AU2002331720B2 - Proaerolysin containing protease activation sequences and methods of use for treatment of prostate cancer - Google Patents
Proaerolysin containing protease activation sequences and methods of use for treatment of prostate cancer Download PDFInfo
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- AU2002331720B2 AU2002331720B2 AU2002331720A AU2002331720A AU2002331720B2 AU 2002331720 B2 AU2002331720 B2 AU 2002331720B2 AU 2002331720 A AU2002331720 A AU 2002331720A AU 2002331720 A AU2002331720 A AU 2002331720A AU 2002331720 B2 AU2002331720 B2 AU 2002331720B2
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- proaerolysin
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- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001193—Prostate associated antigens e.g. Prostate stem cell antigen [PSCA]; Prostate carcinoma tumor antigen [PCTA]; PAP or PSGR
- A61K39/001194—Prostate specific antigen [PSA]
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- A61K39/001195—Prostate specific membrane antigen [PSMA]
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- A61P35/00—Antineoplastic agents
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- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/32—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bacillus (G)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/32—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bacillus (G)
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
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Landscapes
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- Urology & Nephrology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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| PCT/US2002/027061 WO2003018611A2 (en) | 2001-08-24 | 2002-08-23 | Proaerolysin containing protease activation sequences and methods of use for treatment of prostate cancer |
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| WO2004078097A2 (en) * | 2003-03-03 | 2004-09-16 | University Of Victoria Innovation And Development Corporation | Modified aerolysin linked to a lung cancer binding agent and methods of use for treating lung cancer |
| PL1694845T3 (pl) | 2003-11-28 | 2019-01-31 | National Research Council Of Canada | Przeciwciała przeciwko rakowi i ich zastosowania |
| EP1891093B1 (en) | 2005-06-14 | 2011-03-23 | Protox Therapeutics Incorporated | Method of treating or preventing benign prostatic hyperplasia using modified pore-forming proteins |
| CN100443503C (zh) * | 2005-07-18 | 2008-12-17 | 四川大学华西医院 | 人源化ctla-4单链抗体与人穿孔素通道形成肽p34的重组免疫毒素 |
| US20090016988A1 (en) * | 2005-11-21 | 2009-01-15 | Buckley J Thomas | Modified Pore-Forming Protein Toxins and Use Thereof |
| US8993295B2 (en) | 2006-07-20 | 2015-03-31 | The General Hospital Corporation | Methods, compositions, and kits for the selective activation of protoxins through combinatorial targeting |
| CA2696627C (en) | 2007-08-17 | 2016-09-27 | Purdue Research Foundation | Psma binding ligand-linker conjugates and methods for using |
| WO2010069060A1 (en) * | 2008-12-15 | 2010-06-24 | Protox Therapeutics Inc. | Method for treating prostatitis utilizing modified pore-forming protein proaerolysin |
| ES2625470T3 (es) | 2009-11-09 | 2017-07-19 | Alexion Pharmaceuticals, Inc.. | Reactivos y métodos para detectar glóbulos blancos asociados a HPN de tipo II y su identificación como factores de riesgo para trastornos trombóticos |
| US9951324B2 (en) | 2010-02-25 | 2018-04-24 | Purdue Research Foundation | PSMA binding ligand-linker conjugates and methods for using |
| EP2629788A4 (en) * | 2010-10-22 | 2014-03-19 | Protox Therapeutics Corp | USE OF HUMAN SERUM ALBUMIN TO REDUCE THE ANTIGENICITY OF THERAPEUTIC PROTEINS |
| KR102354613B1 (ko) | 2012-11-15 | 2022-01-21 | 엔도사이트, 인코포레이티드 | Psma 발현 세포에 의해 야기되는 질병을 치료하기 위한 컨쥬게이트 |
| US9789209B2 (en) | 2013-03-14 | 2017-10-17 | The Regents Of The University Of California, Berke | Activatable membrane-interacting peptides and methods of use |
| HUE066137T2 (hu) | 2013-10-18 | 2024-07-28 | Novartis Ag | A prosztata-specifikus membrán antigén (PSMA) jelzett inhibitorai, alkalmazásuk képalkotásban és gyógyszerkészítmények prosztatarák kezelésére |
| US10464970B2 (en) | 2013-10-23 | 2019-11-05 | The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Compounds that bind to human immunodeficiency virus rev response element |
| JP6464166B2 (ja) | 2013-11-14 | 2019-02-06 | エンドサイト・インコーポレイテッドＥｎｄｏｃｙｔｅ， Ｉｎｃ． | 陽電子放出断層撮影用の化合物 |
| US10188759B2 (en) | 2015-01-07 | 2019-01-29 | Endocyte, Inc. | Conjugates for imaging |
| US10596226B2 (en) * | 2015-01-16 | 2020-03-24 | The Johns Hopkins University | Albumin-proaerolysin prodrugs |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| EP3407906A4 (en) * | 2016-01-27 | 2019-10-09 | Sophiris Bio, Inc. | METHOD FOR THE TARGETED INTRAPROSTATIC ADMINISTRATION OF PRX302 FOR THE TREATMENT OF PROSTATE CANCER |
| CN109790206A (zh) * | 2016-09-22 | 2019-05-21 | 分子组合公司 | 重组结合蛋白及其用途 |
| US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
| WO2019073299A1 (en) | 2017-10-10 | 2019-04-18 | Medicenna Therapeutics, Inc. | IL-4 FUSION FORMULATIONS FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM (CNS) TUMORS |
| CA3097381A1 (en) | 2018-04-17 | 2019-10-24 | Endocyte, Inc. | Methods of treating cancer |
| CN120097930A (zh) | 2019-05-20 | 2025-06-06 | 因多塞特股份有限公司 | 制备psma缀合物的方法 |
| WO2021156890A2 (en) * | 2020-02-03 | 2021-08-12 | Premas Biotech Private Limited | Recombinant expression platform, constructs and methods for expression of difficult to express proteins (dte-ps) |
| US11845779B2 (en) * | 2020-10-28 | 2023-12-19 | Ecole Polytechnique Federale De Lausanne (Epfl) | Mutant aerolysin and uses thereof |
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| US7053042B1 (en) * | 1999-07-29 | 2006-05-30 | Samuel Denmeade | Activation of peptide prodrugs by hK2 |
| EP1224312A1 (en) | 1999-10-12 | 2002-07-24 | The University of North Carolina at Chapel Hill | Adeno-associated virus vectors encoding factor viii and methods of using the same |
| JP2003513046A (ja) * | 1999-11-01 | 2003-04-08 | アルコン，インコーポレイテッド | フルオロキノロン抗生薬およびキサンタンガムを含有する薬学的組成物 |
| EP1282642B1 (en) | 2000-05-09 | 2006-09-06 | Greenville Hospital System | Therapeutic pore-forming peptides |
| US20020041880A1 (en) * | 2000-07-05 | 2002-04-11 | Defeo-Jones Deborah | Method of treating cancer |
| FI116467B (fi) | 2000-09-29 | 2005-11-30 | Licentia Oy | Uudet peptidiligandit |
| AU2002223316A1 (en) * | 2000-11-07 | 2002-05-21 | University Of Victoria Innovation And Development Corporation | Detection of proteases and screening for protease inhibitors |
| AU2002239403A1 (en) | 2000-12-01 | 2002-06-11 | The Johns Hopkins University | Tissue specific prodrugs |
| US7456146B2 (en) * | 2001-05-09 | 2008-11-25 | Ghc Research Development Corporation | Lytic peptide prodrugs |
-
2002
- 2002-08-23 DK DK02768702.9T patent/DK1567641T3/da active
- 2002-08-23 EP EP10177191.3A patent/EP2518142B1/en not_active Expired - Lifetime
- 2002-08-23 US US10/487,115 patent/US7282476B2/en not_active Expired - Lifetime
- 2002-08-23 PT PT02768702T patent/PT1567641E/pt unknown
- 2002-08-23 CN CNB028166221A patent/CN100488981C/zh not_active Expired - Fee Related
- 2002-08-23 ES ES10177191.3T patent/ES2542888T3/es not_active Expired - Lifetime
- 2002-08-23 CA CA2457903A patent/CA2457903C/en not_active Expired - Fee Related
- 2002-08-23 ES ES02768702T patent/ES2388170T3/es not_active Expired - Lifetime
- 2002-08-23 WO PCT/US2002/027061 patent/WO2003018611A2/en not_active Ceased
- 2002-08-23 AU AU2002331720A patent/AU2002331720B2/en not_active Ceased
- 2002-08-23 JP JP2003523270A patent/JP4319908B2/ja not_active Expired - Fee Related
- 2002-08-23 EP EP02768702A patent/EP1567641B1/en not_active Expired - Lifetime
-
2004
- 2004-03-23 ZA ZA200402319A patent/ZA200402319B/xx unknown
-
2007
- 2007-09-17 US US11/856,543 patent/US7745395B2/en not_active Expired - Fee Related
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2010
- 2010-05-27 US US12/788,913 patent/US7838266B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US7282476B2 (en) | 2007-10-16 |
| CA2457903A1 (en) | 2003-03-06 |
| US20080089869A1 (en) | 2008-04-17 |
| WO2003018611A2 (en) | 2003-03-06 |
| CN1636017A (zh) | 2005-07-06 |
| US7838266B2 (en) | 2010-11-23 |
| WO2003018611A3 (en) | 2005-06-30 |
| HK1178563A1 (en) | 2013-09-13 |
| US7745395B2 (en) | 2010-06-29 |
| ES2542888T3 (es) | 2015-08-12 |
| EP1567641A4 (en) | 2005-12-28 |
| JP4319908B2 (ja) | 2009-08-26 |
| JP2005520490A (ja) | 2005-07-14 |
| US20040235095A1 (en) | 2004-11-25 |
| EP1567641A2 (en) | 2005-08-31 |
| CA2457903C (en) | 2018-04-17 |
| ES2388170T3 (es) | 2012-10-09 |
| CN100488981C (zh) | 2009-05-20 |
| PT1567641E (pt) | 2012-08-21 |
| ZA200402319B (en) | 2005-08-30 |
| EP1567641B1 (en) | 2012-05-23 |
| EP2518142B1 (en) | 2015-07-15 |
| DK1567641T3 (da) | 2012-08-27 |
| EP2518142A1 (en) | 2012-10-31 |
| US20100234300A1 (en) | 2010-09-16 |
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