AU2005211773B2 - Nicotinamide riboside kinase compositions and methods for using the same - Google Patents

Nicotinamide riboside kinase compositions and methods for using the same Download PDF

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Publication number
AU2005211773B2
AU2005211773B2 AU2005211773A AU2005211773A AU2005211773B2 AU 2005211773 B2 AU2005211773 B2 AU 2005211773B2 AU 2005211773 A AU2005211773 A AU 2005211773A AU 2005211773 A AU2005211773 A AU 2005211773A AU 2005211773 B2 AU2005211773 B2 AU 2005211773B2
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Prior art keywords
nicotinamide riboside
cell
seq
nrk
nicotinamide
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AU2005211773A
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AU2005211773A1 (en
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Pawel Bieganowski
Charles M. Brenner
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Dartmouth College
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Dartmouth College
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/12Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU2005211773A 2004-02-10 2005-02-09 Nicotinamide riboside kinase compositions and methods for using the same Ceased AU2005211773B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US54334704P 2004-02-10 2004-02-10
US60/543,347 2004-02-10
PCT/US2005/004337 WO2005077091A2 (en) 2004-02-10 2005-02-09 Nicotinamide riboside kinase compositions and methods for using the same

Publications (2)

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AU2005211773A1 AU2005211773A1 (en) 2005-08-25
AU2005211773B2 true AU2005211773B2 (en) 2009-06-25

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AU2005211773A Ceased AU2005211773B2 (en) 2004-02-10 2005-02-09 Nicotinamide riboside kinase compositions and methods for using the same

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US (3) US8197807B2 (https=)
EP (1) EP1723227A4 (https=)
JP (1) JP2007521835A (https=)
AU (1) AU2005211773B2 (https=)
CA (1) CA2555675A1 (https=)
WO (1) WO2005077091A2 (https=)

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US20050227327A1 (en) * 2004-02-10 2005-10-13 Brenner Charles M Nicotinamide riboside kinase compositions and methods for using the same
CN1964627B (zh) * 2004-06-04 2011-10-19 华盛顿大学 治疗神经病变的方法和组合物
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US20060292099A1 (en) * 2005-05-25 2006-12-28 Michael Milburn Treatment of eye disorders with sirtuin modulators
US20070149466A1 (en) * 2005-07-07 2007-06-28 Michael Milburn Methods and related compositions for treating or preventing obesity, insulin resistance disorders, and mitochondrial-associated disorders
US20100047177A1 (en) * 2007-01-26 2010-02-25 Washington University Methods and compositions for treating neuropathies
CA2928656C (en) 2013-10-30 2020-07-28 ChromaDex Inc. Nicotinamide riboside compositions for topical use in treating skin conditions
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CN106715454B (zh) 2014-07-24 2020-06-16 格雷斯公司 烟酰胺核苷的结晶形式
KR102629310B1 (ko) 2015-03-09 2024-01-24 더블유.알. 그레이스 앤드 캄파니-콘. 니코틴아미드 리보사이드의 결정 형태
CN107531738B (zh) * 2015-03-16 2021-02-19 可劳迈戴斯有限公司 烟酸核苷或烟酰胺核苷组合物、其还原衍生物及其用途
WO2016178945A1 (en) * 2015-05-01 2016-11-10 The Procter & Gamble Company Method of improving the appearance of skin and compositions therefor using nicotinamide riboside
WO2017004102A1 (en) 2015-06-29 2017-01-05 The Procter & Gamble Company Multi-component skin care product comprising nicoinamide riboside in a multi-chambered container
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CA3017254C (en) 2016-03-16 2023-08-22 ChromaDex Inc. B-vitamin and amino acid conjugates of nicotinoyl ribosides and reduced nicotinoyl ribosides, derivatives thereof, and methods of preparation thereof
US10183036B2 (en) 2016-04-20 2019-01-22 ChromaDex Inc. Use of nicotinic acid riboside or nicotinamide riboside derivatives, and reduced derivatives thereof, as NAD+ increasing precursors
CA3045876A1 (en) 2016-11-11 2018-05-17 The Queen's University Of Belfast Scalable syntheses of nicotinoyl ribosides and reduced nic otinoyl ribosides, modified derivatives thereof, phosphorylated analogs thereof, adenylyl dinucleotide conjugates thereof, and novel crystalline forms thereof
US11071747B2 (en) 2016-11-29 2021-07-27 University Of Iowa Research Foundation Use of NAD precursors for breast enhancement
MX2019006278A (es) 2016-11-29 2019-08-21 Univ Iowa Res Found Uso de precursores de nad para mejorar la salud materna y/o salud de la descendencia.
US10376528B2 (en) 2017-03-10 2019-08-13 Tecton Group, Llc Composition comprising ketone body and nicotinamide adenine dinucleotide modulator and methyl donor
EP3642214A2 (en) 2017-06-19 2020-04-29 Gangadhara Ganapati Nicotinamide riboside derivatives and their uses
WO2018237218A1 (en) 2017-06-23 2018-12-27 The Procter & Gamble Company COMPOSITION AND METHOD FOR ENHANCING SKIN APPEARANCE
EP3727400A4 (en) 2017-12-22 2021-10-20 Elysium Health, Inc. CRYSTALLINE FORMS OF NICOTINAMIDE RIBOSIDE CHLORIDE
KR20210011964A (ko) 2018-07-03 2021-02-02 더 프록터 앤드 갬블 캄파니 피부 병태를 치료하는 방법
CN112654264A (zh) 2018-09-27 2021-04-13 雀巢产品有限公司 使用至少一种甘氨酸或其衍生物、至少一种n-乙酰半胱氨酸或其衍生物和至少一种烟酰胺核糖核苷或nad+前体的组合物和方法
EP3897666A2 (en) 2018-12-17 2021-10-27 Mitopower LLC Nicotinyl riboside compounds and their uses
WO2020172338A1 (en) * 2019-02-19 2020-08-27 Whitehead Institute For Biomedical Research Methods and agents for modulating mitochondrial nad levels
US20220125814A1 (en) * 2019-03-21 2022-04-28 Fred Hutchinson Cancer Research Center Cancer combination therapies utilizing a nicotinamide phosphoribosyltransferase inhibitor in combination with a nicotinamide adenine dinucleotide salvage pathway precursor
US20220168271A1 (en) * 2019-03-29 2022-06-02 Societe Des Produits Nestle S.A. Compositions and methods for increasing t cell function
US20200397807A1 (en) 2019-06-18 2020-12-24 MitoPower, LLC Nicotinyl riboside compounds and their uses
CN110412157A (zh) * 2019-07-17 2019-11-05 广州金评检测研究院有限公司 一种烟酰胺原料中烟酸的测定方法
EP3999518A2 (en) 2019-07-19 2022-05-25 Biosynth AG Method of making nicotinamide ribofuranoside salts, nicotinamide ribofuranoside salts as such, and uses thereof
EP4125852A1 (en) 2020-04-01 2023-02-08 Société des Produits Nestlé S.A. Compositions and methods containing n-acetylcystein and nicotinamide riboside for prevention and treatment of neurological diseases and conditions
CN115843238B (zh) 2020-06-01 2025-06-10 宝洁公司 改善维生素b3化合物渗透到皮肤中的方法
US10959933B1 (en) 2020-06-01 2021-03-30 The Procter & Gamble Company Low pH skin care composition and methods of using the same
WO2022106407A1 (en) 2020-11-18 2022-05-27 Société des Produits Nestlé S.A. Compositions and methods using a combination of oleuropein and nicotinamide riboside for cellular energy
CN112553178B (zh) * 2020-12-25 2023-03-10 中山俊凯生物技术开发有限公司 热稳定性和活性增强的烟酰胺核糖激酶突变体及其编码基因和应用
US12295960B2 (en) 2021-10-17 2025-05-13 University of South Alabama Foundation for Research and Commercialization Cancer treatment
LT7046B (lt) 2022-04-15 2024-02-12 Vilniaus Universitetas Hidrolazės ir jų panaudojimas
CN115896062B (zh) * 2022-08-10 2024-10-01 福建师范大学 一种烟酰胺核糖苷激酶突变体及其相关产品和应用
LT7066B (lt) 2023-11-17 2024-06-25 Vilimas Vladas Didelės talpos medžio sulos atitirpinimo būdas

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Also Published As

Publication number Publication date
EP1723227A2 (en) 2006-11-22
JP2007521835A (ja) 2007-08-09
US20120251463A1 (en) 2012-10-04
US8197807B2 (en) 2012-06-12
CA2555675A1 (en) 2005-08-25
US20070027095A1 (en) 2007-02-01
AU2005211773A1 (en) 2005-08-25
WO2005077091A8 (en) 2006-09-14
WO2005077091A3 (en) 2005-12-22
EP1723227A4 (en) 2007-09-19
US20080206221A1 (en) 2008-08-28
WO2005077091A2 (en) 2005-08-25
US8383086B2 (en) 2013-02-26

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