AU2001263827B2 - 2-hydroxy-mutilin carbamate derivatives for antibacterial use - Google Patents

2-hydroxy-mutilin carbamate derivatives for antibacterial use Download PDF

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Publication number
AU2001263827B2
AU2001263827B2 AU2001263827A AU2001263827A AU2001263827B2 AU 2001263827 B2 AU2001263827 B2 AU 2001263827B2 AU 2001263827 A AU2001263827 A AU 2001263827A AU 2001263827 A AU2001263827 A AU 2001263827A AU 2001263827 B2 AU2001263827 B2 AU 2001263827B2
Authority
AU
Australia
Prior art keywords
ester
carbamic acid
compound
formula
hydroxymutilin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2001263827A
Other languages
English (en)
Other versions
AU2001263827A1 (en
Inventor
Gerald Brooks
Steven Howard
Eric Hunt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
SmithKline Beecham Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0008260.2A external-priority patent/GB0008260D0/en
Priority claimed from GB0027182A external-priority patent/GB0027182D0/en
Application filed by SmithKline Beecham Ltd filed Critical SmithKline Beecham Ltd
Publication of AU2001263827A1 publication Critical patent/AU2001263827A1/en
Application granted granted Critical
Publication of AU2001263827B2 publication Critical patent/AU2001263827B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
AU2001263827A 2000-04-04 2001-03-29 2-hydroxy-mutilin carbamate derivatives for antibacterial use Ceased AU2001263827B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB0008260.2A GB0008260D0 (en) 2000-04-04 2000-04-04 Novel compounds
GB0008260.2 2000-04-04
GB0027182A GB0027182D0 (en) 2000-11-04 2000-11-04 Novel comounds
GB0027182.5 2000-11-04
PCT/EP2001/003594 WO2001074788A1 (en) 2000-04-04 2001-03-29 2-hydroxy-mutilin carbamate derivatives for antibacterial use

Publications (2)

Publication Number Publication Date
AU2001263827A1 AU2001263827A1 (en) 2002-01-03
AU2001263827B2 true AU2001263827B2 (en) 2004-06-17

Family

ID=26244040

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2001263827A Ceased AU2001263827B2 (en) 2000-04-04 2001-03-29 2-hydroxy-mutilin carbamate derivatives for antibacterial use
AU6382701A Withdrawn AU6382701A (en) 2000-04-04 2001-03-29 2-hydroxy-mutilin carbamate derivatives for antibacterial use

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU6382701A Withdrawn AU6382701A (en) 2000-04-04 2001-03-29 2-hydroxy-mutilin carbamate derivatives for antibacterial use

Country Status (21)

Country Link
US (1) US6972297B2 (enExample)
EP (1) EP1268443B1 (enExample)
JP (1) JP2003529593A (enExample)
KR (1) KR100758441B1 (enExample)
CN (1) CN1210267C (enExample)
AR (1) AR030203A1 (enExample)
AT (1) ATE437860T1 (enExample)
AU (2) AU2001263827B2 (enExample)
BR (1) BR0109809A (enExample)
CA (1) CA2405132A1 (enExample)
CO (1) CO5280223A1 (enExample)
CZ (1) CZ20023290A3 (enExample)
DE (1) DE60139382D1 (enExample)
ES (1) ES2328109T3 (enExample)
HU (1) HUP0300370A3 (enExample)
IL (1) IL151887A0 (enExample)
MX (1) MXPA02009816A (enExample)
NO (1) NO324229B1 (enExample)
NZ (1) NZ521536A (enExample)
PL (1) PL358666A1 (enExample)
WO (1) WO2001074788A1 (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0024811D0 (en) 2000-10-10 2000-11-22 Smithkline Beecham Plc Novel compounds
US7176310B1 (en) 2002-04-09 2007-02-13 Ucb Sa Pyrimidinecarboxamide derivatives and their use as anti-inflammatory agents
GB0209262D0 (en) * 2002-04-23 2002-06-05 Biochemie Gmbh Organic compounds
AU2003257493A1 (en) * 2002-07-24 2004-02-16 Sandoz Ag Pleuromutilin derivatives as antimicrobbials
GB0218578D0 (en) * 2002-08-09 2002-09-18 Glaxo Group Ltd Novel method
GB0308114D0 (en) * 2003-04-08 2003-05-14 Glaxo Group Ltd Novel compounds
FR2856685B1 (fr) * 2003-06-25 2005-09-23 Merck Sante Sas Derives de thiazolylpiperidine, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
JP2008523016A (ja) * 2004-12-13 2008-07-03 グラクソ グループ リミテッド （５−アミノ−６−メトキシ−３−ピリジンカルボニル）カルバミン酸２−（ｓ）−ヒドロキシムチリン１４−エステルの新規の多形
EP1832591A1 (en) * 2004-12-27 2007-09-12 Kyorin Pharmaceutical Co., Ltd. 12-position substituted mutilin derivative
US20080139626A1 (en) * 2005-03-10 2008-06-12 Rittenhouse Stephen F Novel Method
TW200738701A (en) 2005-07-26 2007-10-16 Du Pont Fungicidal carboxamides
KR100695541B1 (ko) * 2005-10-31 2007-03-16 한국단자공업 주식회사 연결터미널
WO2007079173A2 (en) * 2005-12-30 2007-07-12 Emergent Biosolutions Inc. Novel 2-heteroaryloxy-phenol derivatives as antibacterial agents
EP2149571A4 (en) * 2007-05-24 2010-09-01 Kyorin Seiyaku Kk MUTILINE DERIVATIVE WITH A RINGED, HETEROCYCLIC AND AROMATIC CARBOXYLIC ACID STRUCTURE IN A SUBSTITUTE AT POSITION 14
EP2014640A1 (en) * 2007-07-13 2009-01-14 Nabriva Therapeutics AG Pleuromutilin derivatives
JP2010100582A (ja) * 2008-10-24 2010-05-06 Kyorin Pharmaceut Co Ltd １４位置換基に複素芳香環カルボン酸構造を有するムチリン誘導体
EP2184273A1 (de) 2008-11-05 2010-05-12 Bayer CropScience AG Halogen-substituierte Verbindungen als Pestizide
EP2253617A1 (de) 2009-05-20 2010-11-24 Bayer CropScience AG Halogen-substituierte Verbindungen als Pestizide
JP6818019B2 (ja) * 2015-06-17 2021-01-20 ナブリヴァ セラピュティクス ゲーエムベーハー レファムリンの注射可能医薬組成物
CA3130138A1 (en) * 2019-02-27 2020-09-03 Oticara, Inc. Method for treating nasal, sinonasal, and nasopharyngeal tissue infection and/or inflammation

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998005659A1 (en) * 1996-08-02 1998-02-12 Smithkline Beecham Plc Azabicyclic carbamoyloxy mutilin derivatives for antibacterial use

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP9900973A3 (en) * 1996-01-03 2000-04-28 Smithkline Beecham Plc Carbamoyloxy derivatives of mutiline with antibacterial activity, pharmaceutical compns. contg. them and process for preparing the said compds.
UY25225A1 (es) 1997-10-29 2000-12-29 Smithkline Beecham Plc Derivados de pleuromutilina utiles como agentes antimicrobianos
FR2771008B1 (fr) 1997-11-17 2000-04-28 Hoechst Marion Roussel Inc Utilisation des ketolides pour la preparation de compositions pharmaceutiques destinees a prevenir les complications thrombotiques arterielles liees a l'atherosclerose
GB9817029D0 (en) * 1998-08-05 1998-09-30 Smithkline Beecham Plc Novel compounds

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998005659A1 (en) * 1996-08-02 1998-02-12 Smithkline Beecham Plc Azabicyclic carbamoyloxy mutilin derivatives for antibacterial use

Also Published As

Publication number Publication date
MXPA02009816A (es) 2003-03-27
ATE437860T1 (de) 2009-08-15
HUP0300370A3 (en) 2005-07-28
PL358666A1 (en) 2004-08-09
CO5280223A1 (es) 2003-05-30
CN1427827A (zh) 2003-07-02
HUP0300370A2 (hu) 2003-06-28
KR100758441B1 (ko) 2007-09-14
US6972297B2 (en) 2005-12-06
NO20024745D0 (no) 2002-10-02
AR030203A1 (es) 2003-08-13
NO20024745L (no) 2002-11-19
JP2003529593A (ja) 2003-10-07
WO2001074788A1 (en) 2001-10-11
CN1210267C (zh) 2005-07-13
DE60139382D1 (de) 2009-09-10
KR20030011815A (ko) 2003-02-11
US20030114674A1 (en) 2003-06-19
CZ20023290A3 (cs) 2003-03-12
NO324229B1 (no) 2007-09-10
ES2328109T3 (es) 2009-11-10
NZ521536A (en) 2004-05-28
AU6382701A (en) 2001-10-15
WO2001074788A8 (en) 2001-12-20
IL151887A0 (en) 2003-04-10
BR0109809A (pt) 2003-01-21
CA2405132A1 (en) 2001-10-11
EP1268443B1 (en) 2009-07-29
EP1268443A1 (en) 2003-01-02

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Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired