AU2001268481A1 - Regulatable, catalytically active nucleic acids - Google Patents

Regulatable, catalytically active nucleic acids

Info

Publication number
AU2001268481A1
AU2001268481A1 AU2001268481A AU6848101A AU2001268481A1 AU 2001268481 A1 AU2001268481 A1 AU 2001268481A1 AU 2001268481 A AU2001268481 A AU 2001268481A AU 6848101 A AU6848101 A AU 6848101A AU 2001268481 A1 AU2001268481 A1 AU 2001268481A1
Authority
AU
Australia
Prior art keywords
nucleic acid
effector
catalytic
nucleic acids
regulatable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001268481A
Other languages
English (en)
Inventor
J. Colin Cox
Eric Davidson
Andrew D. Ellington
Jay Hesselberth
Kris Marshall
Timothy Reidel
Michael Robertson
Letha Sooter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Texas System
Original Assignee
University of Texas System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Texas System filed Critical University of Texas System
Publication of AU2001268481A1 publication Critical patent/AU2001268481A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1093—General methods of preparing gene libraries, not provided for in other subgroups
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C12N2310/111—Antisense spanning the whole gene, or a large part of it
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
    • C12N2310/124—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes based on group I or II introns

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
AU2001268481A 2000-06-15 2001-06-14 Regulatable, catalytically active nucleic acids Abandoned AU2001268481A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US21209700P 2000-06-15 2000-06-15
US60/212,097 2000-06-15
PCT/US2001/019302 WO2001096559A2 (en) 2000-06-15 2001-06-14 Regulatable, catalytically active nucleic acids

Publications (1)

Publication Number Publication Date
AU2001268481A1 true AU2001268481A1 (en) 2001-12-24

Family

ID=22789548

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001268481A Abandoned AU2001268481A1 (en) 2000-06-15 2001-06-14 Regulatable, catalytically active nucleic acids

Country Status (6)

Country Link
US (2) US20030104520A1 (de)
EP (1) EP1364009A2 (de)
JP (1) JP2004515219A (de)
AU (1) AU2001268481A1 (de)
CA (1) CA2412664A1 (de)
WO (1) WO2001096559A2 (de)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7115396B2 (en) * 1998-12-10 2006-10-03 Compound Therapeutics, Inc. Protein scaffolds for antibody mimics and other binding proteins
US6818418B1 (en) * 1998-12-10 2004-11-16 Compound Therapeutics, Inc. Protein scaffolds for antibody mimics and other binding proteins
JP2005533862A (ja) 2002-07-25 2005-11-10 アーケミックス コーポレイション 調節されたアプタマー治療剤
US20050074865A1 (en) * 2002-08-27 2005-04-07 Compound Therapeutics, Inc. Adzymes and uses thereof
JP2005537032A (ja) * 2002-08-27 2005-12-08 コンパウンド セラピューティクス インコーポレーティッド アドザイムおよびその用途
US20050026178A1 (en) * 2003-03-28 2005-02-03 Marit Nilsen-Hamilton Allosteric probes and methods
AU2004296376B2 (en) * 2003-12-05 2010-03-04 Bristol-Myers Squibb Company Inhibitors of type 2 vascular endothelial growth factor receptors
US20080220049A1 (en) * 2003-12-05 2008-09-11 Adnexus, A Bristol-Myers Squibb R&D Company Compositions and methods for intraocular delivery of fibronectin scaffold domain proteins
DE602005014475D1 (de) * 2004-05-11 2009-06-25 Nat Univ Corp Yokohama Nat Uni Nukleinsäure/enzym-komplex
US20060057627A1 (en) * 2004-09-08 2006-03-16 Board Of Regents, The University Of Texas System Selection scheme for enzymatic function
WO2006042112A2 (en) * 2004-10-05 2006-04-20 California Institute Of Technology Aptamer regulated nucleic acids and uses thereof
JP5188808B2 (ja) 2004-11-03 2013-04-24 アイリス モレキュラー ダイアグノスティクス， インコーポレイテッド 同種の分析物検出
WO2008058291A2 (en) 2006-11-09 2008-05-15 California Institute Of Technology Modular aptamer-regulated ribozymes
US8470332B2 (en) 2006-11-22 2013-06-25 Bristol-Myers Squibb Company Targeted therapeutics based on engineered proteins for tyrosine kinases receptors, including IGF-IR
US20090082217A1 (en) * 2007-07-16 2009-03-26 California Institute Of Technology Selection of nucleic acid-based sensor domains within nucleic acid switch platform
US20120165387A1 (en) 2007-08-28 2012-06-28 Smolke Christina D General composition framework for ligand-controlled RNA regulatory systems
US8367815B2 (en) * 2007-08-28 2013-02-05 California Institute Of Technology Modular polynucleotides for ligand-controlled regulatory systems
US8865667B2 (en) * 2007-09-12 2014-10-21 California Institute Of Technology Higher-order cellular information processing devices
US9029524B2 (en) * 2007-12-10 2015-05-12 California Institute Of Technology Signal activated RNA interference
US8242092B2 (en) 2008-02-05 2012-08-14 Brent Townshend Protein tyrosine phosphatase inhibitors
MX2010008874A (es) 2008-02-14 2010-09-22 Bristol Myers Squibb Co Terapeuticos dirigidos a base de proteinas manipuladas que se unen al receptor de factor de crecimiento epidermico.
ES2433745T3 (es) * 2008-02-21 2013-12-12 Iris International, Inc. Procedimiento para la determinación temprana de recidivas tras la terapia para el cáncer de próstata
KR100958293B1 (ko) * 2008-03-27 2010-05-19 단국대학교 산학협력단 테오필린에 의해 표적 특이적 ｒｎａ 치환 활성이 조절되는알로스테릭 트랜스―스플라이싱 그룹 ｉ 리보자임
AR071874A1 (es) 2008-05-22 2010-07-21 Bristol Myers Squibb Co Proteinas de dominio de armazon basadas en fibronectina multivalentes
TWI496582B (zh) 2008-11-24 2015-08-21 必治妥美雅史谷比公司 雙重專一性之ｅｇｆｒ／ｉｇｆｉｒ結合分子
US20100305197A1 (en) * 2009-02-05 2010-12-02 Massachusetts Institute Of Technology Conditionally Active Ribozymes And Uses Thereof
US8329882B2 (en) 2009-02-18 2012-12-11 California Institute Of Technology Genetic control of mammalian cells with synthetic RNA regulatory systems
US9145555B2 (en) 2009-04-02 2015-09-29 California Institute Of Technology Integrated—ligand-responsive microRNAs
TW201138808A (en) 2010-05-03 2011-11-16 Bristol Myers Squibb Co Serum albumin binding molecules
WO2011150133A2 (en) 2010-05-26 2011-12-01 Bristol-Myers Squibb Company Fibronectin based scaffold proteins having improved stability
US9512422B2 (en) * 2013-02-26 2016-12-06 Illumina, Inc. Gel patterned surfaces
KR102472862B1 (ko) 2014-03-20 2022-12-05 브리스톨-마이어스 스큅 컴퍼니 혈청 알부민-결합 피브로넥틴 유형 iii 도메인
WO2016025750A2 (en) * 2014-08-13 2016-02-18 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for regulation of gene expression with, and detection of, folinic acid and folates
WO2017030659A2 (en) 2015-07-23 2017-02-23 The Board Of Trustees Of The Leland Stanford Junior University Molecular sensor selection
ES2781207T3 (es) 2015-09-23 2020-08-31 Bristol Myers Squibb Co Dominios de fibronectina de tipo iii de unión a seroalbúmina con velocidad de disociación rápida
US20200363406A1 (en) * 2017-10-26 2020-11-19 The University Of Houston System Highly-specific assays
EP3911334A4 (de) * 2019-01-17 2023-07-26 The Regents of the University of Colorado, a body corporate Kleinmolekülige regulierung von crispr-cas9 mittels rna-aptameren

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2633310A1 (fr) * 1988-06-24 1989-12-29 Pasteur Institut Appareil d'execution automatique repetee d'un cycle thermique en plusieurs etapes successives, notamment pour l'amplification enzymatique de sequences d'acides nucleiques
WO1991016675A1 (en) * 1990-04-06 1991-10-31 Applied Biosystems, Inc. Automated molecular biology laboratory
AU679525B2 (en) * 1992-12-04 1997-07-03 Innovir Laboratories, Inc. Regulatable nucleic acid therapeutic and methods of use thereof
AU675482B2 (en) * 1992-12-04 1997-02-06 Innovir Laboratories, Inc. Ribozyme amplified diagnostics
US5688670A (en) * 1994-09-01 1997-11-18 The General Hospital Corporation Self-modifying RNA molecules and methods of making
US5663064A (en) * 1995-01-13 1997-09-02 University Of Vermont Ribozymes with RNA protein binding site
DE69735684T2 (de) * 1996-08-26 2007-04-05 Genetico Ltd. Katalytische Nukleinsäure und deren medizinische Verwendung
EP0958303A4 (de) * 1996-12-19 2004-03-31 Univ Yale Bioreaktive allosterische polynukleotide
DE19743518A1 (de) * 1997-10-01 1999-04-15 Roche Diagnostics Gmbh Automatisierbare universell anwendbare Probenvorbereitungsmethode
IL164182A0 (en) * 1998-03-05 2005-12-18 Johnson & Johnson Res Pty Ltd Zymogenic nucleic acid detection methods, and related molecules and kits
ATE426456T1 (de) * 1998-05-01 2009-04-15 Gen Probe Inc Automatische diagnostische analysevorrichtung
CA2348779A1 (en) * 1998-11-03 2000-05-11 Yale University Multidomain polynucleotide molecular sensors
MXPA01007352A (es) * 1999-01-19 2003-06-06 Somalogic Inc Metodo y aparato para la generacion automatizada de ligandos de acido nucleico.

Also Published As

Publication number Publication date
US20070077571A1 (en) 2007-04-05
WO2001096559A2 (en) 2001-12-20
EP1364009A2 (de) 2003-11-26
JP2004515219A (ja) 2004-05-27
CA2412664A1 (en) 2001-12-20
WO2001096559A3 (en) 2003-07-10
US20030104520A1 (en) 2003-06-05

Similar Documents

Publication Publication Date Title
US20030104520A1 (en) Regulatable, catalytically active nucleic acids
US20040126882A1 (en) Regulatable, catalytically active nucleic acids
JP4262778B2 (ja) 生体分子相互作用を検出するためのタンパク質断片相補性アッセイ
US20200239863A1 (en) Tracking and Manipulating Cellular RNA via Nuclear Delivery of CRISPR/CAS9
AU772881B2 (en) Multidomain polynucleotide molecular sensors
US20200248229A1 (en) Unbiased detection of nucleic acid modifications
PT1496120E (pt) Método de ordenamento in vitro
JP2000517181A (ja) 触媒核酸及びその医学的使用
Hesslein et al. Exploration of the conserved A+ C wobble pair within the ribosomal peptidyl transferase center using affinity purified mutant ribosomes
Lamond Pre-mRNA processing
JP7526498B2 (ja) 細胞内のインビトロディスプレイライブラリのスクリーニング方法
US20060121510A1 (en) Multidomain polynucleotide molecular sensors
JP2002238575A (ja) 微量ｍＲＮＡ及びｃＤＮＡの増幅方法
US20070128657A1 (en) Molecular libraries
WO2003027310A2 (en) Regulatable, catalytically active nucleic acids
AU2007201954A1 (en) Regulatable, Catalytically Active Nucleic Acids
JP2002523059A (ja) 基質置換での酵素活性スクリーン
US20080248958A1 (en) System for pulling out regulatory elements in vitro
US20080248467A1 (en) System for pulling out regulatory elements using yeast
WO2001096541A2 (en) Allosterically regulated ribozymes
Zaric Oligomerization of Biomacromolecules–Example of RNA Binding Sm/LSm Proteins
Marshall Group I aptazymes as genetic regulatory switches
WO1999010487A2 (en) Novel transcriptional regulators and uses therefor
Marshall et al. Analytical biotechnology
EP1630170A1 (de) Verfahren zur Herstellung eines Kristalles eines Moleküles von Interesse, und Kit dafür

Legal Events

Date Code Title Description
MK5 Application lapsed section 142(2)(e) - patent request and compl. specification not accepted