AU2002259306B2 - Substituted azole acid derivatives useful as antidiabetic and antiobesity agents and method - Google Patents
Substituted azole acid derivatives useful as antidiabetic and antiobesity agents and method Download PDFInfo
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- AU2002259306B2 AU2002259306B2 AU2002259306A AU2002259306A AU2002259306B2 AU 2002259306 B2 AU2002259306 B2 AU 2002259306B2 AU 2002259306 A AU2002259306 A AU 2002259306A AU 2002259306 A AU2002259306 A AU 2002259306A AU 2002259306 B2 AU2002259306 B2 AU 2002259306B2
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- Prior art keywords
- compound
- mmol
- inhibitor
- alkyl
- acid
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- 239000003472 antidiabetic agent Substances 0.000 title claims description 32
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- 239000002253 acid Substances 0.000 title description 62
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- 150000003851 azoles Chemical class 0.000 title description 3
- 150000001875 compounds Chemical class 0.000 claims description 372
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Diabetes (AREA)
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29438001P | 2001-05-30 | 2001-05-30 | |
| US60/294,380 | 2001-05-30 | ||
| PCT/US2002/016633 WO2002096358A2 (en) | 2001-05-30 | 2002-05-23 | Substituted azole acid derivatives useful as antidiabetic and antiobesity agents and method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2002259306A1 AU2002259306A1 (en) | 2003-05-08 |
| AU2002259306B2 true AU2002259306B2 (en) | 2007-02-08 |
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| Application Number | Title | Priority Date | Filing Date |
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| AU2002259306A Ceased AU2002259306B2 (en) | 2001-05-30 | 2002-05-23 | Substituted azole acid derivatives useful as antidiabetic and antiobesity agents and method |
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| AU2003256419A1 (en) * | 2002-08-21 | 2004-03-11 | Merck & Co., Inc. | Combination therapy using a dual ppar alpha/gamma agonist and an angiotensin ii type i receptor antagonist |
| EP1424070A1 (en) * | 2002-11-28 | 2004-06-02 | Fournier Laboratories Ireland Limited | Combination of a PPAR alpha agonist and metformin for decreasing the serum triglycerides |
| SE0300988D0 (sv) * | 2003-04-03 | 2003-04-03 | Astrazeneca Ab | New use |
| WO2004108126A1 (en) * | 2003-06-06 | 2004-12-16 | Snowden Pharmaceuticals, Llc | Fibric acid derivatives for the treatment of irritable bowel syndrome |
| WO2005005421A1 (en) * | 2003-07-08 | 2005-01-20 | Novartis Ag | Benzenesulfonylamino compounds and pharmaceutical compositions containing these compounds |
| KR20060121884A (ko) * | 2003-09-22 | 2006-11-29 | 오노 야꾸힝 고교 가부시키가이샤 | 페닐초산 유도체, 그 제조 방법 및 용도 |
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| US8226977B2 (en) | 2004-06-04 | 2012-07-24 | Teva Pharmaceutical Industries Ltd. | Pharmaceutical composition containing irbesartan |
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| WO2006057503A1 (en) * | 2004-11-25 | 2006-06-01 | Lg Life Sciences, Ltd. | NOVEL COMPOUNDS AS AGONIST FOR PPARϜ AND PPARα, METHOD FOR PREPARATION OF THE SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME |
| WO2006057505A1 (en) * | 2004-11-25 | 2006-06-01 | Lg Life Sciences, Ltd. | NOVEL COMPOUNDS AS AGONIST FOR PPARϜ AND PPARα, METHOD FOR PREPARATION OF THE SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME |
| WO2007058504A1 (en) * | 2005-11-21 | 2007-05-24 | Lg Life Sciences, Ltd. | Novel compounds as agonist for ppar gamma and ppar alpha, method for preparation of the same, and pharmaceutical composition containing the same |
| US20090048199A1 (en) * | 2007-03-09 | 2009-02-19 | Hiberna Corporation | Hibernation-Related Genes and Proteins, Activators and Inhibitors Thereof and Methods of Use |
| GB2466912B (en) * | 2007-11-29 | 2012-01-04 | Hospital For Sick Children | Compositions and methods for treating lysosomal disorders |
| BRPI0920765A2 (pt) * | 2008-10-29 | 2015-08-18 | Deciphera Pharmaceuticals Llc | Amidas de cilopropano e análogos que exibem atividades anticâncer e antiproliferativas |
| AU2019387370A1 (en) | 2018-11-30 | 2021-06-10 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
| CN109498622A (zh) * | 2018-12-28 | 2019-03-22 | 成都恒瑞制药有限公司 | 一种氯沙坦钾与罗格列酮组合物及其制备方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6506781B1 (en) * | 1999-09-08 | 2003-01-14 | Smithkline Beecham Corporation | Oxazole PPAR antagonist |
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| CN1003445B (zh) * | 1984-10-03 | 1989-03-01 | 武田药品工业株式会社 | 噻唑烷二酮衍生物，其制备方法和用途 |
| US5591862A (en) * | 1993-06-11 | 1997-01-07 | Takeda Chemical Industries, Ltd. | Tetrazole derivatives, their production and use |
| CA2371308A1 (en) * | 1999-04-28 | 2000-11-02 | Aventis Pharma Deutschland Gmbh | Tri-aryl acid derivatives as ppar receptor ligands |
| HK1045991B (en) * | 1999-11-10 | 2004-12-10 | Takeda Pharmaceutical Company Limited | 5-membered n-heterocyclic compounds with hypoglycemic and hypolipidemic activity |
| EP1394154A4 (en) * | 2001-03-23 | 2005-05-18 | Takeda Pharmaceutical | FIVE-GLASS HETEROCYCLIC ALKANIC ACID DERIVATIVE |
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2002
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- 2002-05-23 AU AU2002259306A patent/AU2002259306B2/en not_active Ceased
- 2002-05-23 CA CA002449160A patent/CA2449160A1/en not_active Abandoned
- 2002-05-23 HU HU0401504A patent/HUP0401504A3/hu unknown
- 2002-05-23 TR TR2004/00650T patent/TR200400650T3/xx unknown
- 2002-05-23 EP EP02729306A patent/EP1390363A4/en not_active Withdrawn
- 2002-05-23 JP JP2002592871A patent/JP2004536070A/ja active Pending
- 2002-05-23 ES ES02729306T patent/ES2214168T1/es active Pending
- 2002-05-23 CZ CZ20033230A patent/CZ20033230A3/cs unknown
- 2002-05-23 DE DE0001390363T patent/DE02729306T1/de active Pending
- 2002-05-23 MX MXPA03010997A patent/MXPA03010997A/es active IP Right Grant
- 2002-05-23 WO PCT/US2002/016633 patent/WO2002096358A2/en not_active Ceased
- 2002-05-23 PL PL02367066A patent/PL367066A1/xx not_active Application Discontinuation
- 2002-05-24 TW TW091111100A patent/TWI235061B/zh not_active IP Right Cessation
- 2002-05-30 UY UY27316A patent/UY27316A1/es not_active Application Discontinuation
- 2002-05-30 PE PE2002000455A patent/PE20030043A1/es not_active Application Discontinuation
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6506781B1 (en) * | 1999-09-08 | 2003-01-14 | Smithkline Beecham Corporation | Oxazole PPAR antagonist |
Also Published As
| Publication number | Publication date |
|---|---|
| US20030092736A1 (en) | 2003-05-15 |
| ES2214168T1 (es) | 2004-09-16 |
| PE20030043A1 (es) | 2003-02-05 |
| UY27316A1 (es) | 2002-12-31 |
| HUP0401504A3 (en) | 2008-05-28 |
| TR200400650T3 (tr) | 2004-06-21 |
| JP2004536070A (ja) | 2004-12-02 |
| TWI235061B (en) | 2005-07-01 |
| DE02729306T1 (de) | 2004-08-26 |
| CA2449160A1 (en) | 2002-12-05 |
| HUP0401504A2 (hu) | 2004-11-29 |
| MXPA03010997A (es) | 2004-02-27 |
| PL367066A1 (en) | 2005-02-21 |
| CZ20033230A3 (cs) | 2004-02-18 |
| WO2002096358A2 (en) | 2002-12-05 |
| NO327089B1 (no) | 2009-04-20 |
| WO2002096358A3 (en) | 2003-03-27 |
| EP1390363A2 (en) | 2004-02-25 |
| EP1390363A4 (en) | 2011-01-05 |
| NO20035312D0 (no) | 2003-11-28 |
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