AU2001289617A1 - Diagnosis of diseases associated with signal transduction - Google Patents

Diagnosis of diseases associated with signal transduction

Info

Publication number
AU2001289617A1
AU2001289617A1 AU2001289617A AU8961701A AU2001289617A1 AU 2001289617 A1 AU2001289617 A1 AU 2001289617A1 AU 2001289617 A AU2001289617 A AU 2001289617A AU 8961701 A AU8961701 A AU 8961701A AU 2001289617 A1 AU2001289617 A1 AU 2001289617A1
Authority
AU
Australia
Prior art keywords
diagnosis
signal transduction
diseases associated
diseases
transduction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001289617A
Other languages
English (en)
Inventor
Kurt Berlin
Alexander Olek
Christian Piepenbrock
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Epigenomics AG
Original Assignee
Epigenomics AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10032529A external-priority patent/DE10032529A1/de
Application filed by Epigenomics AG filed Critical Epigenomics AG
Publication of AU2001289617A1 publication Critical patent/AU2001289617A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82Translation products from oncogenes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702Regulators; Modulating activity
    • C07K14/4703Inhibitors; Suppressors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2523/00Reactions characterised by treatment of reaction samples
    • C12Q2523/10Characterised by chemical treatment
    • C12Q2523/125Bisulfite(s)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/154Methylation markers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Hospice & Palliative Care (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AU2001289617A 2000-06-30 2001-06-29 Diagnosis of diseases associated with signal transduction Abandoned AU2001289617A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE10032529.7 2000-06-30
DE10032529A DE10032529A1 (de) 2000-06-30 2000-06-30 Diagnose von bedeutenden genetischen Parametern innerhalb des Major Histocompatibility Complex (MHC)
DE10043826.1 2000-09-01
DE10043826 2000-09-01
PCT/EP2001/007472 WO2002000926A2 (en) 2000-06-30 2001-06-29 Diagnosis of diseases associated with signal transduction

Publications (1)

Publication Number Publication Date
AU2001289617A1 true AU2001289617A1 (en) 2002-01-08

Family

ID=26006285

Family Applications (8)

Application Number Title Priority Date Filing Date
AU2001276371A Abandoned AU2001276371A1 (en) 2000-06-30 2001-06-29 Method and nucleic acids for analysing the methylation of genes implicated pharmacogenomics
AU2001289617A Abandoned AU2001289617A1 (en) 2000-06-30 2001-06-29 Diagnosis of diseases associated with signal transduction
AU2001277521A Abandoned AU2001277521A1 (en) 2000-06-30 2001-06-29 Diagnosis of diseases associated with cell signalling
AU2001287575A Abandoned AU2001287575A1 (en) 2000-06-30 2001-07-02 Diagnosis of diseases associated with the immune system by determining cytosine methylation
AU2001287576A Abandoned AU2001287576A1 (en) 2000-06-30 2001-07-02 Method and nucleic acids for the differentiation of astrocytoma, oligoastrocytoma and oligodendroglioma tumor cells
AU2001283915A Abandoned AU2001283915A1 (en) 2000-06-30 2001-07-02 Diagnosis of diseases associated with development by means of assessing their methylation status
AU2001279707A Abandoned AU2001279707A1 (en) 2000-06-30 2001-07-02 Diagnosis of behavioural disorders, neurological disorders and cancer
AU2001283916A Abandoned AU2001283916A1 (en) 2000-06-30 2001-07-02 Method and nucleic acids for the analysis of astrocytomas

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AU2001276371A Abandoned AU2001276371A1 (en) 2000-06-30 2001-06-29 Method and nucleic acids for analysing the methylation of genes implicated pharmacogenomics

Family Applications After (6)

Application Number Title Priority Date Filing Date
AU2001277521A Abandoned AU2001277521A1 (en) 2000-06-30 2001-06-29 Diagnosis of diseases associated with cell signalling
AU2001287575A Abandoned AU2001287575A1 (en) 2000-06-30 2001-07-02 Diagnosis of diseases associated with the immune system by determining cytosine methylation
AU2001287576A Abandoned AU2001287576A1 (en) 2000-06-30 2001-07-02 Method and nucleic acids for the differentiation of astrocytoma, oligoastrocytoma and oligodendroglioma tumor cells
AU2001283915A Abandoned AU2001283915A1 (en) 2000-06-30 2001-07-02 Diagnosis of diseases associated with development by means of assessing their methylation status
AU2001279707A Abandoned AU2001279707A1 (en) 2000-06-30 2001-07-02 Diagnosis of behavioural disorders, neurological disorders and cancer
AU2001283916A Abandoned AU2001283916A1 (en) 2000-06-30 2001-07-02 Method and nucleic acids for the analysis of astrocytomas

Country Status (5)

Country Link
US (5) US20040023230A1 (ja)
EP (9) EP1297182A2 (ja)
JP (1) JP2004501666A (ja)
AU (8) AU2001276371A1 (ja)
WO (8) WO2002000926A2 (ja)

