AU2001238507C9 - Micelles - Google Patents
Micelles Download PDFInfo
- Publication number
- AU2001238507C9 AU2001238507C9 AU2001238507A AU2001238507A AU2001238507C9 AU 2001238507 C9 AU2001238507 C9 AU 2001238507C9 AU 2001238507 A AU2001238507 A AU 2001238507A AU 2001238507 A AU2001238507 A AU 2001238507A AU 2001238507 C9 AU2001238507 C9 AU 2001238507C9
- Authority
- AU
- Australia
- Prior art keywords
- micelle
- och
- patient
- compound
- hydrodynamic diameter
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
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- 239000000693 micelle Substances 0.000 title claims description 212
- 150000001875 compounds Chemical class 0.000 claims description 112
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- 239000008194 pharmaceutical composition Substances 0.000 claims description 45
- 125000000217 alkyl group Chemical group 0.000 claims description 44
- 230000002378 acidificating effect Effects 0.000 claims description 39
- 230000007935 neutral effect Effects 0.000 claims description 38
- 239000012670 alkaline solution Substances 0.000 claims description 37
- 239000007853 buffer solution Substances 0.000 claims description 32
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical group [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 27
- 229910021645 metal ion Inorganic materials 0.000 claims description 26
- 239000003929 acidic solution Substances 0.000 claims description 16
- 229910052760 oxygen Inorganic materials 0.000 claims description 15
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- 239000002253 acid Substances 0.000 claims description 11
- 229910052751 metal Inorganic materials 0.000 claims description 11
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- 229910052717 sulfur Inorganic materials 0.000 claims description 8
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- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 7
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 7
- 229910052728 basic metal Inorganic materials 0.000 claims description 7
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 7
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- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims description 4
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 4
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- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 4
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- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
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- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 2
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7024—Esters of saccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/665—Phosphorus compounds having oxygen as a ring hetero atom, e.g. fosfomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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| US18376800P | 2000-02-18 | 2000-02-18 | |
| US60/183,768 | 2000-02-18 | ||
| PCT/US2001/005297 WO2001060382A1 (en) | 2000-02-18 | 2001-02-20 | Micelles |
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| AU2001238507A1 AU2001238507A1 (en) | 2001-11-08 |
| AU2001238507B2 AU2001238507B2 (en) | 2004-04-22 |
| AU2001238507C1 AU2001238507C1 (en) | 2005-02-24 |
| AU2001238507C9 true AU2001238507C9 (en) | 2005-07-07 |
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| AU3850701A Pending AU3850701A (en) | 2000-02-18 | 2001-02-20 | Micelles |
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| EP (2) | EP2452684B1 (enExample) |
| JP (2) | JP4959085B2 (enExample) |
| KR (1) | KR100841813B1 (enExample) |
| AU (2) | AU2001238507C9 (enExample) |
| CA (1) | CA2400371C (enExample) |
| ES (1) | ES2664818T3 (enExample) |
| HK (1) | HK1052872A1 (enExample) |
| IL (2) | IL151314A0 (enExample) |
| WO (1) | WO2001060382A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US20030130212A1 (en) * | 1999-01-14 | 2003-07-10 | Rossignol Daniel P. | Administration of an anti-endotoxin drug by intravenous infusion |
| AU2001238507C9 (en) * | 2000-02-18 | 2005-07-07 | Eisai R&D Management Co., Ltd. | Micelles |
| JP4366081B2 (ja) * | 2001-05-22 | 2009-11-18 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 高度に精製されたアンチエンドトキシン化合物 |
| US7727974B2 (en) | 2001-08-10 | 2010-06-01 | Eisai R & D Management Co., Ltd. | Methods of reducing the severity of mucositis |
| WO2003013440A2 (en) * | 2001-08-10 | 2003-02-20 | Eisai Co., Ltd. | Treatment and prevention of heat shock protein-associated diseases and conditions |
| WO2003082303A1 (en) * | 2002-03-29 | 2003-10-09 | Wisconsin Alumni Research Foundation | Polymeric micelle formulations of hydrophobic compounds and methods |
| WO2004034992A2 (en) * | 2002-10-15 | 2004-04-29 | Wisconsin Alumni Research Foundation | Encapsulation and deaggregation of polyene antibiotics using poly(ethylene glycol)-phospholipid micelles |
| CA2536283A1 (en) * | 2003-08-20 | 2005-03-03 | Ajinomoto Co., Inc. | Pharmaceutical preparations having an improved solubility |
| ATE446581T1 (de) * | 2004-03-12 | 2009-11-15 | Trinity College Dublin | Magnetoresistives medium |
| WO2007026675A1 (ja) * | 2005-08-31 | 2007-03-08 | Eisai R & D Management Co., Ltd. | リピッドａ類縁体の製造方法 |
| US20070249572A1 (en) * | 2005-12-20 | 2007-10-25 | Verus Pharmaceuticals, Inc. | Systems and methods for the delivery of corticosteroids |
| US20070178049A1 (en) * | 2005-12-20 | 2007-08-02 | Verus Pharmaceuticals, Inc. | Systems and methods for the delivery of corticosteroids having an enhanced pharmacokinetic profile |
| US20070197486A1 (en) * | 2005-12-20 | 2007-08-23 | Verus Pharmaceuticals, Inc. | Methods and systems for the delivery of corticosteroids |
| US20070160542A1 (en) * | 2005-12-20 | 2007-07-12 | Verus Pharmaceuticals, Inc. | Methods and systems for the delivery of corticosteroids having an enhanced pharmacokinetic profile |
| US20070185066A1 (en) * | 2005-12-20 | 2007-08-09 | Verus Pharmaceuticals, Inc. | Systems and methods for the delivery of corticosteroids |
| JP2009526619A (ja) * | 2006-02-15 | 2009-07-23 | ティカ レーケメデル アーベー | 質量減量を伴うコルチコステロイドの滅菌 |
| BR112014024139A8 (pt) | 2012-03-28 | 2018-01-16 | Univ Maryland | administração de eritoran ou sais farmaceuticamente aceitáveis do mesmo para tratar infecções de ortomixovírus |
| WO2018053073A1 (en) | 2016-09-16 | 2018-03-22 | Eisai R&D Management Co., Ltd. | Method of use of eritoran as a tlr4 antagonist for treatment of ebola and marburg disease |
| BR112021010717A2 (pt) | 2018-12-17 | 2021-08-31 | Eisai R&D Management Co., Ltd. | Formulação que compreende lipossomas |
| US11198831B2 (en) | 2019-01-31 | 2021-12-14 | Kvi Llc | Lubricant for a device |
| WO2021207218A1 (en) | 2020-04-06 | 2021-10-14 | Eisai R&D Management Co., Ltd. | Treatment of nidovirales infection with eritoran |
Family Cites Families (17)
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| US5530113A (en) | 1991-10-11 | 1996-06-25 | Eisai Co., Ltd. | Anti-endotoxin compounds |
| US6417172B1 (en) | 1995-06-05 | 2002-07-09 | Eisai Co., Ltd. | Prevention and treatment of pulmonary bacterial infection or symptomatic pulmonary exposure to endotoxin by inhalation of antiendotoxin drugs |
| US5681824A (en) | 1995-06-05 | 1997-10-28 | Eisai Co., Ltd. | Substituted liposaccharides useful in the treatment and prevention of endotoxemia |
| AU7254396A (en) * | 1995-09-29 | 1997-04-17 | Eisai Research Institute | Method for treating alcoholic liver disease |
| JP4326030B2 (ja) * | 1996-07-03 | 2009-09-02 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | リピッドａ類縁体含有注射用製剤及びその製造方法 |
| US6235724B1 (en) * | 1996-07-03 | 2001-05-22 | Eisai Co., Ltd. | Injections containing lipid a analogues and process for the preparation thereof |
| US6495532B1 (en) | 1997-03-19 | 2002-12-17 | Sky High, Llc | Compositions containing lysophosphotidic acids which inhibit apoptosis and uses thereof |
| JP2002501540A (ja) | 1997-05-23 | 2002-01-15 | エーザイ株式会社 | 製薬製剤を調製するための方法 |
| US6437006B1 (en) | 1999-09-27 | 2002-08-20 | American Cyanamid Company | Pharmaceutical carrier formulation |
| EP1250141A4 (en) | 2000-01-14 | 2007-05-16 | Eisai Co Ltd | Prevention and treatment of endotoxemia and related complications in the field of surgery |
