AU2003270722A1 - Method and apparatus for sorting particles - Google Patents
Method and apparatus for sorting particles Download PDFInfo
- Publication number
- AU2003270722A1 AU2003270722A1 AU2003270722A AU2003270722A AU2003270722A1 AU 2003270722 A1 AU2003270722 A1 AU 2003270722A1 AU 2003270722 A AU2003270722 A AU 2003270722A AU 2003270722 A AU2003270722 A AU 2003270722A AU 2003270722 A1 AU2003270722 A1 AU 2003270722A1
- Authority
- AU
- Australia
- Prior art keywords
- cells
- particles
- sorting
- particle
- predetermined characteristic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000002245 particle Substances 0.000 title claims description 244
- 238000000034 method Methods 0.000 title claims description 33
- 239000007788 liquid Substances 0.000 claims description 37
- 150000001875 compounds Chemical class 0.000 claims description 34
- 238000001514 detection method Methods 0.000 claims description 29
- 239000012530 fluid Substances 0.000 claims description 26
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- 230000000694 effects Effects 0.000 claims description 17
- 238000012216 screening Methods 0.000 claims description 16
- 108090000790 Enzymes Proteins 0.000 claims description 13
- 102000004190 Enzymes Human genes 0.000 claims description 13
- 238000012360 testing method Methods 0.000 claims description 13
- 239000003550 marker Substances 0.000 claims description 10
- 239000000758 substrate Substances 0.000 claims description 10
- 238000006073 displacement reaction Methods 0.000 claims description 9
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- 238000004113 cell culture Methods 0.000 claims 1
- 230000001413 cellular effect Effects 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 210000004027 cell Anatomy 0.000 description 46
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- 230000003834 intracellular effect Effects 0.000 description 4
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- 238000005516 engineering process Methods 0.000 description 3
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- 230000002829 reductive effect Effects 0.000 description 3
- BCHIXGBGRHLSBE-UHFFFAOYSA-N (4-methyl-2-oxochromen-7-yl) dihydrogen phosphate Chemical compound C1=C(OP(O)(O)=O)C=CC2=C1OC(=O)C=C2C BCHIXGBGRHLSBE-UHFFFAOYSA-N 0.000 description 2
- 238000011161 development Methods 0.000 description 2
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- 102000004169 proteins and genes Human genes 0.000 description 2
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- 238000000926 separation method Methods 0.000 description 2
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- YGTNHTPZQUQMKP-UHFFFAOYSA-N 1-[(1e)-1-diazoethyl]-4,5-dimethoxy-2-nitrobenzene Chemical compound COC1=CC(C(C)=[N+]=[N-])=C([N+]([O-])=O)C=C1OC YGTNHTPZQUQMKP-UHFFFAOYSA-N 0.000 description 1
- LYIIBVSRGJSHAV-UHFFFAOYSA-N 2-aminoacetaldehyde Chemical compound NCC=O LYIIBVSRGJSHAV-UHFFFAOYSA-N 0.000 description 1
- 108020002663 Aldehyde Dehydrogenase Proteins 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- IGXWBGJHJZYPQS-SSDOTTSWSA-N D-Luciferin Chemical compound OC(=O)[C@H]1CSC(C=2SC3=CC=C(O)C=C3N=2)=N1 IGXWBGJHJZYPQS-SSDOTTSWSA-N 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 208000026350 Inborn Genetic disease Diseases 0.000 description 1
- 208000024556 Mendelian disease Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 description 1
- 108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 description 1
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- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 210000001772 blood platelet Anatomy 0.000 description 1
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- 238000012512 characterization method Methods 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
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- 210000002308 embryonic cell Anatomy 0.000 description 1
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- 238000012239 gene modification Methods 0.000 description 1
- 230000005017 genetic modification Effects 0.000 description 1
- 235000013617 genetically modified food Nutrition 0.000 description 1
- 230000036571 hydration Effects 0.000 description 1
- 238000006703 hydration reaction Methods 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- PNDZEEPOYCVIIY-UHFFFAOYSA-N indo-1 Chemical compound CC1=CC=C(N(CC(O)=O)CC(O)=O)C(OCCOC=2C(=CC=C(C=2)C=2N=C3[CH]C(=CC=C3C=2)C(O)=O)N(CC(O)=O)CC(O)=O)=C1 PNDZEEPOYCVIIY-UHFFFAOYSA-N 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- FNEZBBILNYNQGC-UHFFFAOYSA-N methyl 2-(3,6-diamino-9h-xanthen-9-yl)benzoate Chemical compound COC(=O)C1=CC=CC=C1C1C2=CC=C(N)C=C2OC2=CC(N)=CC=C21 FNEZBBILNYNQGC-UHFFFAOYSA-N 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000002831 pharmacologic agent Substances 0.000 description 1
- 102000040430 polynucleotide Human genes 0.000 description 1
- 108091033319 polynucleotide Proteins 0.000 description 1
- 239000002157 polynucleotide Substances 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000004064 recycling Methods 0.000 description 1
- 230000010076 replication Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000001890 transfection Methods 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Electro-optical investigation, e.g. flow cytometers
- G01N15/1456—Electro-optical investigation, e.g. flow cytometers without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
- G01N15/1459—Electro-optical investigation, e.g. flow cytometers without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03B—SEPARATING SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS
- B03B5/00—Washing granular, powdered or lumpy materials; Wet separating
- B03B5/02—Washing granular, powdered or lumpy materials; Wet separating using shaken, pulsated or stirred beds as the principal means of separation
- B03B5/10—Washing granular, powdered or lumpy materials; Wet separating using shaken, pulsated or stirred beds as the principal means of separation on jigs
- B03B5/22—Washing granular, powdered or lumpy materials; Wet separating using shaken, pulsated or stirred beds as the principal means of separation on jigs using pulses generated by liquid injection
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B07—SEPARATING SOLIDS FROM SOLIDS; SORTING
- B07C—POSTAL SORTING; SORTING INDIVIDUAL ARTICLES, OR BULK MATERIAL FIT TO BE SORTED PIECE-MEAL, e.g. BY PICKING
- B07C5/00—Sorting according to a characteristic or feature of the articles or material being sorted, e.g. by control effected by devices which detect or measure such characteristic or feature; Sorting by manually actuated devices, e.g. switches
- B07C5/34—Sorting according to other particular properties
-
- G01N15/149—
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Electro-optical investigation, e.g. flow cytometers
- G01N2015/1477—Multiparameters
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Electro-optical investigation, e.g. flow cytometers
- G01N2015/1497—Particle shape
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41105802P | 2002-09-16 | 2002-09-16 | |
| US41114302P | 2002-09-16 | 2002-09-16 | |
| US60/411,058 | 2002-09-16 | ||
| US60/411,143 | 2002-09-16 | ||
| US10/329,008 | 2002-12-23 | ||
| US10/329,008 US6976590B2 (en) | 2002-06-24 | 2002-12-23 | Method and apparatus for sorting particles |
| PCT/US2003/029198 WO2004025266A2 (en) | 2002-09-16 | 2003-09-16 | Method and apparatus for sorting particles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2003270722A1 true AU2003270722A1 (en) | 2004-04-30 |
Family
ID=31999089
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2003270722A Abandoned AU2003270722A1 (en) | 2002-09-16 | 2003-09-16 | Method and apparatus for sorting particles |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1581350A4 (ko) |
| JP (1) | JP2005538727A (ko) |
| KR (1) | KR100990016B1 (ko) |
| AU (1) | AU2003270722A1 (ko) |
| BR (1) | BR0314268A (ko) |
| CA (1) | CA2499245A1 (ko) |
| WO (1) | WO2004025266A2 (ko) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4047336B2 (ja) * | 2005-02-08 | 2008-02-13 | 独立行政法人科学技術振興機構 | ゲル電極付セルソーターチップ |
| JP4509166B2 (ja) * | 2007-11-02 | 2010-07-21 | ソニー株式会社 | 微小粒子の測定方法、及び測定装置 |
| KR100940099B1 (ko) * | 2008-04-02 | 2010-02-02 | 한국기계연구원 | 암세포와 정상세포를 구별하기 위한 세포구별장치 및 그세포구별방법 |
| JP4661942B2 (ja) | 2008-05-13 | 2011-03-30 | ソニー株式会社 | マイクロチップとその流路構造 |
| JP2010226978A (ja) * | 2009-03-26 | 2010-10-14 | Mitsui Eng & Shipbuild Co Ltd | セルソータ |
| EP2462245B1 (en) | 2009-08-06 | 2016-10-05 | Cornell University | Device and methods for epigenetic analysis |
| KR101252829B1 (ko) * | 2009-10-06 | 2013-04-11 | 한국전자통신연구원 | 단일세포 분주용 어레이 장치 |
| US9522344B2 (en) | 2010-11-18 | 2016-12-20 | The Regents Of The University Of California | Method and device for high-throughput solution exchange for cell and particle suspension |
| US9815060B2 (en) | 2010-11-18 | 2017-11-14 | The Regents Of The University Of California | Method and device for high-throughput solution exchange for cell and particle suspensions |
| JP5720233B2 (ja) | 2010-12-17 | 2015-05-20 | ソニー株式会社 | マイクロチップ及び微小粒子分取装置 |
| EP2602608B1 (en) * | 2011-12-07 | 2016-09-14 | Imec | Analysis and sorting of biological cells in flow |
| US9304065B2 (en) | 2012-02-29 | 2016-04-05 | Fluidigm Corporation | Methods, systems and devices for multiple single-cell capturing and processing using microfluidics |
| EP2852682B1 (en) * | 2012-05-21 | 2017-10-04 | Fluidigm Corporation | Single-particle analysis of particle populations |
| WO2014013802A1 (ja) | 2012-07-18 | 2014-01-23 | ソニー株式会社 | 微小粒子分取装置、微小粒子分取用マイクロチップ及び微小粒子分取方法 |
| JP6036496B2 (ja) | 2012-07-24 | 2016-11-30 | ソニー株式会社 | 微小粒子分取方法 |
| JP5910412B2 (ja) | 2012-08-16 | 2016-04-27 | ソニー株式会社 | 微小粒子分取方法及び微小粒子分取用マイクロチップ |
| JP2016521350A (ja) | 2013-03-15 | 2016-07-21 | フリューダイム・コーポレイション | 規定された多細胞の組み合わせの分析のための方法および装置 |
| EP3017308A4 (en) | 2013-07-05 | 2017-04-26 | University Of Washington Through Its Center For Commercialization | Methods, compositions and systems for microfluidic assays |
| CN107110780B (zh) | 2014-08-14 | 2021-08-31 | 宾夕法尼亚大学托管会 | 用于分析微流体装置的输出的设备和方法 |
| US10828639B2 (en) * | 2015-04-30 | 2020-11-10 | Hewlett-Packard Development Company L.P. | Target constituent location and discharge |
| US11254557B2 (en) | 2016-05-17 | 2022-02-22 | Sony Corporation | Particle extraction apparatus and particle extraction method |
| CN108251291A (zh) * | 2016-12-29 | 2018-07-06 | 上海新微技术研发中心有限公司 | 一种细胞筛选装置和细胞筛选方法 |
