AU2002228849A1

AU2002228849A1 - Semicarbazides and their uses as cyclin dependent kinase inhibitors

Semicarbazides and their uses as cyclin dependent kinase inhibitors

Info

Publication number: AU2002228849A1
Authority: AU; Australia
Prior art keywords: compound according; substituted; phenyl; indeno; methyl
Prior art date: 2000-12-08
Legal status : Abandoned

Application number

AU2002228849A

Other languages

English (en)

Inventor

David J. Carini

Current Assignee

Bristol Myers Squibb Pharma Co

Original Assignee

Bristol Myers Squibb Co

Priority date

2000-12-08

Filing date

2001-12-07

Publication date

2002-06-18

2001-12-07 Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co

2002-06-18 Publication of AU2002228849A1 publication Critical patent/AU2002228849A1/en

Status Abandoned legal-status Critical Current

Links

229940043378 cyclin-dependent kinase inhibitor Drugs 0.000 title description 13
239000002875 cyclin dependent kinase inhibitor Substances 0.000 title description 7
150000003349 semicarbazides Chemical class 0.000 title description 4
150000001875 compounds Chemical class 0.000 claims description 192
-1 thienopyrimidyl Chemical group 0.000 claims description 161
150000003839 salts Chemical class 0.000 claims description 95
238000000034 method Methods 0.000 claims description 87
125000000623 heterocyclic group Chemical group 0.000 claims description 64
239000000203 mixture Substances 0.000 claims description 56
230000002401 inhibitory effect Effects 0.000 claims description 55
229940002612 prodrug Drugs 0.000 claims description 47
239000000651 prodrug Substances 0.000 claims description 47
230000000694 effects Effects 0.000 claims description 46
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 43
229910052757 nitrogen Inorganic materials 0.000 claims description 37
206010028980 Neoplasm Diseases 0.000 claims description 35
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 33
108091007914 CDKs Proteins 0.000 claims description 29
125000004429 atom Chemical group 0.000 claims description 29
229910052717 sulfur Inorganic materials 0.000 claims description 29
125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 26
125000001316 cycloalkyl alkyl group Chemical group 0.000 claims description 25
125000005842 heteroatom Chemical group 0.000 claims description 25
201000010099 disease Diseases 0.000 claims description 24
201000011510 cancer Diseases 0.000 claims description 23
GHFDYLOGYDGRHI-UHFFFAOYSA-N 1h-indeno[1,2-c]pyrazol-4-one Chemical compound C12=CC=CC=C2C(=O)C2=C1NN=C2 GHFDYLOGYDGRHI-UHFFFAOYSA-N 0.000 claims description 22
125000001072 heteroaryl group Chemical group 0.000 claims description 22
239000003795 chemical substances by application Substances 0.000 claims description 20
125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 19
210000004027 cell Anatomy 0.000 claims description 19
125000005843 halogen group Chemical group 0.000 claims description 16
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125000004432 carbon atom Chemical group C* 0.000 claims description 14
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125000001544 thienyl group Chemical group 0.000 claims description 11
JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 claims description 10
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