| AU2001238507C9 (en) | 2000-02-18 | 2005-07-07 | Eisai R&D Management Co., Ltd. | Micelles |
| US6861512B2 (en) | 2000-03-01 | 2005-03-01 | Eisai Co., Ltd. | Separation of olefinic isomers |
| US20030105033A1 (en) | 2000-06-09 | 2003-06-05 | Rossignol Daniel P. | Administration of an anti-endotoxin drug by bolus or intermittent intravenous infusion |
| JP4179881B2 (ja) | 2000-12-06 | 2008-11-12 | エーザイ株式会社 | 凍結乾燥ケークの抵抗を測定するためのシステム及び方法 |
| WO2002089743A2 (en) | 2001-05-09 | 2002-11-14 | The Regents Of The University Of Michigan | Use of compositions for treating rosacea |
| US7727974B2 (en) | 2001-08-10 | 2010-06-01 | Eisai R & D Management Co., Ltd. | Methods of reducing the severity of mucositis |
| AU2004218358A1 (en) | 2003-03-05 | 2004-09-16 | Eisai R&D Management Co., Ltd. | Compositions and methods for preventing and treating endotoxin-related diseases and conditions |
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2001
- 2001-02-20 AU AU2001238507A patent/AU2001238507C9/en not_active Expired
- 2001-02-20 IL IL15131401A patent/IL151314A0/xx active IP Right Grant
- 2001-02-20 WO PCT/US2001/005297 patent/WO2001060382A1/en not_active Ceased
- 2001-02-20 EP EP12154683.2A patent/EP2452684B1/en not_active Expired - Lifetime
- 2001-02-20 ES ES12154683.2T patent/ES2664818T3/es not_active Expired - Lifetime
- 2001-02-20 JP JP2001559478A patent/JP4959085B2/ja not_active Expired - Lifetime
- 2001-02-20 AU AU3850701A patent/AU3850701A/xx active Pending
- 2001-02-20 US US10/204,227 patent/US6906042B2/en not_active Expired - Lifetime
- 2001-02-20 HK HK03105085.2A patent/HK1052872A1/zh unknown
- 2001-02-20 CA CA002400371A patent/CA2400371C/en not_active Expired - Lifetime
- 2001-02-20 EP EP01910952.9A patent/EP1274443B1/en not_active Expired - Lifetime
- 2001-02-20 KR KR1020027010810A patent/KR100841813B1/ko not_active Expired - Lifetime
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2002
- 2002-08-18 IL IL151314A patent/IL151314A/en unknown
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2005
- 2005-04-15 US US11/106,654 patent/US7390793B2/en not_active Expired - Lifetime
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2008
- 2008-06-19 US US12/142,608 patent/US7989432B2/en not_active Expired - Fee Related
-
2012
- 2012-02-09 JP JP2012025659A patent/JP2012116860A/ja active Pending
Non-Patent Citations (1)
| Title |
|---|
| References cited in WO 01/60382 * |
Also Published As
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| AU2001238507B2 (en) | 2004-04-22 |
| AU2001238507C1 (en) | 2005-02-24 |
| WO2001060382A1 (en) | 2001-08-23 |
| JP2012116860A (ja) | 2012-06-21 |
| EP2452684B1 (en) | 2018-01-24 |
| US6906042B2 (en) | 2005-06-14 |
| IL151314A (en) | 2007-06-03 |
| CA2400371A1 (en) | 2001-08-23 |
| HK1052872A1 (zh) | 2003-10-03 |
| US7989432B2 (en) | 2011-08-02 |
| EP1274443B1 (en) | 2017-05-10 |
| KR100841813B1 (ko) | 2008-06-26 |
| US20030216331A1 (en) | 2003-11-20 |
| KR20030011774A (ko) | 2003-02-11 |
| JP2003522797A (ja) | 2003-07-29 |
| US20050181039A1 (en) | 2005-08-18 |
| ES2664818T3 (es) | 2018-04-23 |
| EP2452684A3 (en) | 2012-10-03 |
| US7390793B2 (en) | 2008-06-24 |
| JP4959085B2 (ja) | 2012-06-20 |
| AU3850701A (en) | 2001-08-27 |
| EP2452684A2 (en) | 2012-05-16 |
| EP1274443A1 (en) | 2003-01-15 |
| IL151314A0 (en) | 2003-04-10 |
| US20090136564A1 (en) | 2009-05-28 |
| EP1274443A4 (en) | 2008-12-31 |
| CA2400371C (en) | 2009-12-08 |
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Free format text: THE NATURE OF THE AMENDMENT IS AS SHOWN IN THE STATEMENT(S) FILED 02 JUN 2004. |
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| DA3 | Amendments made section 104 |
Free format text: THE NATURE OF THE AMENDMENT IS AS SHOWN IN THE STATEMENT(S) FILED 02 JUN 2004 |
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| SREP | Specification republished | ||
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Owner name: EISAI R&D MANAGEMENT CO., LTD. Free format text: FORMER OWNER WAS: EISAI CO., LTD. |
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| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |