AU2004279248B2 - Composition for promoting collagen production - Google Patents
Composition for promoting collagen production Download PDFInfo
- Publication number
- AU2004279248B2 AU2004279248B2 AU2004279248A AU2004279248A AU2004279248B2 AU 2004279248 B2 AU2004279248 B2 AU 2004279248B2 AU 2004279248 A AU2004279248 A AU 2004279248A AU 2004279248 A AU2004279248 A AU 2004279248A AU 2004279248 B2 AU2004279248 B2 AU 2004279248B2
- Authority
- AU
- Australia
- Prior art keywords
- nucleic acid
- related substance
- collagen production
- composition
- promoting collagen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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Classifications
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
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- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
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- A61P17/16—Emollients or protectives, e.g. against radiation
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Landscapes
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- Veterinary Medicine (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
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Applications Claiming Priority (3)
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|---|---|---|---|
| JP2003349156 | 2003-10-08 | ||
| JP2003-349156 | 2003-10-08 | ||
| PCT/JP2004/015298 WO2005034902A1 (ja) | 2003-10-08 | 2004-10-08 | コラーゲン産生促進用組成物 |
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| AU2004279248A1 AU2004279248A1 (en) | 2005-04-21 |
| AU2004279248B2 true AU2004279248B2 (en) | 2011-05-12 |
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| AU2004279248A Ceased AU2004279248B2 (en) | 2003-10-08 | 2004-10-08 | Composition for promoting collagen production |
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| Country | Link |
|---|---|
| US (1) | US7557093B2 (https=) |
| EP (1) | EP1671618B1 (https=) |
| JP (2) | JP4614886B2 (https=) |
| KR (1) | KR20060132817A (https=) |
| CN (1) | CN100569213C (https=) |
| AT (1) | ATE536167T1 (https=) |
| AU (1) | AU2004279248B2 (https=) |
| BR (1) | BRPI0415229A (https=) |
| CA (1) | CA2541584C (https=) |
| ES (1) | ES2376062T3 (https=) |
| TW (1) | TW200514575A (https=) |
| WO (1) | WO2005034902A1 (https=) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2006225271A (ja) * | 2005-02-15 | 2006-08-31 | Otsuka Pharmaceut Co Ltd | シワの予防又は改善剤 |
| AU2008284807B2 (en) * | 2007-08-06 | 2013-03-14 | Otsuka Pharmaceutical Co., Ltd. | Gel composition for external application containing an adenine compound |
| KR100903654B1 (ko) | 2007-10-10 | 2009-06-18 | (주)더페이스샵코리아 | 하고초 추출물과 아데노신을 함유하는 화장료 조성물 |
| ES2671040T3 (es) | 2008-06-09 | 2018-06-04 | Otsuka Pharmaceutical Co., Ltd. | Composición para uso externo |
| KR20130120450A (ko) | 2010-06-25 | 2013-11-04 | 오츠카 세이야쿠 가부시키가이샤 | 광 노출에 의한 비정상적인 피부 세포 형성 억제제 |
