AU2004243070B2 - Localized temperature control for spatial arrays of reaction media - Google Patents

Localized temperature control for spatial arrays of reaction media Download PDF

Info

Publication number
AU2004243070B2
AU2004243070B2 AU2004243070A AU2004243070A AU2004243070B2 AU 2004243070 B2 AU2004243070 B2 AU 2004243070B2 AU 2004243070 A AU2004243070 A AU 2004243070A AU 2004243070 A AU2004243070 A AU 2004243070A AU 2004243070 B2 AU2004243070 B2 AU 2004243070B2
Authority
AU
Australia
Prior art keywords
heat
regions
thermal
thermoelectric modules
region
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2004243070A
Other languages
English (en)
Other versions
AU2004243070A1 (en
Inventor
German Arciniegas
Jeff Ceremony
Daniel Y. Chu
Charles W. Ragsdale
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bio Rad Laboratories Inc
Original Assignee
Bio Rad Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33490545&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU2004243070(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bio Rad Laboratories Inc filed Critical Bio Rad Laboratories Inc
Publication of AU2004243070A1 publication Critical patent/AU2004243070A1/en
Application granted granted Critical
Publication of AU2004243070B2 publication Critical patent/AU2004243070B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/54—Heating or cooling apparatus; Heat insulating devices using spatial temperature gradients
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • B01L3/50851—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates specially adapted for heating or cooling samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/06—Test-tube stands; Test-tube holders
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/044—Connecting closures to device or container pierceable, e.g. films, membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0829—Multi-well plates; Microtitration plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/12—Specific details about materials
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1822—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using Peltier elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1838—Means for temperature control using fluid heat transfer medium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1883—Means for temperature control using thermal insulation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B01L2400/049—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics vacuum

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Control Of Temperature (AREA)
AU2004243070A 2003-05-23 2004-05-20 Localized temperature control for spatial arrays of reaction media Ceased AU2004243070B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US47296403P 2003-05-23 2003-05-23
US60/472,964 2003-05-23
PCT/US2004/016025 WO2004105947A2 (en) 2003-05-23 2004-05-20 Localized temperature control for spatial arrays of reaction media

Publications (2)

Publication Number Publication Date
AU2004243070A1 AU2004243070A1 (en) 2004-12-09
AU2004243070B2 true AU2004243070B2 (en) 2010-04-15

Family

ID=33490545

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2004243070A Ceased AU2004243070B2 (en) 2003-05-23 2004-05-20 Localized temperature control for spatial arrays of reaction media

Country Status (7)

Country Link
US (4) US7771933B2 (enExample)
EP (1) EP1641563B1 (enExample)
JP (1) JP4705035B2 (enExample)
AU (1) AU2004243070B2 (enExample)
CA (1) CA2523040C (enExample)
DE (1) DE04752947T1 (enExample)
WO (1) WO2004105947A2 (enExample)

Families Citing this family (86)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8676383B2 (en) 2002-12-23 2014-03-18 Applied Biosystems, Llc Device for carrying out chemical or biological reactions
AU2004243070B2 (en) 2003-05-23 2010-04-15 Bio-Rad Laboratories, Inc. Localized temperature control for spatial arrays of reaction media
US20040241048A1 (en) 2003-05-30 2004-12-02 Applera Corporation Thermal cycling apparatus and method for providing thermal uniformity
JP4695851B2 (ja) * 2003-07-10 2011-06-08 シチズンホールディングス株式会社 マイクロ化学チップ温度調節装置
US7833709B2 (en) * 2004-05-28 2010-11-16 Wafergen, Inc. Thermo-controllable chips for multiplex analyses
EP1710017B1 (en) * 2005-04-04 2012-12-19 Roche Diagnostics GmbH Thermocycling of a block comprising multiple samples
CN100405625C (zh) * 2005-07-18 2008-07-23 财团法人工业技术研究院 制作微型热电元件的方法及其整合热电元件的结构
CN101341030A (zh) * 2005-12-22 2009-01-07 皇家飞利浦电子股份有限公司 用于将物质放置到基板上的喷墨设备，用于将物质放置到基板上的方法以及喷墨设备的使用
US8232091B2 (en) 2006-05-17 2012-07-31 California Institute Of Technology Thermal cycling system
WO2008070198A2 (en) * 2006-05-17 2008-06-12 California Institute Of Technology Thermal cycling system
WO2007141700A2 (en) 2006-06-08 2007-12-13 Koninklijke Philips Electronics N. V. Microelectronic sensor device for dna detection
US7629124B2 (en) 2006-06-30 2009-12-08 Canon U.S. Life Sciences, Inc. Real-time PCR in micro-channels
WO2008014389A2 (en) * 2006-07-26 2008-01-31 Board Of Governors For Higher Education State Of Rhode Island And Providence Plantations Streaming-based micro/mini channel electronic cooling techniques
WO2008091626A1 (en) * 2007-01-22 2008-07-31 Wafergen, Inc. Apparatus for high throughput chemical reactions
US9475051B2 (en) * 2007-02-27 2016-10-25 Sony Corporation Nucleic acid amplifier
WO2008127330A1 (en) * 2007-04-12 2008-10-23 Duke Manufacturing Co. A food serving bar
US7958736B2 (en) * 2007-05-24 2011-06-14 Bio-Rad Laboratories, Inc. Thermoelectric device and heat sink assembly with reduced edge heat loss
JP5045268B2 (ja) 2007-06-28 2012-10-10 ソニー株式会社 反応処理装置
US8828712B2 (en) 2007-06-29 2014-09-09 Toppan Printing Co., Ltd. Genetic detection and determination apparatus and method, gene reactor, and incubator
WO2009034988A1 (ja) * 2007-09-14 2009-03-19 Shimane Prefectural Government Ｐｃｒ用温度制御装置
EP2060324A1 (en) 2007-11-13 2009-05-20 F.Hoffmann-La Roche Ag Thermal block unit
WO2009105499A1 (en) * 2008-02-20 2009-08-27 Termaat Joel R Thermocycler and sample vessel for rapid amplification of dna
DE102008023299A1 (de) * 2008-05-08 2009-11-19 Micropelt Gmbh Aufnahme für eine Probe
EP2127751B1 (en) * 2008-05-19 2012-05-16 Roche Diagnostics GmbH Improved cooler / heater arrangement with solid film lubricant
EP2123360A1 (en) * 2008-05-20 2009-11-25 F.Hoffmann-La Roche Ag Thermocycling device having a thermocycler module with a thermal switch, method of cooling a heating block in a thermocycler module of a thermocycling device and analytical apparatus
WO2010003423A2 (en) * 2008-07-05 2010-01-14 Unisense Fertilitech A/S One to one identification system
