AU2006284860A1 - Benzopyran and pyranopyridine derivatives as potassium channel openers - Google Patents

Benzopyran and pyranopyridine derivatives as potassium channel openers Download PDF

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Publication number
AU2006284860A1
AU2006284860A1 AU2006284860A AU2006284860A AU2006284860A1 AU 2006284860 A1 AU2006284860 A1 AU 2006284860A1 AU 2006284860 A AU2006284860 A AU 2006284860A AU 2006284860 A AU2006284860 A AU 2006284860A AU 2006284860 A1 AU2006284860 A1 AU 2006284860A1
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alkyl
group
amino
phenyl
compound
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AU2006284860A
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Xiaojie Li
Zhihua Sui
Xuqing Zhang
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Janssen Pharmaceutica NV
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Janssen Pharmaceutica NV
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    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
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    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/60Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2
    • C07D311/62Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2 with oxygen atoms directly attached in position 3, e.g. anthocyanidins
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    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
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  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
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  • Hospice & Palliative Care (AREA)
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  • Biochemistry (AREA)
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  • Otolaryngology (AREA)
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  • Psychiatry (AREA)
  • Dermatology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
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  • Pyrane Compounds (AREA)
AU2006284860A 2005-09-01 2006-08-30 Benzopyran and pyranopyridine derivatives as potassium channel openers Abandoned AU2006284860A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US71355005P 2005-09-01 2005-09-01
US60/713,550 2005-09-01
PCT/US2006/033871 WO2007027780A2 (en) 2005-09-01 2006-08-30 Benzopyran and pyranopyridine derivatives as potassium channel openers

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AU2006284860A1 true AU2006284860A1 (en) 2007-03-08

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AU2006284860A Abandoned AU2006284860A1 (en) 2005-09-01 2006-08-30 Benzopyran and pyranopyridine derivatives as potassium channel openers

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US (1) US7812183B2 (enExample)
EP (1) EP1940516A2 (enExample)
JP (1) JP2009509927A (enExample)
CN (1) CN101296731A (enExample)
AU (1) AU2006284860A1 (enExample)
CA (1) CA2620846A1 (enExample)
WO (1) WO2007027780A2 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2620846A1 (en) * 2005-09-01 2007-03-08 Janssen Pharmaceutica N.V. Benzopyran and pyranopyridine derivatives as potassium channel openers
ES2379098T3 (es) * 2005-09-01 2012-04-20 Janssen Pharmaceutica Nv Derivados de benzopirano novedosos como abridores del canal de potasio
US20110207729A1 (en) * 2007-08-10 2011-08-25 Astellas Pharma Inc. Bicyclic acylguanidine derivative
EP2817877A4 (en) 2012-02-22 2016-01-27 Int Electronic Machines Corp ENERGY
EP2948147B1 (en) 2013-01-28 2019-03-13 H. Lundbeck A/S N-substituted-5-substituted phthalamic acids as sortilin inhibitors
US9573921B2 (en) * 2013-09-30 2017-02-21 Polfarmex S.A. Substituted N, N-dimethylaminoalkyl ethers of isoflavanone oximes as H1-receptor antagonists
KR20230005827A (ko) * 2020-04-24 2023-01-10 스미토모 파마 가부시키가이샤 2-헤테로아릴아미노퀴나졸리논 유도체

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH594675A5 (enExample) * 1976-01-30 1978-01-13 Ciba Geigy Ag
DE3579390D1 (de) * 1984-06-22 1990-10-04 Beecham Group Plc Wirksame benzopyranverbindungen.
DE3682331D1 (de) 1985-06-08 1991-12-12 Beecham Group Plc Pyrano(3,2-c)pyridinderivate, verfahren und zwischenprodukte zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen.
GB8521857D0 (en) 1985-09-03 1985-10-09 Beecham Group Plc Active compounds
EP0218373B1 (en) 1985-09-11 1990-03-07 Beecham Group Plc Chroman derivatives and analogues having antihypertensive activity
DE3726261A1 (de) 1986-12-23 1988-07-07 Merck Patent Gmbh Chromanderivate
US5387587A (en) 1986-12-23 1995-02-07 Merck Patent Gesellschaft Mit Beschrankter Haftung Chroman derivatives
DE3835011A1 (de) * 1988-10-14 1990-04-19 Merck Patent Gmbh Chromanderivate
US5284838A (en) 1987-06-23 1994-02-08 Elf Sanofi Use of 2,2-dimethylchroman-3-ol derivatives in the treatment of asthma
US4971982A (en) 1987-07-06 1990-11-20 Hoffmann-La Roche Inc. Benzopyran derivatives
EP0301713A3 (en) * 1987-07-07 1990-05-02 Beecham Group Plc Chroman derivatives for treatment of pulmonary hypertension
DE3732146A1 (de) 1987-09-24 1989-04-06 Merck Patent Gmbh Azachromanderivate
US5254557A (en) * 1988-05-09 1993-10-19 Beecham Group P.L.C. Compound and treatment
DE3823533A1 (de) * 1988-07-12 1990-02-08 Beiersdorf Ag Substituierte 4-heterocyclyl-2h-benzo(b)pyrane, verfahren und 4-hydroxy-3-brom-, 3,4-oxiranyl-3,4-dehydro-2h-benzo(b)pyrane als zwischenprodukte zu ihrer herstellung, sowie sie enthaltende pharmazeutsche praeparate
DE68921972T2 (de) * 1988-12-13 1995-11-16 Beecham Group Plc Benzopyran und verwandte Verbindungen.
DE3918041A1 (de) * 1989-06-02 1990-12-06 Merck Patent Gmbh Chromanderivate
DE3922392A1 (de) 1989-07-07 1991-01-17 Merck Patent Gmbh Chromanderivate
GB8916683D0 (en) * 1989-07-21 1989-09-06 Beecham Group Plc Novel compounds
US4983612A (en) 1989-10-05 1991-01-08 American Home Products Corporation Antihypertensive benzopyran derivatives
US5254555A (en) 1989-10-30 1993-10-19 Beecham Group P.L.C. Amino pyrimidin-7-yl substituted benzopyrans for treatment of hypertension
US5171857A (en) * 1990-03-29 1992-12-15 American Home Products Corporation Antihypertensive benzopyran derivatives
GB2242628A (en) * 1990-04-06 1991-10-09 Sandoz Ltd Asthma prophylactic use of K+ channel activators
US5254578A (en) * 1990-10-24 1993-10-19 Sankyo Company, Limited Benzopyran derivatives having anti-hypertensive and vasodilatory activity and their therapeutic use
ES2030627A6 (es) * 1990-11-28 1992-11-01 Uriach & Cia Sa J Procedimiento para la obtencion de compuestos benzopiranicos.
DE4038752A1 (de) * 1990-12-05 1992-06-11 Merck Patent Gmbh Chromanderivate
FR2670780B1 (fr) * 1990-12-20 1993-07-09 Synthelabo Derives de 4-(acylamino)benzopyranes, leur preparation et leur application en therapeutique.
US5310932A (en) 1991-04-15 1994-05-10 E. R. Squibb & Sons, Inc. Chromanyl substituted indole potassium channel openers
US5225566A (en) * 1992-05-08 1993-07-06 American Home Products Corporation Indazolanonyl derivative of benzopyran
US5206252A (en) 1992-05-08 1993-04-27 American Home Products Corporation Thiadiazolyl-amino derivatives of benzopyrans and indanes
US5236935A (en) * 1992-05-21 1993-08-17 Korea Research Institute Of Chemical Technology Benzopyran derivatives and processes for the preparation thereof
DE69328366T2 (de) * 1992-08-17 2000-08-10 Chugai Seiyaku K.K., Tokio/Tokyo Benzopyran und benzoxazin-derivate
US6268388B1 (en) * 1997-08-22 2001-07-31 Bristol-Myers Squibb Company Method for preventing or treating erectile dysfunction by administering an endothelin antagonist
BRPI0415165A (pt) * 2003-10-01 2007-01-09 Adolor Corp composto heterocìclico espirocìclico, composição farmacêutica, método para ligar receptores opióides, métodos para prevenir ou tratar dor, disfunção gastrointestinal, um distúrbio do trato urogenital, um distúrbio imunomodulatório, um distúrbio inflamatório, um distúrbio de função respiratória, ansiedade, distúrbio do humor, um distúrbio relacionado a estresse, distúrbio do sistema nervoso simpático, tosse, e um distúrbio motor, método para tratar uma lesão traumática ao sistema nervoso central, métodos para prevenir ou tratar acidente vascular, arritmia cardìaca, glaucoma, e disfunção sexual, métodos para tratar uma condição selecionada do grupo consistindo de choque, edema cerebral, isquemia cerebral, déficit cerebral após cirurgia cardìaca (bypass) e enxerto, lupus eritematoso sistêmico, doença de hodgkin, doença de sjogren, epilepsia, e rejeição em transplantes de órgão e enxertos de pele, e para tratar dependência de substáncias, métodos para melhorar a sobrevivência de órgãos e células, e cardioproteção após infarto do miocárdio, métodos para reduzir a necessidade de anestesia, para produzir ou manter um estado anestésico, derivado radiomarcado de um composto, derivado isotopicamente marcado de um composto, composto e método de diagnóstico por imagem
ES2379098T3 (es) 2005-09-01 2012-04-20 Janssen Pharmaceutica Nv Derivados de benzopirano novedosos como abridores del canal de potasio
CA2620846A1 (en) * 2005-09-01 2007-03-08 Janssen Pharmaceutica N.V. Benzopyran and pyranopyridine derivatives as potassium channel openers

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CA2620846A1 (en) 2007-03-08
US7812183B2 (en) 2010-10-12
EP1940516A2 (en) 2008-07-09
WO2007027780A2 (en) 2007-03-08
US20070072832A1 (en) 2007-03-29
WO2007027780A3 (en) 2007-07-12

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