AU2003240667C1 - Enzyme containing composition, process of producing said composition and its use - Google Patents
Enzyme containing composition, process of producing said composition and its use Download PDFInfo
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- AU2003240667C1 AU2003240667C1 AU2003240667A AU2003240667A AU2003240667C1 AU 2003240667 C1 AU2003240667 C1 AU 2003240667C1 AU 2003240667 A AU2003240667 A AU 2003240667A AU 2003240667 A AU2003240667 A AU 2003240667A AU 2003240667 C1 AU2003240667 C1 AU 2003240667C1
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- Prior art keywords
- pepsin
- enzyme
- component
- present
- caries
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- 235000010987 pectin Nutrition 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 229940045950 pep-20 Drugs 0.000 description 1
- 108010091212 pepstatin Proteins 0.000 description 1
- FAXGPCHRFPCXOO-LXTPJMTPSA-N pepstatin A Chemical compound OC(=O)C[C@H](O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)C[C@H](O)[C@H](CC(C)C)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)NC(=O)CC(C)C FAXGPCHRFPCXOO-LXTPJMTPSA-N 0.000 description 1
- 125000001151 peptidyl group Chemical group 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- PJNZPQUBCPKICU-UHFFFAOYSA-N phosphoric acid;potassium Chemical compound [K].OP(O)(O)=O PJNZPQUBCPKICU-UHFFFAOYSA-N 0.000 description 1
- 229910052615 phyllosilicate Inorganic materials 0.000 description 1
- 125000004193 piperazinyl group Chemical group 0.000 description 1
- 150000003053 piperidines Chemical class 0.000 description 1
- 229920000656 polylysine Polymers 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 239000011736 potassium bicarbonate Substances 0.000 description 1
- 235000015497 potassium bicarbonate Nutrition 0.000 description 1
- 229910000028 potassium bicarbonate Inorganic materials 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- 235000011181 potassium carbonates Nutrition 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 1
- 229940086066 potassium hydrogencarbonate Drugs 0.000 description 1
- 239000008057 potassium phosphate buffer Substances 0.000 description 1
- 235000011009 potassium phosphates Nutrition 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 235000019260 propionic acid Nutrition 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 1
- 108020001775 protein parts Proteins 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
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- 238000007142 ring opening reaction Methods 0.000 description 1
- 208000008655 root caries Diseases 0.000 description 1
- 238000007788 roughening Methods 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
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- 230000007017 scission Effects 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 239000012064 sodium phosphate buffer Substances 0.000 description 1
- 235000011008 sodium phosphates Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 229940034610 toothpaste Drugs 0.000 description 1
- 239000000606 toothpaste Substances 0.000 description 1
- IEDVJHCEMCRBQM-UHFFFAOYSA-N trimethoprim Chemical group COC1=C(OC)C(OC)=CC(CC=2C(=NC(N)=NC=2)N)=C1 IEDVJHCEMCRBQM-UHFFFAOYSA-N 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical class [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
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- JNELGWHKGNBSMD-UHFFFAOYSA-N xanthone Chemical compound C1=CC=C2C(=O)C3=CC=CC=C3OC2=C1 JNELGWHKGNBSMD-UHFFFAOYSA-N 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- 150000003751 zinc Chemical class 0.000 description 1
- JLYXXMFPNIAWKQ-UHFFFAOYSA-N γ Benzene hexachloride Chemical compound ClC1C(Cl)C(Cl)C(Cl)C(Cl)C1Cl JLYXXMFPNIAWKQ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/488—Aspartic endopeptidases (3.4.23), e.g. pepsin, chymosin, renin, cathepsin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicinal Preparation (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2010201297A AU2010201297B2 (en) | 2002-08-15 | 2010-03-31 | Enzyme containing composition, process of producing said composition and its use |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10237317A DE10237317B4 (de) | 2002-08-15 | 2002-08-15 | Enzymhaltige Zusammensetzung, Verfahren zu deren Herstellung und deren Verwendung |
| DE10237317.5 | 2002-08-15 | ||
| PCT/EP2003/005183 WO2004017988A1 (en) | 2002-08-15 | 2003-05-16 | Enzyme containing composition, process of producing said composition and its use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2010201297A Division AU2010201297B2 (en) | 2002-08-15 | 2010-03-31 | Enzyme containing composition, process of producing said composition and its use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| AU2003240667A1 AU2003240667A1 (en) | 2004-03-11 |
| AU2003240667B2 AU2003240667B2 (en) | 2010-02-11 |
| AU2003240667C1 true AU2003240667C1 (en) | 2010-07-15 |
Family
ID=31501753
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2003240667A Ceased AU2003240667C1 (en) | 2002-08-15 | 2003-05-16 | Enzyme containing composition, process of producing said composition and its use |
| AU2010201297A Ceased AU2010201297B2 (en) | 2002-08-15 | 2010-03-31 | Enzyme containing composition, process of producing said composition and its use |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2010201297A Ceased AU2010201297B2 (en) | 2002-08-15 | 2010-03-31 | Enzyme containing composition, process of producing said composition and its use |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20060115436A1 (https=) |
| EP (2) | EP1530481B1 (https=) |
| JP (2) | JP4571859B2 (https=) |
| CN (2) | CN1674930A (https=) |
| AT (1) | ATE541583T1 (https=) |
| AU (2) | AU2003240667C1 (https=) |
| CA (1) | CA2490721A1 (https=) |
| DE (1) | DE10237317B4 (https=) |
| WO (1) | WO2004017988A1 (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10237317B4 (de) * | 2002-08-15 | 2010-04-08 | 3M Espe Ag | Enzymhaltige Zusammensetzung, Verfahren zu deren Herstellung und deren Verwendung |
| EP1720661B1 (en) | 2004-02-27 | 2008-12-24 | 3M Espe Ag | Dose delivery system |
| EP1600141B1 (en) | 2004-05-24 | 2013-04-17 | 3M Deutschland GmbH | Collagenolytic active enzyme containing compositions for the treatment of dental caries |
| EP1634948A1 (en) | 2004-09-10 | 2006-03-15 | Basf Aktiengesellschaft | Means and methods for preventing and/or treating caries |
| EP1754464A1 (en) * | 2005-08-17 | 2007-02-21 | 3M Innovative Properties Company | Enzyme comprising dental composition |
| EP1844727A1 (en) | 2006-04-12 | 2007-10-17 | 3M Innovative Properties Company | Dental instrument for removing solely unremineralisable carious dentin |
| EP2094830B1 (en) | 2006-12-19 | 2013-04-10 | Basf Se | Uses and methods for preventing and/or treating caries caused by mutans streptococci |
| EP2139979B1 (en) | 2007-03-27 | 2015-02-25 | Novozymes A/S | Stable enzyme solutions and method of manufacturing |
| USD588446S1 (en) * | 2007-12-12 | 2009-03-17 | Hashim Paul R | Tree nail |
| WO2009100456A2 (en) * | 2008-02-08 | 2009-08-13 | Prothera, Inc. | Inhibition and treatment of gastrointestinal biofilms |
| MX2012009705A (es) | 2010-02-25 | 2012-12-17 | Novozymes As | Variantes de lisozima y polinucleotidos que codifican la misma. |
| WO2012035103A1 (en) | 2010-09-16 | 2012-03-22 | Novozymes A/S | Lysozymes |
| RU2619051C2 (ru) | 2011-11-25 | 2017-05-11 | Новозимс А/С | Полипептиды с лизоцимной активностью и полинуклеотиды, кодирующие их |
| ES2582802T3 (es) | 2012-01-23 | 2016-09-15 | Morphosys Ag | Uso de lisozima como marcador |
| EP3149034B1 (en) * | 2014-05-30 | 2022-07-13 | New England Biolabs, Inc. | Deglycosylation reagents and methods |
| US11685911B2 (en) | 2016-02-16 | 2023-06-27 | Monaghan Mushroom S Group | Fungal polypeptides having lysozyme activity |
| US10451599B2 (en) | 2016-09-02 | 2019-10-22 | Zepto Life Technology, LLC | Methods of isolating and detecting metal ions from proteins |
| CN110621779B (zh) | 2017-05-12 | 2024-05-14 | 诺维信公司 | 具有溶菌酶活性的多肽、编码其的多核苷酸以及其用途和组合物 |
| US11571367B2 (en) * | 2018-04-05 | 2023-02-07 | Terrell F. Pannkuk | Composition and method for endodontic debridement |
| EP4629838A1 (en) | 2022-12-08 | 2025-10-15 | Novozymes A/S | Polypeptide having lysozyme activity and polynucleotides encoding same |
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| WO1997038669A1 (en) * | 1996-04-16 | 1997-10-23 | Novo Nordisk A/S | Compositions for the removal of dental plaque |
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| NL148236B (nl) * | 1967-07-28 | 1976-01-15 | Merck & Co Inc | Werkwijze voor het bereiden van enzym bevattende tand- en mondverzorgingsmiddelen en aldus verkregen gevormde produkten. |
| DE2309440A1 (de) * | 1973-02-26 | 1974-09-05 | Katz | Verfahren zum isolieren von lysozym |
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| DE10237317B4 (de) | 2002-08-15 | 2010-04-08 | 3M Espe Ag | Enzymhaltige Zusammensetzung, Verfahren zu deren Herstellung und deren Verwendung |
| AU2003285325A1 (en) | 2002-11-22 | 2004-06-18 | Unilever Plc | Oral compositions comprising salts of alkyl hydroxybenzoates |
| US20040120901A1 (en) | 2002-12-20 | 2004-06-24 | Dong Wu | Dental compositions including enzymes and methods |
| EP1600141B1 (en) * | 2004-05-24 | 2013-04-17 | 3M Deutschland GmbH | Collagenolytic active enzyme containing compositions for the treatment of dental caries |
| EP1754464A1 (en) * | 2005-08-17 | 2007-02-21 | 3M Innovative Properties Company | Enzyme comprising dental composition |
-
2002
- 2002-08-15 DE DE10237317A patent/DE10237317B4/de not_active Expired - Fee Related
-
2003
- 2003-05-16 US US10/525,294 patent/US20060115436A1/en not_active Abandoned
- 2003-05-16 CN CNA038194724A patent/CN1674930A/zh active Pending
- 2003-05-16 AT AT03730062T patent/ATE541583T1/de active
- 2003-05-16 EP EP03730062A patent/EP1530481B1/en not_active Expired - Lifetime
- 2003-05-16 CN CN201010147372.9A patent/CN101810856B/zh not_active Expired - Fee Related
- 2003-05-16 JP JP2004529962A patent/JP4571859B2/ja not_active Expired - Fee Related
- 2003-05-16 WO PCT/EP2003/005183 patent/WO2004017988A1/en not_active Ceased
- 2003-05-16 CA CA002490721A patent/CA2490721A1/en not_active Abandoned
- 2003-05-16 AU AU2003240667A patent/AU2003240667C1/en not_active Ceased
- 2003-05-16 EP EP10011837.1A patent/EP2314307B1/en not_active Expired - Lifetime
-
2008
- 2008-05-16 US US12/122,027 patent/US9050332B2/en not_active Expired - Fee Related
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2009
- 2009-12-25 JP JP2009294987A patent/JP5087611B2/ja not_active Expired - Fee Related
-
2010
- 2010-03-31 AU AU2010201297A patent/AU2010201297B2/en not_active Ceased
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1265468A (https=) * | 1969-09-01 | 1972-03-01 | ||
| WO1997038669A1 (en) * | 1996-04-16 | 1997-10-23 | Novo Nordisk A/S | Compositions for the removal of dental plaque |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2006501225A (ja) | 2006-01-12 |
| JP5087611B2 (ja) | 2012-12-05 |
| AU2003240667A1 (en) | 2004-03-11 |
| JP2010090164A (ja) | 2010-04-22 |
| JP4571859B2 (ja) | 2010-10-27 |
| CN1674930A (zh) | 2005-09-28 |
| AU2010201297B2 (en) | 2012-12-13 |
| EP1530481B1 (en) | 2012-01-18 |
| US9050332B2 (en) | 2015-06-09 |
| CA2490721A1 (en) | 2004-03-04 |
| DE10237317A1 (de) | 2004-03-11 |
| EP2314307B1 (en) | 2014-03-12 |
| DE10237317B4 (de) | 2010-04-08 |
| CN101810856B (zh) | 2015-05-13 |
| AU2010201297A1 (en) | 2010-04-22 |
| WO2004017988A1 (en) | 2004-03-04 |
| ATE541583T1 (de) | 2012-02-15 |
| EP2314307A1 (en) | 2011-04-27 |
| EP1530481A1 (en) | 2005-05-18 |
| US20060115436A1 (en) | 2006-06-01 |
| US20080213196A1 (en) | 2008-09-04 |
| CN101810856A (zh) | 2010-08-25 |
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