PDFInfo
- Publication number
- AU2007224229B2 AU2007224229B2 AU2007224229A AU2007224229A AU2007224229B2 AU 2007224229 B2 AU2007224229 B2 AU 2007224229B2 AU 2007224229 A AU2007224229 A AU 2007224229A AU 2007224229 A AU2007224229 A AU 2007224229A AU 2007224229 B2 AU2007224229 B2 AU 2007224229B2
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- drug
- pharmaceutical composition
- dosage form
- patient
- nsaid
- Prior art date
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- 239000003814 drug Substances 0.000 title claims abstract description 222
- 229940079593 drug Drugs 0.000 title claims abstract description 196
- 239000002552 dosage form Substances 0.000 title claims abstract description 79
- 238000010521 absorption reaction Methods 0.000 claims abstract description 53
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims abstract description 50
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims abstract description 49
- 239000000014 opioid analgesic Substances 0.000 claims abstract description 41
- 210000001035 gastrointestinal tract Anatomy 0.000 claims abstract description 29
- 208000019695 Migraine disease Diseases 0.000 claims abstract description 19
- 206010027599 migraine Diseases 0.000 claims abstract description 19
- 208000002193 Pain Diseases 0.000 claims abstract description 18
- 230000036407 pain Effects 0.000 claims abstract description 14
- ZISSAWUMDACLOM-UHFFFAOYSA-N triptane Chemical compound CC(C)C(C)(C)C ZISSAWUMDACLOM-UHFFFAOYSA-N 0.000 claims description 70
- 239000008194 pharmaceutical composition Substances 0.000 claims description 43
- 239000012528 membrane Substances 0.000 claims description 28
- 239000010410 layer Substances 0.000 claims description 26
- 230000037406 food intake Effects 0.000 claims description 23
- 238000000034 method Methods 0.000 claims description 19
- CMWTZPSULFXXJA-UHFFFAOYSA-N Naproxen Natural products C1=C(C(C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-UHFFFAOYSA-N 0.000 claims description 16
- 239000002775 capsule Substances 0.000 claims description 16
- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 claims description 16
- 229960002009 naproxen Drugs 0.000 claims description 16
- CMWTZPSULFXXJA-VIFPVBQESA-N naproxen Chemical compound C1=C([C@H](C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-VIFPVBQESA-N 0.000 claims description 16
- 239000000730 antalgic agent Substances 0.000 claims description 15
- KQKPFRSPSRPDEB-UHFFFAOYSA-N sumatriptan Chemical compound CNS(=O)(=O)CC1=CC=C2NC=C(CCN(C)C)C2=C1 KQKPFRSPSRPDEB-UHFFFAOYSA-N 0.000 claims description 13
- BLXXJMDCKKHMKV-UHFFFAOYSA-N Nabumetone Chemical compound C1=C(CCC(C)=O)C=CC2=CC(OC)=CC=C21 BLXXJMDCKKHMKV-UHFFFAOYSA-N 0.000 claims description 10
- XFBVBWWRPKNWHW-UHFFFAOYSA-N etodolac Chemical compound C1COC(CC)(CC(O)=O)C2=N[C]3C(CC)=CC=CC3=C21 XFBVBWWRPKNWHW-UHFFFAOYSA-N 0.000 claims description 10
- OROGSEYTTFOCAN-UHFFFAOYSA-N hydrocodone Natural products C1C(N(CCC234)C)C2C=CC(O)C3OC2=C4C1=CC=C2OC OROGSEYTTFOCAN-UHFFFAOYSA-N 0.000 claims description 10
- 230000036470 plasma concentration Effects 0.000 claims description 10
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- XYYVYLMBEZUESM-UHFFFAOYSA-N dihydrocodeine Natural products C1C(N(CCC234)C)C2C=CC(=O)C3OC2=C4C1=CC=C2OC XYYVYLMBEZUESM-UHFFFAOYSA-N 0.000 claims description 9
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- SYTBZMRGLBWNTM-UHFFFAOYSA-N flurbiprofen Chemical compound FC1=CC(C(C(O)=O)C)=CC=C1C1=CC=CC=C1 SYTBZMRGLBWNTM-UHFFFAOYSA-N 0.000 claims description 8
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- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 claims description 8
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- QYSPLQLAKJAUJT-UHFFFAOYSA-N piroxicam Chemical compound OC=1C2=CC=CC=C2S(=O)(=O)N(C)C=1C(=O)NC1=CC=CC=N1 QYSPLQLAKJAUJT-UHFFFAOYSA-N 0.000 claims description 8
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 claims description 7
- LLPOLZWFYMWNKH-CMKMFDCUSA-N hydrocodone Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)CC(=O)[C@@H]1OC1=C2C3=CC=C1OC LLPOLZWFYMWNKH-CMKMFDCUSA-N 0.000 claims description 7
- HYYBABOKPJLUIN-UHFFFAOYSA-N mefenamic acid Chemical compound CC1=CC=CC(NC=2C(=CC=CC=2)C(O)=O)=C1C HYYBABOKPJLUIN-UHFFFAOYSA-N 0.000 claims description 7
- 229960000590 celecoxib Drugs 0.000 claims description 6
- RZEKVGVHFLEQIL-UHFFFAOYSA-N celecoxib Chemical compound C1=CC(C)=CC=C1C1=CC(C(F)(F)F)=NN1C1=CC=C(S(N)(=O)=O)C=C1 RZEKVGVHFLEQIL-UHFFFAOYSA-N 0.000 claims description 6
- 229960000240 hydrocodone Drugs 0.000 claims description 6
- 229960001680 ibuprofen Drugs 0.000 claims description 6
- DKYWVDODHFEZIM-UHFFFAOYSA-N ketoprofen Chemical compound OC(=O)C(C)C1=CC=CC(C(=O)C=2C=CC=CC=2)=C1 DKYWVDODHFEZIM-UHFFFAOYSA-N 0.000 claims description 6
- 229960000991 ketoprofen Drugs 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 6
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- 229960000371 rofecoxib Drugs 0.000 claims description 6
- RZJQGNCSTQAWON-UHFFFAOYSA-N rofecoxib Chemical compound C1=CC(S(=O)(=O)C)=CC=C1C1=C(C=2C=CC=CC=2)C(=O)OC1 RZJQGNCSTQAWON-UHFFFAOYSA-N 0.000 claims description 6
- LLPOLZWFYMWNKH-UHFFFAOYSA-N trans-dihydrocodeinone Natural products C1C(N(CCC234)C)C2CCC(=O)C3OC2=C4C1=CC=C2OC LLPOLZWFYMWNKH-UHFFFAOYSA-N 0.000 claims description 6
- 239000013543 active substance Substances 0.000 claims description 5
- 239000002245 particle Substances 0.000 claims description 5
- TVYLLZQTGLZFBW-ZBFHGGJFSA-N (R,R)-tramadol Chemical compound COC1=CC=CC([C@]2(O)[C@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-ZBFHGGJFSA-N 0.000 claims description 4
- USSIQXCVUWKGNF-UHFFFAOYSA-N 6-(dimethylamino)-4,4-diphenylheptan-3-one Chemical compound C=1C=CC=CC=1C(CC(C)N(C)C)(C(=O)CC)C1=CC=CC=C1 USSIQXCVUWKGNF-UHFFFAOYSA-N 0.000 claims description 4
- WKEMJKQOLOHJLZ-UHFFFAOYSA-N Almogran Chemical compound C1=C2C(CCN(C)C)=CNC2=CC=C1CS(=O)(=O)N1CCCC1 WKEMJKQOLOHJLZ-UHFFFAOYSA-N 0.000 claims description 4
- JAQUASYNZVUNQP-USXIJHARSA-N Levorphanol Chemical compound C1C2=CC=C(O)C=C2[C@]23CCN(C)[C@H]1[C@@H]2CCCC3 JAQUASYNZVUNQP-USXIJHARSA-N 0.000 claims description 4
- XADCESSVHJOZHK-UHFFFAOYSA-N Meperidine Chemical compound C=1C=CC=CC=1C1(C(=O)OCC)CCN(C)CC1 XADCESSVHJOZHK-UHFFFAOYSA-N 0.000 claims description 4
- IDBPHNDTYPBSNI-UHFFFAOYSA-N N-(1-(2-(4-Ethyl-5-oxo-2-tetrazolin-1-yl)ethyl)-4-(methoxymethyl)-4-piperidyl)propionanilide Chemical compound C1CN(CCN2C(N(CC)N=N2)=O)CCC1(COC)N(C(=O)CC)C1=CC=CC=C1 IDBPHNDTYPBSNI-UHFFFAOYSA-N 0.000 claims description 4
- BRUQQQPBMZOVGD-XFKAJCMBSA-N Oxycodone Chemical compound O=C([C@@H]1O2)CC[C@@]3(O)[C@H]4CC5=CC=C(OC)C2=C5[C@@]13CCN4C BRUQQQPBMZOVGD-XFKAJCMBSA-N 0.000 claims description 4
- UQCNKQCJZOAFTQ-ISWURRPUSA-N Oxymorphone Chemical compound O([C@H]1C(CC[C@]23O)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O UQCNKQCJZOAFTQ-ISWURRPUSA-N 0.000 claims description 4
- 229960001391 alfentanil Drugs 0.000 claims description 4
- 229960002133 almotriptan Drugs 0.000 claims description 4
- 229960001736 buprenorphine Drugs 0.000 claims description 4
- RMRJXGBAOAMLHD-IHFGGWKQSA-N buprenorphine Chemical compound C([C@]12[C@H]3OC=4C(O)=CC=C(C2=4)C[C@@H]2[C@]11CC[C@]3([C@H](C1)[C@](C)(O)C(C)(C)C)OC)CN2CC1CC1 RMRJXGBAOAMLHD-IHFGGWKQSA-N 0.000 claims description 4
- 229960004126 codeine Drugs 0.000 claims description 4
- 229960004193 dextropropoxyphene Drugs 0.000 claims description 4
- XLMALTXPSGQGBX-GCJKJVERSA-N dextropropoxyphene Chemical compound C([C@](OC(=O)CC)([C@H](C)CN(C)C)C=1C=CC=CC=1)C1=CC=CC=C1 XLMALTXPSGQGBX-GCJKJVERSA-N 0.000 claims description 4
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- VTMVHDZWSFQSQP-VBNZEHGJSA-N dezocine Chemical compound C1CCCC[C@H]2CC3=CC=C(O)C=C3[C@]1(C)[C@H]2N VTMVHDZWSFQSQP-VBNZEHGJSA-N 0.000 claims description 4
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- WVLOADHCBXTIJK-YNHQPCIGSA-N hydromorphone Chemical compound O([C@H]1C(CC[C@H]23)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O WVLOADHCBXTIJK-YNHQPCIGSA-N 0.000 claims description 4
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Classifications
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- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
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- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Biomedical Technology (AREA)
- Emergency Medicine (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (5)
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| US77937306P | 2006-03-06 | 2006-03-06 | |
| US60/779,373 | 2006-03-06 | ||
| US11/712,969 | 2007-03-02 | ||
| PCT/US2007/005266 WO2007103113A2 (en) | 2006-03-06 | 2007-03-02 | Dosage forms for administering combinations of drugs |
| US11/712,969 US20070207200A1 (en) | 2006-03-06 | 2007-03-02 | Dosage forms for administering combinations of drugs |
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| AU2007224229A1 AU2007224229A1 (en) | 2007-09-13 |
| AU2007224229B2 true AU2007224229B2 (en) | 2012-10-11 |
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| US (1) | US20070207200A1 (enExample) |
| EP (1) | EP1993518A4 (enExample) |
| JP (1) | JP5349059B2 (enExample) |
| CN (1) | CN101410095B (enExample) |
| AU (1) | AU2007224229B2 (enExample) |
| BR (1) | BRPI0708640A8 (enExample) |
| CA (1) | CA2644435C (enExample) |
| EA (1) | EA020867B1 (enExample) |
| IL (1) | IL193727A (enExample) |
| MX (1) | MX2008011441A (enExample) |
| NO (1) | NO20083876L (enExample) |
| WO (1) | WO2007103113A2 (enExample) |
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| US8206741B2 (en) | 2001-06-01 | 2012-06-26 | Pozen Inc. | Pharmaceutical compositions for the coordinated delivery of NSAIDs |
| US20060178349A1 (en) * | 2005-01-24 | 2006-08-10 | Pozen Inc. | Compositions and therapeutic methods utilizing a combination of a 5-HT1F inhibitor and an NSAID |
| US8795721B2 (en) * | 2006-12-18 | 2014-08-05 | Eatlittle Inc. | Device for delivery of a substance |
| GB0625646D0 (en) * | 2006-12-21 | 2007-01-31 | Jagotec Ag | Improvements in or relating to organic compounds |
| BRPI0700133A (pt) * | 2007-01-29 | 2008-09-16 | Incrementha P D & I Pesquisa D | composição farmacêutica compreendendo tramadol e cetoprofeno em combinação |
| US20090068262A1 (en) * | 2007-04-04 | 2009-03-12 | Ilan Zalit | Rapid dissolution of combination products |
| MX2010000803A (es) * | 2007-07-20 | 2010-06-23 | Abbott Gmbh & Co Kg | Formulaciones de analgesicos no opioides y opioides confinados. |
| GB0714790D0 (en) * | 2007-07-30 | 2007-09-12 | Jagotec Ag | Improvements in or relating to organic compounds |
| EP2203166B1 (en) * | 2007-10-16 | 2015-05-06 | Paladin Labs Inc. | Bilayer composition for the sustained release of acetaminophen and tramadol |
| RS51313B (sr) * | 2007-11-09 | 2010-12-31 | Acino Pharma Ag.51311 | Retard tablete sa hidromorfonom |
| US20090186086A1 (en) * | 2008-01-17 | 2009-07-23 | Par Pharmaceutical, Inc. | Solid multilayer oral dosage forms |
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- 2007-03-02 BR BRPI0708640A patent/BRPI0708640A8/pt not_active Application Discontinuation
- 2007-03-02 WO PCT/US2007/005266 patent/WO2007103113A2/en not_active Ceased
- 2007-03-02 JP JP2008558308A patent/JP5349059B2/ja not_active Expired - Fee Related
- 2007-03-02 MX MX2008011441A patent/MX2008011441A/es active IP Right Grant
- 2007-03-02 US US11/712,969 patent/US20070207200A1/en not_active Abandoned
- 2007-03-02 EP EP07751994A patent/EP1993518A4/en not_active Withdrawn
- 2007-03-02 CN CN200780011121.4A patent/CN101410095B/zh not_active Expired - Fee Related
- 2007-03-02 CA CA2644435A patent/CA2644435C/en not_active Expired - Fee Related
- 2007-03-02 EA EA200870325A patent/EA020867B1/ru not_active IP Right Cessation
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2008
- 2008-08-27 IL IL193727A patent/IL193727A/en not_active IP Right Cessation
- 2008-09-10 NO NO20083876A patent/NO20083876L/no not_active Application Discontinuation
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| US20040180089A1 (en) * | 2002-12-26 | 2004-09-16 | Pozen Inc. | Multilayer dosage forms containing NSAIDs and triptans |
| US20040247677A1 (en) * | 2003-06-06 | 2004-12-09 | Pascal Oury | Multilayer orodispersible tablet |
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0708640A8 (pt) | 2018-04-24 |
| EA020867B1 (ru) | 2015-02-27 |
| EP1993518A2 (en) | 2008-11-26 |
| IL193727A (en) | 2015-07-30 |
| CN101410095B (zh) | 2015-07-01 |
| JP5349059B2 (ja) | 2013-11-20 |
| MX2008011441A (es) | 2008-11-18 |
| CA2644435C (en) | 2015-04-07 |
| NO20083876L (no) | 2008-12-02 |
| AU2007224229A1 (en) | 2007-09-13 |
| WO2007103113A3 (en) | 2007-11-01 |
| HK1128230A1 (en) | 2009-10-23 |
| EA200870325A1 (ru) | 2009-02-27 |
| EP1993518A4 (en) | 2012-12-12 |
| CA2644435A1 (en) | 2007-09-13 |
| BRPI0708640A2 (pt) | 2011-06-07 |
| CN101410095A (zh) | 2009-04-15 |
| US20070207200A1 (en) | 2007-09-06 |
| WO2007103113A2 (en) | 2007-09-13 |
| JP2009539761A (ja) | 2009-11-19 |
| IL193727A0 (en) | 2009-05-04 |
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