AU2005328701B2 - Drinkable immediate release tablet made with direct compression of memantine or neramexane - Google Patents
Drinkable immediate release tablet made with direct compression of memantine or neramexane Download PDFInfo
- Publication number
- AU2005328701B2 AU2005328701B2 AU2005328701A AU2005328701A AU2005328701B2 AU 2005328701 B2 AU2005328701 B2 AU 2005328701B2 AU 2005328701 A AU2005328701 A AU 2005328701A AU 2005328701 A AU2005328701 A AU 2005328701A AU 2005328701 B2 AU2005328701 B2 AU 2005328701B2
- Authority
- AU
- Australia
- Prior art keywords
- dosage form
- oral dosage
- immediate release
- solid oral
- release solid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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- 229960004640 memantine Drugs 0.000 title claims description 92
- 239000012729 immediate-release (IR) formulation Substances 0.000 title claims description 88
- OGZQTTHDGQBLBT-UHFFFAOYSA-N neramexane Chemical compound CC1(C)CC(C)(C)CC(C)(N)C1 OGZQTTHDGQBLBT-UHFFFAOYSA-N 0.000 title claims description 34
- 229950004543 neramexane Drugs 0.000 title claims description 26
- BUGYDGFZZOZRHP-UHFFFAOYSA-N memantine Chemical compound C1C(C2)CC3(C)CC1(C)CC2(N)C3 BUGYDGFZZOZRHP-UHFFFAOYSA-N 0.000 title description 92
- 238000007907 direct compression Methods 0.000 title description 5
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 50
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 50
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 50
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 50
- 239000006186 oral dosage form Substances 0.000 claims description 49
- 239000007787 solid Substances 0.000 claims description 46
- 239000004480 active ingredient Substances 0.000 claims description 38
- 239000011248 coating agent Substances 0.000 claims description 38
- 238000000576 coating method Methods 0.000 claims description 37
- 239000002552 dosage form Substances 0.000 claims description 37
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 37
- 238000000034 method Methods 0.000 claims description 36
- 150000003839 salts Chemical class 0.000 claims description 28
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 25
- 239000000945 filler Substances 0.000 claims description 24
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 23
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 23
- LDDHMLJTFXJGPI-UHFFFAOYSA-N memantine hydrochloride Chemical group Cl.C1C(C2)CC3(C)CC1(C)CC2(N)C3 LDDHMLJTFXJGPI-UHFFFAOYSA-N 0.000 claims description 21
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 20
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 18
- 235000019359 magnesium stearate Nutrition 0.000 claims description 18
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 16
- -1 anti-adherants Substances 0.000 claims description 15
- 239000000454 talc Substances 0.000 claims description 15
- 229910052623 talc Inorganic materials 0.000 claims description 15
- 208000024827 Alzheimer disease Diseases 0.000 claims description 12
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 12
- 229940075614 colloidal silicon dioxide Drugs 0.000 claims description 12
- 229920002785 Croscarmellose sodium Polymers 0.000 claims description 11
- 229960001681 croscarmellose sodium Drugs 0.000 claims description 11
- 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 claims description 11
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 11
- CLUKHUGGXSIGRX-UHFFFAOYSA-N methanesulfonic acid;1,3,3,5,5-pentamethylcyclohexan-1-amine Chemical group CS(O)(=O)=O.CC1(C)CC(C)(C)CC(C)(N)C1 CLUKHUGGXSIGRX-UHFFFAOYSA-N 0.000 claims description 11
- 239000000314 lubricant Substances 0.000 claims description 10
- 239000007884 disintegrant Substances 0.000 claims description 8
- 229960000967 memantine hydrochloride Drugs 0.000 claims description 8
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- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 description 26
- RWRDLPDLKQPQOW-UHFFFAOYSA-N tetrahydropyrrole Substances C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 description 22
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- 125000002947 alkylene group Chemical group 0.000 description 18
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- LDDHMLJTFXJGPI-LFPUEVJFSA-N [(3s,5r)-3,5-dimethyl-1-adamantyl]azanium;chloride Chemical compound Cl.C1C(C2)C[C@@]3(C)C[C@]1(C)CC2(N)C3 LDDHMLJTFXJGPI-LFPUEVJFSA-N 0.000 description 17
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- PAFZNILMFXTMIY-UHFFFAOYSA-N cyclohexylamine Chemical group NC1CCCCC1 PAFZNILMFXTMIY-UHFFFAOYSA-N 0.000 description 17
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- ORILYTVJVMAKLC-UHFFFAOYSA-N Adamantane Natural products C1C(C2)CC3CC1CC2C3 ORILYTVJVMAKLC-UHFFFAOYSA-N 0.000 description 6
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- HOKKHZGPKSLGJE-GSVOUGTGSA-N N-Methyl-D-aspartic acid Chemical compound CN[C@@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-GSVOUGTGSA-N 0.000 description 5
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- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 4
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- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 4
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- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 4
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- OVDULOGIHPNNKW-UHFFFAOYSA-N 1-(1,3,3,5,5-pentamethylcyclohexyl)pyrrolidine Chemical compound C1C(C)(C)CC(C)(C)CC1(C)N1CCCC1 OVDULOGIHPNNKW-UHFFFAOYSA-N 0.000 description 3
- 108091006146 Channels Proteins 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
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- DKNWSYNQZKUICI-UHFFFAOYSA-N amantadine Chemical class C1C(C2)CC3CC2CC1(N)C3 DKNWSYNQZKUICI-UHFFFAOYSA-N 0.000 description 3
- 125000003277 amino group Chemical group 0.000 description 3
- MGNZXYYWBUKAII-UHFFFAOYSA-N cyclohexediene Natural products C1CC=CC=C1 MGNZXYYWBUKAII-UHFFFAOYSA-N 0.000 description 3
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- JVUYSNBGWFWRLJ-UHFFFAOYSA-N n-ethyl-1,3,3,5,5-pentamethylcyclohexan-1-amine Chemical compound CCNC1(C)CC(C)(C)CC(C)(C)C1 JVUYSNBGWFWRLJ-UHFFFAOYSA-N 0.000 description 3
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 3
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- AEWYCWAJLDLBGX-UHFFFAOYSA-N 1-(1,3,3,5-tetramethylcyclohexyl)pyrrolidine Chemical compound C1C(C)CC(C)(C)CC1(C)N1CCCC1 AEWYCWAJLDLBGX-UHFFFAOYSA-N 0.000 description 1
- QVEQDLBYFRYKKW-UHFFFAOYSA-N 1-(1,3,5-trimethylcyclohexyl)pyrrolidine Chemical compound C1C(C)CC(C)CC1(C)N1CCCC1 QVEQDLBYFRYKKW-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58124404P | 2004-06-17 | 2004-06-17 | |
| US60/581,244 | 2004-06-17 | ||
| PCT/US2005/021284 WO2006096194A2 (en) | 2004-06-17 | 2005-06-16 | Drinkable immediate release tablet made with direct compression of memantine or neramexane |
Publications (2)
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| AU2005328701A1 AU2005328701A1 (en) | 2006-09-14 |
| AU2005328701B2 true AU2005328701B2 (en) | 2009-08-13 |
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|---|---|---|---|
| AU2005328701A Ceased AU2005328701B2 (en) | 2004-06-17 | 2005-06-16 | Drinkable immediate release tablet made with direct compression of memantine or neramexane |
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| EP (3) | EP2601937A1 (enExample) |
| JP (1) | JP5025468B2 (enExample) |
| KR (1) | KR20090033410A (enExample) |
| CN (1) | CN101389315A (enExample) |
| AU (1) | AU2005328701B2 (enExample) |
| BR (1) | BRPI0512263A (enExample) |
| CA (1) | CA2568445C (enExample) |
| EA (1) | EA011290B1 (enExample) |
| ES (1) | ES2483126T3 (enExample) |
| IL (1) | IL179992A (enExample) |
| WO (1) | WO2006096194A2 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2203163B1 (en) * | 2007-09-12 | 2014-08-27 | Merz Pharma GmbH & Co. KGaA | Titration package for neramexane and its use in the treatment of an inner ear disorder |
| CA2765609A1 (en) * | 2009-06-29 | 2011-01-06 | Merz Pharma Gmbh & Co. Kgaa | Method of preparing neramexane |
| DK2448910T3 (da) * | 2009-06-29 | 2013-06-03 | Merz Pharma Gmbh & Co Kgaa | Fremgangsmåde til fremstilling af neramexan |
| PL2448909T3 (pl) * | 2009-06-29 | 2013-09-30 | Merz Pharma Gmbh & Co Kgaa | Sposób wytwarzania 1-amino-1,3,3,5,5-pentametylocykloheksanu |
| EP2316434A1 (en) * | 2009-10-22 | 2011-05-04 | Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi | Orally disintegrating tablets of memantine |
| US20110294890A1 (en) * | 2010-05-28 | 2011-12-01 | Merz Pharma Gmbh & Co. Kgaa | Neramexane for the treatment or prevention of inner ear disorders |
| US8980318B2 (en) * | 2010-06-24 | 2015-03-17 | Merz Pharma Gmbh & Co. Kgaa | Neramexane multiple unit dosage form |
| MX2013004123A (es) | 2010-10-12 | 2013-12-16 | Univ Johns Hopkins | Composiciones antitusigenas que comprenden memantina. |
| WO2012048871A1 (en) | 2010-10-12 | 2012-04-19 | Merz Pharma Gmbh & Co. Kgaa | Memantine for improving cognitive performance in subjects |
| EP2526925A1 (en) | 2011-05-23 | 2012-11-28 | Deva Holding Anonim Sirketi | A dose adjustable oral pump spray or aerosol spray containing memantine |
| CN107334744B (zh) * | 2017-07-24 | 2020-09-04 | 湖南洞庭药业股份有限公司 | 盐酸美金刚药物组合物和制法 |
| EP4238555A3 (en) * | 2019-05-31 | 2023-09-20 | Tecnimede, Sociedade Técnico-Medicinal, SA | Immediate release fixed-dose combination of memantine and donepezil |
| CN114199812A (zh) * | 2021-12-28 | 2022-03-18 | 南通联亚药业有限公司 | 一种盐酸美金刚缓释制剂中盐酸美金刚的检测方法 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5061703A (en) * | 1989-04-14 | 1991-10-29 | Merz + Co. Gmbh & Co. | Adamantane derivatives in the prevention and treatment of cerebral ischemia |
| US6034134A (en) * | 1997-06-30 | 2000-03-07 | Merz + Co. Gmbh & Co. | 1-Amino-alkylcyclohexane NMDA receptor antagonists |
| US20030166634A1 (en) * | 2001-11-07 | 2003-09-04 | Markus Henrich | Unsaturated 1-Amino-alkylcyclohexane NMDA, 5HT3, and neuronal nicotinic receptor antagonists |
| AU2004249151A1 (en) * | 2003-06-16 | 2004-12-29 | Allergan, Inc. | Memantine oral dosage forms |
| AU2005209310A1 (en) * | 2004-01-29 | 2005-08-11 | Neuromolecular, Inc. | Combination of a NMDA receptor antagonist and a MAO-inhibitor or a GADPH-inhibitor for the treatment of central nervous system-related conditions |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL7305644A (enExample) | 1972-04-20 | 1973-10-23 | ||
| DE2856393C2 (de) | 1978-12-27 | 1983-04-28 | Merz + Co GmbH & Co, 6000 Frankfurt | Arzneimittel zur Behandlung von Morbus Parkinson |
| US4346112A (en) * | 1981-06-29 | 1982-08-24 | University Patents Inc. | Composition and method for treating patients having Parkinson's Disease |
| JPS6216413A (ja) * | 1985-07-12 | 1987-01-24 | Teijin Ltd | キチン類誘導体を用いた徐放性医薬品組成物 |
| US5506231A (en) | 1989-03-31 | 1996-04-09 | The Children's Medical Center Corporation | Treatment of aids dementia, myelopathy and blindness |
| US5334618A (en) | 1991-04-04 | 1994-08-02 | The Children's Medical Center Corporation | Method of preventing NMDA receptor-mediated neuronal damage |
| DE4014672A1 (de) * | 1990-05-08 | 1991-11-14 | Werner E G Prof Dr Mueller | Verwendung von adamantan-derivaten zur zytoprotektion von nicht-infizierten und virus-infizierten lymphozyten als auch anderen zelltypen |
| US5614560A (en) | 1991-04-04 | 1997-03-25 | Children's Medical Center Corporation | Method of preventing NMDA receptor-mediated neuronal damage |
| US5455279A (en) | 1991-04-19 | 1995-10-03 | The Children's Medical Center Corporation | Regimen method of mediating neuronal damage using nitroglycerine |
| EP0581856B1 (en) | 1991-04-19 | 1999-07-14 | The Children's Medical Center Corporation | Method of preventing nmda receptor complex-mediated neuronal damage |
| DE4225730C2 (de) | 1992-08-04 | 2003-04-30 | Merz Pharma Gmbh & Co Kgaa | Verfahren zur Herstellung von festen Arzneiformkörpern mit protrahierter 2-Stufen-Freisetzung |
| GB9517062D0 (en) * | 1995-08-18 | 1995-10-25 | Scherer Ltd R P | Pharmaceutical compositions |
| JPH0971523A (ja) * | 1995-09-07 | 1997-03-18 | Riyuukakusan:Kk | 口腔内で崩壊性の速い錠剤 |
| AUPN605795A0 (en) | 1995-10-19 | 1995-11-09 | F.H. Faulding & Co. Limited | Analgesic pharmaceutical composition |
| US6071966A (en) | 1997-06-30 | 2000-06-06 | Merz + Co. Gmbh & Co. | 1-amino-alkylcyclohexane NMDA receptor antagonists |
| US6413556B1 (en) | 1999-01-08 | 2002-07-02 | Sky High, Llc | Aqueous anti-apoptotic compositions |
| SE9901077D0 (sv) | 1999-03-23 | 1999-03-23 | Astra Ab | Novel use |
| US6444702B1 (en) | 2000-02-22 | 2002-09-03 | Neuromolecular, Inc. | Aminoadamantane derivatives as therapeutic agents |
| TW593223B (en) * | 2000-06-20 | 2004-06-21 | Merz Pharma Gmbh & Co Kgaa | 1-amino-alkylcyclohexanes as 5-HT3 and neuronal nicotinic receptor antagonists |
| CA2473536A1 (en) * | 2002-01-16 | 2003-07-31 | Endo Pharmaceuticals, Inc. | Pharmaceutical composition and method for treating disorders of the central nervous system |
| TW200306189A (en) | 2002-03-21 | 2003-11-16 | Merz Pharma Gmbh & Co Kgaa | Azabicyclic, azatricyclic and azaspirocyclic derivatives of aminocyclohexane NMDA, 5HT3, and neuronal nicotinic receptor antagonists |
| FR2841138B1 (fr) * | 2002-06-25 | 2005-02-25 | Cll Pharma | Composition pharmaceutique solide contenant un principe actif lipophile, son procede de preparation |
| US20040127541A1 (en) * | 2002-07-31 | 2004-07-01 | Janet Codd | Bicifadine formulation |
| AR046314A1 (es) * | 2003-11-05 | 2005-11-30 | Merz Pharma Gmbh & Co Kgaa | Composiciones que comprenden ciclohexilaminas y aminoadamantanos |
| NZ548351A (en) * | 2004-01-20 | 2009-08-28 | Novartis Ag | Direct compression formulation and process |
| GT200600008A (es) * | 2005-01-18 | 2006-08-09 | Formulacion de compresion directa y proceso |
-
2005
- 2005-06-16 CA CA2568445A patent/CA2568445C/en not_active Expired - Fee Related
- 2005-06-16 EP EP13153135.2A patent/EP2601937A1/en not_active Withdrawn
- 2005-06-16 BR BRPI0512263-5A patent/BRPI0512263A/pt not_active IP Right Cessation
- 2005-06-16 EA EA200700055A patent/EA011290B1/ru not_active IP Right Cessation
- 2005-06-16 CN CNA2005800198789A patent/CN101389315A/zh active Pending
- 2005-06-16 AU AU2005328701A patent/AU2005328701B2/en not_active Ceased
- 2005-06-16 WO PCT/US2005/021284 patent/WO2006096194A2/en not_active Ceased
- 2005-06-16 KR KR1020097005872A patent/KR20090033410A/ko not_active Withdrawn
- 2005-06-16 JP JP2007516731A patent/JP5025468B2/ja not_active Expired - Lifetime
- 2005-06-16 EP EP05857458A patent/EP1765287A2/en not_active Withdrawn
- 2005-06-16 ES ES11179637.1T patent/ES2483126T3/es not_active Expired - Lifetime
- 2005-06-16 EP EP11179637.1A patent/EP2397122B1/en not_active Expired - Lifetime
-
2006
- 2006-12-11 IL IL179992A patent/IL179992A/en not_active IP Right Cessation
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5061703A (en) * | 1989-04-14 | 1991-10-29 | Merz + Co. Gmbh & Co. | Adamantane derivatives in the prevention and treatment of cerebral ischemia |
| US6034134A (en) * | 1997-06-30 | 2000-03-07 | Merz + Co. Gmbh & Co. | 1-Amino-alkylcyclohexane NMDA receptor antagonists |
| US20030166634A1 (en) * | 2001-11-07 | 2003-09-04 | Markus Henrich | Unsaturated 1-Amino-alkylcyclohexane NMDA, 5HT3, and neuronal nicotinic receptor antagonists |
| AU2004249151A1 (en) * | 2003-06-16 | 2004-12-29 | Allergan, Inc. | Memantine oral dosage forms |
| AU2005209310A1 (en) * | 2004-01-29 | 2005-08-11 | Neuromolecular, Inc. | Combination of a NMDA receptor antagonist and a MAO-inhibitor or a GADPH-inhibitor for the treatment of central nervous system-related conditions |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006096194A8 (en) | 2007-01-11 |
| CN101389315A (zh) | 2009-03-18 |
| WO2006096194A2 (en) | 2006-09-14 |
| BRPI0512263A (pt) | 2008-02-26 |
| IL179992A (en) | 2012-02-29 |
| ES2483126T3 (es) | 2014-08-05 |
| EP2397122B1 (en) | 2014-05-14 |
| EP1765287A2 (en) | 2007-03-28 |
| WO2006096194A3 (en) | 2007-11-22 |
| KR20090033410A (ko) | 2009-04-02 |
| EP2601937A1 (en) | 2013-06-12 |
| IL179992A0 (en) | 2007-05-15 |
| EA200700055A1 (ru) | 2007-10-26 |
| JP5025468B2 (ja) | 2012-09-12 |
| JP2008509089A (ja) | 2008-03-27 |
| EP2397122A3 (en) | 2012-01-25 |
| AU2005328701A1 (en) | 2006-09-14 |
| EP2397122A2 (en) | 2011-12-21 |
| CA2568445C (en) | 2011-05-24 |
| CA2568445A1 (en) | 2006-09-14 |
| EA011290B1 (ru) | 2009-02-27 |
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