AU2003263937B2 - Evolving new molecular function - Google Patents
Evolving new molecular function Download PDFInfo
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- AU2003263937B2 AU2003263937B2 AU2003263937A AU2003263937A AU2003263937B2 AU 2003263937 B2 AU2003263937 B2 AU 2003263937B2 AU 2003263937 A AU2003263937 A AU 2003263937A AU 2003263937 A AU2003263937 A AU 2003263937A AU 2003263937 B2 AU2003263937 B2 AU 2003263937B2
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1068—Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis
Landscapes
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- General Health & Medical Sciences (AREA)
- Bioinformatics & Computational Biology (AREA)
- Analytical Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Immunology (AREA)
- Plant Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
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| WO (1) | WO2004016767A2 (https=) |
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| EP1401850A1 (en) | 2001-06-20 | 2004-03-31 | Nuevolution A/S | Nucleoside derivatives for library preparation |
| DE10147074A1 (de) * | 2001-09-25 | 2003-05-08 | Beru Ag | Verfahren zum Betreiben einer aus mehreren Heizelementen bestehenden mehrstufigen elektrischen Heizung |
| EP1487978B1 (en) | 2002-03-15 | 2008-11-19 | Nuevolution A/S | An improved method for synthesising templated molecules |
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| AU2003263937B2 (en) * | 2002-08-19 | 2010-04-01 | The President And Fellows Of Harvard College | Evolving new molecular function |
| US8791053B2 (en) | 2002-09-27 | 2014-07-29 | Mpm-Holding Aps | Spatially encoded polymer matrix |
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| US20070026397A1 (en) | 2003-02-21 | 2007-02-01 | Nuevolution A/S | Method for producing second-generation library |
| DE602004019764D1 (de) * | 2003-03-20 | 2009-04-16 | Nuevolution As | Ligationsvermittelnde codierung von kleinen molekülen |
| US8017323B2 (en) * | 2003-03-26 | 2011-09-13 | President And Fellows Of Harvard College | Free reactant use in nucleic acid-templated synthesis |
| EP1611546B1 (en) * | 2003-04-04 | 2013-01-02 | Icosystem Corporation | Methods and systems for interactive evolutionary computing (iec) |
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| EP1670939B1 (en) * | 2003-09-18 | 2009-11-04 | Nuevolution A/S | A method for obtaining structural information concerning an encoded molecule and method for selecting compounds |
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| US7972994B2 (en) | 2003-12-17 | 2011-07-05 | Glaxosmithkline Llc | Methods for synthesis of encoded libraries |
| EP1723255B1 (en) * | 2004-02-17 | 2010-12-29 | Nuevolution A/S | Method for enrichment involving elimination by mismatch hybridisation |
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| DK1809743T3 (da) | 2004-11-08 | 2009-05-04 | Vipergen Aps | Strukturel nukleinsyre-styret kemisk syntese |
| EP1828381B1 (en) | 2004-11-22 | 2009-01-07 | Peter Birk Rasmussen | Template directed split and mix systhesis of small molecule libraries |
| JP4969459B2 (ja) * | 2005-01-21 | 2012-07-04 | プレジデント アンド フェロウズ オブ ハーバード カレッジ | 核酸鋳型合成において使用される遊離反応体 |
| JP2008541698A (ja) * | 2005-05-03 | 2008-11-27 | アンサンブル ディスカバリー コーポレイション | 核酸検出のためのターンオーバープローブおよびその使用 |
| JP2006320271A (ja) * | 2005-05-20 | 2006-11-30 | Tokyo Institute Of Technology | 低分子化合物とタンパク質の結合評価方法 |
| KR20080028886A (ko) * | 2005-05-26 | 2008-04-02 | 앙상블 디스커버리 코포레이션 | 핵산-템플레이팅된 화학 반응에 의한 생검출 |
| EP1891242A2 (en) * | 2005-05-31 | 2008-02-27 | Ensemble Discovery Corporation | Anchor-assisted fragment selection and directed assembly |
| ATE461279T1 (de) * | 2005-06-07 | 2010-04-15 | Harvard College | Geordnete mehrschrittsynthese mittels nukleinsäurevermittelter chemie |
| US20090203530A1 (en) * | 2005-06-07 | 2009-08-13 | Liu David R | Polymer evolution via templated synthesis |
| CA2611512C (en) * | 2005-06-09 | 2018-05-22 | Praecis Pharmaceuticals, Inc. | Methods for synthesis of encoded libraries |
| US20090035824A1 (en) * | 2005-06-17 | 2009-02-05 | Liu David R | Nucleic acid-templated chemistry in organic solvents |
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- 2003-08-19 CA CA2495881A patent/CA2495881C/en not_active Expired - Fee Related
- 2003-08-19 JP JP2005502071A patent/JP4657919B2/ja not_active Expired - Fee Related
- 2003-08-19 US US10/643,752 patent/US7491494B2/en not_active Expired - Fee Related
- 2003-08-19 WO PCT/US2003/025984 patent/WO2004016767A2/en not_active Ceased
- 2003-08-19 EP EP03788662.9A patent/EP1540013B1/en not_active Expired - Lifetime
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- 2004-09-24 US US10/950,367 patent/US7771935B2/en not_active Expired - Lifetime
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- 2009-11-18 JP JP2009263415A patent/JP5254934B2/ja not_active Expired - Fee Related
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- 2010-07-12 US US12/834,072 patent/US8206914B2/en not_active Expired - Fee Related
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Also Published As
| Publication number | Publication date |
|---|---|
| US7491494B2 (en) | 2009-02-17 |
| US20110190141A1 (en) | 2011-08-04 |
| US7771935B2 (en) | 2010-08-10 |
| EP1540013B1 (en) | 2015-07-08 |
| AU2010202702A1 (en) | 2010-07-15 |
| JP4657919B2 (ja) | 2011-03-23 |
| JP2005536234A (ja) | 2005-12-02 |
| AU2003263937A1 (en) | 2004-03-03 |
| EP1540013A2 (en) | 2005-06-15 |
| AU2010202702B2 (en) | 2012-12-06 |
| WO2004016767A3 (en) | 2005-03-24 |
| US20050170376A1 (en) | 2005-08-04 |
| EP1540013A4 (en) | 2006-06-28 |
| WO2004016767A2 (en) | 2004-02-26 |
| JP2010046092A (ja) | 2010-03-04 |
| US8206914B2 (en) | 2012-06-26 |
| US20040180412A1 (en) | 2004-09-16 |
| JP5254934B2 (ja) | 2013-08-07 |
| CA2495881C (en) | 2014-07-08 |
| CA2495881A1 (en) | 2004-02-29 |
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