JP4959085B2 - ミセル - Google Patents

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Publication number
JP4959085B2
JP4959085B2 JP2001559478A JP2001559478A JP4959085B2 JP 4959085 B2 JP4959085 B2 JP 4959085B2 JP 2001559478 A JP2001559478 A JP 2001559478A JP 2001559478 A JP2001559478 A JP 2001559478A JP 4959085 B2 JP4959085 B2 JP 4959085B2
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JP
Japan
Prior art keywords
hydrodynamic diameter
micelle
aqueous solution
compound
branched
Prior art date
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Expired - Lifetime
Application number
JP2001559478A
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English (en)
Japanese (ja)
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JP2003522797A5 (enExample
JP2003522797A (ja
Inventor
ジェームズ マクシェイン
トーリー アレンズ
和裕 金子
知仁 渡邊
一英 芦澤
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai R&D Management Co Ltd
Original Assignee
Eisai R&D Management Co Ltd
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Publication date
Application filed by Eisai R&D Management Co Ltd filed Critical Eisai R&D Management Co Ltd
Publication of JP2003522797A publication Critical patent/JP2003522797A/ja
Publication of JP2003522797A5 publication Critical patent/JP2003522797A5/ja
Application granted granted Critical
Publication of JP4959085B2 publication Critical patent/JP4959085B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7024—Esters of saccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/665—Phosphorus compounds having oxygen as a ring hetero atom, e.g. fosfomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2001559478A 2000-02-18 2001-02-20 ミセル Expired - Lifetime JP4959085B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18376800P 2000-02-18 2000-02-18
US60/183,768 2000-02-18
PCT/US2001/005297 WO2001060382A1 (en) 2000-02-18 2001-02-20 Micelles

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2012025659A Division JP2012116860A (ja) 2000-02-18 2012-02-09 ミセル

Publications (3)

Publication Number Publication Date
JP2003522797A JP2003522797A (ja) 2003-07-29
JP2003522797A5 JP2003522797A5 (enExample) 2011-11-04
JP4959085B2 true JP4959085B2 (ja) 2012-06-20

Family

ID=22674206

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2001559478A Expired - Lifetime JP4959085B2 (ja) 2000-02-18 2001-02-20 ミセル
JP2012025659A Pending JP2012116860A (ja) 2000-02-18 2012-02-09 ミセル

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2012025659A Pending JP2012116860A (ja) 2000-02-18 2012-02-09 ミセル

Country Status (10)

Country Link
US (3) US6906042B2 (enExample)
EP (2) EP2452684B1 (enExample)
JP (2) JP4959085B2 (enExample)
KR (1) KR100841813B1 (enExample)
AU (2) AU2001238507C9 (enExample)
CA (1) CA2400371C (enExample)
ES (1) ES2664818T3 (enExample)
HK (1) HK1052872A1 (enExample)
IL (2) IL151314A0 (enExample)
WO (1) WO2001060382A1 (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030130212A1 (en) * 1999-01-14 2003-07-10 Rossignol Daniel P. Administration of an anti-endotoxin drug by intravenous infusion
AU2001238507C9 (en) * 2000-02-18 2005-07-07 Eisai R&D Management Co., Ltd. Micelles
JP4366081B2 (ja) * 2001-05-22 2009-11-18 エーザイ・アール・アンド・ディー・マネジメント株式会社 高度に精製されたアンチエンドトキシン化合物
US7727974B2 (en) 2001-08-10 2010-06-01 Eisai R & D Management Co., Ltd. Methods of reducing the severity of mucositis
WO2003013440A2 (en) * 2001-08-10 2003-02-20 Eisai Co., Ltd. Treatment and prevention of heat shock protein-associated diseases and conditions
WO2003082303A1 (en) * 2002-03-29 2003-10-09 Wisconsin Alumni Research Foundation Polymeric micelle formulations of hydrophobic compounds and methods
WO2004034992A2 (en) * 2002-10-15 2004-04-29 Wisconsin Alumni Research Foundation Encapsulation and deaggregation of polyene antibiotics using poly(ethylene glycol)-phospholipid micelles
CA2536283A1 (en) * 2003-08-20 2005-03-03 Ajinomoto Co., Inc. Pharmaceutical preparations having an improved solubility
ATE446581T1 (de) * 2004-03-12 2009-11-15 Trinity College Dublin Magnetoresistives medium
WO2007026675A1 (ja) * 2005-08-31 2007-03-08 Eisai R & D Management Co., Ltd. リピッドａ類縁体の製造方法
US20070249572A1 (en) * 2005-12-20 2007-10-25 Verus Pharmaceuticals, Inc. Systems and methods for the delivery of corticosteroids
US20070178049A1 (en) * 2005-12-20 2007-08-02 Verus Pharmaceuticals, Inc. Systems and methods for the delivery of corticosteroids having an enhanced pharmacokinetic profile
US20070197486A1 (en) * 2005-12-20 2007-08-23 Verus Pharmaceuticals, Inc. Methods and systems for the delivery of corticosteroids
US20070160542A1 (en) * 2005-12-20 2007-07-12 Verus Pharmaceuticals, Inc. Methods and systems for the delivery of corticosteroids having an enhanced pharmacokinetic profile
US20070185066A1 (en) * 2005-12-20 2007-08-09 Verus Pharmaceuticals, Inc. Systems and methods for the delivery of corticosteroids
JP2009526619A (ja) * 2006-02-15 2009-07-23 ティカ レーケメデル アーベー 質量減量を伴うコルチコステロイドの滅菌
BR112014024139A8 (pt) 2012-03-28 2018-01-16 Univ Maryland administração de eritoran ou sais farmaceuticamente aceitáveis do mesmo para tratar infecções de ortomixovírus
WO2018053073A1 (en) 2016-09-16 2018-03-22 Eisai R&D Management Co., Ltd. Method of use of eritoran as a tlr4 antagonist for treatment of ebola and marburg disease
BR112021010717A2 (pt) 2018-12-17 2021-08-31 Eisai R&D Management Co., Ltd. Formulação que compreende lipossomas
US11198831B2 (en) 2019-01-31 2021-12-14 Kvi Llc Lubricant for a device
WO2021207218A1 (en) 2020-04-06 2021-10-14 Eisai R&D Management Co., Ltd. Treatment of nidovirales infection with eritoran

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH1171284A (ja) * 1996-07-03 1999-03-16 Eisai Co Ltd リピッドａ類縁体含有注射用製剤及びその製造方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5530113A (en) 1991-10-11 1996-06-25 Eisai Co., Ltd. Anti-endotoxin compounds
US6417172B1 (en) 1995-06-05 2002-07-09 Eisai Co., Ltd. Prevention and treatment of pulmonary bacterial infection or symptomatic pulmonary exposure to endotoxin by inhalation of antiendotoxin drugs
US5681824A (en) 1995-06-05 1997-10-28 Eisai Co., Ltd. Substituted liposaccharides useful in the treatment and prevention of endotoxemia
AU7254396A (en) * 1995-09-29 1997-04-17 Eisai Research Institute Method for treating alcoholic liver disease
US6235724B1 (en) * 1996-07-03 2001-05-22 Eisai Co., Ltd. Injections containing lipid a analogues and process for the preparation thereof
US6495532B1 (en) 1997-03-19 2002-12-17 Sky High, Llc Compositions containing lysophosphotidic acids which inhibit apoptosis and uses thereof
JP2002501540A (ja) 1997-05-23 2002-01-15 エーザイ株式会社 製薬製剤を調製するための方法
US6437006B1 (en) 1999-09-27 2002-08-20 American Cyanamid Company Pharmaceutical carrier formulation
EP1250141A4 (en) 2000-01-14 2007-05-16 Eisai Co Ltd Prevention and treatment of endotoxemia and related complications in the field of surgery
AU2001238507C9 (en) 2000-02-18 2005-07-07 Eisai R&D Management Co., Ltd. Micelles
US6861512B2 (en) 2000-03-01 2005-03-01 Eisai Co., Ltd. Separation of olefinic isomers
US20030105033A1 (en) 2000-06-09 2003-06-05 Rossignol Daniel P. Administration of an anti-endotoxin drug by bolus or intermittent intravenous infusion
JP4179881B2 (ja) 2000-12-06 2008-11-12 エーザイ株式会社 凍結乾燥ケークの抵抗を測定するためのシステム及び方法
WO2002089743A2 (en) 2001-05-09 2002-11-14 The Regents Of The University Of Michigan Use of compositions for treating rosacea
US7727974B2 (en) 2001-08-10 2010-06-01 Eisai R & D Management Co., Ltd. Methods of reducing the severity of mucositis
AU2004218358A1 (en) 2003-03-05 2004-09-16 Eisai R&D Management Co., Ltd. Compositions and methods for preventing and treating endotoxin-related diseases and conditions

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH1171284A (ja) * 1996-07-03 1999-03-16 Eisai Co Ltd リピッドａ類縁体含有注射用製剤及びその製造方法

Also Published As

Publication number Publication date
AU2001238507B2 (en) 2004-04-22
AU2001238507C1 (en) 2005-02-24
WO2001060382A1 (en) 2001-08-23
JP2012116860A (ja) 2012-06-21
EP2452684B1 (en) 2018-01-24
US6906042B2 (en) 2005-06-14
IL151314A (en) 2007-06-03
CA2400371A1 (en) 2001-08-23
HK1052872A1 (zh) 2003-10-03
US7989432B2 (en) 2011-08-02
EP1274443B1 (en) 2017-05-10
KR100841813B1 (ko) 2008-06-26
US20030216331A1 (en) 2003-11-20
KR20030011774A (ko) 2003-02-11
JP2003522797A (ja) 2003-07-29
AU2001238507C9 (en) 2005-07-07
US20050181039A1 (en) 2005-08-18
ES2664818T3 (es) 2018-04-23
EP2452684A3 (en) 2012-10-03
US7390793B2 (en) 2008-06-24
AU3850701A (en) 2001-08-27
EP2452684A2 (en) 2012-05-16
EP1274443A1 (en) 2003-01-15
IL151314A0 (en) 2003-04-10
US20090136564A1 (en) 2009-05-28
EP1274443A4 (en) 2008-12-31
CA2400371C (en) 2009-12-08

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