AU2001281287B8 - Device and method for intravaginal or transvaginal treatment of fungal, bacterial, viral or parasitic infections - Google Patents
Device and method for intravaginal or transvaginal treatment of fungal, bacterial, viral or parasitic infections Download PDFInfo
- Publication number
- AU2001281287B8 AU2001281287B8 AU2001281287A AU2001281287A AU2001281287B8 AU 2001281287 B8 AU2001281287 B8 AU 2001281287B8 AU 2001281287 A AU2001281287 A AU 2001281287A AU 2001281287 A AU2001281287 A AU 2001281287A AU 2001281287 B8 AU2001281287 B8 AU 2001281287B8
- Authority
- AU
- Australia
- Prior art keywords
- vaginal
- tampon
- agent
- composition
- incorporated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 238000011282 treatment Methods 0.000 title claims description 95
- 238000000034 method Methods 0.000 title claims description 32
- 206010017533 Fungal infection Diseases 0.000 title claims description 18
- 230000001580 bacterial effect Effects 0.000 title claims description 17
- 230000003612 virological effect Effects 0.000 title claims description 14
- 230000002538 fungal effect Effects 0.000 title claims description 13
- 208000031888 Mycoses Diseases 0.000 title claims description 12
- 208000030852 Parasitic disease Diseases 0.000 title claims description 12
- 208000035143 Bacterial infection Diseases 0.000 title claims description 11
- 208000036142 Viral infection Diseases 0.000 title claims description 11
- 208000022362 bacterial infectious disease Diseases 0.000 title claims description 11
- 239000000203 mixture Substances 0.000 claims description 97
- 239000006260 foam Substances 0.000 claims description 54
- 239000003795 chemical substances by application Substances 0.000 claims description 51
- 238000012377 drug delivery Methods 0.000 claims description 44
- 210000003679 cervix uteri Anatomy 0.000 claims description 40
- 210000004877 mucosa Anatomy 0.000 claims description 39
- 210000004291 uterus Anatomy 0.000 claims description 38
- 210000001215 vagina Anatomy 0.000 claims description 38
- 210000000981 epithelium Anatomy 0.000 claims description 36
- 239000008177 pharmaceutical agent Substances 0.000 claims description 35
- 230000003232 mucoadhesive effect Effects 0.000 claims description 32
- 229960000282 metronidazole Drugs 0.000 claims description 29
- VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 claims description 29
- 239000000499 gel Substances 0.000 claims description 27
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 claims description 24
- 239000003242 anti bacterial agent Substances 0.000 claims description 23
- 229940121375 antifungal agent Drugs 0.000 claims description 22
- 206010046914 Vaginal infection Diseases 0.000 claims description 20
- 238000001179 sorption measurement Methods 0.000 claims description 20
- 229960002227 clindamycin Drugs 0.000 claims description 18
- KDLRVYVGXIQJDK-AWPVFWJPSA-N clindamycin Chemical compound CN1C[C@H](CCC)C[C@H]1C(=O)N[C@H]([C@H](C)Cl)[C@@H]1[C@H](O)[C@H](O)[C@@H](O)[C@@H](SC)O1 KDLRVYVGXIQJDK-AWPVFWJPSA-N 0.000 claims description 18
- 239000000243 solution Substances 0.000 claims description 18
- 239000006071 cream Substances 0.000 claims description 17
- -1 Sacyclovir Chemical compound 0.000 claims description 16
- 239000003429 antifungal agent Substances 0.000 claims description 16
- 229960004022 clotrimazole Drugs 0.000 claims description 16
- VNFPBHJOKIVQEB-UHFFFAOYSA-N clotrimazole Chemical compound ClC1=CC=CC=C1C(N1C=NC=C1)(C=1C=CC=CC=1)C1=CC=CC=C1 VNFPBHJOKIVQEB-UHFFFAOYSA-N 0.000 claims description 16
- 239000012052 hydrophilic carrier Substances 0.000 claims description 16
- 208000015181 infectious disease Diseases 0.000 claims description 16
- 239000006210 lotion Substances 0.000 claims description 16
- 239000003826 tablet Substances 0.000 claims description 16
- BYBLEWFAAKGYCD-UHFFFAOYSA-N Miconazole Chemical compound ClC1=CC(Cl)=CC=C1COC(C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 BYBLEWFAAKGYCD-UHFFFAOYSA-N 0.000 claims description 15
- 239000000227 bioadhesive Substances 0.000 claims description 15
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 15
- 229960004150 aciclovir Drugs 0.000 claims description 14
- MKUXAQIIEYXACX-UHFFFAOYSA-N aciclovir Chemical group N1C(N)=NC(=O)C2=C1N(COCCO)C=N2 MKUXAQIIEYXACX-UHFFFAOYSA-N 0.000 claims description 14
- 229960002509 miconazole Drugs 0.000 claims description 14
- XMAYWYJOQHXEEK-OZXSUGGESA-N (2R,4S)-ketoconazole Chemical compound C1CN(C(=O)C)CCN1C(C=C1)=CC=C1OC[C@@H]1O[C@@](CN2C=NC=C2)(C=2C(=CC(Cl)=CC=2)Cl)OC1 XMAYWYJOQHXEEK-OZXSUGGESA-N 0.000 claims description 13
- 239000004098 Tetracycline Substances 0.000 claims description 13
- 208000005448 Trichomonas Infections Diseases 0.000 claims description 13
- 206010044620 Trichomoniasis Diseases 0.000 claims description 13
- 229960004125 ketoconazole Drugs 0.000 claims description 13
- 239000002674 ointment Substances 0.000 claims description 13
- 239000003961 penetration enhancing agent Substances 0.000 claims description 13
- 229960002180 tetracycline Drugs 0.000 claims description 13
- 229930101283 tetracycline Natural products 0.000 claims description 13
- 235000019364 tetracycline Nutrition 0.000 claims description 13
- 150000003522 tetracyclines Chemical class 0.000 claims description 13
- 206010018612 Gonorrhoea Diseases 0.000 claims description 12
- 229960003276 erythromycin Drugs 0.000 claims description 12
- 239000006213 vaginal ring Substances 0.000 claims description 12
- 230000000843 anti-fungal effect Effects 0.000 claims description 11
- 229960004884 fluconazole Drugs 0.000 claims description 11
- RFHAOTPXVQNOHP-UHFFFAOYSA-N fluconazole Chemical compound C1=NC=NN1CC(C=1C(=CC(F)=CC=1)F)(O)CN1C=NC=N1 RFHAOTPXVQNOHP-UHFFFAOYSA-N 0.000 claims description 11
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 11
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 11
- 229960000988 nystatin Drugs 0.000 claims description 11
- VQOXZBDYSJBXMA-NQTDYLQESA-N nystatin A1 Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/CC/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 VQOXZBDYSJBXMA-NQTDYLQESA-N 0.000 claims description 11
- 229940044953 vaginal ring Drugs 0.000 claims description 11
- ZCJYUTQZBAIHBS-UHFFFAOYSA-N 1-[2-(2,4-dichlorophenyl)-2-{[4-(phenylsulfanyl)benzyl]oxy}ethyl]imidazole Chemical compound ClC1=CC(Cl)=CC=C1C(OCC=1C=CC(SC=2C=CC=CC=2)=CC=1)CN1C=NC=C1 ZCJYUTQZBAIHBS-UHFFFAOYSA-N 0.000 claims description 10
- LEZWWPYKPKIXLL-UHFFFAOYSA-N 1-{2-(4-chlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl}imidazole Chemical compound C1=CC(Cl)=CC=C1COC(C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 LEZWWPYKPKIXLL-UHFFFAOYSA-N 0.000 claims description 10
- 229960003022 amoxicillin Drugs 0.000 claims description 10
- LSQZJLSUYDQPKJ-NJBDSQKTSA-N amoxicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=C(O)C=C1 LSQZJLSUYDQPKJ-NJBDSQKTSA-N 0.000 claims description 10
- 239000003443 antiviral agent Substances 0.000 claims description 10
- SWLMUYACZKCSHZ-UHFFFAOYSA-N butoconazole Chemical compound C1=CC(Cl)=CC=C1CCC(SC=1C(=CC=CC=1Cl)Cl)CN1C=NC=C1 SWLMUYACZKCSHZ-UHFFFAOYSA-N 0.000 claims description 10
- 229960005074 butoconazole Drugs 0.000 claims description 10
- 230000004087 circulation Effects 0.000 claims description 10
- 229960003913 econazole Drugs 0.000 claims description 10
- 229960001274 fenticonazole Drugs 0.000 claims description 10
- LSQZJLSUYDQPKJ-UHFFFAOYSA-N p-Hydroxyampicillin Natural products O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)C(N)C1=CC=C(O)C=C1 LSQZJLSUYDQPKJ-UHFFFAOYSA-N 0.000 claims description 10
- 239000006072 paste Substances 0.000 claims description 10
- BLSQLHNBWJLIBQ-OZXSUGGESA-N (2R,4S)-terconazole Chemical compound C1CN(C(C)C)CCN1C(C=C1)=CC=C1OC[C@@H]1O[C@@](CN2N=CN=C2)(C=2C(=CC(Cl)=CC=2)Cl)OC1 BLSQLHNBWJLIBQ-OZXSUGGESA-N 0.000 claims description 9
- SGKRLCUYIXIAHR-AKNGSSGZSA-N (4s,4ar,5s,5ar,6r,12ar)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1=CC=C2[C@H](C)[C@@H]([C@H](O)[C@@H]3[C@](C(O)=C(C(N)=O)C(=O)[C@H]3N(C)C)(O)C3=O)C3=C(O)C2=C1O SGKRLCUYIXIAHR-AKNGSSGZSA-N 0.000 claims description 9
- 229960003722 doxycycline Drugs 0.000 claims description 9
- 229960000580 terconazole Drugs 0.000 claims description 9
- 229960000723 ampicillin Drugs 0.000 claims description 8
- AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 claims description 8
- 230000000844 anti-bacterial effect Effects 0.000 claims description 8
- 229940088710 antibiotic agent Drugs 0.000 claims description 8
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 8
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 8
- 229920001223 polyethylene glycol Polymers 0.000 claims description 8
- MPIPASJGOJYODL-SFHVURJKSA-N (R)-isoconazole Chemical compound ClC1=CC(Cl)=CC=C1[C@@H](OCC=1C(=CC=CC=1Cl)Cl)CN1C=NC=C1 MPIPASJGOJYODL-SFHVURJKSA-N 0.000 claims description 7
- 238000013270 controlled release Methods 0.000 claims description 7
- 229960004849 isoconazole Drugs 0.000 claims description 7
- 231100000252 nontoxic Toxicity 0.000 claims description 7
- 230000003000 nontoxic effect Effects 0.000 claims description 7
- OGJPXUAPXNRGGI-UHFFFAOYSA-N norfloxacin Chemical compound C1=C2N(CC)C=C(C(O)=O)C(=O)C2=CC(F)=C1N1CCNCC1 OGJPXUAPXNRGGI-UHFFFAOYSA-N 0.000 claims description 7
- 229960001180 norfloxacin Drugs 0.000 claims description 7
- 230000002963 trichomonacidal effect Effects 0.000 claims description 7
- 239000006216 vaginal suppository Substances 0.000 claims description 7
- QXHHHPZILQDDPS-UHFFFAOYSA-N 1-{2-[(2-chloro-3-thienyl)methoxy]-2-(2,4-dichlorophenyl)ethyl}imidazole Chemical compound S1C=CC(COC(CN2C=NC=C2)C=2C(=CC(Cl)=CC=2)Cl)=C1Cl QXHHHPZILQDDPS-UHFFFAOYSA-N 0.000 claims description 6
- VHVPQPYKVGDNFY-DFMJLFEVSA-N 2-[(2r)-butan-2-yl]-4-[4-[4-[4-[[(2r,4s)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one Chemical compound O=C1N([C@H](C)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@@H]3O[C@](CN4N=CN=C4)(OC3)C=3C(=CC(Cl)=CC=3)Cl)=CC=2)C=C1 VHVPQPYKVGDNFY-DFMJLFEVSA-N 0.000 claims description 6
- 241000222122 Candida albicans Species 0.000 claims description 6
- 206010007134 Candida infections Diseases 0.000 claims description 6
- 206010061041 Chlamydial infection Diseases 0.000 claims description 6
- 239000002202 Polyethylene glycol Substances 0.000 claims description 6
- 230000000840 anti-viral effect Effects 0.000 claims description 6
- 239000003096 antiparasitic agent Substances 0.000 claims description 6
- 201000003984 candidiasis Diseases 0.000 claims description 6
- 229960004130 itraconazole Drugs 0.000 claims description 6
- 239000011859 microparticle Substances 0.000 claims description 6
- 229960004214 tioconazole Drugs 0.000 claims description 6
- HDOVUKNUBWVHOX-QMMMGPOBSA-N Valacyclovir Chemical compound N1C(N)=NC(=O)C2=C1N(COCCOC(=O)[C@@H](N)C(C)C)C=N2 HDOVUKNUBWVHOX-QMMMGPOBSA-N 0.000 claims description 5
- 125000005456 glyceride group Chemical group 0.000 claims description 5
- 229940120293 vaginal suppository Drugs 0.000 claims description 5
- 229940093257 valacyclovir Drugs 0.000 claims description 5
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 claims description 4
- 230000000590 parasiticidal effect Effects 0.000 claims description 4
- 229940044977 vaginal tablet Drugs 0.000 claims description 4
- 239000000003 vaginal tablet Substances 0.000 claims description 4
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical group O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims description 3
- 229940072056 alginate Drugs 0.000 claims description 3
- 235000010443 alginic acid Nutrition 0.000 claims description 3
- 229920000615 alginic acid Polymers 0.000 claims description 3
- 230000001358 anti-chlamydial effect Effects 0.000 claims description 3
- 239000003833 bile salt Substances 0.000 claims description 3
- 210000000754 myometrium Anatomy 0.000 claims description 3
- 239000001814 pectin Substances 0.000 claims description 3
- 235000010987 pectin Nutrition 0.000 claims description 3
- 229920001277 pectin Polymers 0.000 claims description 3
- 235000003441 saturated fatty acids Nutrition 0.000 claims description 3
- 150000004671 saturated fatty acids Chemical class 0.000 claims description 3
- 239000004094 surface-active agent Substances 0.000 claims description 3
- 229930182555 Penicillin Natural products 0.000 claims description 2
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 claims description 2
- 229940049954 penicillin Drugs 0.000 claims description 2
- 229960004099 azithromycin Drugs 0.000 claims 3
- MQTOSJVFKKJCRP-BICOPXKESA-N azithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)N(C)C[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 MQTOSJVFKKJCRP-BICOPXKESA-N 0.000 claims 3
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- DVWJFTGEISXVSH-CWVFEVJCSA-N (1R,3S,5S,7Z,11R,12S,13Z,15Z,17Z,19Z,21R,23S,24R,25S)-21-[(2R,3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy-12-ethyl-1,3,5,25-tetrahydroxy-11-methyl-9-oxo-10,27-dioxabicyclo[21.3.1]heptacosa-7,13,15,17,19-pentaene-24-carboxylic acid Chemical compound CC[C@H]1\C=C/C=C\C=C/C=C\[C@@H](C[C@@H]2O[C@@](O)(C[C@H](O)[C@H]2C(O)=O)C[C@@H](O)C[C@@H](O)C\C=C/C(=O)O[C@@H]1C)O[C@@H]1O[C@H](C)[C@@H](O)[C@H](N)[C@@H]1O DVWJFTGEISXVSH-CWVFEVJCSA-N 0.000 claims 1
- 239000002736 nonionic surfactant Substances 0.000 claims 1
- 229930183279 tetramycin Natural products 0.000 claims 1
- 239000003814 drug Substances 0.000 description 169
- 229940079593 drug Drugs 0.000 description 166
- 238000009472 formulation Methods 0.000 description 37
- 239000000829 suppository Substances 0.000 description 24
- 230000002745 absorbent Effects 0.000 description 19
- 239000002250 absorbent Substances 0.000 description 19
- 239000008280 blood Substances 0.000 description 17
- 210000004369 blood Anatomy 0.000 description 17
- 239000000463 material Substances 0.000 description 15
- 208000028659 discharge Diseases 0.000 description 12
- 238000002360 preparation method Methods 0.000 description 12
- 208000004926 Bacterial Vaginosis Diseases 0.000 description 11
- 208000037009 Vaginitis bacterial Diseases 0.000 description 10
- 230000000699 topical effect Effects 0.000 description 10
- 230000002175 menstrual effect Effects 0.000 description 9
- 230000017531 blood circulation Effects 0.000 description 8
- 239000012530 fluid Substances 0.000 description 8
- 238000003780 insertion Methods 0.000 description 8
- 230000037431 insertion Effects 0.000 description 8
- 208000024891 symptom Diseases 0.000 description 8
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 7
- 208000001688 Herpes Genitalis Diseases 0.000 description 7
- 201000008100 Vaginitis Diseases 0.000 description 7
- XXJWXESWEXIICW-UHFFFAOYSA-N diethylene glycol monoethyl ether Chemical compound CCOCCOCCO XXJWXESWEXIICW-UHFFFAOYSA-N 0.000 description 7
- 239000000835 fiber Substances 0.000 description 7
- 201000004946 genital herpes Diseases 0.000 description 7
- 208000001786 gonorrhea Diseases 0.000 description 7
- 239000007788 liquid Substances 0.000 description 7
- 210000000056 organ Anatomy 0.000 description 7
- 208000004145 Endometritis Diseases 0.000 description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 206010062233 Uterine infection Diseases 0.000 description 6
- 210000003756 cervix mucus Anatomy 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 230000009885 systemic effect Effects 0.000 description 6
- 230000001225 therapeutic effect Effects 0.000 description 6
- 210000001519 tissue Anatomy 0.000 description 6
- 206010046901 vaginal discharge Diseases 0.000 description 6
- 241000701806 Human papillomavirus Species 0.000 description 5
- 201000007096 Vulvovaginal Candidiasis Diseases 0.000 description 5
- 201000010099 disease Diseases 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 239000004033 plastic Substances 0.000 description 5
- 229920003023 plastic Polymers 0.000 description 5
- 230000032258 transport Effects 0.000 description 5
- 229960002555 zidovudine Drugs 0.000 description 5
- 208000006374 Uterine Cervicitis Diseases 0.000 description 4
- 238000010521 absorption reaction Methods 0.000 description 4
- 239000004480 active ingredient Substances 0.000 description 4
- 230000003115 biocidal effect Effects 0.000 description 4
- 239000000969 carrier Substances 0.000 description 4
- 206010008323 cervicitis Diseases 0.000 description 4
- 239000011248 coating agent Substances 0.000 description 4
- 238000000576 coating method Methods 0.000 description 4
- 238000013461 design Methods 0.000 description 4
- 229920001971 elastomer Polymers 0.000 description 4
- 239000003205 fragrance Substances 0.000 description 4
- 239000004615 ingredient Substances 0.000 description 4
- 230000003902 lesion Effects 0.000 description 4
- 230000035515 penetration Effects 0.000 description 4
- 239000011148 porous material Substances 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 229920000742 Cotton Polymers 0.000 description 3
- 229920003091 Methocel™ Polymers 0.000 description 3
- 239000008118 PEG 6000 Substances 0.000 description 3
- 229920002535 Polyethylene Glycol 1500 Polymers 0.000 description 3
- 229920002565 Polyethylene Glycol 400 Polymers 0.000 description 3
- 229920002584 Polyethylene Glycol 6000 Polymers 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 208000003251 Pruritus Diseases 0.000 description 3
- 208000025865 Ulcer Diseases 0.000 description 3
- 230000000884 anti-protozoa Effects 0.000 description 3
- 239000002775 capsule Substances 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 239000000806 elastomer Substances 0.000 description 3
- 239000003623 enhancer Substances 0.000 description 3
- 235000011187 glycerol Nutrition 0.000 description 3
- 230000007803 itching Effects 0.000 description 3
- 235000010446 mineral oil Nutrition 0.000 description 3
- 239000002480 mineral oil Substances 0.000 description 3
- 229940042472 mineral oil Drugs 0.000 description 3
- 239000008194 pharmaceutical composition Substances 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 230000001737 promoting effect Effects 0.000 description 3
- 230000001850 reproductive effect Effects 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 239000000725 suspension Substances 0.000 description 3
- 230000001839 systemic circulation Effects 0.000 description 3
- VUYXVWGKCKTUMF-UHFFFAOYSA-N tetratriacontaethylene glycol monomethyl ether Chemical compound COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO VUYXVWGKCKTUMF-UHFFFAOYSA-N 0.000 description 3
- 238000002560 therapeutic procedure Methods 0.000 description 3
- 230000036269 ulceration Effects 0.000 description 3
- 210000003905 vulva Anatomy 0.000 description 3
- 241000606161 Chlamydia Species 0.000 description 2
- 102000008186 Collagen Human genes 0.000 description 2
- 108010035532 Collagen Proteins 0.000 description 2
- 206010018143 Genital candidiasis Diseases 0.000 description 2
- 241000725303 Human immunodeficiency virus Species 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 241001313288 Labia Species 0.000 description 2
- 241000588653 Neisseria Species 0.000 description 2
- 235000019482 Palm oil Nutrition 0.000 description 2
- 229920000148 Polycarbophil calcium Polymers 0.000 description 2
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 229920002125 Sokalan® Polymers 0.000 description 2
- 241000224527 Trichomonas vaginalis Species 0.000 description 2
- 238000007792 addition Methods 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 239000003716 antitrichomonal agent Substances 0.000 description 2
- WZPBZJONDBGPKJ-VEHQQRBSSA-N aztreonam Chemical compound O=C1N(S([O-])(=O)=O)[C@@H](C)[C@@H]1NC(=O)C(=N/OC(C)(C)C(O)=O)\C1=CSC([NH3+])=N1 WZPBZJONDBGPKJ-VEHQQRBSSA-N 0.000 description 2
- 229920001436 collagen Polymers 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 2
- 206010013990 dysuria Diseases 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 2
- 239000004744 fabric Substances 0.000 description 2
- 229960004396 famciclovir Drugs 0.000 description 2
- GGXKWVWZWMLJEH-UHFFFAOYSA-N famcyclovir Chemical compound N1=C(N)N=C2N(CCC(COC(=O)C)COC(C)=O)C=NC2=C1 GGXKWVWZWMLJEH-UHFFFAOYSA-N 0.000 description 2
- 239000013020 final formulation Substances 0.000 description 2
- 210000001035 gastrointestinal tract Anatomy 0.000 description 2
- 238000007429 general method Methods 0.000 description 2
- 229960005150 glycerol Drugs 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- 239000003094 microcapsule Substances 0.000 description 2
- 230000003387 muscular Effects 0.000 description 2
- 239000002540 palm oil Substances 0.000 description 2
- 230000001575 pathological effect Effects 0.000 description 2
- 239000002831 pharmacologic agent Substances 0.000 description 2
- 210000003800 pharynx Anatomy 0.000 description 2
- 239000002985 plastic film Substances 0.000 description 2
- 229920006255 plastic film Polymers 0.000 description 2
- 229950005134 polycarbophil Drugs 0.000 description 2
- 229920002635 polyurethane Polymers 0.000 description 2
- 239000004814 polyurethane Substances 0.000 description 2
- DBABZHXKTCFAPX-UHFFFAOYSA-N probenecid Chemical compound CCCN(CCC)S(=O)(=O)C1=CC=C(C(O)=O)C=C1 DBABZHXKTCFAPX-UHFFFAOYSA-N 0.000 description 2
- 229960003081 probenecid Drugs 0.000 description 2
- 230000002035 prolonged effect Effects 0.000 description 2
- 239000008213 purified water Substances 0.000 description 2
- 210000000664 rectum Anatomy 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- 235000010199 sorbic acid Nutrition 0.000 description 2
- 229940075582 sorbic acid Drugs 0.000 description 2
- 239000004334 sorbic acid Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000002459 sustained effect Effects 0.000 description 2
- 238000007910 systemic administration Methods 0.000 description 2
- 229940124597 therapeutic agent Drugs 0.000 description 2
- 210000003708 urethra Anatomy 0.000 description 2
- 208000013464 vaginal disease Diseases 0.000 description 2
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 description 1
- OIQOAYVCKAHSEJ-UHFFFAOYSA-N 2-[2,3-bis(2-hydroxyethoxy)propoxy]ethanol;hexadecanoic acid;octadecanoic acid Chemical compound OCCOCC(OCCO)COCCO.CCCCCCCCCCCCCCCC(O)=O.CCCCCCCCCCCCCCCCCC(O)=O OIQOAYVCKAHSEJ-UHFFFAOYSA-N 0.000 description 1
- 208000030507 AIDS Diseases 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 102220487426 Actin-related protein 2/3 complex subunit 3_K15M_mutation Human genes 0.000 description 1
- 102000009027 Albumins Human genes 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- 206010059313 Anogenital warts Diseases 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 241000606153 Chlamydia trachomatis Species 0.000 description 1
- 208000000907 Condylomata Acuminata Diseases 0.000 description 1
- 241000186216 Corynebacterium Species 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 206010015150 Erythema Diseases 0.000 description 1
- 241000207201 Gardnerella vaginalis Species 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 206010048461 Genital infection Diseases 0.000 description 1
- 241000606790 Haemophilus Species 0.000 description 1
- 208000009889 Herpes Simplex Diseases 0.000 description 1
- 241000700588 Human alphaherpesvirus 1 Species 0.000 description 1
- 241000701074 Human alphaherpesvirus 2 Species 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 description 1
- 241000204031 Mycoplasma Species 0.000 description 1
- 241000588652 Neisseria gonorrhoeae Species 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 208000012868 Overgrowth Diseases 0.000 description 1
- 239000004264 Petrolatum Substances 0.000 description 1
- 239000004721 Polyphenylene oxide Substances 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 206010057071 Rectal tenesmus Diseases 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 206010042566 Superinfection Diseases 0.000 description 1
- 241000224526 Trichomonas Species 0.000 description 1
- 208000036029 Uterine contractions during pregnancy Diseases 0.000 description 1
- 206010046935 Vaginal odour Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 206010047786 Vulvovaginal discomfort Diseases 0.000 description 1
- 206010056530 Vulvovaginal pruritus Diseases 0.000 description 1
- 208000000260 Warts Diseases 0.000 description 1
- 241000212749 Zesius chrysomallus Species 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 229940035674 anesthetics Drugs 0.000 description 1
- 208000025009 anogenital human papillomavirus infection Diseases 0.000 description 1
- 201000004201 anogenital venereal wart Diseases 0.000 description 1
- 230000001139 anti-pruritic effect Effects 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 229940125687 antiparasitic agent Drugs 0.000 description 1
- 239000003908 antipruritic agent Substances 0.000 description 1
- 210000004883 areola Anatomy 0.000 description 1
- 150000007980 azole derivatives Chemical class 0.000 description 1
- 229940093761 bile salts Drugs 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 229940095731 candida albicans Drugs 0.000 description 1
- 229960001631 carbomer Drugs 0.000 description 1
- 229940049638 carbomer homopolymer type c Drugs 0.000 description 1
- 229940043234 carbomer-940 Drugs 0.000 description 1
- 229920002678 cellulose Chemical class 0.000 description 1
- 239000001913 cellulose Chemical class 0.000 description 1
- 229940106189 ceramide Drugs 0.000 description 1
- 150000001783 ceramides Chemical class 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 229940038705 chlamydia trachomatis Drugs 0.000 description 1
- HGAZMNJKRQFZKS-UHFFFAOYSA-N chloroethene;ethenyl acetate Chemical compound ClC=C.CC(=O)OC=C HGAZMNJKRQFZKS-UHFFFAOYSA-N 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 229940124558 contraceptive agent Drugs 0.000 description 1
- 239000003433 contraceptive agent Substances 0.000 description 1
- 239000003246 corticosteroid Substances 0.000 description 1
- 229960001334 corticosteroids Drugs 0.000 description 1
- 230000009849 deactivation Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 235000012489 doughnuts Nutrition 0.000 description 1
- 239000000890 drug combination Substances 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 239000003974 emollient agent Substances 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000008029 eradication Effects 0.000 description 1
- 231100000321 erythema Toxicity 0.000 description 1
- 229960005309 estradiol Drugs 0.000 description 1
- 229930182833 estradiol Natural products 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000013213 extrapolation Methods 0.000 description 1
- 210000001508 eye Anatomy 0.000 description 1
- 239000002657 fibrous material Substances 0.000 description 1
- 238000010579 first pass effect Methods 0.000 description 1
- 239000006261 foam material Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 210000005095 gastrointestinal system Anatomy 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 239000003193 general anesthetic agent Substances 0.000 description 1
- 210000004392 genitalia Anatomy 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 229940116364 hard fat Drugs 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000010224 hepatic metabolism Effects 0.000 description 1
- 229920003063 hydroxymethyl cellulose Polymers 0.000 description 1
- 229940031574 hydroxymethyl cellulose Drugs 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- OZWKMVRBQXNZKK-UHFFFAOYSA-N ketorolac Chemical compound OC(=O)C1CCN2C1=CC=C2C(=O)C1=CC=CC=C1 OZWKMVRBQXNZKK-UHFFFAOYSA-N 0.000 description 1
- 229960004752 ketorolac Drugs 0.000 description 1
- 201000002364 leukopenia Diseases 0.000 description 1
- 231100001022 leukopenia Toxicity 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000001926 lymphatic effect Effects 0.000 description 1
- 210000004324 lymphatic system Anatomy 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 230000009245 menopause Effects 0.000 description 1
- 230000005906 menstruation Effects 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
- 229940096441 metronidazole 500 mg Drugs 0.000 description 1
- 239000004005 microsphere Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229940000973 monistat Drugs 0.000 description 1
- 230000004682 mucosal barrier function Effects 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 230000027758 ovulation cycle Effects 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 210000002640 perineum Anatomy 0.000 description 1
- 229940066842 petrolatum Drugs 0.000 description 1
- 235000019271 petrolatum Nutrition 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 239000004584 polyacrylic acid Substances 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920000570 polyether Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 239000012254 powdered material Substances 0.000 description 1
- 208000037920 primary disease Diseases 0.000 description 1
- MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 description 1
- 229960004919 procaine Drugs 0.000 description 1
- 229960003387 progesterone Drugs 0.000 description 1
- 239000000186 progesterone Substances 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- 210000004061 pubic symphysis Anatomy 0.000 description 1
- 238000011555 rabbit model Methods 0.000 description 1
- 210000005000 reproductive tract Anatomy 0.000 description 1
- 239000011369 resultant mixture Substances 0.000 description 1
- 229920002379 silicone rubber Polymers 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 239000004575 stone Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 208000012271 tenesmus Diseases 0.000 description 1
- 238000011287 therapeutic dose Methods 0.000 description 1
- 229940126585 therapeutic drug Drugs 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 238000011269 treatment regimen Methods 0.000 description 1
- 241001148471 unidentified anaerobic bacterium Species 0.000 description 1
- 241001529453 unidentified herpesvirus Species 0.000 description 1
- 210000000689 upper leg Anatomy 0.000 description 1
- 208000000143 urethritis Diseases 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 210000005166 vasculature Anatomy 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F6/00—Contraceptive devices; Pessaries; Applicators therefor
- A61F6/06—Contraceptive devices; Pessaries; Applicators therefor for use by females
- A61F6/08—Pessaries, i.e. devices worn in the vagina to support the uterus, remedy a malposition or prevent conception, e.g. combined with devices protecting against contagion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/15—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
- A61F13/20—Tampons, e.g. catamenial tampons; Accessories therefor
- A61F13/2051—Tampons, e.g. catamenial tampons; Accessories therefor characterised by the material or the structure of the inner absorbing core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
- A61K9/0036—Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Reproductive Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Gynecology & Obstetrics (AREA)
- Communicable Diseases (AREA)
- Heart & Thoracic Surgery (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Endocrinology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
- Absorbent Articles And Supports Therefor (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/613,441 | 2000-07-11 | ||
| US09/613,441 US6416779B1 (en) | 1997-06-11 | 2000-07-11 | Device and method for intravaginal or transvaginal treatment of fungal, bacterial, viral or parasitic infections |
| PCT/US2001/041128 WO2002003896A1 (en) | 2000-07-11 | 2001-06-25 | Device and method for intravaginal or transvaginal treatment of fungal, bacterial, viral or parasitic infections |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| AU2001281287A1 AU2001281287A1 (en) | 2002-04-18 |
| AU2001281287B2 AU2001281287B2 (en) | 2006-10-19 |
| AU2001281287B8 true AU2001281287B8 (en) | 2006-12-07 |
Family
ID=24457329
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2001281287A Ceased AU2001281287B8 (en) | 2000-07-11 | 2001-06-25 | Device and method for intravaginal or transvaginal treatment of fungal, bacterial, viral or parasitic infections |
| AU8128701A Pending AU8128701A (en) | 2000-07-11 | 2001-06-25 | Device and method for intravaginal or transvaginal treatment of fungal, bacterial, viral or parasitic infections |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU8128701A Pending AU8128701A (en) | 2000-07-11 | 2001-06-25 | Device and method for intravaginal or transvaginal treatment of fungal, bacterial, viral or parasitic infections |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6416779B1 (enExample) |
| EP (1) | EP1301150A4 (enExample) |
| JP (1) | JP2004508296A (enExample) |
| CN (1) | CN1306919C (enExample) |
| AU (2) | AU2001281287B8 (enExample) |
| BR (1) | BR0112571A (enExample) |
| CA (1) | CA2416050A1 (enExample) |
| HK (1) | HK1054676A1 (enExample) |
| IL (2) | IL153719A0 (enExample) |
| MX (1) | MXPA02012819A (enExample) |
| NZ (1) | NZ524047A (enExample) |
| WO (1) | WO2002003896A1 (enExample) |
Families Citing this family (131)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6905701B2 (en) * | 1997-06-11 | 2005-06-14 | Umd, Inc. | Formulations for transmucosal vaginal delivery of bisphosphonates |
| US20040043071A1 (en) * | 2002-06-21 | 2004-03-04 | Pauletti Giovanni M. | Intravaginal mucosal or transmucosal delivery of antimigraine and antinausea drugs |
| US7022683B1 (en) | 1998-05-13 | 2006-04-04 | Carrington Laboratories, Inc. | Pharmacological compositions comprising pectins having high molecular weights and low degrees of methoxylation |
| US20050137181A1 (en) * | 1999-03-17 | 2005-06-23 | Bonner Ernest L. | Method for treatment of reactive arthritis or bursitis |
| US7691831B2 (en) * | 1999-03-17 | 2010-04-06 | Ernest L. Bonner, Jr. | Pharmaceutical combination and method for treatment of reactive arthritis or bursitis |
| US6765000B2 (en) * | 1999-03-17 | 2004-07-20 | Bonner Jr Ernest L | Treatment for reactive arthritis or bursitis |
| US7884090B2 (en) * | 1999-03-17 | 2011-02-08 | Ernest L. Bonner, Jr. | Compositions and methods for the treatment of arthritis |
| US6964949B2 (en) * | 2000-05-24 | 2005-11-15 | Shanghai Jiao Da Onlly Co., Ltd. | Pharmaceutical compositions for promoting the growth of gram-positive bacilli and increasing the acidity in the vagina and the use thereof |
| US6777000B2 (en) * | 2001-02-28 | 2004-08-17 | Carrington Laboratories, Inc. | In-situ gel formation of pectin |
| US7494669B2 (en) * | 2001-02-28 | 2009-02-24 | Carrington Laboratories, Inc. | Delivery of physiological agents with in-situ gels comprising anionic polysaccharides |
| US20030017207A1 (en) * | 2001-05-01 | 2003-01-23 | Lin Shun Y. | Compositions and methods for treating vulvovaginitis and vaginosis |
| US20060172007A1 (en) * | 2001-05-01 | 2006-08-03 | Nawaz Ahmad | Compositions and methods for reducing vaginal pH |
| US20030064103A1 (en) * | 2001-05-01 | 2003-04-03 | Lin Shun Y. | Compositions and methods for treating vulvovaginitis and vaginosis |
| US7267670B2 (en) * | 2001-08-30 | 2007-09-11 | Mulholland S Grant | Reinforced urethral suppository |
| US20030135173A1 (en) * | 2001-10-02 | 2003-07-17 | Kimberly-Clark Worldwide, Inc. | Inhibition of exoprotein production in absorbent articles using aromatic compositions |
| US7022333B2 (en) * | 2001-10-02 | 2006-04-04 | Kimberly-Clark Worldwide, Inc. | Inhibition of exoprotein production in non-absorbent articles uisng aromatic compositions |
| US7026354B2 (en) * | 2001-10-02 | 2006-04-11 | Kimberly-Clark Worldwide, Inc. | Aromatic compositions for the inhibition of exoprotein production from gram positive bacteria |
| FR2837102B1 (fr) * | 2002-03-18 | 2004-10-08 | Palbian Snc | Composition a l'etat de gel aqueux, procede de fabrication et utilisation pour la fabrication d'un medicament, notamment antiherpetique |
| US20060105008A1 (en) * | 2002-03-28 | 2006-05-18 | Nawaz Ahmad | Compositions and methods for reducing vaginal pH |
| JP2005531570A (ja) * | 2002-05-23 | 2005-10-20 | ユーエムディー， インコーポレイテッド | 貫粘膜薬物送達及び凍結保護のための組成物及び方法 |
| GB0222522D0 (en) | 2002-09-27 | 2002-11-06 | Controlled Therapeutics Sct | Water-swellable polymers |
| US20040126369A1 (en) * | 2002-12-30 | 2004-07-01 | Richard Payne | Delivery of peroxide-generating enzymes to the vaginal tract |
| ATE461681T1 (de) * | 2003-04-29 | 2010-04-15 | Gen Hospital Corp | Verfahren und vorrichtungen für die verzögerte freisetzung von mehreren arzneimitteln |
| US8404272B2 (en) | 2003-06-26 | 2013-03-26 | Poly-Med, Inc. | Fiber-reinforced composite rings for intravaginal controlled drug delivery |
| US8399013B2 (en) * | 2003-06-26 | 2013-03-19 | Poly-Med, Inc. | Partially absorbable fiber-reinforced composites for controlled drug delivery |
| EP1500394A1 (en) * | 2003-07-22 | 2005-01-26 | Polichem S.A. | Pharmaceutical compositions comprising ascorbic acid or the treatment of fungal superinfections and fungal recurrences |
| ITMI20031640A1 (it) * | 2003-08-08 | 2005-02-09 | Mipharm S P A | Base per gel bioadesivi. |
| US20060140990A1 (en) * | 2003-09-19 | 2006-06-29 | Drugtech Corporation | Composition for topical treatment of mixed vaginal infections |
| JP2007505927A (ja) * | 2003-09-19 | 2007-03-15 | ドラッグテック コーポレイション | 薬物送達システム |
| SE0303123D0 (sv) * | 2003-11-24 | 2003-11-24 | Sca Hygiene Prod Ab | Absorberande alster med hudvårdande medel |
| US20050113730A1 (en) * | 2003-11-24 | 2005-05-26 | Sca Hygiene Products Ab | Absorbent Article Containing A Skin Care Product |
| US8309103B2 (en) * | 2004-01-22 | 2012-11-13 | Alparis, S.A. De C.V. | Association of fluconazole-tinidazole for the treatment of vaginal infections, its composition, preparation process and usage |
| GB0405406D0 (en) * | 2004-03-10 | 2004-04-21 | Edko Pazarlama Tanitim Ltd Sti | Anti-vaginitis compositions |
| US7276486B2 (en) * | 2004-03-15 | 2007-10-02 | Kimberly-Clark Worldwide, Inc. | Compositions for vaginal treatment |
| US20050214364A1 (en) * | 2004-03-23 | 2005-09-29 | Hutman Herbert W | Products and methods for treating vaginal infections |
| US20070065504A1 (en) * | 2004-03-23 | 2007-03-22 | Lin Shun Y | Products and methods for treating vaginal infections |
| US20050244402A1 (en) * | 2004-04-30 | 2005-11-03 | Villanueva Julie M | Absorption of pain-causing agents |
| US20060127468A1 (en) | 2004-05-19 | 2006-06-15 | Kolodney Michael S | Methods and related compositions for reduction of fat and skin tightening |
| US7754230B2 (en) * | 2004-05-19 | 2010-07-13 | The Regents Of The University Of California | Methods and related compositions for reduction of fat |
| PL2422789T3 (pl) * | 2004-05-19 | 2018-09-28 | Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center | Wstrzykiwalna kompozycja zawierająca deoksycholan sodu |
| GB0417401D0 (en) * | 2004-08-05 | 2004-09-08 | Controlled Therapeutics Sct | Stabilised prostaglandin composition |
| US20060078616A1 (en) * | 2004-08-30 | 2006-04-13 | Georgewill Dawaye A | Thermoreversible pharmaceutical formulation for anti-microbial agents comprising poloxamer polymers and hydroxy fatty acid ester of polyethylene glycol |
| US20060093675A1 (en) * | 2004-10-29 | 2006-05-04 | Mathew Ebmeier | Intravaginal treatment of vaginal infections with metronidazole compositions |
| US20060100566A1 (en) * | 2004-11-05 | 2006-05-11 | Women's Medical Research Group, Llc | Apparatus and method for the treatment of dysmenorrhea |
| US20060137684A1 (en) * | 2004-12-01 | 2006-06-29 | Celeste Evans | Compositions and methods of treating irritation and kit therefor |
| US8062658B2 (en) | 2004-12-14 | 2011-11-22 | Poly-Med, Inc. | Multicomponent bioactive intravaginal ring |
| US7919453B2 (en) * | 2005-03-25 | 2011-04-05 | Kimberly-Clark Worldwide, Inc. | Dosage cap assembly for an applicator |
| US7744556B2 (en) * | 2005-03-25 | 2010-06-29 | Kimberly-Clark Worldwide, Inc. | Delivery tube assembly for an applicator |
| US7993667B2 (en) | 2005-03-25 | 2011-08-09 | Kimberly-Clark Worldwide, Inc. | Methods of manufacturing a medicated tampon assembly |
| US7527614B2 (en) * | 2005-03-25 | 2009-05-05 | Kimberly-Clark Worldwide, Inc. | Protective tube for a medicated tampon |
| US9295289B2 (en) * | 2005-04-01 | 2016-03-29 | Leslie Jane James | Waist-fastening, hip-encompassing apparel with at least one concealed storage compartment |
| US7708726B2 (en) * | 2005-04-28 | 2010-05-04 | Kimberly-Clark Worldwide, Inc. | Dosage form cap for an applicator |
| WO2006121979A2 (en) * | 2005-05-09 | 2006-11-16 | Drugtech Corporation | Modified-release pharmaceutical compositions |
| CN100446774C (zh) * | 2005-05-31 | 2008-12-31 | 黑龙江龙桂制药有限公司 | 盐酸克林霉素阴道泡腾片及其制备方法 |
| US20070016156A1 (en) * | 2005-07-15 | 2007-01-18 | The Procter & Gamble Company | Absorbent tampon comprising a visually distinct withdrawal member |
| US20090062909A1 (en) | 2005-07-15 | 2009-03-05 | Micell Technologies, Inc. | Stent with polymer coating containing amorphous rapamycin |
| ES2691646T3 (es) | 2005-07-15 | 2018-11-28 | Micell Technologies, Inc. | Revestimientos poliméricos que contienen polvo de fármaco de morfología controlada |
| US20070141118A1 (en) * | 2005-12-15 | 2007-06-21 | Damico Joyce A | Layered dosage form for a medicated tampon assembly |
| BRPI0620908A2 (pt) * | 2006-01-05 | 2011-11-29 | Drugtech Corp | composição farmacêutica, sistema de distribuição antibacteriana e antifúngica vaginal e uso da composição farmacêutica |
| US20070154516A1 (en) * | 2006-01-05 | 2007-07-05 | Drugtech Corporation | Drug delivery system |
| US8852625B2 (en) | 2006-04-26 | 2014-10-07 | Micell Technologies, Inc. | Coatings containing multiple drugs |
| RS56044B1 (sr) * | 2006-05-12 | 2017-09-29 | Christian Noe | Primena kombinovanih preparata koji sadrže antimikotike |
| US8137327B2 (en) * | 2006-06-16 | 2012-03-20 | Family Health International | Vaginal drug delivery system and method |
| US7824383B2 (en) * | 2006-06-16 | 2010-11-02 | Family Health International | Vaginal drug delivery system and method |
| EP1872775A1 (en) * | 2006-06-29 | 2008-01-02 | Polichem S.A. | Use of a hydrophilic matrix comprising a polyacrylic acid derivative, a cellulose ether and a disintegrant for the manufacture of a medicament for treating female genital disorders |
| GB0613333D0 (en) | 2006-07-05 | 2006-08-16 | Controlled Therapeutics Sct | Hydrophilic polyurethane compositions |
| GB0613638D0 (en) | 2006-07-08 | 2006-08-16 | Controlled Therapeutics Sct | Polyurethane elastomers |
| US20080160065A1 (en) * | 2006-07-12 | 2008-07-03 | Janet Anne Halliday | Drug delivery polymer with hydrochloride salt of clindamycin |
| US20080077106A1 (en) * | 2006-09-22 | 2008-03-27 | Ryo Minoguchi | Tampon having an asymmetric insertion end and a finger pocket |
| GB0620685D0 (en) | 2006-10-18 | 2006-11-29 | Controlled Therapeutics Sct | Bioresorbable polymers |
| US9539593B2 (en) | 2006-10-23 | 2017-01-10 | Micell Technologies, Inc. | Holder for electrically charging a substrate during coating |
| CN101711137B (zh) | 2007-01-08 | 2014-10-22 | 米歇尔技术公司 | 具有可生物降解层的支架 |
| US11426494B2 (en) | 2007-01-08 | 2022-08-30 | MT Acquisition Holdings LLC | Stents having biodegradable layers |
| CN101815540B (zh) * | 2007-05-25 | 2015-08-19 | 米歇尔技术公司 | 用于医疗器材涂层的聚合物膜 |
| US8747346B2 (en) * | 2007-06-01 | 2014-06-10 | Martin Hochberg | Hemostatic agent applicator for survical procedures |
| PL3441054T3 (pl) * | 2007-11-05 | 2021-05-04 | Abigo Medical Ab | Urządzenie do leczenia infekcji grzybiczych pochwy |
| DE102008006416A1 (de) * | 2008-01-28 | 2009-07-30 | Mayer, Thomas, Dr. med. | Clindamycin zur Verwendung bei der Behandlung oder Vorbeugung der bakteriellen Vaginosis |
| EA020655B1 (ru) | 2008-04-17 | 2014-12-30 | Миселл Текнолоджиз, Инк. | Стенты, имеющие биорассасывающиеся слои |
| US9034365B2 (en) * | 2008-05-20 | 2015-05-19 | Poly-Med, Inc. | Biostable, multipurpose, microbicidal intravaginal devices |
| CA2730995C (en) | 2008-07-17 | 2016-11-22 | Micell Technologies, Inc. | Drug delivery medical device |
| US9510856B2 (en) | 2008-07-17 | 2016-12-06 | Micell Technologies, Inc. | Drug delivery medical device |
| US8263115B2 (en) * | 2008-09-11 | 2012-09-11 | Abigo Medical Ab | Method and a product to reduce and treat problems associated with tinea pedis |
| ZA200908494B (en) * | 2008-11-30 | 2010-12-29 | Univ Of The Witwatersrand | A controlled release intravaginal polymeric pharmaceutical dosage form |
| US10893983B2 (en) | 2008-12-03 | 2021-01-19 | Abigo Medical Ab | Method for dressing a wound |
| US8834913B2 (en) | 2008-12-26 | 2014-09-16 | Battelle Memorial Institute | Medical implants and methods of making medical implants |
| ITFI20090011A1 (it) * | 2009-01-22 | 2010-07-23 | Enrica Badiani | Dispositivo intravaginale |
| US8101593B2 (en) | 2009-03-03 | 2012-01-24 | Kythera Biopharmaceuticals, Inc. | Formulations of deoxycholic acid and salts thereof |
| EP2411083A4 (en) | 2009-03-23 | 2013-11-13 | Micell Technologies Inc | MEDICAL ACTIVE COMPOSITION DEVICE |
| CN102481195B (zh) | 2009-04-01 | 2015-03-25 | 米歇尔技术公司 | 涂覆支架 |
| US8691235B2 (en) * | 2009-04-03 | 2014-04-08 | Poly-Med, Inc. | Absorbable crystalline polyether-ester-urethane-based bioactive luminal liner compositions |
| EP3366326A1 (en) | 2009-04-17 | 2018-08-29 | Micell Technologies, Inc. | Stents having controlled elution |
| EP2243482A1 (en) * | 2009-04-20 | 2010-10-27 | Polichem SA | Use of nifuratel to treat infections caused by atopobium species |
| CA2760775C (en) | 2009-05-05 | 2019-03-05 | Vapogenix, Inc. | Novel formulations of volatile anesthetics and methods of use for reducing inflammation |
| WO2011068874A2 (en) | 2009-12-01 | 2011-06-09 | University Of South Florida | Drug delivery device for ovarian cancer |
| EP2531140B1 (en) | 2010-02-02 | 2017-11-01 | Micell Technologies, Inc. | Stent and stent delivery system with improved deliverability |
| US8795762B2 (en) | 2010-03-26 | 2014-08-05 | Battelle Memorial Institute | System and method for enhanced electrostatic deposition and surface coatings |
| EP2560576B1 (en) | 2010-04-22 | 2018-07-18 | Micell Technologies, Inc. | Stents and other devices having extracellular matrix coating |
| CA2805631C (en) | 2010-07-16 | 2018-07-31 | Micell Technologies, Inc. | Drug delivery medical device |
| WO2012092990A2 (de) | 2011-01-05 | 2012-07-12 | Udo Wenske | Medizinprodukt zur verbesserung der konzeptionsfähigkeit eines säugetiers |
| US20120237492A1 (en) | 2011-02-18 | 2012-09-20 | Kythera Biopharmaceuticals, Inc. | Treatment of submental fat |
| US8476221B2 (en) | 2011-03-18 | 2013-07-02 | Halimed Pharmaceuticals, Inc. | Methods and compositions for the treatment of metabolic disorders |
| US8653058B2 (en) | 2011-04-05 | 2014-02-18 | Kythera Biopharmaceuticals, Inc. | Compositions comprising deoxycholic acid and salts thereof suitable for use in treating fat deposits |
| WO2012158779A1 (en) * | 2011-05-17 | 2012-11-22 | Reprotect, Inc. | Reusable intravaginal delivery device, system, and method |
| US10464100B2 (en) | 2011-05-31 | 2019-11-05 | Micell Technologies, Inc. | System and process for formation of a time-released, drug-eluting transferable coating |
| WO2013012689A1 (en) | 2011-07-15 | 2013-01-24 | Micell Technologies, Inc. | Drug delivery medical device |
| MX357598B (es) * | 2011-07-20 | 2018-07-16 | F Kiser Patrick | Dispositivos intravaginales para administración de fármaco. |
| US10188772B2 (en) | 2011-10-18 | 2019-01-29 | Micell Technologies, Inc. | Drug delivery medical device |
| ITRM20120404A1 (it) * | 2012-08-09 | 2014-02-10 | Univ Roma | Uso del kgf nel trattamento di disturbi della menopausa |
| US11039943B2 (en) | 2013-03-12 | 2021-06-22 | Micell Technologies, Inc. | Bioabsorbable biomedical implants |
| CA2912387C (en) | 2013-05-15 | 2019-04-16 | Micell Technologies, Inc. | Bioabsorbable biomedical implants |
| GB2519055A (en) * | 2013-08-01 | 2015-04-15 | Calla Lily Personal Care Ltd | Drug delivery device |
| DE102014012206A1 (de) * | 2014-05-26 | 2015-11-26 | Jean-Jacques Becciolini | Arzneimittelträger zum Behandeln und Vorbeugen von krankhaften Zuständen im urogenitalen Raum |
| US10004918B2 (en) * | 2014-07-03 | 2018-06-26 | Gregg Alan Klang | LED based vaginal light therapy device |
| CN104546267B (zh) * | 2015-01-13 | 2017-01-04 | 安徽农业大学 | 一种犬用宫外节育装置及其节育方法 |
| MA41629A (fr) | 2015-03-04 | 2018-01-09 | Center For Human Reproduction | Compositions et méthodes d'utilisation de l'hormone anti-müllérienne pour le traitement de l'infertilité |
| CN109152668A (zh) * | 2015-12-30 | 2019-01-04 | V-维尔-阿普-制药有限公司 | 形态解剖学柔性网状件 |
| US20210330599A1 (en) | 2016-08-01 | 2021-10-28 | University Of Rochester | Nanoparticles for Controlled Release of Anti-Biofilm Agents and Methods of Use |
| AU201617347S (en) * | 2016-12-23 | 2017-01-23 | Jurox Pty Ltd | intravaginal device |
| USD848630S1 (en) * | 2017-01-17 | 2019-05-14 | Gregg A. Klang | Vaginal light treatment device |
| US11124547B2 (en) * | 2017-05-11 | 2021-09-21 | The Lundquist Institute For Biomedical Innovation | Antimicrobial type-II bacteriocins |
| US11083634B2 (en) * | 2017-08-15 | 2021-08-10 | Binyarco Llc | Method and device for packing a body cavity and delivering a medicament to a subject |
| CN114886651A (zh) * | 2017-09-18 | 2022-08-12 | 德瑞克·席安 | 装配阴道治疗装置的方法 |
| US20200390425A1 (en) * | 2017-11-28 | 2020-12-17 | V-Veil-Up Pharma Ltd. | Self sampling universal kit, methods and use |
| WO2020076578A1 (en) | 2018-10-09 | 2020-04-16 | University Of Rochester | Treatment of vulvovaginal disorders |
| US11382799B2 (en) | 2018-11-26 | 2022-07-12 | Bluegrass Farmaceuticals, LLC | Tampon with intravaginal cannabinoid delivery device |
| CN109771804A (zh) * | 2019-03-18 | 2019-05-21 | 郑岩 | 一种多种高分子材料制作的阴道霉菌治疗装置 |
| US10857151B1 (en) * | 2020-02-21 | 2020-12-08 | Villya LLC | Treatment of female genital schistosomiasis |
| US20220047506A1 (en) | 2020-08-12 | 2022-02-17 | Villya LLC | Praziquantel Formulations |
| MX2023007586A (es) | 2021-01-14 | 2023-07-07 | Herphoric Inc | Un sistema de suministro para un componente farmaceutico, holistico o medicinal. |
| CN112999452B (zh) * | 2021-04-23 | 2023-02-28 | 杨璐 | 一种妇产科用洗剂注射装置 |
| WO2024158694A1 (en) | 2023-01-23 | 2024-08-02 | Villya LLC | Compositions and methods for improving the solubility of erectile dysfunction therapeutics |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5741525A (en) * | 1995-10-24 | 1998-04-21 | Marshall University Research Corporation | Vaginal pharmaceutical hydrogen peroxide composition |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3852155A (en) | 1971-09-02 | 1974-12-03 | R Moore | Cryopreservation of equine cell cultures |
| US3885564A (en) * | 1972-07-24 | 1975-05-27 | Harvey H Groves | Vaginal medicator |
| IL48277A (en) * | 1974-10-18 | 1978-03-10 | Schering Ag | Vaginal ring |
| US4073743A (en) | 1975-04-17 | 1978-02-14 | Merck & Co., Inc. | Process for preparing an emulsion |
| US4016270A (en) | 1975-10-31 | 1977-04-05 | Alza Corporation | Method for treating dysmenorrhea with a uterine therapeutic system |
| US4250166A (en) | 1977-05-27 | 1981-02-10 | Shionogi & Co., Ltd. | Long acting preparation of cefalexin for effective treatments of bacterial infection sensitive to cefalexin |
| US4420474A (en) * | 1979-10-15 | 1983-12-13 | E. R. Squibb & Sons, Inc. | Synergistic antifungal compositions |
| US4318405A (en) | 1980-07-24 | 1982-03-09 | Sneider Vincent R | Tampon and drug delivery device |
| US4405323A (en) | 1981-09-08 | 1983-09-20 | Sidney Auerbach | Sanitary napkin |
| US4863725A (en) | 1982-10-27 | 1989-09-05 | Deckner George E | Novel clear oil-free moisturizer composition |
| US4540581A (en) | 1984-01-31 | 1985-09-10 | Bristol-Myers Company | Topical nonsteroidal anti-inflammatory compositions and uses |
| US4553972A (en) * | 1983-05-20 | 1985-11-19 | Syntex (U.S.A.) Inc. | Disposable intravaginal contraceptive devices releasing 1-substituted imidazoles |
| US4560549A (en) | 1983-08-24 | 1985-12-24 | Lever Brothers Company | Method of relieving pain and inflammatory conditions employing substituted salicylamides |
| US4983392A (en) | 1983-11-14 | 1991-01-08 | Bio-Mimetics, Inc. | Bioadhesive compositions and methods of treatment therewith |
| ATE151286T1 (de) | 1983-11-14 | 1997-04-15 | Columbia Lab Inc | Bioadhäsive mittel |
| US5231112A (en) * | 1984-04-12 | 1993-07-27 | The Liposome Company, Inc. | Compositions containing tris salt of cholesterol hemisuccinate and antifungal |
| US4542020A (en) * | 1984-08-17 | 1985-09-17 | E. R. Squibb & Sons, Inc. | Long-lasting adhesive antifungal suppositories |
| JPS6160620A (ja) | 1984-09-03 | 1986-03-28 | Teijin Ltd | ピログルタミン酸エステル類を含有する医薬品組成物 |
| ATE68686T1 (de) | 1985-10-31 | 1991-11-15 | Kv Pharm Co | System zum freigeben von stoffen in der vagina. |
| ES2052685T3 (es) | 1987-03-17 | 1994-07-16 | Akzo Nv | Metodo para producir un adyuvante libre. |
| US4983393A (en) * | 1987-07-21 | 1991-01-08 | Maximed Corporation | Intra-vaginal device and method for sustained drug release |
| GB8723846D0 (en) | 1987-10-10 | 1987-11-11 | Danbiosyst Ltd | Bioadhesive microsphere drug delivery system |
| CA1341245C (en) | 1988-01-12 | 2001-06-05 | F. Hoffmann-La Roche Ag | Recombinant vaccinia virus mva |
| EP0352352B1 (en) * | 1988-07-28 | 1991-10-16 | J. URIACH & CIA. S.A. | 1-[(2-Fluorophenyl)(4-fluorophenyl)phenylmethyl]-1H-imidazole |
| US5084277A (en) | 1988-08-30 | 1992-01-28 | Greco John C | Vaginal progesterone tablet |
| WO1990007325A1 (en) * | 1988-12-30 | 1990-07-12 | Edko Trading And Representation Company Limited | A pessary containing antibacterial drugs |
| US5002540A (en) * | 1989-05-22 | 1991-03-26 | Warren Kirschbaum | Intravaginal device and method for delivering a medicament |
| IT1230157B (it) | 1989-06-16 | 1991-10-14 | Lisapharma Spa | Uso di sucralfato gel umido per il trattamento di ulcere del derma e come veicolo di farmaci ad attivita' topica |
| DE3928677C2 (de) | 1989-08-30 | 1998-05-14 | Kimberly Clark Gmbh | Tampon für medizinische oder hygienische Zwecke sowie Verfahren zu seiner Herstellung |
| FR2665357B1 (fr) | 1990-07-31 | 1995-03-31 | Aiache Jean Marc | Procede de preparation d'une forme galenique bio-adhesive et forme galenique ainsi preparee. |
| US5275820A (en) | 1990-12-27 | 1994-01-04 | Allergan, Inc. | Stable suspension formulations of bioerodible polymer matrix microparticles incorporating drug loaded ion exchange resin particles |
| JPH0735335B2 (ja) * | 1991-02-28 | 1995-04-19 | 五十嵐 正雄 | 子宮内膜症の治療薬 |
| WO1992018101A1 (en) * | 1991-04-12 | 1992-10-29 | The Upjohn Company | Vaginal drug delivery device |
| US5192802A (en) | 1991-09-25 | 1993-03-09 | Mcneil-Ppc, Inc. | Bioadhesive pharmaceutical carrier |
| US5393528A (en) | 1992-05-07 | 1995-02-28 | Staab; Robert J. | Dissolvable device for contraception or delivery of medication |
| US5273521A (en) | 1992-08-26 | 1993-12-28 | Peiler Frances K | Tampon applicator for delivery of a medicament |
| US5458884A (en) * | 1992-09-10 | 1995-10-17 | Britton; Peter | Bioerodible device for administering active ingredients |
| DE69332954D1 (de) | 1992-10-21 | 2003-06-12 | Gynetech Lab Inc | Abgabesystem bestehend aus einem vaginaschwamm |
| US5330761A (en) | 1993-01-29 | 1994-07-19 | Edward Mendell Co. Inc. | Bioadhesive tablet for non-systemic use products |
| GB9318641D0 (en) * | 1993-09-08 | 1993-10-27 | Edko Trading Representation | Compositions |
| TW438601B (en) * | 1994-05-18 | 2001-06-07 | Janssen Pharmaceutica Nv | New mucoadhesive emulsion compositions and a process for the preparation thereof |
| US5742525A (en) * | 1995-01-10 | 1998-04-21 | Ye; Yuancai | Method for eliminating the fluctuation and drift of spectral line intensities |
| IT1275816B1 (it) * | 1995-10-27 | 1997-10-17 | Montefarmaco Spa | Composizioni farmaceutiche solide per uso vaginale |
| GB9522403D0 (en) | 1995-11-01 | 1996-01-03 | Hoechst Roussel Ltd | Intravaginal drug delivery device |
| US5827543A (en) * | 1995-12-07 | 1998-10-27 | The Procter & Gamble Company | Methods and compositions for the prevention and treatment of urogenital disorders |
| US5993856A (en) * | 1997-01-24 | 1999-11-30 | Femmepharma | Pharmaceutical preparations and methods for their administration |
| US6197327B1 (en) * | 1997-06-11 | 2001-03-06 | Umd, Inc. | Device and method for treatment of dysmenorrhea |
-
2000
- 2000-07-11 US US09/613,441 patent/US6416779B1/en not_active Expired - Fee Related
-
2001
- 2001-06-25 JP JP2002508356A patent/JP2004508296A/ja active Pending
- 2001-06-25 EP EP01959766A patent/EP1301150A4/en not_active Ceased
- 2001-06-25 MX MXPA02012819A patent/MXPA02012819A/es not_active Application Discontinuation
- 2001-06-25 HK HK03106688.1A patent/HK1054676A1/zh unknown
- 2001-06-25 IL IL15371901A patent/IL153719A0/xx unknown
- 2001-06-25 NZ NZ524047A patent/NZ524047A/en not_active IP Right Cessation
- 2001-06-25 BR BR0112571-0A patent/BR0112571A/pt not_active Application Discontinuation
- 2001-06-25 AU AU2001281287A patent/AU2001281287B8/en not_active Ceased
- 2001-06-25 CN CNB01812514XA patent/CN1306919C/zh not_active Expired - Fee Related
- 2001-06-25 AU AU8128701A patent/AU8128701A/xx active Pending
- 2001-06-25 CA CA002416050A patent/CA2416050A1/en not_active Abandoned
- 2001-06-25 WO PCT/US2001/041128 patent/WO2002003896A1/en not_active Ceased
-
2002
- 2002-12-27 IL IL153719A patent/IL153719A/en not_active IP Right Cessation
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5741525A (en) * | 1995-10-24 | 1998-04-21 | Marshall University Research Corporation | Vaginal pharmaceutical hydrogen peroxide composition |
Also Published As
| Publication number | Publication date |
|---|---|
| NZ524047A (en) | 2005-08-26 |
| IL153719A0 (en) | 2003-07-06 |
| EP1301150A4 (en) | 2004-08-11 |
| JP2004508296A (ja) | 2004-03-18 |
| AU2001281287B2 (en) | 2006-10-19 |
| CN1306919C (zh) | 2007-03-28 |
| IL153719A (en) | 2009-12-24 |
| CN1592600A (zh) | 2005-03-09 |
| MXPA02012819A (es) | 2003-09-22 |
| CA2416050A1 (en) | 2002-01-17 |
| WO2002003896A1 (en) | 2002-01-17 |
| AU8128701A (en) | 2002-01-21 |
| HK1054676A1 (zh) | 2003-12-12 |
| BR0112571A (pt) | 2003-05-27 |
| EP1301150A1 (en) | 2003-04-16 |
| US6416779B1 (en) | 2002-07-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2001281287B8 (en) | Device and method for intravaginal or transvaginal treatment of fungal, bacterial, viral or parasitic infections | |
| AU2001281287A1 (en) | Device and method for intravaginal or transvaginal treatment of fungal, bacterial, viral or parasitic infections | |
| US7744916B2 (en) | Coated vaginal device for delivery of anti-migraine and anti-nausea drugs | |
| US6197327B1 (en) | Device and method for treatment of dysmenorrhea | |
| US20040043071A1 (en) | Intravaginal mucosal or transmucosal delivery of antimigraine and antinausea drugs | |
| AU2001278920B2 (en) | Vaginal delivery of bisphosphonates | |
| US20050276836A1 (en) | Coated vaginal devices for vaginal delivery of therapeutically effective and/or health-promoting agents | |
| JP2005507874A (ja) | 癌治療のための化学療法剤及び膜流出システム阻害剤の経膣送達 | |
| AU2001278920A1 (en) | Vaginal Delivery of Bisphosphonates | |
| US6905701B2 (en) | Formulations for transmucosal vaginal delivery of bisphosphonates | |
| KR102159904B1 (ko) | 약물 방출 고리를 구비한 월경컵 | |
| AU765269B2 (en) | Device and method for treatment of dysmenorrhea | |
| NZ508130A (en) | Compositions in the manufacture of a medicament for treatment of dysmenorrhea | |
| MXPA99011480A (en) | Device and method for treatment of dysmenorrhea |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| TH | Corrigenda |
Free format text: IN VOL 20, NO 40, PAGE(S) 3971 UNDER THE HEADING APPLICATIONS ACCEPTED - NAME INDEX UNDER THE NAME UMD, INC, APPLICATION NO. 2001281287, UNDER INID (72). CORRECT THE CO-INVENTORS TO PAULETTI, GIOVANNI AND RITSCHEL, WOLFGANG |
|
| FGA | Letters patent sealed or granted (standard patent) | ||
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |