AU2001252084B2 - 3-nitrogen-6,7-dioxygen steroids and uses related thereto - Google Patents

3-nitrogen-6,7-dioxygen steroids and uses related thereto Download PDF

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Publication number
AU2001252084B2
AU2001252084B2 AU2001252084A AU2001252084A AU2001252084B2 AU 2001252084 B2 AU2001252084 B2 AU 2001252084B2 AU 2001252084 A AU2001252084 A AU 2001252084A AU 2001252084 A AU2001252084 A AU 2001252084A AU 2001252084 B2 AU2001252084 B2 AU 2001252084B2
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AU
Australia
Prior art keywords
compound
substituted
carbon
hydrogen
mmol
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Ceased
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AU2001252084A
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English (en)
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AU2001252084A1 (en
Inventor
Claudia E. Kasserra
Jeffery R. Raymond
Yaping Shen
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Inflazyme Pharmaceuticals Ltd
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Inflazyme Pharmaceuticals Ltd
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Publication of AU2001252084A1 publication Critical patent/AU2001252084A1/en
Application granted granted Critical
Publication of AU2001252084B2 publication Critical patent/AU2001252084B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C07J41/0011—Unsubstituted amino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036—Nitrogen-containing hetero ring
    • C07J71/0042—Nitrogen only
    • C07J71/0047—Nitrogen only at position 2(3)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036—Nitrogen-containing hetero ring
    • C07J71/0057—Nitrogen and oxygen
    • C07J71/0063—Nitrogen and oxygen at position 2(3)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Virology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Communicable Diseases (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2001252084A 2000-04-28 2001-04-30 3-nitrogen-6,7-dioxygen steroids and uses related thereto Ceased AU2001252084B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US20061700P 2000-04-28 2000-04-28
US60/200,617 2000-04-28
PCT/CA2001/000581 WO2001083512A1 (en) 2000-04-28 2001-04-30 3-nitrogen-6,7-dioxygen steroids and uses related thereto

Publications (2)

Publication Number Publication Date
AU2001252084A1 AU2001252084A1 (en) 2002-01-31
AU2001252084B2 true AU2001252084B2 (en) 2006-07-06

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
AU2001252084A Ceased AU2001252084B2 (en) 2000-04-28 2001-04-30 3-nitrogen-6,7-dioxygen steroids and uses related thereto
AU5208401A Pending AU5208401A (en) 2000-04-28 2001-04-30 3-nitrogen-6,7-dioxygen steroids and uses related thereto

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU5208401A Pending AU5208401A (en) 2000-04-28 2001-04-30 3-nitrogen-6,7-dioxygen steroids and uses related thereto

Country Status (33)

Country Link
US (4) US20040034216A1 (enExample)
EP (1) EP1278763B1 (enExample)
JP (1) JP2003531916A (enExample)
KR (1) KR20030045671A (enExample)
CN (1) CN1214039C (enExample)
AP (1) AP1825A (enExample)
AT (1) ATE353909T1 (enExample)
AU (2) AU2001252084B2 (enExample)
BG (1) BG107289A (enExample)
BR (1) BR0110419A (enExample)
CA (1) CA2418748A1 (enExample)
CO (1) CO5590904A2 (enExample)
DE (1) DE60126597T2 (enExample)
DK (1) DK1278763T3 (enExample)
DZ (1) DZ3355A1 (enExample)
EE (1) EE200200613A (enExample)
ES (1) ES2282247T3 (enExample)
HR (1) HRP20020944A2 (enExample)
HU (1) HUP0300908A2 (enExample)
IL (2) IL152448A0 (enExample)
MA (1) MA25808A1 (enExample)
MX (1) MXPA02010645A (enExample)
NO (1) NO324873B1 (enExample)
NZ (1) NZ522181A (enExample)
OA (1) OA12255A (enExample)
PL (1) PL365798A1 (enExample)
PT (1) PT1278763E (enExample)
RU (1) RU2291873C2 (enExample)
SK (1) SK15692002A3 (enExample)
UA (1) UA79229C2 (enExample)
WO (1) WO2001083512A1 (enExample)
YU (1) YU88102A (enExample)
ZA (1) ZA200208631B (enExample)

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US20050070487A1 (en) * 2001-04-24 2005-03-31 Nyce Jonathan W. Composition, formulations and kit for treatment of respiratory and lung disease with non-glucocorticoid steroids and/or ubiquinone and a bronchodilating agent
JP2004534042A (ja) 2001-05-22 2004-11-11 インフラジム ファーマシューティカルズ リミテッド ステロイド−５−エン化合物のステロイド−５−エン−７−オン化合物へのアリル酸化、続くヒドロホウ素化および酸化による、６，７−ジヒドロキシステロイドの生成のための方法およびこの方法の中間体
DE60324562D1 (de) 2002-08-01 2008-12-18 Astellas Pharma Inc Kaliumabhängiger natrium-calcium-austauscher
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US20050101545A1 (en) * 2003-07-31 2005-05-12 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an anticholinergic bronchodilator for treatment of asthma or chronic obstructive pulmonary disease
US20050113318A1 (en) * 2003-07-31 2005-05-26 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a beta-agonist bronchodilator for treatment of asthma or chronic obstructive pulmonary disease
US20090317476A1 (en) * 2003-07-31 2009-12-24 Robinson Cynthia B Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a leukotriene receptor antagonist for treatment of asthma or chronic obstructive pulmonary disease
US20050038004A1 (en) * 2003-07-31 2005-02-17 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an anticholinergic bronchodilator for treatment of asthma or chronic obstructive pulmonary disease
US20050026882A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a leukotriene receptor antagonist for treatment of asthma or chronic obstructive pulmonary disease
US20050026881A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an anti-IgE antibody for treatment of asthma or chronic obstructive pulmonary disease
US20090297611A1 (en) * 2003-07-31 2009-12-03 Robinson Cynthia B Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a tyrosine kinase inhibitor, delta opioid receptor antagonist, neurokinin receptor antagonist, or vcam inhibitor for treatment of asthma or chronic obstructive pulmonary disease
US20090263381A1 (en) * 2003-07-31 2009-10-22 Robinson Cynthia B Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an anti-ige antibody for treatment of asthma or chronic obstructive pulmonary disease
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US20050026879A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a tyrosine kinase inhibitor, delta opioid receptor antagonist, neurokinin receptor antagonist, or VCAM inhibitor for treatment of asthma or chronic obstructive pulmonary disease
US20050026884A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a beta-agonist bronchodilator for treatment of asthma or chronic obstructive pulmonary disease
US20110209699A1 (en) * 2003-07-31 2011-09-01 Robinson Cynthia B Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a lipoxygenase inhibitor for treatment of asthma or chronic obstructive pulmonary disease
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CA2542821A1 (fr) * 2003-10-20 2005-04-28 Inflazyme Pharmaceuticals, Ltd Formes cristallines du chlorhydrate de 3-beta-amino, 17-methylene, androstane-6-alpha, 7-beta-diol
FR2861077B1 (fr) * 2003-10-20 2006-03-03 Aventis Pharma Sa Formes cristallines du chlorydrate de 3-beta-amino, 17-methylene, androstane-6-alpha, 7-beta-diol
US20090317477A1 (en) * 2004-03-31 2009-12-24 Robinson Cynthia B Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a glucocorticosteroid for treatment of asthma, chronic obstructive pulmonary disease or allergic rhinitis
US20050222049A1 (en) * 2004-03-31 2005-10-06 Robinson Cynthia B Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a glucocorticosteroid for treatment of asthma, chronic obstructive pulmonary disease or allergic rhinitis
US20050227927A1 (en) * 2004-03-31 2005-10-13 Robinson Cynthia B Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a glucocorticosteroid for treatment of asthma, chronic obstructive pulmonary disease or allergic rhinitis
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JP5655243B2 (ja) * 2009-10-19 2015-01-21 国立大学法人 熊本大学 インドキシル硫酸の産生の阻害剤のスクリーニング方法、インドキシル硫酸代謝産生阻害剤、及び腎障害軽減剤
ES2857626T3 (es) 2010-01-15 2021-09-29 Suzhou Neupharma Co Ltd Ciertas entidades químicas, composiciones y métodos
CN103140237A (zh) 2010-07-09 2013-06-05 比奥根艾迪克依蒙菲利亚公司 因子ix多肽及其使用方法
EP2670763B1 (en) 2011-02-02 2018-08-01 Suzhou Neupharma Co., Ltd Certain chemical entities, compositions, and methods
WO2013165924A1 (en) 2012-04-29 2013-11-07 Neupharma, Inc. Certain chemical entities, compositions, and methods
TW201427685A (zh) 2012-09-25 2014-07-16 Biogen Idec Inc Ｆｉｘ多肽的應用
KR20220110337A (ko) 2013-03-14 2022-08-05 에퀴녹스 파머수티칼스 (캐나다) 인코포레이티드 Ship1 조절제 및 그와 관련된 방법
RU2015143675A (ru) 2013-03-14 2017-04-27 Экуинокс Фармасьютикалз (Кэнэда) Инк. Ship1 модуляторы и относящиеся к ним способы
EA037906B1 (ru) 2013-03-15 2021-06-04 Биовератив Терапьютикс Инк. Препараты полипептида фактора ix
CN104744547B (zh) * 2013-12-27 2017-02-15 天津医科大学 一种抗乳腺癌转移作用的孕甾烷生物碱衍生物及医药用途
US9944590B2 (en) 2015-06-26 2018-04-17 Aquinox Pharmaceuticals (Canada) Inc. Crystalline solid forms of the acetate salt of (1S,3S,4R)-4-((3aS,4R,5S,7aS)-4-(aminomethyl)-7a-methyl-1-methyleneoctahydro-1H-inden-5-yl)-3-(hydroxymethyl)-4-methylcyclohexanol
US10053415B2 (en) 2016-01-20 2018-08-21 Aquinox Pharmaceuticals (Canada) Inc. Synthesis of a substituted indene derivative
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CN112533905A (zh) 2018-04-06 2021-03-19 塔罗制药公司 可用于治疗疼痛和炎症的茚衍生物
CN112654632A (zh) 2018-04-06 2021-04-13 塔罗制药公司 可用于治疗疼痛和炎症的十六氢-1H-环戊二烯并[a]菲衍生物

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US5847172A (en) * 1995-06-07 1998-12-08 Magainin Pharmaceuticals Inc. Certain aminosterol compounds and pharmaceutical compositions including these compounds
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US20070060553A1 (en) 2007-03-15
US20020072510A1 (en) 2002-06-13
BG107289A (bg) 2003-07-31
CN1214039C (zh) 2005-08-10
BR0110419A (pt) 2004-02-25
NZ522181A (en) 2005-04-29
OA12255A (en) 2006-05-11
DZ3355A1 (fr) 2001-11-08
DE60126597T2 (de) 2007-10-31
MA25808A1 (fr) 2003-07-01
US20040034216A1 (en) 2004-02-19
EE200200613A (et) 2004-04-15
US20050215534A9 (en) 2005-09-29
EP1278763A1 (en) 2003-01-29
ATE353909T1 (de) 2007-03-15
RU2291873C2 (ru) 2007-01-20
MXPA02010645A (es) 2004-04-20
IL152448A0 (en) 2003-05-29
SK15692002A3 (sk) 2003-11-04
DE60126597D1 (de) 2007-03-29
NO20025106L (no) 2002-12-18
UA79229C2 (en) 2007-06-11
EP1278763B1 (en) 2007-02-14
ZA200208631B (en) 2004-02-23
HRP20020944A2 (en) 2004-02-29
CA2418748A1 (en) 2001-11-08
AP1825A (en) 2008-02-03
CO5590904A2 (es) 2005-12-30
NO20025106D0 (no) 2002-10-24
YU88102A (sh) 2006-01-16
IL152448A (en) 2006-12-31
ES2282247T3 (es) 2007-10-16
HUP0300908A2 (hu) 2003-07-28
DK1278763T3 (da) 2007-06-11
PT1278763E (pt) 2007-05-31
CN1430625A (zh) 2003-07-16
US6635629B2 (en) 2003-10-21
KR20030045671A (ko) 2003-06-11
HK1050694A1 (en) 2003-07-04
AP2002002659A0 (en) 2002-12-31
WO2001083512A1 (en) 2001-11-08
US7112580B2 (en) 2006-09-26
US20040138186A1 (en) 2004-07-15
AU5208401A (en) 2001-11-12
JP2003531916A (ja) 2003-10-28
PL365798A1 (en) 2005-01-10
NO324873B1 (no) 2007-12-17

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