AU2005304112B2 - Potent LNA oligonucleotides for the inhibition of HIF-1a expression - Google Patents

Potent LNA oligonucleotides for the inhibition of HIF-1a expression Download PDF

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Publication number
AU2005304112B2
AU2005304112B2 AU2005304112A AU2005304112A AU2005304112B2 AU 2005304112 B2 AU2005304112 B2 AU 2005304112B2 AU 2005304112 A AU2005304112 A AU 2005304112A AU 2005304112 A AU2005304112 A AU 2005304112A AU 2005304112 B2 AU2005304112 B2 AU 2005304112B2
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Australia
Prior art keywords
lna
seq
effective amount
cells
cancer
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Ceased
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AU2005304112A
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AU2005304112A1 (en
Inventor
Henrik Frydenlund Hansen
Frank Winther Rasmussen
Charlotte Albaek Thrue
Majken Westergaard
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Roche Innovation Center Copenhagen AS
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Santaris Pharma AS
Enzon Pharmaceuticals Inc
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Application filed by Santaris Pharma AS, Enzon Pharmaceuticals Inc filed Critical Santaris Pharma AS
Publication of AU2005304112A1 publication Critical patent/AU2005304112A1/en
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Publication of AU2005304112B2 publication Critical patent/AU2005304112B2/en
Assigned to ENZON PHARMACEUTICALS, INC., SANTARIS PHARMA A/S reassignment ENZON PHARMACEUTICALS, INC. Request for Assignment Assignors: SANTARIS PHARMA A/S
Assigned to ROCHE INNOVATION CENTER COPENHAGEN A/S reassignment ROCHE INNOVATION CENTER COPENHAGEN A/S Request to Amend Deed and Register Assignors: SANTARIS PHARMA A/S
Assigned to SANTARIS PHARMA A/S reassignment SANTARIS PHARMA A/S Request for Assignment Assignors: ENZON PHARMACEUTICALS, INC., SANTARIS PHARMA A/S
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
    • C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C12N2310/334—Modified C
    • C12N2310/3341—5-Methylcytosine
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/341—Gapmers, i.e. of the type ===---===
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    • C12N2310/30—Chemical structure
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    • C12N2310/345—Spatial arrangement of the modifications having at least two different backbone modifications
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2005304112A 2004-11-09 2005-11-09 Potent LNA oligonucleotides for the inhibition of HIF-1a expression Ceased AU2005304112B2 (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US62656304P 2004-11-09 2004-11-09
US60/626,563 2004-11-09
US64718605P 2005-01-25 2005-01-25
US60/647,186 2005-01-25
US69972105P 2005-07-15 2005-07-15
US60/699,721 2005-07-15
US72462105P 2005-10-07 2005-10-07
US60/724,621 2005-10-07
PCT/DK2005/000721 WO2006050734A2 (en) 2004-11-09 2005-11-09 Potent lna oligonucleotides for the inhibition of hif-1a expression

Publications (2)

Publication Number Publication Date
AU2005304112A1 AU2005304112A1 (en) 2006-05-18
AU2005304112B2 true AU2005304112B2 (en) 2009-06-04

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ID=36177326

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Application Number Title Priority Date Filing Date
AU2005304112A Ceased AU2005304112B2 (en) 2004-11-09 2005-11-09 Potent LNA oligonucleotides for the inhibition of HIF-1a expression

Country Status (16)

Country Link
US (3) US7589190B2 (https=)
EP (1) EP1833840B9 (https=)
JP (3) JP4825807B2 (https=)
KR (1) KR101176245B1 (https=)
AT (1) ATE476441T1 (https=)
AU (1) AU2005304112B2 (https=)
BR (1) BRPI0515726A8 (https=)
CA (1) CA2587173C (https=)
DE (1) DE602005022768D1 (https=)
DK (1) DK1833840T3 (https=)
EA (1) EA014097B1 (https=)
IL (1) IL183054A0 (https=)
MX (1) MX2007005558A (https=)
NO (1) NO341878B1 (https=)
NZ (1) NZ555644A (https=)
WO (1) WO2006050734A2 (https=)

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