AU2002246817B2 - Thienopyrimidine-based inhibitors of the SRC family - Google Patents

Thienopyrimidine-based inhibitors of the SRC family Download PDF

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Publication number
AU2002246817B2
AU2002246817B2 AU2002246817A AU2002246817A AU2002246817B2 AU 2002246817 B2 AU2002246817 B2 AU 2002246817B2 AU 2002246817 A AU2002246817 A AU 2002246817A AU 2002246817 A AU2002246817 A AU 2002246817A AU 2002246817 B2 AU2002246817 B2 AU 2002246817B2
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AU
Australia
Prior art keywords
hydrazone
methylthieno
phenyl
hydroxy
pyrimidin
Prior art date
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Ceased
Application number
AU2002246817A
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English (en)
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AU2002246817A1 (en
Inventor
Michele A. Benish
Raymond J. A. Budde
Michael Lawless
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University of Texas System
Original Assignee
University of Texas System
University of Texas at Austin
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Publication of AU2002246817A1 publication Critical patent/AU2002246817A1/en
Application granted granted Critical
Publication of AU2002246817B2 publication Critical patent/AU2002246817B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Virology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AU2002246817A 2000-10-23 2001-10-23 Thienopyrimidine-based inhibitors of the SRC family Ceased AU2002246817B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/694,145 US6503914B1 (en) 2000-10-23 2000-10-23 Thienopyrimidine-based inhibitors of the Src family
US09/694,145 2000-10-23
PCT/US2001/050198 WO2002057271A2 (en) 2000-10-23 2001-10-23 Thienopyrimidine-based inhibitors of the src family

Publications (2)

Publication Number Publication Date
AU2002246817A1 AU2002246817A1 (en) 2003-02-13
AU2002246817B2 true AU2002246817B2 (en) 2007-07-26

Family

ID=24787577

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002246817A Ceased AU2002246817B2 (en) 2000-10-23 2001-10-23 Thienopyrimidine-based inhibitors of the SRC family

Country Status (8)

Country Link
US (3) US6503914B1 (enExample)
EP (1) EP1409491A2 (enExample)
JP (1) JP2004517898A (enExample)
KR (1) KR20030040554A (enExample)
AU (1) AU2002246817B2 (enExample)
CA (1) CA2426775A1 (enExample)
MX (1) MXPA03003580A (enExample)
WO (1) WO2002057271A2 (enExample)

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Also Published As

Publication number Publication date
WO2002057271A3 (en) 2003-01-30
MXPA03003580A (es) 2005-04-08
EP1409491A2 (en) 2004-04-21
US20040077663A1 (en) 2004-04-22
KR20030040554A (ko) 2003-05-22
US7285556B2 (en) 2007-10-23
WO2002057271A2 (en) 2002-07-25
CA2426775A1 (en) 2002-07-25
USRE39267E1 (en) 2006-09-05
JP2004517898A (ja) 2004-06-17
US6503914B1 (en) 2003-01-07

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