| EP3662254A1 (en) * | 2017-08-04 | 2020-06-10 | SBT Instruments A/S | Microfluidic particle analysis device |
| CN111565845B (zh) * | 2017-08-22 | 2023-01-13 | 依利根公司 | 微流体设备中的位置跟踪和编码 |
| JP2020041881A (ja) * | 2018-09-10 | 2020-03-19 | ソニー株式会社 | 制御装置、該制御装置を用いた微小粒子分取装置及び微小粒子分取システム、並びに制御方法、及び制御プログラム |
| WO2021257068A1 (en) * | 2020-06-17 | 2021-12-23 | Hewlett-Packard Development Company, L.P. | Determining an error in detected passage of a target particle population |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3574617D1 (de) * | 1984-09-11 | 1990-01-11 | Partec Ag | Verfahren und vorrichtung zur sortierung von mikroskopischen partikeln. |
| JPS63259466A (ja) * | 1987-04-16 | 1988-10-26 | Hitachi Ltd | 細胞分析装置 |
| JPH01170853A (ja) * | 1987-12-25 | 1989-07-05 | Hitachi Ltd | 細胞選別装置 |
| CA1328861C (en) * | 1988-09-30 | 1994-04-26 | Occam Marine Technologies Ltd. | Low speed particle concentrator |
| HU203288B (en) * | 1989-04-01 | 1991-07-29 | Mta Mueszaki Kemiai Kutato Int | Apparatus for carrying out biocatalytic processes by means of biocatalyzer of solid phase |
| US5204884A (en) * | 1991-03-18 | 1993-04-20 | University Of Rochester | System for high-speed measurement and sorting of particles |
| AU6541596A (en) * | 1995-06-16 | 1997-01-15 | University Of Washington | Microfabricated differential extraction device and method |
| JP3226012B2 (ja) * | 1995-11-17 | 2001-11-05 | 矢崎総業株式会社 | 培養液中微小物分離装置 |
| DE69709377T2 (de) * | 1996-09-04 | 2002-08-14 | Scandinavian Micro Biodevices | Mikrofliesssystem für die teilchenanalyse und trennung |
| US6221654B1 (en) * | 1996-09-25 | 2001-04-24 | California Institute Of Technology | Method and apparatus for analysis and sorting of polynucleotides based on size |
| JP2002503336A (ja) * | 1997-05-16 | 2002-01-29 | アルバータ リサーチ カウンシル | 微量流通システムおよびその使用方法 |
| IT1295939B1 (it) * | 1997-10-31 | 1999-05-28 | Giammaria Sitar | Dispositivo e metodo per la separazione di cellule umane od animali aventi densita' diverse da dispersioni cellulari che le contengono |
| US6592821B1 (en) * | 1999-05-17 | 2003-07-15 | Caliper Technologies Corp. | Focusing of microparticles in microfluidic systems |
| AU2001290879A1 (en) * | 2000-09-15 | 2002-03-26 | California Institute Of Technology | Microfabricated crossflow devices and methods |
-
2003
- 2003-09-16 WO PCT/US2003/029198 patent/WO2004025266A2/en active Search and Examination
- 2003-09-16 EP EP03752432A patent/EP1581350A4/en not_active Withdrawn
- 2003-09-16 CA CA002499245A patent/CA2499245A1/en not_active Abandoned
- 2003-09-16 KR KR1020057004433A patent/KR100990016B1/ko active IP Right Grant
- 2003-09-16 JP JP2004536583A patent/JP2005538727A/ja active Pending
- 2003-09-16 AU AU2003270722A patent/AU2003270722A1/en not_active Abandoned
- 2003-09-16 BR BR0314268-0A patent/BR0314268A/pt not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2499245A1 (en) | 2004-03-25 |
| KR100990016B1 (ko) | 2010-10-26 |
| KR20050047540A (ko) | 2005-05-20 |
| WO2004025266A3 (en) | 2005-08-04 |
| WO2004025266A2 (en) | 2004-03-25 |
| BR0314268A (pt) | 2005-07-26 |
| EP1581350A4 (en) | 2009-09-23 |
| EP1581350A2 (en) | 2005-10-05 |
| JP2005538727A (ja) | 2005-12-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC1 | Assignment before grant (sect. 113) |
Owner name: CYTONOME/ST, LLC Free format text: FORMER APPLICANT(S): CYTONOME, INC. |
|
| MK4 | Application lapsed section 142(2)(d) - no continuation fee paid for the application |