JP5743891B2 (ja) * 2008-09-23 2015-07-01 コーニンクレッカ フィリップス エヌ ヴェ サーモサイクルデバイス
TWI368651B (en) * 2008-10-24 2012-07-21 Quanta Comp Inc Temperature variation apparatus
DE202010010523U1 (de) 2009-09-09 2010-11-18 Helixis, Inc., Carlsbad Optisches System für Mehrfachreaktionen
CN102021114B (zh) * 2009-09-23 2013-08-21 清华大学 聚合酵素连锁反应器
DE102010003365A1 (de) * 2010-03-26 2011-09-29 Micropelt Gmbh Vorrichtung zur Durchführung der PCR und PCR-Verfahren
CN103003448B (zh) 2010-04-09 2015-06-17 生命技术公司 使用动态控制改进热循环仪的热均匀性
CN102939161B (zh) * 2010-04-30 2016-01-20 比格科技私人有限公司 一种非接触式实时微聚合酶链式反应系统及其方法
JP5249988B2 (ja) * 2010-05-07 2013-07-31 株式会社日立ハイテクノロジーズ 核酸増幅装置及びそれを用いた核酸検査装置
JP5582049B2 (ja) * 2010-05-31 2014-09-03 横河電機株式会社 化学処理用カートリッジシステム
JP5689274B2 (ja) * 2010-10-05 2015-03-25 株式会社日立ハイテクノロジーズ 核酸検査装置及び容器搬送方法
CN106268992A (zh) * 2010-12-17 2017-01-04 Bjs Ip有限公司 用于快速pcr加热的方法及系统
US9168531B2 (en) * 2011-03-24 2015-10-27 Fluidigm Corporation Method for thermal cycling of microfluidic samples
EP2704835A4 (en) * 2011-05-06 2014-12-24 Bio Rad Laboratories THERMOCYCLE COMPRISING A STEAM CHAMBER FOR RAPID TEMPERATURE CHANGES
CA2835654A1 (en) 2011-06-01 2012-12-06 Streck, Inc. Rapid thermocycler system for rapid amplification of nucleic acids and related methods
US20130137144A1 (en) * 2011-06-08 2013-05-30 Bio-Rad Laboratories, Inc. LSG - GXD Division Thermal block with built-in thermoelectric elements
DE112012002529B4 (de) * 2011-06-24 2015-09-10 Hitachi High-Technologies Corp. Nukleinsäurevervielfältigungsvorrichtung und Nukleinsäureanalysevorrichtung
US20130005372A1 (en) * 2011-06-29 2013-01-03 Rosemount Inc. Integral thermoelectric generator for wireless devices
JP5759818B2 (ja) * 2011-07-25 2015-08-05 株式会社日立ハイテクノロジーズ 核酸検査装置
DE102011119174A1 (de) 2011-11-23 2013-05-23 Inheco Industrial Heating And Cooling Gmbh Vapor Chamber
EP2608088B1 (en) * 2011-12-20 2018-12-12 F. Hoffmann-La Roche AG Improved method for nucleic acid analysis
US8397518B1 (en) 2012-02-20 2013-03-19 Dhama Innovations PVT. Ltd. Apparel with integral heating and cooling device
WO2013175218A1 (en) 2012-05-24 2013-11-28 Bjs Ip Limited Clamp for fast pcr heating
CN104736316B (zh) * 2012-07-31 2017-05-24 3M创新有限公司 包括具有热可控阵列的模具腔体表面的注塑设备和方法
AU2013202808B2 (en) * 2012-07-31 2014-11-13 Gen-Probe Incorporated System and method for performing multiplex thermal melt analysis
AU2013202793B2 (en) 2012-07-31 2014-09-18 Gen-Probe Incorporated System, method and apparatus for automated incubation
JP5801334B2 (ja) * 2013-03-08 2015-10-28 株式会社日立ハイテクノロジーズ 核酸増幅装置及びそれを用いた核酸検査装置
AU2013202805B2 (en) 2013-03-14 2015-07-16 Gen-Probe Incorporated System and method for extending the capabilities of a diagnostic analyzer
EP3014251A1 (en) 2013-06-28 2016-05-04 Streck Inc. Devices for real-time polymerase chain reaction
CN105518462A (zh) 2013-09-12 2016-04-20 西门子医疗保健诊断公司 动态测定选择和样本制备装置和方法及其机器可读介质
CA2922854A1 (en) 2013-09-16 2015-03-19 Life Technologies Corporation Apparatuses, systems and methods for providing thermocycler thermal uniformity
JP5820459B2 (ja) * 2013-12-18 2015-11-24 コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ． サーモサイクルデバイス
KR20160123356A (ko) 2014-02-18 2016-10-25 라이프 테크놀로지스 코포레이션 스케일러블 유전자증폭기를 제공하고 열전 장치를 격리시키기 위한 장치, 시스템 및 방법
CN103990501A (zh) * 2014-06-18 2014-08-20 云南师范大学 一种高效传热与热隔离的微热控芯片系统
DE102014018308A1 (de) * 2014-12-10 2016-06-16 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Temperierkörper für eine Multiwell-Platte und Verfahren und Vorrichtung zum Einfrieren und/oder Auftauen von biologischen Proben
EP3245283B1 (en) * 2015-01-16 2020-09-23 The Regents of The University of California Led driven plasmonic heating apparatus for nucleic acids amplification
WO2016134342A1 (en) 2015-02-20 2016-08-25 Wafergen, Inc. Method for rapid accurate dispensing, visualization and analysis of single cells
US9585237B2 (en) * 2015-04-09 2017-02-28 Honeywell International Inc. Micro-structured atomic source system
JP2017146127A (ja) * 2016-02-15 2017-08-24 株式会社島津製作所 成分抽出装置
CN109070044B (zh) 2016-07-21 2021-07-30 宝生物工程（美国)有限公司 使用多孔装置进行的多z平面成像和分配
MX2019002099A (es) * 2016-08-22 2019-05-16 Biocontrol Systems Inc Soporte de separacion variable.
EP3747546B1 (en) * 2016-09-01 2022-04-13 Roche Diagnostics GmbH Assembly, instrument for performing a temperature-dependent reaction and method for performing a temperature-dependent reaction in an assembly
EP3519098B1 (en) * 2016-09-29 2024-07-03 DIALUNOX GmbH Sample container arrangement
CN110168344A (zh) * 2017-05-29 2019-08-23 株式会社岛津制作所 成分萃取装置
US10527355B2 (en) 2017-06-13 2020-01-07 Microsoft Technology Licensing, Llc Devices, methods, and systems for thermal management
US20190004576A1 (en) * 2017-06-30 2019-01-03 Microsoft Technology Licensing, Llc Adaptive cooling heat spreader
CN110651033B (zh) * 2017-09-19 2022-11-01 瑞基海洋生物科技股份有限公司 生化反应装置的加热机构
US10511135B2 (en) 2017-12-19 2019-12-17 Raytheon Company Laser system with mechanically-robust monolithic fused planar waveguide (PWG) structure
KR20210006337A (ko) * 2018-03-15 2021-01-18 크립토스 바이오테크놀로지스, 인코포레이티드 열 보조 생화학 반응을 수행하기 위한 방법 및 시스템
CN109082373A (zh) * 2018-08-15 2018-12-25 湖南圣湘生物科技有限公司 生化反应加热装置及其制作方法
WO2020047512A1 (en) * 2018-08-31 2020-03-05 The Trustees Of Dartmouth College Multi-coil induction hob and method
CN113287208B (zh) 2019-01-14 2025-08-26 生物辐射实验室股份有限公司 热泵设备和组件
JP7300099B2 (ja) * 2019-02-22 2023-06-29 ウシオ電機株式会社 細胞培養チップ
KR102204931B1 (ko) * 2019-03-12 2021-01-20 퓨쳐이엔지 주식회사 독립적 온도 제어가 가능한 pcr용 블록
WO2020190035A1 (en) * 2019-03-18 2020-09-24 Seegene, Inc. Thermal cycler comprising sample holder assembly
US20220178918A1 (en) * 2019-03-20 2022-06-09 Citizen Watch Co., Ltd. Device for detecting substance to be measured, and method for detecting substance to be measured
CN110205242B (zh) * 2019-06-18 2024-04-26 苏州锐讯生物科技有限公司 一种快速实现数字pcr反应的微流控芯片组件及其应用
WO2021100189A1 (ja) * 2019-11-22 2021-05-27 株式会社日立ハイテク Ｐｃｒ容器、ｐｃｒ容器支持装置、サーマルサイクラーおよび遺伝子検査装置
US11732964B2 (en) * 2020-04-15 2023-08-22 Navinta Iii Inc Lyophilization promoting element
WO2023049349A1 (en) 2021-09-23 2023-03-30 N6 Tec, Inc. Methods and systems for sample analysis
WO2024252648A1 (ja) * 2023-06-09 2024-12-12 株式会社日立ハイテク 液体処理装置、核酸抽出装置、及び遺伝子検査装置