Families Citing this family (108)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1247567A (zh) 1997-01-14 2000-03-15 人体基因组科学有限公司 肿瘤坏死因子受体6α和6β
US7285267B2 (en) 1997-01-14 2007-10-23 Human Genome Sciences, Inc. Tumor necrosis factor receptors 6α & 6β
US6818404B2 (en) 1997-10-23 2004-11-16 Exact Sciences Corporation Methods for detecting hypermethylated nucleic acid in heterogeneous biological samples
US8076063B2 (en) * 2000-02-07 2011-12-13 Illumina, Inc. Multiplexed methylation detection methods
US7955794B2 (en) 2000-09-21 2011-06-07 Illumina, Inc. Multiplex nucleic acid reactions
US7611869B2 (en) * 2000-02-07 2009-11-03 Illumina, Inc. Multiplexed methylation detection methods
US7582420B2 (en) 2001-07-12 2009-09-01 Illumina, Inc. Multiplex nucleic acid reactions
AU2001276331A1 (en) 2000-04-06 2001-10-23 Epigenomics Ag Diagnosis of diseases associated with metastasis
AU2001281311A1 (en) * 2000-07-10 2002-01-21 Epigenx Pharmaceutical, Inc. Detecting methylated cytosine in polynucleotides
JP2002034575A (ja) * 2000-07-28 2002-02-05 Shiseido Co Ltd ヒトII型5α−レダクターゼのプロモーター遺伝子およびその用途
DE10054974A1 (de) * 2000-11-06 2002-06-06 Epigenomics Ag Diagnose von mit Cdk4 assoziierten Krankheiten
DE10061338A1 (de) * 2000-12-06 2002-06-20 Epigenomics Ag Diagnose von mit Angiogenese assoziierten Krankheiten
US6756200B2 (en) * 2001-01-26 2004-06-29 The Johns Hopkins University School Of Medicine Aberrantly methylated genes as markers of breast malignancy
EP1410304A2 (en) * 2001-03-26 2004-04-21 Epigenomics AG Method for epigenetic feature selection
WO2002083921A2 (en) 2001-04-10 2002-10-24 Agensys, Inc. Nuleic acids and corresponding proteins useful in the detection and treatment of various cancers
US7235358B2 (en) 2001-06-08 2007-06-26 Expression Diagnostics, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
DE10128508A1 (de) 2001-06-14 2003-02-06 Epigenomics Ag Verfahren und Nukleinsäuren für die Differenzierung von Prostata-Tumoren
US7432050B2 (en) 2001-10-05 2008-10-07 Case Western Reserve University Methods and compositions for detecting colon cancers
US20110151438A9 (en) * 2001-11-19 2011-06-23 Affymetrix, Inc. Methods of Analysis of Methylation
EP1468104A4 (en) * 2002-01-18 2006-02-01 Genzyme Corp METHODS FOR DETECTION OF FETAL DNA AND QUANTIFICATION OF ALLELES
US20030215842A1 (en) * 2002-01-30 2003-11-20 Epigenomics Ag Method for the analysis of cytosine methylation patterns
EP1340818A1 (en) * 2002-02-27 2003-09-03 Epigenomics AG Method and nucleic acids for the analysis of a colon cell proliferative disorder
JP2005518822A (ja) * 2002-03-07 2005-06-30 ザ ジョンズ ホプキンス ユニバーシティー スクール オブ メディシン 後生的に沈黙化されたガン関連遺伝子のゲノムスクリーニング
SG167667A1 (en) * 2002-07-03 2011-01-28 Coley Pharm Group Inc Nucleic acid compositions for stimulating immune responses
US7807803B2 (en) 2002-07-03 2010-10-05 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
US20040053880A1 (en) 2002-07-03 2004-03-18 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
US7605138B2 (en) * 2002-07-03 2009-10-20 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
US20040029128A1 (en) * 2002-08-08 2004-02-12 Epigenomics, Inc. Methods and nucleic acids for the analysis of CpG dinucleotide methylation status associated with the calcitonin gene
CA2500255A1 (en) 2002-10-01 2004-04-29 Epigenomics Ag Method and nucleic acids for the treatment of breast cell proliferative disorders
US20060094016A1 (en) * 2002-12-02 2006-05-04 Niall Gormley Determination of methylation of nucleic acid sequences
WO2004087044A2 (en) * 2002-12-20 2004-10-14 Bioseek, Inc. Drug target
ITRM20030149A1 (it) 2003-04-02 2004-10-03 Giuliani Spa Oligonucleotidi (odn) antisenso per smad7 e loro usi in campo medico
US20050009059A1 (en) * 2003-05-07 2005-01-13 Affymetrix, Inc. Analysis of methylation status using oligonucleotide arrays
US7430335B2 (en) 2003-08-13 2008-09-30 Apple Inc Pre-processing method and system for data reduction of video sequences and bit rate reduction of compressed video sequences using spatial filtering
US7403568B2 (en) 2003-08-13 2008-07-22 Apple Inc. Pre-processing method and system for data reduction of video sequences and bit rate reduction of compressed video sequences using temporal filtering
WO2005042713A2 (en) * 2003-10-28 2005-05-12 The Johns Hopkins University Quantitative multiplex methylation-specific pcr
US9181587B2 (en) 2003-12-01 2015-11-10 Epigenomics Ag Methods and nucleic acids for the analysis of gene expression associated with the development of prostate cell proliferative disorders
EP1561821B1 (en) 2003-12-11 2011-02-16 Epigenomics AG Prognostic markers for prediction of treatment response and/or survival of breast cell proliferative disorder patients
EP2474616B1 (en) 2004-05-28 2015-07-08 Asuragen, Inc. Methods and compositions involving microRNA
EP2281902A1 (en) * 2004-07-18 2011-02-09 Epigenomics AG Epigenetic methods and nucleic acids for the detection of breast cell proliferative disorders
WO2006034879A2 (en) * 2004-09-30 2006-04-06 Epigenomics Ag Epigenetic methods and nucleic acids for the detection of lung cell proliferative disorders
EP2281887A1 (en) 2004-11-12 2011-02-09 Asuragen, Inc. Methods and compositions involving miRNA and miRNA inhibitor molecules
US20060134650A1 (en) * 2004-12-21 2006-06-22 Illumina, Inc. Methylation-sensitive restriction enzyme endonuclease method of whole genome methylation analysis
WO2006088978A1 (en) 2005-02-16 2006-08-24 Epigenomics, Inc. Method for determining the methylation pattern of a polynucleic acid
EP1748080A3 (en) * 2005-03-11 2007-04-11 Epiontis GmbH Specific DNAs for epigenetic characterisation of cells and tissues
EP1863924A2 (en) * 2005-03-11 2007-12-12 Epiontis GmbH Specific dnas for epigenetic characterisation of cells and tissues
DK1871912T3 (da) 2005-04-15 2012-05-14 Epigenomics Ag Fremgangsmåde til bestemmelse af DNA-methylering i blod- eller urinprøver
WO2006111586A2 (es) * 2005-04-20 2006-10-26 Proyecto De Biomedicina Cima, S.L. Procedimiento para la determinación in vitro del grado de metilación del promotor de line-1
US20060292585A1 (en) * 2005-06-24 2006-12-28 Affymetrix, Inc. Analysis of methylation using nucleic acid arrays
WO2007003397A2 (en) * 2005-07-01 2007-01-11 Epigenomics Ag Method and nucleic acids for the improved treatment of cancers
WO2007032748A1 (en) * 2005-09-15 2007-03-22 Agency For Science, Technology & Research Method for detecting dna methylation
JP2009514555A (ja) * 2005-11-08 2009-04-09 ユークリッド ダイアグノスティックス リミテッド ライアビリティー カンパニー 癌評価の遺伝子関連CpGアイランドのメチル化アッセイのための材料と方法
US20070161006A1 (en) * 2006-01-10 2007-07-12 Vita Genomics, Inc. Single nucleotide polymorphisms in protein-tyrosine phosphatase receptor-type delta for the diagnosis of susceptibility to infection and asthma
WO2007095032A2 (en) * 2006-02-09 2007-08-23 Novartis Ag Mutations and polymorphisms of ptk2b
US20070238115A1 (en) * 2006-02-27 2007-10-11 Dwinell Michael B Method of Diagnosing and Treating Colon Cancer
US7901882B2 (en) 2006-03-31 2011-03-08 Affymetrix, Inc. Analysis of methylation using nucleic acid arrays
US8084734B2 (en) * 2006-05-26 2011-12-27 The George Washington University Laser desorption ionization and peptide sequencing on laser induced silicon microcolumn arrays
AU2007254983A1 (en) * 2006-05-31 2007-12-13 Orion Genomics Llc Gene methylation in cancer diagnosis
ES2546182T3 (es) * 2006-07-21 2015-09-21 Epigenomics Ag Métodos y kits para análisis de metilación en trastornos proliferativos celulares colorrectales
AU2007299828C1 (en) * 2006-09-19 2014-07-17 Interpace Diagnostics, Llc MicroRNAs differentially expressed in pancreatic diseases and uses thereof
CN101622349A (zh) * 2006-12-08 2010-01-06 奥斯瑞根公司 作为治疗性干预靶标的miR-21调节的基因和途径
GB0625321D0 (en) * 2006-12-19 2007-01-24 Univ Surrey Cancer biomarker
CA2667302C (en) 2007-01-18 2013-06-25 Molecor Tecnologia S.L. System for the manufacturing of integrated sockets in biaxially oriented plastic pipes
US20090075263A1 (en) * 2007-02-02 2009-03-19 Orion Genomics Llc Gene methylation in ovarian cancer diagnosis
WO2008096146A1 (en) * 2007-02-07 2008-08-14 Solexa Limited Preparation of templates for methylation analysis
US20090131354A1 (en) * 2007-05-22 2009-05-21 Bader Andreas G miR-126 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION
US8361714B2 (en) 2007-09-14 2013-01-29 Asuragen, Inc. Micrornas differentially expressed in cervical cancer and uses thereof
WO2009052386A1 (en) * 2007-10-18 2009-04-23 Asuragen, Inc. Micrornas differentially expressed in lung diseases and uses thereof
US8071562B2 (en) 2007-12-01 2011-12-06 Mirna Therapeutics, Inc. MiR-124 regulated genes and pathways as targets for therapeutic intervention
WO2009108917A2 (en) * 2008-02-29 2009-09-03 Oncomethylome Sciences, S.A. Markers for improved detection of breast cancer
WO2009111643A2 (en) * 2008-03-06 2009-09-11 Asuragen, Inc. Microrna markers for recurrence of colorectal cancer
WO2009137807A2 (en) 2008-05-08 2009-11-12 Asuragen, Inc. Compositions and methods related to mirna modulation of neovascularization or angiogenesis
EP2340314B8 (en) 2008-10-22 2015-02-18 Illumina, Inc. Preservation of information related to genomic dna methylation
US8110796B2 (en) 2009-01-17 2012-02-07 The George Washington University Nanophotonic production, modulation and switching of ions by silicon microcolumn arrays
US9279157B2 (en) * 2009-02-06 2016-03-08 The Regents Of The University Of California EMX2 in cancer diagnosis and prognosis
US9490113B2 (en) * 2009-04-07 2016-11-08 The George Washington University Tailored nanopost arrays (NAPA) for laser desorption ionization in mass spectrometry
AU2010258757A1 (en) * 2009-06-09 2012-01-12 Banner Sun Health Research Institute Method and system to detect, diagnose, and monitor the progression of Alzheimer's disease
CA2777906A1 (en) * 2009-10-28 2011-05-05 Signature Diagnostics Ag Method for the prognosis of ovarian carcinoma
US9394570B2 (en) * 2010-04-21 2016-07-19 The Chinese University Of Hong Kong Marker for colon cancer and method for detecting colon cancer
PT2614952E (pt) 2010-09-06 2016-06-02 Molecor Tecnologia Sl Dispositivo e método para abocardar tubos de plástico orientados biaxialmente com juntas de vedação integradas
CA2815212A1 (en) * 2010-10-22 2012-04-26 Curna, Inc. Treatment of alpha-l-iduronidase (idua) related diseases by inhibition of natural antisense transcript to idua
WO2012162139A1 (en) 2011-05-20 2012-11-29 The Regents Of The University Of California Method to estimate age of individual based on epigenetic markers in biological sample
WO2013026104A1 (en) * 2011-08-25 2013-02-28 Clinical Genomics Pty. Ltd. Dna methylation in colorectal and breast cancer diagnostic methods
WO2013040251A2 (en) 2011-09-13 2013-03-21 Asurgen, Inc. Methods and compositions involving mir-135b for distinguishing pancreatic cancer from benign pancreatic disease
EP2820157B1 (en) * 2012-03-02 2019-05-01 Winthrop-University Hospital Method for using probe based pcr detection to measure the levels of circulating demethylated beta cell derived dna as a measure of beta cell loss in diabetes
US10865446B2 (en) 2012-11-02 2020-12-15 The Johns Hopkins University DNA methylation biomarkers of post-partum depression risk
EP3543360B1 (en) 2013-03-14 2021-02-17 Mayo Foundation for Medical Education and Research Detecting neoplasm
ES2527724B1 (es) * 2013-05-29 2015-11-10 Fundación Para La Investigación Biomédica Del Hospital Universitario La Paz Método para predecir la respuesta al tratamiento con radioterapia combinada con quimioterapia basada en cisplatino
EP4234722A3 (en) 2014-03-31 2023-09-20 Mayo Foundation for Medical Education and Research Detecting colorectal neoplasm
US9840742B2 (en) * 2014-06-16 2017-12-12 JBS Science Inc. Detection of hepatitis B virus (HBV) DNA and methylated HBV DNA in urine of patients with HBV-associated hepatocellular carcinoma
US10184154B2 (en) 2014-09-26 2019-01-22 Mayo Foundation For Medical Education And Research Detecting cholangiocarcinoma
US10030272B2 (en) 2015-02-27 2018-07-24 Mayo Foundation For Medical Education And Research Detecting gastrointestinal neoplasms
US20180230539A1 (en) * 2015-07-21 2018-08-16 Indiana University Research And Technology Corporation Cell-free methylated and unmethylated dna in diseases resulting from abnormalities in blood glucose levels
WO2017040627A1 (en) 2015-08-31 2017-03-09 Mayo Foundation For Medical Education And Research Detecting gastric neoplasm
US10370726B2 (en) 2016-04-14 2019-08-06 Mayo Foundation For Medical Education And Research Detecting colorectal neoplasia
CA3020628A1 (en) 2016-04-14 2017-10-19 Mayo Foundation For Medical Education And Research Detecting pancreatic high-grade dysplasia
CN105734152B (zh) * 2016-04-20 2019-02-26 苏州吉诺瑞生物科技有限公司 检测人srpk2基因的表达水平的特异引物对及其应用
WO2018045322A1 (en) * 2016-09-02 2018-03-08 Mayo Foundation For Medical Education And Research Detecting hepatocellular carcinoma
US20190284636A1 (en) * 2016-10-26 2019-09-19 Brown University A method to measure myeloid suppressor cells for diagnosis and prognosis of cancer
CN110431241B (zh) 2017-02-28 2024-04-19 梅约医学教育与研究基金会 检测前列腺癌
EP3717644A4 (en) 2017-11-30 2021-12-29 Mayo Foundation for Medical Education and Research Detecting breast cancer
KR102512282B1 (ko) * 2017-12-01 2023-03-23 바이오체인 (베이징) 사이언스 앤드 테크놀로지, 인크. 식도암 검출용 조성물 및 이의 용도
CN108977457B (zh) * 2018-08-31 2021-04-02 长江大学 一种黄鳝抗菌肽的制备方法
CN114599797A (zh) 2019-01-18 2022-06-07 加利福尼亚大学董事会 基于保守基因座的哺乳动物dna甲基化测量
DE102020111423B4 (de) 2020-04-27 2022-03-03 Precision For Medicine Gmbh MYH11/NDE1 Region als epigenetischer Marker für die Identifizierung von Endothel-Vorläuferzellen (EPCs)
AU2021297245A1 (en) * 2020-06-23 2023-02-02 Illumina Software, Inc. Methods for diagnosing respiratory pathogens and predicting covid-19 related outcomes
JP2023538557A (ja) 2020-08-15 2023-09-08 リジェネロン・ファーマシューティカルズ・インコーポレイテッド カルシトニン受容体(calcr)をコードするバリアント核酸分子を有する対象における肥満の治療
WO2023175019A1 (en) 2022-03-15 2023-09-21 Genknowme S.A. Method determining the difference between the biological age and the chronological age of a subject

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683202A (en) * 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4965188A (en) * 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US4683195A (en) * 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US5744101A (en) * 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US5843654A (en) * 1992-12-07 1998-12-01 Third Wave Technologies, Inc. Rapid detection of mutations in the p53 gene
US5837832A (en) * 1993-06-25 1998-11-17 Affymetrix, Inc. Arrays of nucleic acid probes on biological chips
WO1995011995A1 (en) * 1993-10-26 1995-05-04 Affymax Technologies N.V. Arrays of nucleic acid probes on biological chips
US5804407A (en) * 1993-11-04 1998-09-08 University Technologies International, Inc. Method of expressing genes in mammalian cells
US5756668A (en) * 1994-11-15 1998-05-26 The Johns Hopkins University School Of Medicine Hypermethylated in cancer polypeptide, HIC-1
US6017704A (en) * 1996-06-03 2000-01-25 The Johns Hopkins University School Of Medicine Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids
US6251594B1 (en) * 1997-06-09 2001-06-26 Usc/Norris Comprehensive Cancer Ctr. Cancer diagnostic method based upon DNA methylation differences
US6342350B1 (en) * 1997-09-05 2002-01-29 The General Hospital Corporation Alpha-2-macroglobulin diagnostic test
DE19754482A1 (de) * 1997-11-27 1999-07-01 Epigenomics Gmbh Verfahren zur Herstellung komplexer DNA-Methylierungs-Fingerabdrücke
DK1036202T3 (da) * 1997-12-05 2002-08-12 Max Planck Gesellschaft Fremgangsmåde til identifikation af nucleinsyrer ved matriksassisteret laserdesorptions/ionisationsmassespektrometri
DE19905082C1 (de) * 1999-01-29 2000-05-18 Epigenomics Gmbh Verfahren zur Identifikation von Cytosin-Methylierungsmustern in genomischen DNA-Proben
AU2001248352A1 (en) * 2000-03-15 2001-09-24 Epigenomics Ag Diagnosis of diseases associated with the cell cycle
AU2001276331A1 (en) * 2000-04-06 2001-10-23 Epigenomics Ag Diagnosis of diseases associated with metastasis
DE10128508A1 (de) * 2001-06-14 2003-02-06 Epigenomics Ag Verfahren und Nukleinsäuren für die Differenzierung von Prostata-Tumoren
WO2003004696A2 (en) * 2001-07-02 2003-01-16 Epigenomics Ag A distributed system for epigenetic based prediction of complex phenotypes

Also Published As

Publication number Publication date
EP1297185A2 (en) 2003-04-02
AU2001283915A1 (en) 2002-01-08
US20080145839A1 (en) 2008-06-19
WO2002002809A2 (en) 2002-01-10
EP1676927A3 (en) 2006-12-06
WO2002002808A3 (en) 2003-09-04
EP1355932A2 (en) 2003-10-29
US20040115630A1 (en) 2004-06-17
EP1294948A2 (en) 2003-03-26
AU2001277521A1 (en) 2002-01-14
WO2002000928A3 (de) 2002-08-01
EP1294951A2 (de) 2003-03-26
AU2001276371A1 (en) 2002-01-14
WO2002000926A2 (en) 2002-01-03
WO2002000928A2 (de) 2002-01-03
WO2002002809A3 (en) 2003-01-30
WO2002002807A8 (en) 2002-05-30
EP1294947A2 (en) 2003-03-26
US20080026396A1 (en) 2008-01-31
WO2002002808A2 (en) 2002-01-10
JP2004501666A (ja) 2004-01-22
WO2002000705A2 (en) 2002-01-03
WO2002000705A3 (en) 2003-08-14
AU2001287576A1 (en) 2002-01-08
WO2002000927A2 (en) 2002-01-03
WO2002000926A3 (en) 2002-11-21
EP1356099A2 (en) 2003-10-29
EP1294950A2 (en) 2003-03-26
WO2002002806A2 (en) 2002-01-10
WO2002000927A8 (en) 2002-03-21
WO2002000926A8 (en) 2002-07-18
WO2002002807A2 (en) 2002-01-10
US20040023230A1 (en) 2004-02-05
AU2001279707A1 (en) 2002-01-14
AU2001287575A1 (en) 2002-01-08
EP1297182A2 (en) 2003-04-02
WO2002002806A3 (en) 2002-05-16
AU2001283916A1 (en) 2002-01-14
US20030143606A1 (en) 2003-07-31
WO2002000927A3 (en) 2002-07-18
EP1676927A2 (en) 2006-07-05
WO2002002807A3 (en) 2002-08-08

Similar Documents

Publication Publication Date Title
AU2001289617A1 (en) Diagnosis of diseases associated with signal transduction
AU2002356324A1 (en) Analysis of acoustic medical signals
HRP20030033A2 (en) Early diagnosis of conformational diseases
AU2002212187A1 (en) Diagnosis of illnesses or predisposition to certain illnesses
AU2002239370A1 (en) Signal tampon
AU2003287735A1 (en) Non-invasive measurement of analytes
AU2001288462A1 (en) Medical instrument
AU2001232360A1 (en) Medical instrument
AU2001227815A1 (en) Chemically specific imaging of tissue
AU2001245382A1 (en) Simultaneous multimodal measurement of physiological function
AU2001245989A1 (en) Preparation of epothilone intermediates
AU2001256020A1 (en) Biological sounds monitor
AU2001277653A1 (en) Diagnosis of known genetic parameters within the MHC
AU2002217091A1 (en) Diagnosis of diseases associated with angiogenesis by determining the methylation of genes associated with angiogenesis
AU2001264631A1 (en) Medical instrument
AU2002218283A1 (en) Diagnosis of diseases associated with cdk4 by determining the methyl delivery state of cdk4
IL141950A0 (en) Diagnosis of prion diseases
AU2001276874A1 (en) Continuous preparation of polycarbonate
AU2002210438A1 (en) Diagnosis of diseases which are associated with cd24
AU2002226088A1 (en) Enhanced diagnosis of psychiatric disorders with heartbeat data
AU3566200A (en) Human signal transduction serine/threonine protein kinase
AU2002250041A1 (en) Putative human enzymes
AU2003253850A1 (en) NON-INVASIVE MEASUREMENT OF pH
AU2001249446A1 (en) Diagnostic polymorphisms of tgf-beta-rii promoter
AUPQ048799A0 (en) Diagnosis of cardiovascular disease