| US9492368B2 (en) | 2011-02-01 | 2016-11-15 | Hayashibara Co., Ltd. | External preparation for skin |
| CN103347505B (zh) | 2011-02-14 | 2015-02-04 | J-制油株式会社 | 皮肤胶原蛋白增强剂 |
| JP2013193985A (ja) * | 2012-03-19 | 2013-09-30 | Kao Corp | 育毛剤 |
| JP6332902B2 (ja) * | 2012-10-29 | 2018-05-30 | 株式会社ピカソ美化学研究所 | 美容用組成物 |
| JP2014141475A (ja) * | 2012-12-27 | 2014-08-07 | Daiichi Sankyo Co Ltd | 新規美白剤 |
| KR101507224B1 (ko) * | 2013-05-29 | 2015-03-30 | 부산대학교 산학협력단 | 마늘 유래 우라실을 유효성분으로 함유하는 주름 개선용 조성물 |
| US9937119B2 (en) | 2013-10-29 | 2018-04-10 | Mary Kay Inc. | Cosmetic compositions |
| US11219632B2 (en) | 2017-02-08 | 2022-01-11 | Oriental Yeast Co., Ltd. | Skin pigmentation inhibitor |
| SG11202000615VA (en) * | 2017-07-24 | 2020-02-27 | Otsuka Pharma Co Ltd | Topical composition |
| KR102026365B1 (ko) * | 2018-05-11 | 2019-11-04 | 주식회사 네이처인랩 | 우리딘 및 활성촉진 복합체를 포함하는 화장료 조성물 |
| CN118175986A (zh) | 2021-10-07 | 2024-06-11 | 雅玛山酱油株式会社 | 皮肤外用组合物及其利用、以及皮肤外用组合物原料 |
| KR20240165441A (ko) * | 2022-03-30 | 2024-11-22 | 야마사 쇼유 가부시키가이샤 | 콜라겐 산생 촉진제, 화장료 조성물 또는 피부 외용제 및 경구 투여제 |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63183535A (ja) * | 1986-09-18 | 1988-07-28 | Lion Corp | 皮膚外用剤 |
| JPH0648934A (ja) * | 1992-06-02 | 1994-02-22 | Sansho Seiyaku Co Ltd | 皮膚外用剤 |
| JPH09295915A (ja) * | 1996-04-26 | 1997-11-18 | Kikkoman Corp | 皮膚化粧料 |
| JP2001031549A (ja) * | 1999-07-14 | 2001-02-06 | Pola Chem Ind Inc | 真皮コラーゲン線維束再構築剤及びそれを含有する化粧料 |
| JP2003040729A (ja) * | 2001-07-04 | 2003-02-13 | Basf Ag | 皮膚化粧用組成物における5’−デオキシ−5’−メチルチオアデノシンの使用 |
| WO2003084485A1 (fr) * | 2002-04-09 | 2003-10-16 | Otsuka Pharmaceutical Co., Ltd. | Composition de proliferation cellulaire |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4266855A (en) | 1979-09-24 | 1981-05-12 | Quantor Corporation | Quick change lens system |
| ES8301593A1 (es) * | 1981-11-16 | 1983-01-01 | Union Ind Y Agro Ganader S A U | Procedimiento de obtencion de una leche humanizada adiciona-da de nucleotidos con destino a la alimentacion infantil. |
| ES8503941A1 (es) * | 1982-10-27 | 1985-04-16 | Crinos Industria Farmaco | Procedimiento de obtencion de composiciones para promover el trofismo de la piel y de foliculos piliferosos relacionados |
| EP0256472A3 (en) | 1986-08-11 | 1988-09-07 | Lion Corporation | Cosmetic agent for application to skin |
| US5182269A (en) * | 1987-09-23 | 1993-01-26 | Crinos Industria Farmacobiologica Spa | Composition for topical use having hair stimulating, anti-dandruff and anti-seborrhoic activity |
| JPH07233037A (ja) * | 1993-12-29 | 1995-09-05 | Sansho Seiyaku Co Ltd | 皮膚化粧料 |
| US5602109A (en) * | 1994-01-10 | 1997-02-11 | Abbott Laboratories | Method to enhance the immune system of a human |
| GB9701374D0 (en) | 1997-01-23 | 1997-03-12 | Univ Liverpool | Purinergic agonists and antagonists |
| US6203805B1 (en) * | 1998-11-10 | 2001-03-20 | Color Access, Inc. | Topical compositions containing whey proteins |
| JP2001278783A (ja) | 2000-03-29 | 2001-10-10 | Shiseido Co Ltd | コラーゲン産生促進剤 |
| JP3608078B2 (ja) | 2000-05-11 | 2005-01-05 | 株式会社アルソア本社 | コラーゲン産生促進剤、エストロゲン様作用剤、皮膚化粧料および美容食品 |
| US6759033B2 (en) * | 2000-06-22 | 2004-07-06 | Access Business Group International Llc | Method for slowing the decomposition of a cosmetic composition |
| KR20080070782A (ko) * | 2001-04-13 | 2008-07-30 | 오츠카 세이야쿠 가부시키가이샤 | 당 흡수 촉진제 |
-
2004
- 2004-10-08 ES ES04792515T patent/ES2376062T3/es not_active Expired - Lifetime
- 2004-10-08 WO PCT/JP2004/015298 patent/WO2005034902A1/ja not_active Ceased
- 2004-10-08 TW TW093130588A patent/TW200514575A/zh not_active IP Right Cessation
- 2004-10-08 CN CNB2004800297370A patent/CN100569213C/zh not_active Expired - Fee Related
- 2004-10-08 AU AU2004279248A patent/AU2004279248B2/en not_active Ceased
- 2004-10-08 CA CA2541584A patent/CA2541584C/en not_active Expired - Fee Related
- 2004-10-08 EP EP04792515A patent/EP1671618B1/en not_active Expired - Lifetime
- 2004-10-08 BR BRPI0415229-8A patent/BRPI0415229A/pt not_active Application Discontinuation
- 2004-10-08 US US10/574,696 patent/US7557093B2/en not_active Expired - Lifetime
- 2004-10-08 KR KR1020067006844A patent/KR20060132817A/ko not_active Ceased
- 2004-10-08 JP JP2005514663A patent/JP4614886B2/ja not_active Expired - Lifetime
- 2004-10-08 AT AT04792515T patent/ATE536167T1/de active
-
2010
- 2010-05-31 JP JP2010124971A patent/JP2010215648A/ja not_active Withdrawn
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63183535A (ja) * | 1986-09-18 | 1988-07-28 | Lion Corp | 皮膚外用剤 |
| JPH0648934A (ja) * | 1992-06-02 | 1994-02-22 | Sansho Seiyaku Co Ltd | 皮膚外用剤 |
| JPH09295915A (ja) * | 1996-04-26 | 1997-11-18 | Kikkoman Corp | 皮膚化粧料 |
| JP2001031549A (ja) * | 1999-07-14 | 2001-02-06 | Pola Chem Ind Inc | 真皮コラーゲン線維束再構築剤及びそれを含有する化粧料 |
| JP2003040729A (ja) * | 2001-07-04 | 2003-02-13 | Basf Ag | 皮膚化粧用組成物における5’−デオキシ−5’−メチルチオアデノシンの使用 |
| WO2003084485A1 (fr) * | 2002-04-09 | 2003-10-16 | Otsuka Pharmaceutical Co., Ltd. | Composition de proliferation cellulaire |
Non-Patent Citations (1)
| Title |
|---|
| L.J. Croucher et al * |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1671618A4 (en) | 2009-11-11 |
| JP2010215648A (ja) | 2010-09-30 |
| TW200514575A (en) | 2005-05-01 |
| BRPI0415229A (pt) | 2006-12-05 |
| ES2376062T3 (es) | 2012-03-08 |
| JPWO2005034902A1 (ja) | 2006-12-21 |
| EP1671618A1 (en) | 2006-06-21 |
| TWI347846B (https=) | 2011-09-01 |
| CN1867316A (zh) | 2006-11-22 |
| AU2004279248A1 (en) | 2005-04-21 |
| ATE536167T1 (de) | 2011-12-15 |
| CN100569213C (zh) | 2009-12-16 |
| WO2005034902A1 (ja) | 2005-04-21 |
| EP1671618B1 (en) | 2011-12-07 |
| HK1093891A1 (zh) | 2007-03-16 |
| JP4614886B2 (ja) | 2011-01-19 |
| KR20060132817A (ko) | 2006-12-22 |
| US20070135374A1 (en) | 2007-06-14 |
| CA2541584C (en) | 2013-02-26 |
| CA2541584A1 (en) | 2005-04-21 |
| US7557093B2 (en) | 2009-07-07 |
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