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4970868A (en) * 1989-06-23 1990-11-20 International Business Machines Corporation Apparatus for temperature control of electronic devices
US5598320A (en) * 1995-03-06 1997-01-28 Ast Research, Inc. Rotable and slideble heat pipe apparatus for reducing heat build up in electronic devices
US5849208A (en) * 1995-09-07 1998-12-15 Microfab Technoologies, Inc. Making apparatus for conducting biochemical analyses
WO1999048608A2 (en) * 1998-03-23 1999-09-30 Cepheid Multi-site reactor system with dynamic, independent control of individual reaction sites
US6145688A (en) * 1996-07-17 2000-11-14 Smith; James C. Closure device for containers
US20030008286A1 (en) * 2001-07-05 2003-01-09 Institute Of Microelectronics Miniaturized multi-chamber thermal cycler for independent thermal multiplexing
US6939477B2 (en) * 1997-06-06 2005-09-06 Ashland, Inc. Temperature-controlled induction heating of polymeric materials

Family Cites Families (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4042012A (en) * 1976-08-27 1977-08-16 Electric Power Research Institute Heat pump system with improved heat transfer
US4081143A (en) * 1977-02-18 1978-03-28 Tire-Gator, Inc. Methods of handling waste
JPS5582091A (en) 1978-12-15 1980-06-20 Seiko Instr & Electronics Ltd Automatic clear circuit
JPS5849797B2 (ja) * 1978-12-19 1983-11-07 松下電器産業株式会社 ヒ−トパイプ
US4481967A (en) * 1979-11-15 1984-11-13 Rosemount Inc. Control circuit for current to pressure converter
US4341000A (en) 1980-03-24 1982-07-27 Combustion Engineering, Inc. Method of charging heat pipe
US4516631A (en) 1981-11-04 1985-05-14 Combustion Engineering, Inc. Nozzle cooled by heat pipe means
US4703796A (en) 1987-02-27 1987-11-03 Stirling Thermal Motors, Inc. Corrosion resistant heat pipe
JPH01288331A (ja) * 1988-05-13 1989-11-20 Hitachi Ltd 熱伝達装置
US4851183A (en) 1988-05-17 1989-07-25 The United States Of America As Represented By The United States Department Of Energy Underground nuclear power station using self-regulating heat-pipe controlled reactors
JP2974337B2 (ja) 1989-09-10 1999-11-10 キヤノン株式会社 自動焦点調節装置
JPH03297378A (ja) * 1990-04-13 1991-12-27 Seiko Instr Inc 自動反応装置
US5935522A (en) 1990-06-04 1999-08-10 University Of Utah Research Foundation On-line DNA analysis system with rapid thermal cycling
US5498392A (en) 1992-05-01 1996-03-12 Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification device and method
US5639423A (en) 1992-08-31 1997-06-17 The Regents Of The University Of Calfornia Microfabricated reactor
EP0636413B1 (en) * 1993-07-28 2001-11-14 PE Corporation (NY) Nucleic acid amplification reaction apparatus and method
WO1995030139A1 (en) 1994-04-29 1995-11-09 Perkin-Elmer Corporation System for real time detection of nucleic acid amplification products
JPH08189788A (ja) * 1994-12-29 1996-07-23 Ichiro Takahashi 磁性流体振動型熱拡散方法及び装置
US5921315A (en) 1995-06-07 1999-07-13 Heat Pipe Technology, Inc. Three-dimensional heat pipe
US6524532B1 (en) 1995-06-20 2003-02-25 The Regents Of The University Of California Microfabricated sleeve devices for chemical reactions
US6521181B1 (en) 1995-06-20 2003-02-18 The Regents Of The University Of Calfornia Microfabricated electrochemiluminescence cell for chemical reaction detection
US5589136A (en) 1995-06-20 1996-12-31 Regents Of The University Of California Silicon-based sleeve devices for chemical reactions
DE69700499T2 (de) 1996-04-03 2000-03-23 Perkin Elmer Corp Vorrichtung und verfahren zum nachweis mehrerer analyten
CA2591550C (en) 1996-06-04 2009-04-28 University Of Utah Research Foundation Monitoring hybridization during pcr
US5817167A (en) 1996-08-21 1998-10-06 Des Champs Laboratories Incorporated Desiccant based dehumidifier
DE29623597U1 (de) 1996-11-08 1999-01-07 Eppendorf - Netheler - Hinz Gmbh, 22339 Hamburg Temperierblock mit Temperiereinrichtungen
JP2874684B2 (ja) 1997-03-27 1999-03-24 日本電気株式会社 プラグインユニットの放熱構造
JP2001521379A (ja) 1997-03-28 2001-11-06 ザ パーキン−エルマー コーポレーション Ｐｃｒのための熱サイクラの改良
US6558947B1 (en) * 1997-09-26 2003-05-06 Applied Chemical & Engineering Systems, Inc. Thermal cycler
US6210882B1 (en) 1998-01-29 2001-04-03 Mayo Foundation For Medical Education And Reseach Rapid thermocycling for sample analysis
US6369893B1 (en) 1998-05-19 2002-04-09 Cepheid Multi-channel optical detection system
US5947111A (en) 1998-04-30 1999-09-07 Hudson Products Corporation Apparatus for the controlled heating of process fluids
US6503750B1 (en) 1998-11-25 2003-01-07 The Regents Of The University Of California PCR thermocycler
US6372484B1 (en) 1999-01-25 2002-04-16 E.I. Dupont De Nemours And Company Apparatus for integrated polymerase chain reaction and capillary electrophoresis
US6225061B1 (en) 1999-03-10 2001-05-01 Sequenom, Inc. Systems and methods for performing reactions in an unsealed environment
EP1045038A1 (en) * 1999-04-08 2000-10-18 Hans-Knöll-Institut Für Naturstoff-Forschung E.V. Rapid heat block thermocycler
US6706519B1 (en) * 1999-06-22 2004-03-16 Tecan Trading Ag Devices and methods for the performance of miniaturized in vitro amplification assays
WO2001007890A2 (en) 1999-07-21 2001-02-01 Dako A/S A method of controlling the temperature of a specimen in or on a solid support member
US6337435B1 (en) 1999-07-30 2002-01-08 Bio-Rad Laboratories, Inc. Temperature control for multi-vessel reaction apparatus
US6633785B1 (en) * 1999-08-31 2003-10-14 Kabushiki Kaisha Toshiba Thermal cycler and DNA amplifier method
DE29917313U1 (de) * 1999-10-01 2001-02-15 MWG-BIOTECH AG, 85560 Ebersberg Vorrichtung zur Durchführung chemischer oder biologischer Reaktionen
WO2001041931A2 (en) * 1999-12-09 2001-06-14 Motorola, Inc. Multilayered microfluidic devices for analyte reactions
WO2001051209A1 (de) * 2000-01-15 2001-07-19 Eppendorf Ag Labortemperiergerät mit temperaturgeregeltem temperierblock
US20020006619A1 (en) * 2000-02-23 2002-01-17 David Cohen Thermal cycler that allows two-dimension temperature gradients and hold time optimization
US6640891B1 (en) 2000-09-05 2003-11-04 Kevin R. Oldenburg Rapid thermal cycling device
US20040043479A1 (en) * 2000-12-11 2004-03-04 Briscoe Cynthia G. Multilayerd microfluidic devices for analyte reactions
US6312929B1 (en) 2000-12-22 2001-11-06 Cepheid Compositions and methods enabling a totally internally controlled amplification reaction
US6509186B1 (en) 2001-02-16 2003-01-21 Institute Of Microelectronics Miniaturized thermal cycler
US6432695B1 (en) 2001-02-16 2002-08-13 Institute Of Microelectronics Miniaturized thermal cycler
WO2002074898A2 (en) * 2001-03-16 2002-09-26 Techne (Cambridge) Ltd Gradient block temperature control device
US6960437B2 (en) * 2001-04-06 2005-11-01 California Institute Of Technology Nucleic acid amplification utilizing microfluidic devices
US6766817B2 (en) 2001-07-25 2004-07-27 Tubarc Technologies, Llc Fluid conduction utilizing a reversible unsaturated siphon with tubarc porosity action
KR100450818B1 (ko) * 2002-03-09 2004-10-01 삼성전자주식회사 다챔버 ｐｃｒ 칩
US6717365B2 (en) 2002-04-18 2004-04-06 Lg Electronics Inc. Magnetron
US6710442B1 (en) 2002-08-27 2004-03-23 Micron Technology, Inc. Microelectronic devices with improved heat dissipation and methods for cooling microelectronic devices
US6875602B2 (en) * 2002-09-24 2005-04-05 The United States Of America As Represented By The Secretary Of The Army Portable thermocycler
AU2004243070B2 (en) * 2003-05-23 2010-04-15 Bio-Rad Laboratories, Inc. Localized temperature control for spatial arrays of reaction media
EP1643249A4 (en) * 2003-07-04 2006-10-04 Kubota Kk BIOCHIP

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4970868A (en) * 1989-06-23 1990-11-20 International Business Machines Corporation Apparatus for temperature control of electronic devices
US5598320A (en) * 1995-03-06 1997-01-28 Ast Research, Inc. Rotable and slideble heat pipe apparatus for reducing heat build up in electronic devices
US5849208A (en) * 1995-09-07 1998-12-15 Microfab Technoologies, Inc. Making apparatus for conducting biochemical analyses
US6145688A (en) * 1996-07-17 2000-11-14 Smith; James C. Closure device for containers
US6939477B2 (en) * 1997-06-06 2005-09-06 Ashland, Inc. Temperature-controlled induction heating of polymeric materials
WO1999048608A2 (en) * 1998-03-23 1999-09-30 Cepheid Multi-site reactor system with dynamic, independent control of individual reaction sites
US20030008286A1 (en) * 2001-07-05 2003-01-09 Institute Of Microelectronics Miniaturized multi-chamber thermal cycler for independent thermal multiplexing

Also Published As

Publication number Publication date
US20150258547A1 (en) 2015-09-17
US8945881B2 (en) 2015-02-03
US20050009070A1 (en) 2005-01-13
US7771933B2 (en) 2010-08-10
JP4705035B2 (ja) 2011-06-22
EP1641563A4 (en) 2012-01-18
WO2004105947A2 (en) 2004-12-09
CA2523040C (en) 2012-01-17
US20170239663A1 (en) 2017-08-24
JP2007503217A (ja) 2007-02-22
CA2523040A1 (en) 2004-12-09
WO2004105947A3 (en) 2005-12-22
US9623414B2 (en) 2017-04-18
US20100099581A1 (en) 2010-04-22
EP1641563A2 (en) 2006-04-05
AU2004243070A1 (en) 2004-12-09
DE04752947T1 (de) 2006-11-16
EP1641563B1 (en) 2018-08-29

Similar Documents

Publication Publication Date Title
AU2004243070B2 (en) Localized temperature control for spatial arrays of reaction media
AU736484B2 (en) Improvements in thermal cycler for PCR
US8735103B2 (en) Natural convection-driven PCR apparatus and method using disposable polymer chip
JP5254874B2 (ja) 改良された冷却器／加熱器の構成
US9180459B2 (en) Devices and methods for thermally-mediated chemical reactions
US10471431B2 (en) Apparatuses, systems and methods for providing scalable thermal cyclers and isolating thermoelectric devices
US20070184548A1 (en) Device for carrying out chemical or biological reactions
US9243624B2 (en) Thermally driven Knudsen pump
US6635492B2 (en) Heating specimen carriers
WO2016004022A2 (en) Floating thermal contact enabled pcr
US20090291487A1 (en) Thermocycling Device
KR100900956B1 (ko) 일회용 폴리머 칩을 이용한 자연대류 ｐｃｒ 장치 및 그방법
US20040265190A1 (en) Microcomponent
US8695355B2 (en) Thermal management techniques, apparatus and methods for use in microfluidic devices
CN101107507B (zh) 用于具有不同热容的少量流体样品的温度控制器
AU774195B2 (en) Heating specimen carriers
Khaji et al. Integrated cooling system for microfluidic PDMS devices used in biological microscopy studies
EP1386666B1 (en) Improvements in thermal cycler for pcr
Rahmat et al. Geometric optimization for a thermal microfluidic chip
KR20080070947A (ko) 냉각장치 및/또는 시료공급제어장치가 구비된 바이오칩

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired