AU2004253649B2 - Thiazolylpiperidine derivatives as MTP inhibitors - Google Patents

Thiazolylpiperidine derivatives as MTP inhibitors Download PDF

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Publication number
AU2004253649B2
AU2004253649B2 AU2004253649A AU2004253649A AU2004253649B2 AU 2004253649 B2 AU2004253649 B2 AU 2004253649B2 AU 2004253649 A AU2004253649 A AU 2004253649A AU 2004253649 A AU2004253649 A AU 2004253649A AU 2004253649 B2 AU2004253649 B2 AU 2004253649B2
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AU
Australia
Prior art keywords
thiazole
pct
carboxamide
piperidin
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2004253649A
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English (en)
Other versions
AU2004253649A1 (en
Inventor
Jacques Barbanton
Francois Collonges
Jacques Decerprit
Herve Dumas
Richard J. Foster
Philippe Guedat
Peter Kane
Jean-Yves Ortholand
Bernd Wendt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
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Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of AU2004253649A1 publication Critical patent/AU2004253649A1/en
Application granted granted Critical
Publication of AU2004253649B2 publication Critical patent/AU2004253649B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AU2004253649A 2003-06-25 2004-06-02 Thiazolylpiperidine derivatives as MTP inhibitors Ceased AU2004253649B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0307670A FR2856685B1 (fr) 2003-06-25 2003-06-25 Derives de thiazolylpiperidine, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
FR03/07670 2003-06-25
PCT/EP2004/005931 WO2005003128A1 (en) 2003-06-25 2004-06-02 Thiazolylpiperidine derivatives as mtp inhibitors

Publications (2)

Publication Number Publication Date
AU2004253649A1 AU2004253649A1 (en) 2005-01-13
AU2004253649B2 true AU2004253649B2 (en) 2009-09-24

Family

ID=33515396

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2004253649A Ceased AU2004253649B2 (en) 2003-06-25 2004-06-02 Thiazolylpiperidine derivatives as MTP inhibitors

Country Status (18)

Country Link
US (1) US7674803B2 (zh)
EP (1) EP1636218B1 (zh)
JP (1) JP4629666B2 (zh)
KR (1) KR20060024812A (zh)
CN (1) CN1809560A (zh)
AR (1) AR044909A1 (zh)
AT (1) ATE426599T1 (zh)
AU (1) AU2004253649B2 (zh)
BR (1) BRPI0411721A (zh)
CA (1) CA2531011C (zh)
DE (1) DE602004020223D1 (zh)
ES (1) ES2323463T3 (zh)
FR (1) FR2856685B1 (zh)
MX (1) MXPA05013521A (zh)
RU (1) RU2006101890A (zh)
TW (1) TW200518751A (zh)
WO (1) WO2005003128A1 (zh)
ZA (1) ZA200600690B (zh)

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US20100267717A1 (en) * 2005-07-29 2010-10-21 4Sc Ag Novel Heterocyclic NF-kB Inhibitors
US7601745B2 (en) 2004-09-27 2009-10-13 4Sc Ag Heterocyclic NF-kB inhibitors
MY179032A (en) 2004-10-25 2020-10-26 Cancer Research Tech Ltd Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors
TW200738701A (en) 2005-07-26 2007-10-16 Du Pont Fungicidal carboxamides
NZ565470A (en) * 2005-07-29 2010-11-26 4Sc Ag Novel heterocyclic NF-kB inhibitors
BRPI0614834A2 (pt) * 2005-08-18 2011-04-19 Hoffmann La Roche compostos, processo para a sua manufatura, composições farmacêuticas que os compreendem e usos destas
EP1832586A1 (en) * 2006-03-10 2007-09-12 Oridis Biomed Forschungs- und Entwicklungs GmbH Thiazole-piperidine derivatives in treatment of diseases of liver and the pancreas
EP1834954A1 (en) * 2006-03-15 2007-09-19 4Sc Ag Thiazoles as NF-kB Inhibitors (proteasome inhibitors)
JP2009529555A (ja) * 2006-03-15 2009-08-20 ４エスツェー アクチェンゲゼルシャフト 新規複素環式ＮＦ−κＢ阻害薬
WO2007115805A2 (en) * 2006-04-05 2007-10-18 European Molecular Biology Laboratory (Embl) Aurora kinase inhibitors
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WO2007125321A2 (en) 2006-04-25 2007-11-08 Astex Therapeutics Limited Purine and deazapurine derivatives as pharmaceutical compounds
WO2008013622A2 (en) 2006-07-27 2008-01-31 E. I. Du Pont De Nemours And Company Fungicidal azocyclic amides
US9090604B2 (en) 2006-07-27 2015-07-28 E I Du Pont De Nemours And Company Fungicidal azocyclic amides
CA2668255A1 (en) * 2006-10-31 2008-05-08 Schering Corporation Anilinopiperazine derivatives and methods of use thereof
WO2008054702A1 (en) * 2006-10-31 2008-05-08 Schering Corporation Anilinopiperazine derivatives and methods of use thereof
CN101663262B (zh) * 2006-12-01 2014-03-26 百时美施贵宝公司 用于治疗动脉粥样硬化和心血管疾病的作为cetp抑制剂的n-(3-苄基)-2,2-(二苯基)-丙-1胺衍生物
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EP2201012B1 (en) 2007-10-11 2014-06-25 AstraZeneca AB Pyrrolo[2,3-d]pyrimidin derivatives as protein kinase b inhibitors
TWI428091B (zh) 2007-10-23 2014-03-01 Du Pont 殺真菌劑混合物
AU2008314922B2 (en) 2007-10-24 2013-08-29 Astellas Pharma Inc. Azolecarboxamide compound or salt thereof
MX2010004875A (es) * 2007-10-29 2010-05-19 Schering Corp Derivados de tiazol y metodos para utilizarlos.
MX2010008102A (es) 2008-01-25 2010-08-04 Du Pont Compuestos fungicidas heterociclicos.
KR20100135952A (ko) 2008-04-30 2010-12-27 바이엘 크롭사이언스 아게 식물 보호제로서의 티아졸-4-카복실산 에스테르 및 티오에스테르
KR20110067052A (ko) * 2008-10-01 2011-06-20 바이엘 크롭사이언스 아게 식물 보호제로서의 헤테로사이클릴 치환된 티아졸
PL2358709T3 (pl) 2008-12-02 2014-06-30 Du Pont Grzybobójcze związki heterocykliczne
JP5642661B2 (ja) * 2009-03-05 2014-12-17 塩野義製薬株式会社 Ｎｐｙｙ５受容体拮抗作用を有するピペリジンおよびピロリジン誘導体
EP2272846A1 (de) * 2009-06-23 2011-01-12 Bayer CropScience AG Thiazolylpiperidin Derivate als Fungizide
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AU2003290335A1 (en) * 2002-12-24 2004-07-22 Metris Therapeutics Limited Piperidinyl-thiazole carboxamide derivatives for altering vascular tone

Also Published As

Publication number Publication date
AU2004253649A1 (en) 2005-01-13
EP1636218B1 (en) 2009-03-25
BRPI0411721A (pt) 2006-05-23
DE602004020223D1 (de) 2009-05-07
FR2856685A1 (fr) 2004-12-31
CN1809560A (zh) 2006-07-26
MXPA05013521A (es) 2006-03-09
ATE426599T1 (de) 2009-04-15
RU2006101890A (ru) 2007-07-27
AR044909A1 (es) 2005-10-05
TW200518751A (en) 2005-06-16
EP1636218A1 (en) 2006-03-22
JP2007506651A (ja) 2007-03-22
FR2856685B1 (fr) 2005-09-23
JP4629666B2 (ja) 2011-02-09
WO2005003128A1 (en) 2005-01-13
CA2531011C (en) 2012-10-09
KR20060024812A (ko) 2006-03-17
US7674803B2 (en) 2010-03-09
CA2531011A1 (en) 2005-01-13
US20070054939A1 (en) 2007-03-08
ZA200600690B (en) 2007-05-30
ES2323463T3 (es) 2009-07-16

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