AU2003260348B2 - Method for the production of monoalkylamino ketones - Google Patents

Method for the production of monoalkylamino ketones Download PDF

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Publication number
AU2003260348B2
AU2003260348B2 AU2003260348A AU2003260348A AU2003260348B2 AU 2003260348 B2 AU2003260348 B2 AU 2003260348B2 AU 2003260348 A AU2003260348 A AU 2003260348A AU 2003260348 A AU2003260348 A AU 2003260348A AU 2003260348 B2 AU2003260348 B2 AU 2003260348B2
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AU
Australia
Prior art keywords
formula
compound
preparation
acid
dht
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2003260348A
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English (en)
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AU2003260348A1 (en
Inventor
Kai Fabian
Karl-Heinz Glusenkamp
Joachim Kralik
Claus-Peter Niesert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of AU2003260348A1 publication Critical patent/AU2003260348A1/en
Application granted granted Critical
Publication of AU2003260348B2 publication Critical patent/AU2003260348B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C221/00—Preparation of compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/02—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C225/14—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated
    • C07C225/16—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Furan Compounds (AREA)
AU2003260348A 2002-08-27 2003-08-01 Method for the production of monoalkylamino ketones Ceased AU2003260348B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10240026A DE10240026A1 (de) 2002-08-27 2002-08-27 Verfahren zur Herstellung von Monoalkylaminoketonen
DE10240026.1 2002-08-27
PCT/EP2003/008514 WO2004020391A1 (de) 2002-08-27 2003-08-01 Verfahren zur herstellung von monoalkylaminoketonen

Publications (2)

Publication Number Publication Date
AU2003260348A1 AU2003260348A1 (en) 2004-03-19
AU2003260348B2 true AU2003260348B2 (en) 2009-09-03

Family

ID=31502148

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003260348A Ceased AU2003260348B2 (en) 2002-08-27 2003-08-01 Method for the production of monoalkylamino ketones

Country Status (14)

Country Link
US (1) US7579484B2 (enExample)
EP (1) EP1532101A1 (enExample)
JP (1) JP4593275B2 (enExample)
KR (1) KR101017885B1 (enExample)
CN (1) CN100368384C (enExample)
AU (1) AU2003260348B2 (enExample)
BR (1) BR0313796A (enExample)
CA (1) CA2497028A1 (enExample)
DE (1) DE10240026A1 (enExample)
MX (1) MXPA05002117A (enExample)
PL (1) PL373599A1 (enExample)
RU (1) RU2340595C2 (enExample)
WO (1) WO2004020391A1 (enExample)
ZA (1) ZA200502457B (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101027358B1 (ko) 2002-07-09 2011-04-11 론자 아게 Ｎ-일치환 β-아미노 알코올의 제조 방법
DE10302595A1 (de) * 2003-01-22 2004-07-29 Basf Ag 3-Methylamino-1-(2-thienyl)-1-proganon, seine Herstellung und Verwendung
CN103214452B (zh) * 2013-05-07 2014-08-06 浙江丽晶化学有限公司 N-甲基-3-羟基-3-（2-噻吩基）-丙胺的制备方法
CN109134427B (zh) * 2018-10-24 2020-06-30 浙江乐普药业股份有限公司 一种3-甲氨基-1-(2-噻吩基)-1-丙酮盐酸盐的合成方法
CN114790146B (zh) * 2022-05-19 2024-03-29 河南省科学院高新技术研究中心 一种3-(甲基氨基)-1-芳香基丙酮的制备方法

Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2017468A1 (en) * 1970-04-11 1971-11-04 Deutsche Gold- U. Silber-Scheideanstalt, Vorm. Roessler, 6000 Frankfurt Phenylalkylaminoalkyl-pyrazoles antiphlogistic
DE2063901A1 (en) * 1970-12-28 1972-07-20 Deutsche Gold- Und Silber-Scheideanstalt Vormals Roessler, 6000 Frankfurt Phenylalkylaminoalkylthiazoles - as antiphlogistics
US3859305A (en) * 1970-03-10 1975-01-07 Degussa Indole aminoketones
DE2353873A1 (de) * 1973-10-26 1975-05-07 Inst Toxikologii Beta-ketoderivate der linearen und cyclischen beta-phenylaethylamine, deren salze und verfahren zu deren herstellung
DD122967A1 (de) * 1975-07-10 1976-11-12 Lothar Luecke Hylamin-derivate
US4948813A (en) * 1987-11-30 1990-08-14 E. I. Du Pont De Nemours And Company Benzylketone phospholipase A2 inhibitors
WO1991009594A1 (en) * 1989-12-28 1991-07-11 Virginia Commonwealth University Sigma receptor ligands and the use thereof
JPH0570412A (ja) * 1991-09-13 1993-03-23 Fuji Yakuhin Kogyo Kk 光学活性なβ−アミノアルコールの製造方法
EP0571685A1 (en) * 1992-05-27 1993-12-01 Novo Nordisk A/S Aryloxyheteroarylpropylamines, their preparation and use
EP0915088A1 (en) * 1997-10-31 1999-05-12 F. Hoffmann-La Roche Ag D-Proline derivatives
JP2000264867A (ja) * 1999-03-18 2000-09-26 Nippon Shokubai Co Ltd 有機アミド化合物およびその製造法
GB2349889A (en) * 1999-05-11 2000-11-15 Rf Procom As A method for inhibiting gas hydrate formation using polymeric amides of molecular mass less than 1000
WO2002053537A1 (en) * 2001-01-04 2002-07-11 Ferrer Internacional, S.A. Process for preparing (±) trans-4-p-fluorophenyl-3-hydroxymethyl-1-methylpiperidine

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5075339A (en) * 1989-07-28 1991-12-24 Du Pont Merck Pharmaceutical Company Benzylketone phospholipase A2 inhibitors
FI96856C (fi) * 1989-08-04 1996-09-10 Mitsui Toatsu Chemicals Menetelmä terapeuttisesti käyttökelpoisten aminoketonijohdannaisten valmistamiseksi
US20050256318A1 (en) * 2002-07-09 2005-11-17 Dominique Michel Process for the preparation of n-monosubstituted beta-amino alcohols
KR101027358B1 (ko) * 2002-07-09 2011-04-11 론자 아게 Ｎ-일치환 β-아미노 알코올의 제조 방법

Patent Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3859305A (en) * 1970-03-10 1975-01-07 Degussa Indole aminoketones
DE2017468A1 (en) * 1970-04-11 1971-11-04 Deutsche Gold- U. Silber-Scheideanstalt, Vorm. Roessler, 6000 Frankfurt Phenylalkylaminoalkyl-pyrazoles antiphlogistic
DE2063901A1 (en) * 1970-12-28 1972-07-20 Deutsche Gold- Und Silber-Scheideanstalt Vormals Roessler, 6000 Frankfurt Phenylalkylaminoalkylthiazoles - as antiphlogistics
DE2353873A1 (de) * 1973-10-26 1975-05-07 Inst Toxikologii Beta-ketoderivate der linearen und cyclischen beta-phenylaethylamine, deren salze und verfahren zu deren herstellung
DD122967A1 (de) * 1975-07-10 1976-11-12 Lothar Luecke Hylamin-derivate
US4948813A (en) * 1987-11-30 1990-08-14 E. I. Du Pont De Nemours And Company Benzylketone phospholipase A2 inhibitors
WO1991009594A1 (en) * 1989-12-28 1991-07-11 Virginia Commonwealth University Sigma receptor ligands and the use thereof
JPH0570412A (ja) * 1991-09-13 1993-03-23 Fuji Yakuhin Kogyo Kk 光学活性なβ−アミノアルコールの製造方法
EP0571685A1 (en) * 1992-05-27 1993-12-01 Novo Nordisk A/S Aryloxyheteroarylpropylamines, their preparation and use
EP0915088A1 (en) * 1997-10-31 1999-05-12 F. Hoffmann-La Roche Ag D-Proline derivatives
JP2000264867A (ja) * 1999-03-18 2000-09-26 Nippon Shokubai Co Ltd 有機アミド化合物およびその製造法
GB2349889A (en) * 1999-05-11 2000-11-15 Rf Procom As A method for inhibiting gas hydrate formation using polymeric amides of molecular mass less than 1000
WO2002053537A1 (en) * 2001-01-04 2002-07-11 Ferrer Internacional, S.A. Process for preparing (±) trans-4-p-fluorophenyl-3-hydroxymethyl-1-methylpiperidine

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Blicke et al. J. Am. Chem. Soc. 1942, 64, 451-454 *
Mannich et al. Berichte Der Deutschen Chemischen Gesellschaft 1922, 55, 356-365 *
Saakyan et al. Armyanskii Khimicheskii Zhumal 1984, 37, 261-265 *

Also Published As

Publication number Publication date
CN100368384C (zh) 2008-02-13
PL373599A1 (en) 2005-09-05
AU2003260348A1 (en) 2004-03-19
JP2005536557A (ja) 2005-12-02
CN1678564A (zh) 2005-10-05
US20060122405A1 (en) 2006-06-08
ZA200502457B (en) 2005-10-25
JP4593275B2 (ja) 2010-12-08
HK1081532A1 (zh) 2006-05-19
EP1532101A1 (de) 2005-05-25
CA2497028A1 (en) 2004-03-11
US7579484B2 (en) 2009-08-25
KR20050059104A (ko) 2005-06-17
RU2340595C2 (ru) 2008-12-10
MXPA05002117A (es) 2005-05-23
WO2004020391A1 (de) 2004-03-11
BR0313796A (pt) 2005-09-27
KR101017885B1 (ko) 2011-03-04
RU2005108974A (ru) 2005-10-27
DE10240026A1 (de) 2004-03-11

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MK14 Patent ceased section 143(a) (annual fees not paid) or expired