AU2007221470B2 - Phosphatase inhibitor Protein-1 as a regulator of cardiac function - Google Patents

Phosphatase inhibitor Protein-1 as a regulator of cardiac function Download PDF

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Publication number
AU2007221470B2
AU2007221470B2 AU2007221470A AU2007221470A AU2007221470B2 AU 2007221470 B2 AU2007221470 B2 AU 2007221470B2 AU 2007221470 A AU2007221470 A AU 2007221470A AU 2007221470 A AU2007221470 A AU 2007221470A AU 2007221470 B2 AU2007221470 B2 AU 2007221470B2
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AU
Australia
Prior art keywords
seq
nucleic acid
protein
amino acid
acid molecule
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2007221470A
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English (en)
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AU2007221470A1 (en
Inventor
Evangelia Kranias
Bryan Mitton
Patricia Rodriguez
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University of Cincinnati
Original Assignee
University of Cincinnati
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Publication date
Application filed by University of Cincinnati filed Critical University of Cincinnati
Publication of AU2007221470A1 publication Critical patent/AU2007221470A1/en
Application granted granted Critical
Publication of AU2007221470B2 publication Critical patent/AU2007221470B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702Regulators; Modulating activity
    • C07K14/4703Inhibitors; Suppressors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AU2007221470A 2006-02-10 2007-02-09 Phosphatase inhibitor Protein-1 as a regulator of cardiac function Ceased AU2007221470B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US77232706P 2006-02-10 2006-02-10
US60/772,327 2006-02-10
PCT/US2007/003470 WO2007100465A2 (en) 2006-02-10 2007-02-09 Phosphatase inhibitor protein-1 as a regulator of cardiac function

Publications (2)

Publication Number Publication Date
AU2007221470A1 AU2007221470A1 (en) 2007-09-07
AU2007221470B2 true AU2007221470B2 (en) 2013-02-14

Family

ID=38459499

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2007221470A Ceased AU2007221470B2 (en) 2006-02-10 2007-02-09 Phosphatase inhibitor Protein-1 as a regulator of cardiac function

Country Status (7)

Country Link
US (2) US7989606B2 (OSRAM)
EP (2) EP1994043A4 (OSRAM)
JP (2) JP2009525757A (OSRAM)
CN (1) CN101437833A (OSRAM)
AU (1) AU2007221470B2 (OSRAM)
CA (1) CA2638913A1 (OSRAM)
WO (1) WO2007100465A2 (OSRAM)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008512484A (ja) 2004-09-09 2008-04-24 ザ ジェネラル ホスピタル コーポレーション 心臓細胞におけるホスファターゼ活性の調節
WO2009090049A1 (en) * 2008-01-14 2009-07-23 European Molecular Biology Laboratory Peptides for the specific binding and regulation of protein targets
EP2396343B1 (en) 2009-02-11 2017-05-17 The University of North Carolina At Chapel Hill Modified virus vectors and methods of making and using the same
CN101942481B (zh) * 2009-04-30 2012-07-25 中南大学 一种针对PKC γ基因RNA干扰的重组慢病毒载体的构建及其应用
MX349622B (es) 2010-09-08 2017-08-07 Halozyme Inc Metodos para evaluar e identificar o evolucionar proteinas terapeuticas condicionalmente activas.
DK2673289T3 (da) 2011-02-10 2023-07-24 Univ North Carolina Chapel Hill Virusvektorer med modificerede transduktionsprofiler og fremgangsmåder til fremstilling og anvendelse deraf
CA2866612C (en) 2012-03-08 2018-01-16 Halozyme, Inc. Conditionally active ph-dependent cetuximab variant anti-epidermal growth factor receptor antibodies and method of use thereof
EP2870171B1 (en) 2012-07-05 2017-06-28 Gwangju Institute of Science and Technology Decoy peptides inhibiting protein phosphatase 1-mediated dephosphorylation of phospholamban
CN110885854A (zh) 2013-03-15 2020-03-17 北卡罗来纳-查佩尔山大学 双重聚糖结合aav载体的方法和组合物
US10907176B2 (en) 2015-01-14 2021-02-02 The University Of North Carolina At Chapel Hill Methods and compositions for targeted gene transfer
CA2977071A1 (en) 2015-02-20 2016-08-25 Board Of Regents, The University Of Texas System Methods and compositions for attenuated chlamydia as vaccine and vector
ES2865487T3 (es) 2015-09-28 2021-10-15 Univ North Carolina Chapel Hill Métodos y composiciones para vectores virales que evaden los anticuerpos
CN110770346B (zh) 2017-03-15 2024-01-12 北卡罗来纳-查佩尔山大学 多倍体腺相关病毒载体及其制备和使用方法
US12281320B2 (en) 2018-02-28 2025-04-22 The University Of North Carolina At Chapel Hill Methods and compositions for antibody-evading virus vectors
SG11202009452WA (en) 2018-04-03 2020-10-29 Stridebio Inc Antibody-evading virus vectors
AU2019247191A1 (en) 2018-04-03 2020-10-15 Ginkgo Bioworks, Inc. Virus vectors for targeting ophthalmic tissues
JP2021519581A (ja) 2018-04-03 2021-08-12 ストライドバイオ,インコーポレイテッド 抗体を回避するウイルスベクター
AR118465A1 (es) 2019-03-21 2021-10-06 Stridebio Inc Vectores de virus adenoasociados recombinantes
US20220194992A1 (en) 2019-04-26 2022-06-23 The University Of North Carolina At Chapel Hill Methods and compositions for dual glycan binding aav2.5 vector
CA3157700A1 (en) 2019-10-17 2021-04-22 Stridebio, Inc. Adeno-associated viral vectors for treatment of niemann-pick disease type c
CA3189878A1 (en) 2020-08-19 2022-02-24 Colin O'BANION Adeno-associated virus vectors for treatment of rett syndrome
WO2022093769A1 (en) 2020-10-28 2022-05-05 The University Of North Carolina At Chapel Hill Methods and compositions for dual glycan binding aav2.5 vector
CA3196036A1 (en) 2020-10-28 2022-05-05 The University Of North Carolina At Chapel Hill Methods and compositions for dual glycan binding aav2.5 vector
TW202242124A (zh) 2021-01-14 2022-11-01 美商史崔德生物公司 靶向t細胞之aav載體
WO2022221529A1 (en) 2021-04-16 2022-10-20 Asklepios Biopharmaceutical, Inc. Rational polyploid aav virions that cross the blood brain barrier and elicit reduced humoral response
TW202342759A (zh) 2022-02-04 2023-11-01 美商史崔德生物公司 重組腺相關病毒載體及其使用方法
WO2024124019A2 (en) 2022-12-07 2024-06-13 Ginkgo Bioworks, Inc. Aav vectors targeting hematopoietic stem cells

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004050894A2 (en) * 2002-11-27 2004-06-17 Artesian Therapeutics, Inc. Heart failure gene determination and therapeutic screening

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5223263A (en) 1988-07-07 1993-06-29 Vical, Inc. Liponucleotide-containing liposomes
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5328470A (en) 1989-03-31 1994-07-12 The Regents Of The University Of Michigan Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor
US5859205A (en) 1989-12-21 1999-01-12 Celltech Limited Humanised antibodies
US5264618A (en) 1990-04-19 1993-11-23 Vical, Inc. Cationic lipids for intracellular delivery of biologically active molecules
US5753258A (en) 1990-10-19 1998-05-19 University Of Florida Artificial viral envelopes
US5252348A (en) 1990-10-19 1993-10-12 Univ. Of Florida Research Foundation, Inc. Artificial viral envelopes
US5858784A (en) 1991-12-17 1999-01-12 The Regents Of The University Of California Expression of cloned genes in the lung by aerosol- and liposome-based delivery
CA2203809C (en) 1994-10-28 2008-06-03 James M. Wilson Recombinant adenovirus and methods of use thereof
JPH11514209A (ja) 1995-04-20 1999-12-07 カイロン コーポレイション 組換えレトロウイルス調製物による造血幹細胞の高効率エクスビボ形質導入
AU7665396A (en) 1995-10-27 1997-05-15 Trustees Of The University Of Pennsylvania, The Recombinant viruses containing mobile genetic elements and methods of use in gene therapy
AU730771B2 (en) 1996-08-19 2001-03-15 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Novel liposome complexes for increased systemic delivery
WO1998017683A2 (en) * 1996-10-23 1998-04-30 Duke University Human phosphatase inhibitor-1 gene and methods of screening for non-insulin dependent diabetes mellitus
US6491907B1 (en) 1998-11-10 2002-12-10 The University Of North Carolina At Chapel Hill Recombinant parvovirus vectors and method of making
AU2001268149B2 (en) 2000-06-01 2005-08-18 University Of North Carolina At Chapel Hill Methods and compounds for controlled release of recombinant parvovirus vectors
ES2256265T3 (es) 2000-06-01 2006-07-16 University Of North Carolina At Chapel Hill Vectores de parvovirus duplicados.
DE60137778D1 (de) 2000-09-11 2009-04-09 Univ California Dominant-negativer PLB Mutant zur Behandlung der Herzerkrankungen
AU2002249947A1 (en) 2001-01-15 2002-07-30 Henry Ford Health System Inhibition of protein-phosphatases for the treatment of heart failure
US20020159978A1 (en) 2001-02-06 2002-10-31 James Allen Muscle-directed gene transfer by use of recombinant AAV-1 and AAV-6 virions
CA2538999A1 (en) 2003-09-19 2005-03-31 Children's Hospital Medical Center Regulation of cardiac contractility and heart failure propensity
JP2008512484A (ja) * 2004-09-09 2008-04-24 ザ ジェネラル ホスピタル コーポレーション 心臓細胞におけるホスファターゼ活性の調節

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004050894A2 (en) * 2002-11-27 2004-06-17 Artesian Therapeutics, Inc. Heart failure gene determination and therapeutic screening

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Bibb, J. A. et al., The Journal of Biological Chemistry 2001, vol. 276, pages 14490-14497 *
Endo, S. et al., Biochemistry 1996, vol. 35, pages 5220-5228 *

Also Published As

Publication number Publication date
US20120053125A1 (en) 2012-03-01
AU2007221470A1 (en) 2007-09-07
CA2638913A1 (en) 2007-09-07
EP1994043A2 (en) 2008-11-26
US20090203596A1 (en) 2009-08-13
US7989606B2 (en) 2011-08-02
US8524683B2 (en) 2013-09-03
WO2007100465A3 (en) 2008-07-31
CN101437833A (zh) 2009-05-20
JP2013027398A (ja) 2013-02-07
JP2009525757A (ja) 2009-07-16
WO2007100465A2 (en) 2007-09-07
EP2441770A1 (en) 2012-04-18
EP1994043A4 (en) 2009-05-20

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MK14 Patent ceased section 143(a) (annual fees not paid) or expired