AU2002353768A1 - 7-alkylidene-3-substituted-3-cephem-4-carboxylates as beta-lactamase inhibitors. - Google Patents

7-alkylidene-3-substituted-3-cephem-4-carboxylates as beta-lactamase inhibitors.

Info

Publication number
AU2002353768A1
AU2002353768A1 AU2002353768A AU2002353768A AU2002353768A1 AU 2002353768 A1 AU2002353768 A1 AU 2002353768A1 AU 2002353768 A AU2002353768 A AU 2002353768A AU 2002353768 A AU2002353768 A AU 2002353768A AU 2002353768 A1 AU2002353768 A1 AU 2002353768A1
Authority
AU
Australia
Prior art keywords
beta
formula
cephem
alkylidene
carboxylates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2002353768A
Other languages
English (en)
Inventor
John D. Buynak
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AlamX LLC
Original Assignee
Buynak John
AlamX LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Buynak John, AlamX LLC filed Critical Buynak John
Publication of AU2002353768A1 publication Critical patent/AU2002353768A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
AU2002353768A 2001-07-24 2002-07-24 7-alkylidene-3-substituted-3-cephem-4-carboxylates as beta-lactamase inhibitors. Abandoned AU2002353768A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30740301P 2001-07-24 2001-07-24
US60/307,403 2001-07-24
PCT/US2002/023613 WO2003020732A2 (en) 2001-07-24 2002-07-24 7-alkylidene-3-substituted-3-cephem-4-carboxylates as beta-lactamase inhibitors.

Publications (1)

Publication Number Publication Date
AU2002353768A1 true AU2002353768A1 (en) 2003-03-18

Family

ID=23189607

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002353768A Abandoned AU2002353768A1 (en) 2001-07-24 2002-07-24 7-alkylidene-3-substituted-3-cephem-4-carboxylates as beta-lactamase inhibitors.

Country Status (9)

Country Link
US (2) US6916801B2 (enExample)
EP (1) EP1430060B1 (enExample)
JP (1) JP2005502687A (enExample)
AT (1) ATE339424T1 (enExample)
AU (1) AU2002353768A1 (enExample)
CA (1) CA2454413A1 (enExample)
DE (1) DE60214740T2 (enExample)
ES (1) ES2272795T3 (enExample)
WO (1) WO2003020732A2 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE219085T1 (de) 1997-12-29 2002-06-15 Res Corp Technologies Inc 2-beta-substituierte-6-alkylidenpenizillansäure derivate als beta-laktamase inhibitoren
US6407091B1 (en) 1999-04-15 2002-06-18 Research Corporation Technologies, Inc. β-lactamase inhibiting compounds
US6544555B2 (en) 2000-02-24 2003-04-08 Advancis Pharmaceutical Corp. Antibiotic product, use and formulation thereof
US20020068078A1 (en) 2000-10-13 2002-06-06 Rudnic Edward M. Antifungal product, use and formulation thereof
US6916801B2 (en) 2001-07-24 2005-07-12 Alamx, Llc 7-Alkylidene-3-substituted-3-cephem-4-carboxylates as β-lactamase inhibitors
WO2003087105A1 (en) 2002-04-04 2003-10-23 Alamx, L.L.C. INHIBITORS OF SERINE AND METALLO-ß-LACTAMASES
CA2536910A1 (en) * 2003-08-25 2005-03-10 Revaax Pharmaceuticals, Llc Oral neurotherapeutic cefazolin compositions
US8299051B2 (en) * 2008-05-13 2012-10-30 Southern Methodist University Beta-lactamase inhibitory compounds
WO2010059943A2 (en) * 2008-11-20 2010-05-27 President And Fellows Of Harvard College Fluorination of organic compounds
CN103596931B (zh) 2011-04-12 2016-10-12 哈佛大学校长及研究员协会 有机化合物的氟化
US9273083B2 (en) 2012-09-26 2016-03-01 President And Fellows Of Harvard College Nickel fluorinating complexes and uses thereof
CN103387584B (zh) * 2013-07-17 2015-02-25 盐城开元医药化工有限公司 一种7-氨基-3-氯-3-头孢环-4-羧酸的合成方法
WO2015058047A2 (en) 2013-10-18 2015-04-23 President And Fellows Of Harvard College Fluorination of organic compounds
CN105254648B (zh) * 2015-11-13 2018-04-03 广东温氏大华农生物科技有限公司 一种头孢维星及其钠盐的合成方法

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4053468A (en) 1976-02-25 1977-10-11 Smithkline Corporation Process for preparing 7-oxo cephalosporins and 6-oxo penicillins
ZA80993B (en) 1979-02-24 1981-02-25 Erba Farmitalia -lactam-containing antibacterial agents and -lactamase inhibitors and preparation thereof
AT368506B (de) 1979-02-24 1982-10-25 Erba Farmitalia Verfahren zur herstellung von neuen penemcarbonsaeuren und deren salzen
GB2076812A (en) 1980-05-22 1981-12-09 Ciba Geigy Ag Penam-dioxide compounds, processes for their manufacture, and their use
DE3173613D1 (en) 1980-07-04 1986-03-13 Fujisawa Pharmaceutical Co 7-oxo-cephalosporins and 6-oxo-penicillins, their analogues and process for their preparation
CA1180005A (en) 1980-10-24 1984-12-27 Solange Adam-Molina .beta.-LACTAMS
ZA826687B (en) 1981-09-14 1983-07-27 Pfizer Beta-lactamase inhibiting 2-beta-substituted-2-alpha-methyl 5(r)penam-3-alpha-carboxylic acid 1,1-dioxides and intermediates therefor
US4559157A (en) 1983-04-21 1985-12-17 Creative Products Resource Associates, Ltd. Cosmetic applicator useful for skin moisturizing
LU84979A1 (fr) 1983-08-30 1985-04-24 Oreal Composition cosmetique ou pharmaceutique sous forme aqueuse ou anhydre dont la phase grasse contient un polyether oligomere et polyethers oligomeres nouveaux
SU1395144A3 (ru) 1984-01-30 1988-05-07 Пфайзер Инк. (Фирма) Способ получени 6-замещенных метиленпенициллановых кислот,или их сложных эфиров,или их солей с щелочными металлами
EP0150984B1 (en) 1984-01-30 1991-09-11 Pfizer Inc. 6-(substituted) methylenepenicillanic and 6-(substituted) hydroxymethylpenicillanic acids and derivatives thereof
US4826833A (en) 1984-01-30 1989-05-02 Pfizer Inc. 6-(Substituted)methylene-penicillanic and 6-(substituted)hydroxymethylpenicillanic acids and derivatives thereof
DE3586021D1 (de) 1984-07-30 1992-06-17 Merck & Co Inc Penicillin-derivate als entzuendungshemmende und degenerierungskaempfende arzneimittel.
US4861768A (en) 1986-02-27 1989-08-29 Taiho Pharmaceutical Company, Limited 2 β-substituted thiomethylpenicillin derivatives and their preparation and use
JPS62198687A (ja) 1986-02-27 1987-09-02 Taiho Yakuhin Kogyo Kk ２β−置換チオメチルペニシリン誘導体
US4820508A (en) 1987-06-23 1989-04-11 Neutrogena Corporation Skin protective composition
JP2603082B2 (ja) 1987-09-07 1997-04-23 大塚化学株式会社 ペニシラン酸誘導体の製造法
US4992478A (en) 1988-04-04 1991-02-12 Warner-Lambert Company Antiinflammatory skin moisturizing composition and method of preparing same
US4938949A (en) 1988-09-12 1990-07-03 University Of New York Treatment of damaged bone marrow and dosage units therefor
IT1227462B (it) 1988-11-04 1991-04-11 Glaxo Spa Procedimento di preparazione di 6-ossopenicillanati
TW383308B (en) 1993-08-24 2000-03-01 Hoffmann La Roche 2-beta-alkenyl penam sulfones as beta-lactamase inhibitors
US5597817A (en) 1994-12-09 1997-01-28 Southern Methodist University 7-vinylidene cephalosporins and methods of using the same
US5629306A (en) 1994-12-09 1997-05-13 Research Corporation Technologies, Inc. 7-alkylidene cephalosporanic acid derivatives and methods of using the same
US5760027A (en) 1996-12-06 1998-06-02 Research Corporation Technologies, Inc. Use of 7-alkylidene cephalosporins to inhibit elastase activity
ATE219085T1 (de) 1997-12-29 2002-06-15 Res Corp Technologies Inc 2-beta-substituierte-6-alkylidenpenizillansäure derivate als beta-laktamase inhibitoren
CA2371389A1 (en) 1999-04-15 2000-10-26 Research Corporation Technologies, Inc. Beta-lactamase inhibiting 7-alkyldiene cephalosporanic acid derivatives
US6391855B1 (en) * 1999-06-02 2002-05-21 Adherex Technologies, Inc. Compounds and methods for modulating junctional adhesion molecule-mediated functions
US6916801B2 (en) * 2001-07-24 2005-07-12 Alamx, Llc 7-Alkylidene-3-substituted-3-cephem-4-carboxylates as β-lactamase inhibitors

Also Published As

Publication number Publication date
US20030092696A1 (en) 2003-05-15
DE60214740T2 (de) 2007-10-04
US20060074065A1 (en) 2006-04-06
ES2272795T3 (es) 2007-05-01
CA2454413A1 (en) 2003-03-13
JP2005502687A (ja) 2005-01-27
ATE339424T1 (de) 2006-10-15
EP1430060B1 (en) 2006-09-13
US6916801B2 (en) 2005-07-12
WO2003020732A2 (en) 2003-03-13
WO2003020732A3 (en) 2003-05-22
US7488724B2 (en) 2009-02-10
DE60214740D1 (en) 2006-10-26
EP1430060A2 (en) 2004-06-23

Similar Documents

Publication Publication Date Title
AU4327600A (en) Aryl sulfonyls as factor xa inhibitors
JO2646B1 (en) Novel heterocyclic compounds which are active as inhibitors of beta-lactamases
AU2002239344A1 (en) Pyrazolopyridines
MY138797A (en) Bacterial gyrase inhibitors and uses thereof
AU2002305143A1 (en) Pyrazolo'1,5-a!pyridine derivatives
DE60214740D1 (en) 3-substituierte 7-alkylidene-3-cephem-4-carbonsäuren als beta-lactamase inhibitoren
PL370991A1 (en) New inhibitors of histone deacetylase
AU2002239348A1 (en) Pyrazolopyridine derivatives
AU4652000A (en) Fab i inhibitors
AP2003002942A0 (en) New derivatives of oxazolidinones as bacterial agents
MXPA04006041A (es) Antivirales de piridoquinoxalina.
AU2003231833A1 (en) Cross-linked glycopeptide-cephalosporin antibiotics
AU2003217712A1 (en) Pyrazolopyrimidine and pyrazolotriazine derivatives and pharmaceutical compositions containing them
IL160846A0 (en) Cross-linked glycopeptide-cephalosporin antibiotics
ATE219085T1 (de) 2-beta-substituierte-6-alkylidenpenizillansäure derivate als beta-laktamase inhibitoren
MXPA02000246A (es) Inhibidores de °-lactamasa de sulfonamidometil fosfonato.
GEP20084437B (en) Novel lincomycin derivatives possessing antimicrobial activity
SG165159A1 (en) Process for preparing 6-alkylidene penem derivatives
MXPA04005484A (es) Procedimiento de preparacion de derivados de equinocandina.
MXPA01010409A (es) Compuestos inhibidores de beta-lactamasa.
AU2002357740A1 (en) Pyrazolo-pyridine derivatives as antiherpes agents
AU2002248531A1 (en) Pyrazolopyriadine derivatives
CA2380455A1 (en) 9a-azalides with antibacterial activity
WO2004044174A3 (en) Topoisomerase-targeting agents
WO2004048393A3 (en) NOVEL INHIBITORS OF β-LACTAMASE

Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase