AU2004299316B2 - Prostaglandin synthesis - Google Patents

Prostaglandin synthesis Download PDF

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Publication number
AU2004299316B2
AU2004299316B2 AU2004299316A AU2004299316A AU2004299316B2 AU 2004299316 B2 AU2004299316 B2 AU 2004299316B2 AU 2004299316 A AU2004299316 A AU 2004299316A AU 2004299316 A AU2004299316 A AU 2004299316A AU 2004299316 B2 AU2004299316 B2 AU 2004299316B2
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AU
Australia
Prior art keywords
compound
formula
thp
give
reacted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2004299316A
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English (en)
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AU2004299316A1 (en
Inventor
Derek Wyndham Clissold
Stuart Wilbert Craig
Rajendrakumar Reddy Gadikota
Min He
Jurjus Fayez Jurayj
Shahrokh Kazerani
Erwin Rannala
Pradeep Kumar Sharma
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Macfarlan Smith Ltd
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Macfarlan Smith Ltd
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Filing date
Publication date
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Publication of AU2004299316A1 publication Critical patent/AU2004299316A1/en
Application granted granted Critical
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Priority to AU2011200763A priority Critical patent/AU2011200763B2/en
Assigned to MACFARLAN SMITH LIMITED reassignment MACFARLAN SMITH LIMITED Request for Assignment Assignors: JOHNSON MATTHEY PUBLIC LIMITED COMPANY
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0016—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing only hydroxy, etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU2004299316A 2003-12-19 2004-12-01 Prostaglandin synthesis Active AU2004299316B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2011200763A AU2011200763B2 (en) 2003-12-19 2011-02-23 Prostaglandin synthesis

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0329379.2 2003-12-19
GBGB0329379.2A GB0329379D0 (en) 2003-12-19 2003-12-19 Prostaglandin synthesis
PCT/GB2004/005028 WO2005058812A2 (fr) 2003-12-19 2004-12-01 Synthese de la prostaglandine

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2011200763A Division AU2011200763B2 (en) 2003-12-19 2011-02-23 Prostaglandin synthesis

Publications (2)

Publication Number Publication Date
AU2004299316A1 AU2004299316A1 (en) 2005-06-30
AU2004299316B2 true AU2004299316B2 (en) 2011-01-06

Family

ID=30471335

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2004299316A Active AU2004299316B2 (en) 2003-12-19 2004-12-01 Prostaglandin synthesis
AU2011200763A Active AU2011200763B2 (en) 2003-12-19 2011-02-23 Prostaglandin synthesis

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2011200763A Active AU2011200763B2 (en) 2003-12-19 2011-02-23 Prostaglandin synthesis

Country Status (14)

Country Link
EP (1) EP1694641B1 (fr)
JP (3) JP4764828B2 (fr)
KR (1) KR20060118555A (fr)
CN (2) CN1894209B (fr)
AT (1) ATE428693T1 (fr)
AU (2) AU2004299316B2 (fr)
CA (2) CA2549056C (fr)
CZ (1) CZ305964B6 (fr)
DE (1) DE602004020667D1 (fr)
DK (1) DK1694641T3 (fr)
ES (1) ES2325266T3 (fr)
GB (1) GB0329379D0 (fr)
IL (2) IL175940A (fr)
WO (1) WO2005058812A2 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008037782A (ja) * 2006-08-04 2008-02-21 Daiichi Fine Chemical Co Ltd プロスタグランジン誘導体の製造方法
US7642370B2 (en) 2006-08-07 2010-01-05 Daiichi Fine Chemical Co., Ltd. Method for preparing prostaglandin derivative
AR071312A1 (es) * 2008-04-09 2010-06-09 Scinopharm Taiwan Ltd Proceso para la preparacion de analogos de prostaglandina y sus intermediarios
EP2135860A1 (fr) * 2008-06-20 2009-12-23 Sandoz AG Procédé amélioré pour la production de Bimatoprost
WO2011008756A1 (fr) 2009-07-13 2011-01-20 Irix Pharmaceuticals Synthèse de prostanoïdes
CN102050772B (zh) * 2009-11-02 2013-08-21 上海天伟生物制药有限公司 一种比马前列素晶体及其制备方法和用途
US9238621B2 (en) * 2011-06-02 2016-01-19 Chinoin Zrt Processes for the preparation of prostaglandin amides
HU231203B1 (hu) * 2011-12-21 2021-10-28 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. Új eljárás travoprost előállítására
WO2013133730A1 (fr) * 2012-03-09 2013-09-12 Instytut Farmaceutyczny Procédé de préparation d'analogues de prostaglandine f2α
EP2911623B1 (fr) 2012-10-26 2019-08-14 Forsight Vision5, Inc. Système ophtalmique pour la libération prolongée de médicament dans l' oeil
US10100028B2 (en) 2013-09-30 2018-10-16 Patheon Api Services Inc. Synthesis routes for prostaglandins and prostaglandin intermediates using metathesis
US20160296532A1 (en) 2015-04-13 2016-10-13 Forsight Vision5, Inc. Ocular Insert Composition of a Semi-Crystalline or Crystalline Pharmaceutically Active Agent
EP3235810A1 (fr) 2016-04-19 2017-10-25 Gentec, S.A. Procédé pour la préparation de bimatoprost

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030187071A1 (en) * 2001-07-17 2003-10-02 Henegar Kevin E. Process and intermediates to prepare latanoprost

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1582853A (en) * 1977-06-16 1981-01-14 Ici Ltd Prostane derivatives
JPS562979A (en) * 1979-06-19 1981-01-13 Ono Pharmaceut Co Ltd Prostaglandin i2 analog compound, its preparation, and pharmaceutical composition containing the same
JPS57171965A (en) * 1981-04-15 1982-10-22 Teijin Ltd Novel prostaglandin intermediate and its preparation
US4708966A (en) * 1986-06-27 1987-11-24 The Procter & Gamble Company Novel anti-inflammatory agents, pharmaceutical compositions and methods for reducing inflammation
JPS63188687A (ja) * 1987-01-30 1988-08-04 Sagami Chem Res Center 有機ケイ素化合物の製造方法
JP2536026B2 (ja) * 1988-03-10 1996-09-18 史衛 佐藤 α，β―置換シクロペンタノン誘導体の製造法
US5698733A (en) * 1994-09-30 1997-12-16 Alcon Laboratories, Inc. Use of 9-deoxy prostaglandin derivatives to treat glaucoma
US6015922A (en) * 1997-12-19 2000-01-18 Alcon Laboratories, Inc. N-alkyl-N-alkoxycarboxamides and methods of use in prostaglandin synthesis
GB9908327D0 (en) * 1999-04-12 1999-06-09 Chirotech Technology Ltd Process for the preparation of prostaglandin precursors
AU770343B2 (en) * 1999-09-06 2004-02-19 Fumie Sato Prostaglandin E analogues
WO2003008368A1 (fr) * 2001-07-17 2003-01-30 Pharmacia & Upjohn Company Procede et produits intermediaires utilises pour produire du latanoprost

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030187071A1 (en) * 2001-07-17 2003-10-02 Henegar Kevin E. Process and intermediates to prepare latanoprost

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Fox M.E. et al, Advanced Synthesis and Catalysis, 2002, vol 344, pp. 50-56 *
Maruyama T. et al, Bioorganic and Medicinal Chemistry, 2002, vol. 10, pp. 975-988 *

Also Published As

Publication number Publication date
JP2011201883A (ja) 2011-10-13
JP2007517780A (ja) 2007-07-05
KR20060118555A (ko) 2006-11-23
WO2005058812A2 (fr) 2005-06-30
JP5795354B2 (ja) 2015-10-14
CA2549056A1 (fr) 2005-06-30
ATE428693T1 (de) 2009-05-15
ES2325266T3 (es) 2009-08-31
CN1894209A (zh) 2007-01-10
CA2854783C (fr) 2017-01-10
IL217670A (en) 2013-02-28
CA2854783A1 (fr) 2005-06-30
CN101486699B (zh) 2012-06-27
JP5653827B2 (ja) 2015-01-14
IL175940A0 (en) 2006-10-05
CA2549056C (fr) 2014-09-02
AU2011200763B2 (en) 2013-05-30
CZ305964B6 (cs) 2016-05-25
JP4764828B2 (ja) 2011-09-07
CZ2006386A3 (cs) 2006-11-15
DE602004020667D1 (en) 2009-05-28
AU2011200763A1 (en) 2011-03-17
EP1694641A2 (fr) 2006-08-30
WO2005058812A3 (fr) 2005-10-13
IL175940A (en) 2012-05-31
EP1694641B1 (fr) 2009-04-15
DK1694641T3 (da) 2009-07-20
GB0329379D0 (en) 2004-01-21
JP2013231053A (ja) 2013-11-14
AU2004299316A1 (en) 2005-06-30
CN1894209B (zh) 2010-12-22
CN101486699A (zh) 2009-07-22

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Owner name: MACFARLAN SMITH LIMITED

Free format text: FORMER OWNER(S): JOHNSON MATTHEY PUBLIC LIMITED COMPANY