AU2002220979A1 - Intracellular delivery of biological effectors by novel transporter peptide sequences - Google Patents
Intracellular delivery of biological effectors by novel transporter peptide sequencesInfo
- Publication number
- AU2002220979A1 AU2002220979A1 AU2002220979A AU2097902A AU2002220979A1 AU 2002220979 A1 AU2002220979 A1 AU 2002220979A1 AU 2002220979 A AU2002220979 A AU 2002220979A AU 2097902 A AU2097902 A AU 2097902A AU 2002220979 A1 AU2002220979 A1 AU 2002220979A1
- Authority
- AU
- Australia
- Prior art keywords
- peptide
- transporter peptide
- effector
- transporter
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
- C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/1013—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1019—Tetrapeptides with the first amino acid being basic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1021—Tetrapeptides with the first amino acid being acidic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Analytical Chemistry (AREA)
- Virology (AREA)
- Oncology (AREA)
- Emergency Medicine (AREA)
- Communicable Diseases (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Obesity (AREA)
- Pulmonology (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US24031500P | 2000-10-13 | 2000-10-13 | |
US60/240,315 | 2000-10-13 | ||
PCT/IB2001/002423 WO2002031109A2 (en) | 2000-10-13 | 2001-10-15 | Intracellular delivery of biological effectors by novel transporter peptide sequences |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2002220979A1 true AU2002220979A1 (en) | 2002-04-22 |
Family
ID=22906054
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2002220979A Abandoned AU2002220979A1 (en) | 2000-10-13 | 2001-10-15 | Intracellular delivery of biological effectors by novel transporter peptide sequences |
Country Status (6)
Country | Link |
---|---|
US (3) | US7034109B2 (ja) |
EP (1) | EP1345956A2 (ja) |
JP (4) | JP4387669B2 (ja) |
AU (1) | AU2002220979A1 (ja) |
CA (1) | CA2425610A1 (ja) |
WO (1) | WO2002031109A2 (ja) |
Families Citing this family (107)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8183339B1 (en) | 1999-10-12 | 2012-05-22 | Xigen S.A. | Cell-permeable peptide inhibitors of the JNK signal transduction pathway |
US20040082509A1 (en) | 1999-10-12 | 2004-04-29 | Christophe Bonny | Cell-permeable peptide inhibitors of the JNK signal transduction pathway |
US20050245451A1 (en) * | 2000-04-05 | 2005-11-03 | Pincus Matthew R | Peptides selectively lethal to malignant and transformed mammalian cells |
CA2416757C (en) * | 2000-07-21 | 2011-02-15 | Gilead Sciences, Inc. | Prodrugs of phosphonate nucleotide analogues and methods for selecting and making same |
JP4387669B2 (ja) | 2000-10-13 | 2009-12-16 | ザイジェン エス.アー. | 新規なトランスポーターペプチド配列による生物学的エフェクターの細胞内送達 |
US7033597B2 (en) * | 2000-10-13 | 2006-04-25 | Université de Lausanne | Intracellular delivery of biological effectors |
AU2008201592C1 (en) * | 2002-06-07 | 2010-08-12 | Xigen Sa | Intracellular Delivery of Biological Effectors |
WO2004067778A2 (en) * | 2003-01-28 | 2004-08-12 | University Of South Florida | Differentially expressed genes in large granular lymphocyte leukemia |
WO2004073650A2 (en) | 2003-02-20 | 2004-09-02 | University Of South Florida | Peptidomimetic inhibitors of stat3 activity and their medical uses |
US7521534B1 (en) * | 2003-03-03 | 2009-04-21 | The University Board Of Regents Of Texas System | IKK gamma gene products and methods for making and using same |
US7189694B2 (en) * | 2003-04-18 | 2007-03-13 | University Of Florida Research Foundation, Inc. | Inhibitors of autophosphorylation protein kinases |
CA2535762A1 (en) * | 2003-08-13 | 2005-03-17 | University Of South Florida | Methods for inhibiting tumor cell proliferation |
US8227434B1 (en) | 2003-11-04 | 2012-07-24 | H. Lee Moffitt Cancer Center & Research Institute, Inc. | Materials and methods for treating oncological disorders |
US20050288365A1 (en) * | 2004-01-06 | 2005-12-29 | Heidi Kay | Platinum complexes and methods for inhibiting tumor cell proliferation |
AU2005214979B2 (en) | 2004-02-17 | 2009-09-10 | The Uab Research Foundation | Cytotoxin compound and method of isolation |
US8669376B2 (en) * | 2004-02-17 | 2014-03-11 | University Of South Florida | Cytotoxin compounds and methods of isolation |
BR122019004903B1 (pt) | 2004-07-27 | 2021-11-03 | The Regents Of The University Of California | Célula hospedeira de saccharomyces cerevisiae geneticamente modificada, composição compreendendo a mesma e método para aumentar a produção de amorfa-4,11-dieno através da via do mevalonato na célula hospedeira |
US8080517B2 (en) | 2005-09-12 | 2011-12-20 | Xigen Sa | Cell-permeable peptide inhibitors of the JNK signal transduction pathway |
WO2007031098A1 (en) * | 2005-09-12 | 2007-03-22 | Xigen S.A. | Cell-permeable peptide inhibitors of the jnk signal transduction pathway |
WO2007047623A2 (en) * | 2005-10-14 | 2007-04-26 | University Of South Florida | Methods of inhibiting cell growth and methods of enhancing radiation responses |
CA2638915A1 (en) * | 2006-02-10 | 2007-08-23 | The Regents Of The University Of California | Transducible delivery of sirna by dsrna binding domain fusions to ptd/cpps |
AU2007272906B2 (en) * | 2006-07-12 | 2013-01-31 | The Regents Of The University Of California | Transducible delivery of nucleic acids by reversible phosphotriester charge neutralization protecting groups |
US7935092B1 (en) | 2006-07-25 | 2011-05-03 | Twin Star Medical, Inc. | Self-introducing injection and aspiration device |
WO2008022015A2 (en) * | 2006-08-11 | 2008-02-21 | Trustees Of Tufts College | Retro-inverso incretin analogues, and methods of use thereof |
DE102006040647A1 (de) * | 2006-08-30 | 2008-03-13 | Robert Bosch Gmbh | Handwerkzeugmaschine |
CU23630A1 (es) * | 2006-10-30 | 2011-02-24 | Ct Ingenieria Genetica Biotech | Moléculas peptídicas quiméricas con propiedades antivirales contra los virus de la familia flaviviridae |
WO2008079945A2 (en) * | 2006-12-20 | 2008-07-03 | University Of South Florida | Rock inhibitors and uses thereof |
US8101565B2 (en) * | 2007-09-20 | 2012-01-24 | Abbott Cardiovascular Systems Inc. | Sustained release of Apo A-I mimetic peptides and methods of treatment |
US7985728B1 (en) | 2007-09-20 | 2011-07-26 | Abbott Cardiovascular Systems Inc. | Sustained release of Apo A-I mimetic peptides and methods of treatment |
US8044021B2 (en) * | 2007-09-20 | 2011-10-25 | Abbott Cardiovascular Systems Inc. | Sustained release of apo A-I mimetic peptides and methods of treatment |
US9173890B2 (en) * | 2007-09-20 | 2015-11-03 | Abbott Cardiovascular Systems Inc. | Sustained release of Apo A-I mimetic peptides and methods of treatment |
US7985727B1 (en) | 2007-09-20 | 2011-07-26 | Abbott Cardiovascular Systems Inc. | Apo A-I mimetic peptides and methods of treatment |
WO2009070650A1 (en) * | 2007-11-26 | 2009-06-04 | The Research Foundation Of State University Of New York | Small molecule cancer treatments that cause necrosis in cancer cells but do not affect normal cells |
ES2951646T3 (es) * | 2008-02-21 | 2023-10-24 | Burnham Institute For Medical Res | Métodos y composiciones relacionados con péptidos y proteínas con elementos C-terminales |
WO2009143864A1 (en) * | 2008-05-30 | 2009-12-03 | Xigen S.A. | Use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of chronic or non-chronic inflammatory digestive diseases |
WO2009143865A1 (en) | 2008-05-30 | 2009-12-03 | Xigen S.A. | Use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of various diseases |
WO2010005534A2 (en) * | 2008-06-30 | 2010-01-14 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Proteasome inhibitors for selectively inducing apoptosis in cancer cells |
US9174969B2 (en) | 2008-07-21 | 2015-11-03 | University Of South Florida | Indoline scaffold SHP-2 inhibitors and cancer treatment method |
ES2334315B1 (es) * | 2008-07-29 | 2011-02-28 | Universitat Pompeu Fabra | Peptidos con capacidad de penetracion celular y sus usos. |
RU2011108560A (ru) | 2008-08-05 | 2012-09-10 | Юниверсити Оф Саут Флорида (Us) | Способы лечения когнитивного нарушения |
US9132168B2 (en) | 2008-08-05 | 2015-09-15 | University Of South Florida | Methods of treating cognitive impairment |
WO2010072228A1 (en) | 2008-12-22 | 2010-07-01 | Xigen S.A. | Novel transporter constructs and transporter cargo conjugate molecules |
EP2445536B1 (en) | 2009-06-22 | 2016-06-08 | Burnham Institute for Medical Research | Methods and compositions using peptides and proteins with c-terminal elements |
JP5457813B2 (ja) * | 2009-12-16 | 2014-04-02 | ルネサスエレクトロニクス株式会社 | Adpll回路、半導体装置及び携帯情報機器 |
US9221808B2 (en) | 2010-04-16 | 2015-12-29 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Pyridylthiazole-based ureas as inhibitors of Rho associated protein kinase (ROCK) and methods of use |
WO2011160653A1 (en) | 2010-06-21 | 2011-12-29 | Xigen S.A. | Novel jnk inhibitor molecules |
JP5857056B2 (ja) | 2010-10-14 | 2016-02-10 | ザイジェン インフラメーション エルティーディー | 慢性又は非慢性の炎症性眼疾患を治療するためのjnkシグナル伝達経路の細胞透過性ペプチド阻害剤の使用 |
US9616064B2 (en) | 2011-03-30 | 2017-04-11 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Rho kinase inhibitors and methods of use |
WO2013091670A1 (en) | 2011-12-21 | 2013-06-27 | Xigen S.A. | Novel jnk inhibitor molecules for treatment of various diseases |
WO2013112722A1 (en) | 2012-01-24 | 2013-08-01 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Inhibitors of rho associated protein kinases (rock) and methods of use |
JP6233812B2 (ja) | 2012-03-07 | 2017-11-22 | エイチ リー モフィット キャンサー センター アンド リサーチ インスティテュート インコーポレイテッド | 選択的ヒストンデアセチラーゼ6阻害剤 |
JP2015529073A (ja) | 2012-08-20 | 2015-10-05 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 生物可逆性基を有するポリヌクレオチド |
US10098967B2 (en) | 2012-12-03 | 2018-10-16 | Ohio State Innovation Foundation | Self-assembly of therapeutic agent-peptide nanostructures |
WO2015197097A1 (en) | 2014-06-26 | 2015-12-30 | Xigen Inflammation Ltd. | New use for jnk inhibitor molecules for treatment of various diseases |
WO2014206427A1 (en) | 2013-06-26 | 2014-12-31 | Xigen Inflammation Ltd. | New use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of various diseases |
JP2016523274A (ja) | 2013-06-26 | 2016-08-08 | ザイジェン インフラメーション リミテッド | 種々の疾患を処置するためのjnkシグナル伝達経路の新規の細胞透過性ペプチド阻害剤の使用 |
CN105592850B (zh) | 2013-08-06 | 2019-11-15 | H·李·莫菲特癌症中心研究所公司 | Ack1/tnk2酪氨酸激酶的抑制剂 |
US10626178B2 (en) | 2013-08-21 | 2020-04-21 | Raz Yirmiya | Treatment of mood and stress related disorders |
WO2015025323A1 (en) | 2013-08-21 | 2015-02-26 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Treatment of mood and stress related disorders |
AU2015209143A1 (en) | 2014-01-23 | 2016-08-04 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Icariin derivatives |
WO2015112904A1 (en) | 2014-01-24 | 2015-07-30 | University Of Florida Research Foundation, Inc. | Socs mimetics for the treatment of diseases |
WO2015116782A1 (en) | 2014-01-29 | 2015-08-06 | Board Of Regents, The University Of Texas System | Nucleobase analogue derivatives and their applications |
WO2015153560A1 (en) | 2014-03-31 | 2015-10-08 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Stabilized peptoid-peptide hybrids and uses thereof |
US9987258B2 (en) | 2014-04-06 | 2018-06-05 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Histone deacetylase as a modulator of PDL1 expression and activity |
WO2015157636A1 (en) | 2014-04-10 | 2015-10-15 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Enhanced expansion of tumor-infiltrating lymphocytes for adoptive cell therapy |
CA2949705A1 (en) | 2014-05-21 | 2015-11-26 | Cycloporters, Inc. | Cell penetrating peptides and methods of making and using thereof |
US10815276B2 (en) | 2014-05-21 | 2020-10-27 | Entrada Therapeutics, Inc. | Cell penetrating peptides and methods of making and using thereof |
WO2016033368A1 (en) | 2014-08-27 | 2016-03-03 | Ohio State Innovation Foundation | Improved peptidyl calcineurin inhibitors |
US10456475B2 (en) | 2015-02-03 | 2019-10-29 | Kennsaw State University Research and Service Foundation, Inc. | Cell penetrating protein adaptor molecules and their application in research and medicine |
WO2016154586A1 (en) | 2015-03-26 | 2016-09-29 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Toll-like receptor 2 ligands and methods of making and using thereof |
EP3294316A4 (en) | 2015-05-06 | 2018-10-17 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Radiotherapeutic and companion imaging agents to target mc1r |
US10435446B2 (en) | 2015-06-03 | 2019-10-08 | Kennesaw State University Research and Service Foundation Inc. | Cell penetrating protein adaptor molecules and their application in research and medicine |
WO2016197067A1 (en) | 2015-06-05 | 2016-12-08 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Gm-csf/cd40l vaccine and checkpoint inhibitor combination therapy |
WO2017023899A1 (en) | 2015-08-02 | 2017-02-09 | H. Lee Moffitt Cancer Center & Research Institute | Inhibitors of ack1/tnk2 tyrosine kinase |
EP3350196A4 (en) | 2015-09-17 | 2019-04-03 | Ohio State Innovation Foundation | CARBORAN COMPOUNDS AND METHODS OF USE |
US10738016B2 (en) | 2015-10-13 | 2020-08-11 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | BRD4-kinase inhibitors as cancer therapeutics |
JP2018536426A (ja) | 2015-12-09 | 2018-12-13 | ヴァンダービルト ユニヴァーシティ | ミクロモノスポラ・カルボナセア変種アウランティアカ(Micromonospora carbonacea var aurantiaca)におけるエベルニノマイシンアナログの生合成 |
WO2017136534A1 (en) | 2016-02-03 | 2017-08-10 | Kennesaw State University Researcha And Service Foundation, Inc. | Signal molecules as cell penetration agents |
WO2017155929A1 (en) * | 2016-03-10 | 2017-09-14 | The University Of Toledo | Targeting of human glucocorticoid receptor beta in cancer |
US11203576B2 (en) | 2016-03-11 | 2021-12-21 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Aurora kinase and Janus kinase inhibitors for prevention of graft versus host disease |
KR102520814B1 (ko) | 2016-03-16 | 2023-04-11 | 에이치 리 모피트 캔서 센터 앤드 리서어치 인스티튜트 아이엔씨 | 작동자 t 세포 기능 개선을 위한 세레브론에 대한 소분자 |
AU2017260460A1 (en) | 2016-05-04 | 2018-12-13 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | A delta-opioid receptor targeted agent for molecular imaging and immunotherapy of cancer |
AU2017312116A1 (en) | 2016-08-17 | 2019-03-07 | Solstice Biologics, Ltd. | Polynucleotide constructs |
CA3043464A1 (en) | 2016-11-09 | 2018-05-17 | Ohio State Innovation Foundation | Di-sulfide containing cell penetrating peptides and methods of making and using thereof |
US10913773B2 (en) | 2016-11-22 | 2021-02-09 | Ohio State Innovation Foundation | Bicyclic peptidyl inhibitor of tumor necrosis factor-alpha |
US11352394B2 (en) | 2016-11-22 | 2022-06-07 | Ohio State Innovation Foundation | Cyclic cell penetrating peptides comprising beta-hairpin motifs and methods of making and using thereof |
US11583525B2 (en) | 2017-06-06 | 2023-02-21 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Geranylgeranyltransferase I inhibitor for treatment of a PTEN defective cancer |
WO2019006455A1 (en) | 2017-06-30 | 2019-01-03 | Solstice Biologics, Ltd. | AUXILIARIES OF CHIRAL PHOSPHORAMIDITIS AND METHODS OF USE THEREOF |
CA3078504A1 (en) | 2017-10-04 | 2019-04-11 | Ohio State Innovation Foundation | Bicyclic peptidyl inhibitors |
JP2021501201A (ja) | 2017-10-27 | 2021-01-14 | オハイオ ステート イノベーション ファウンデーション | ステープルペプチドの細胞内送達のためのポリペプチド接合体 |
WO2019148194A2 (en) | 2018-01-29 | 2019-08-01 | Ohio State Innovation Foundation | Peptidyl inhibitors of calcineurin-nfat interaction |
WO2019165183A1 (en) | 2018-02-22 | 2019-08-29 | Entrada Therapeutics, Inc. | Compositions and methods for treating mitochondrial neurogastrointestinal encephalopathy |
EP3787671A4 (en) | 2018-05-04 | 2022-06-15 | Ohio State Innovation Foundation | NON-PEPTIDE CELL-PENETRATING MOTIFS |
EP3790890A4 (en) | 2018-05-09 | 2022-03-02 | Ohio State Innovation Foundation | CYCLIC PEPTIDES OF CELL PENETRATION WITH ONE OR MORE HYDROPHOBIC RESIDUES |
US20210246185A1 (en) * | 2018-06-04 | 2021-08-12 | Howard Hughes Medical Institute | Inverted transporter polypeptides and methods of using |
CN112512589A (zh) | 2018-07-11 | 2021-03-16 | H·李·莫菲特癌症中心研究有限公司 | 二聚体免疫调节化合物对抗基于cereblon的机制 |
US10898460B1 (en) | 2018-07-20 | 2021-01-26 | University Of South Florida | Leishmania inhibitors |
WO2020028814A1 (en) | 2018-08-03 | 2020-02-06 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Allosteric inhibitor of wee1 kinase |
IL307298A (en) | 2021-03-31 | 2023-11-01 | Entrada Therapeutics Inc | Cell-penetrating circular peptides |
AU2022271873A1 (en) | 2021-05-10 | 2024-01-04 | Entrada Therapeutics, Inc. | Compositions and methods for intracellular therapeutics |
WO2022240721A1 (en) | 2021-05-10 | 2022-11-17 | Entrada Therapeutics, Inc. | Compositions and methods for modulating interferon regulatory factor-5 (irf-5) activity |
EP4337261A2 (en) | 2021-05-10 | 2024-03-20 | Entrada Therapeutics, Inc. | Compositions and methods for modulating mrna splicing |
EP4359006A1 (en) | 2021-06-23 | 2024-05-01 | Entrada Therapeutics, Inc. | Antisense compounds and methods for targeting cug repeats |
AU2022339769A1 (en) | 2021-09-01 | 2024-03-28 | Entrada Therapeutics, Inc. | Compounds and methods for skipping exon 44 in duchenne muscular dystrophy |
WO2023219933A1 (en) | 2022-05-09 | 2023-11-16 | Entrada Therapeutics, Inc. | Compositions and methods for delivery of nucleic acid therapeutics |
WO2024015924A2 (en) | 2022-07-15 | 2024-01-18 | Entrada Therapeutics, Inc. | Hybrid oligonucleotides |
WO2024073042A1 (en) | 2022-09-30 | 2024-04-04 | Entrada Therapeutics, Inc. | Ocular delivery of therapeutic agents |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5804604A (en) * | 1989-12-21 | 1998-09-08 | Biogen, Inc. | Tat-derived transport polypeptides and fusion proteins |
US6316003B1 (en) * | 1989-12-21 | 2001-11-13 | Whitehead Institute For Biomedical Research | Tat-derived transport polypeptides |
US5652122A (en) * | 1989-12-21 | 1997-07-29 | Frankel; Alan | Nucleic acids encoding and methods of making tat-derived transport polypeptides |
JPH0466595A (ja) * | 1990-07-02 | 1992-03-02 | General Hospital Corp | 哺乳動物gap―43組成物および使用方法 |
US5350835A (en) * | 1991-11-05 | 1994-09-27 | Board Of Regents, University Of Texas | Cellular nucleic acid binding protein and uses thereof in regulating gene expression and in the treatment of aids |
US5994108A (en) * | 1991-11-05 | 1999-11-30 | Board Of Regents, The University Of Texas System | Mutant TAR virus and transdominant tat mutants as pharmacological agents |
CA2131620A1 (en) * | 1992-03-20 | 1993-09-30 | Louis C. Smith | A dna transporter system and method of use |
CA2094658A1 (en) | 1992-04-23 | 1993-10-24 | Martin Sumner-Smith | Intracellular delivery of biochemical agents |
WO1994004562A1 (en) * | 1992-08-13 | 1994-03-03 | The General Hospital Corporation | Mammalian gap-43 compositions and methods of use |
US5545551A (en) * | 1992-08-28 | 1996-08-13 | Mt. Sinai School Of Medicine Of The City University Of New York | Cloning and expression of pur protein |
WO1994023751A1 (de) | 1993-04-14 | 1994-10-27 | Boehringer Mannheim Gmbh | Nukleinsäure-transferpeptide und deren verwendung zur einschleusung von nukleinsäuren in eukaryontische zellen |
US6361938B1 (en) | 1996-11-08 | 2002-03-26 | Elan Corporation, Plc | Peptides which enhance transport across tissues and methods of identifying and using the same |
US5989814A (en) * | 1997-04-01 | 1999-11-23 | Reagents Of The University Of California | Screening methods in eucaryotic cells |
JP4129298B2 (ja) | 1997-05-15 | 2008-08-06 | サイトジェン コーポレーション | 胃腸管(git)輸送受容体に結合するランダムペプチド、及び関連した方法 |
FR2766826B1 (fr) | 1997-08-04 | 2001-05-18 | Pasteur Institut | Vecteurs derives d'anticorps pour le transfert de substances dans les cellules |
FR2767323B1 (fr) * | 1997-08-12 | 2001-01-05 | Synt Em | Peptides lineaires derives de peptides antibiotiques, leur preparation et leur utilisation pour vectoriser des substances actives |
US6270956B1 (en) * | 1997-12-11 | 2001-08-07 | The Salk Institute For Biological Studies | Transcriptional coactivator that interacts with Tat protein and regulates its binding to TAR RNA, methods for modulating Tat transactivation, and uses therefor |
ATE258946T1 (de) | 1998-08-28 | 2004-02-15 | Gryphon Sciences | Verfahren zur herstellung von polyamidketten von genauer länge und deren konjugate mit proteinen |
EP1210362A2 (en) * | 1999-09-01 | 2002-06-05 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Identification of peptides that facilitate uptake and cytoplasmic and/or nuclear transport of proteins, dna and viruses |
US20030104622A1 (en) | 1999-09-01 | 2003-06-05 | Robbins Paul D. | Identification of peptides that facilitate uptake and cytoplasmic and/or nuclear transport of proteins, DNA and viruses |
FR2805821B1 (fr) | 2000-03-01 | 2004-01-16 | Diatos | Sequences d'acides amines facilitant la penetration d'une substance d'interet a l'interieur des cellules et/ou des noyaux cellulaires |
JP4387669B2 (ja) * | 2000-10-13 | 2009-12-16 | ザイジェン エス.アー. | 新規なトランスポーターペプチド配列による生物学的エフェクターの細胞内送達 |
-
2001
- 2001-10-15 JP JP2002534479A patent/JP4387669B2/ja not_active Expired - Fee Related
- 2001-10-15 EP EP01986713A patent/EP1345956A2/en not_active Ceased
- 2001-10-15 CA CA002425610A patent/CA2425610A1/en not_active Abandoned
- 2001-10-15 US US10/399,127 patent/US7034109B2/en not_active Expired - Fee Related
- 2001-10-15 AU AU2002220979A patent/AU2002220979A1/en not_active Abandoned
- 2001-10-15 US US09/977,831 patent/US6960648B2/en not_active Expired - Fee Related
- 2001-10-15 WO PCT/IB2001/002423 patent/WO2002031109A2/en active Application Filing
-
2006
- 2006-04-21 US US11/408,393 patent/US7538091B2/en not_active Expired - Lifetime
-
2007
- 2007-07-27 JP JP2007196622A patent/JP4388107B2/ja not_active Expired - Fee Related
-
2008
- 2008-06-04 JP JP2008147345A patent/JP2009005694A/ja active Pending
-
2009
- 2009-06-08 JP JP2009137749A patent/JP2009195253A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
JP2009195253A (ja) | 2009-09-03 |
JP2009005694A (ja) | 2009-01-15 |
JP2004511494A (ja) | 2004-04-15 |
US20060205665A1 (en) | 2006-09-14 |
EP1345956A2 (en) | 2003-09-24 |
JP4388107B2 (ja) | 2009-12-24 |
US7034109B2 (en) | 2006-04-25 |
US20020120100A1 (en) | 2002-08-29 |
US6960648B2 (en) | 2005-11-01 |
WO2002031109A2 (en) | 2002-04-18 |
CA2425610A1 (en) | 2002-04-18 |
US20040110690A1 (en) | 2004-06-10 |
US7538091B2 (en) | 2009-05-26 |
WO2002031109A3 (en) | 2003-01-16 |
JP2007330265A (ja) | 2007-12-27 |
JP4387669B2 (ja) | 2009-12-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US6960648B2 (en) | Intracellular delivery of biological effectors | |
US7033597B2 (en) | Intracellular delivery of biological effectors | |
CN106715462B (zh) | α4β7整联蛋白硫醚肽拮抗剂 | |
JP6499157B2 (ja) | 新規のα4β7ペプチド二量体アンタゴニスト | |
JP2016515620A (ja) | 新規のα4β7ペプチド拮抗薬 | |
JP2013513382A (ja) | 細胞内ターゲット結合用二座ペプチドバインダー | |
Parthasarathy et al. | The medicinal chemistry of therapeutic peptides: Recent developments in synthesis and design optimizations | |
CZ20013318A3 (cs) | Noví LH-RH-antagonisté se zlepąenými vlastnostmi rozpustnosti | |
Park et al. | The use of one-bead one-compound combinatorial library method to identify peptide ligands for α4β1 integrin receptor in non-Hodgkin's lymphoma | |
WO2015055148A1 (zh) | Yap蛋白抑制多肽及其应用 | |
AU2001249789B2 (en) | Binding peptides for carcinoembryonic antigen (cea) | |
JP3805679B2 (ja) | 新規のlhrh拮抗物質、その製造および医薬としてのその使用 | |
AU2008201592B2 (en) | Intracellular Delivery of Biological Effectors | |
AU2007216926A1 (en) | Intracellular Delivery of Biological Effectors by Novel Transporter Peptide Sequences | |
Roberts et al. | Kappa agonist CovX-bodies | |
Chavatte et al. | Rhenium (Re) and technetium (Tc)‐99M oxocomplexes of neurotensin (8‐13) | |
Einsiedel et al. | Development of disulfide-functionalized peptides covalently binding G protein-coupled receptors | |
Klimentzou et al. | Solid‐phase Synthesis of a Peptide Derivative of Thymosin alpha1 and Initial Studies on its 99mTc‐Radiolabelling | |
Hamza et al. | Synthesis of Some Analogues of Polymyxin E1 Antibiotic Using Automated Solid Phase Peptide Synthesis Assisted With Microwave Irradiation | |
WO1999045020A1 (en) | Isolation of tissue specific peptide ligands and their use for targeting pharmaceuticals to organs | |
Chen et al. | Chemobodies as Targeting Moieties of Insulin-Secreting Cells | |
Lian | Development and Optimization of Protein-Protein Interaction Inhibitors by Combinatorial and Medicinal Chemistry | |
JPH1171397A (ja) | 新規生理活性ペプチド |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MK5 | Application lapsed section 142(2)(e) - patent request and compl. specification not accepted |