AU2001234943A1 - A method for synthesizing leflunomide - Google Patents
A method for synthesizing leflunomideInfo
- Publication number
- AU2001234943A1 AU2001234943A1 AU2001234943A AU3494301A AU2001234943A1 AU 2001234943 A1 AU2001234943 A1 AU 2001234943A1 AU 2001234943 A AU2001234943 A AU 2001234943A AU 3494301 A AU3494301 A AU 3494301A AU 2001234943 A1 AU2001234943 A1 AU 2001234943A1
- Authority
- AU
- Australia
- Prior art keywords
- leflunomide
- methylisoxazole
- carboxylic acid
- trifluoromethylphenyl
- acid chloride
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Otolaryngology (AREA)
- Transplantation (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Emergency Medicine (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US18263500P | 2000-02-15 | 2000-02-15 | |
US60182635 | 2000-02-15 | ||
PCT/US2001/004095 WO2001060363A1 (fr) | 2000-02-15 | 2001-02-08 | Procede permettant d'effectuer la synthese du leflunomide |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2001234943A1 true AU2001234943A1 (en) | 2001-08-27 |
Family
ID=22669359
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2001234943A Abandoned AU2001234943A1 (en) | 2000-02-15 | 2001-02-08 | A method for synthesizing leflunomide |
Country Status (18)
Country | Link |
---|---|
US (2) | US6723855B2 (fr) |
EP (1) | EP1257270B1 (fr) |
JP (1) | JP2004500380A (fr) |
KR (1) | KR20020072312A (fr) |
AT (1) | ATE292966T1 (fr) |
AU (1) | AU2001234943A1 (fr) |
CA (1) | CA2400290A1 (fr) |
CZ (1) | CZ20023024A3 (fr) |
DE (1) | DE60110043T2 (fr) |
ES (1) | ES2237553T3 (fr) |
HR (1) | HRP20020671A2 (fr) |
HU (1) | HUP0301865A3 (fr) |
IL (1) | IL151196A0 (fr) |
PL (1) | PL366088A1 (fr) |
SK (1) | SK12992002A3 (fr) |
WO (1) | WO2001060363A1 (fr) |
YU (1) | YU61602A (fr) |
ZA (1) | ZA200206494B (fr) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0903345B1 (fr) * | 1997-08-08 | 2000-10-04 | Aventis Pharma Deutschland GmbH | Forme cristalline de N-(4-trifluorométhylphényl)-5-méthylisoxazole-4-carboxamid |
CA2397601A1 (fr) * | 1999-12-16 | 2001-06-21 | Teva Pharmaceutical Industries, Ltd. | Nouveaux procedes de preparation d'une nouvelle forme cristalline de leflunomide et nouvelle forme cristalline de leflunomide |
GB0123571D0 (en) * | 2001-04-05 | 2001-11-21 | Aventis Pharm Prod Inc | Use of (Z)-2-cyano-3-hydroxy-but-2-enoic acid-(4'-trifluoromethylphenyl)-amide for treating multiple sclerosis |
US20030139606A1 (en) * | 2001-11-09 | 2003-07-24 | Ray Anup Kumar | Process for preparing 5-methylisoxazole-4-carboxylic- (4'-trifluoromethyl)-anilide |
JP4776537B2 (ja) * | 2003-05-27 | 2011-09-21 | ロベルト・ペール・ヘーガークヴィスト | 糖尿病処置のためのチロシンキナーゼ阻害剤の使用 |
AU2003300692A1 (en) * | 2003-10-30 | 2005-05-19 | Lupin Ltd. | Stable formulations of ace inhibitors and methods for preparation thereof |
US20060024376A1 (en) * | 2004-07-30 | 2006-02-02 | The University Of Chicago | Methods and compositions for reducing toxicity associated with leflunomide treatment |
DE102005017592A1 (de) * | 2005-04-16 | 2006-10-19 | Lindner, Jürgen, Dr. med. | Darreichungsformen und Kombinationspräparate von Pyrimidinbiosyntheseinhibitoren zur Erzielung zusätzlicher Wirkungen auf das Immunsystem |
WO2007086076A2 (fr) * | 2006-01-24 | 2007-08-02 | Unichem Laboratories Limited | Procede ameliore de preparation de leflunomide |
CN101817797B (zh) * | 2009-02-26 | 2013-04-10 | 江苏亚邦爱普森药业有限公司 | 高纯度3-甲基-n-[4-(三氟甲基)苯基]-4-异噁唑甲酰胺的合成方法 |
NZ617025A (en) | 2009-09-18 | 2014-03-28 | Sanofi Sa | (z)-2-cyano-3-hydroxy-but-2-enoic acid-(4’-trifluormethylphenyl)-amide tablet formulations with improved stability |
CN102002009B (zh) * | 2010-10-18 | 2012-11-07 | 齐鲁制药有限公司 | 一种5-甲基异恶唑-4-甲酰氯的制备方法 |
KR20180018697A (ko) | 2015-06-17 | 2018-02-21 | 바이오콘 리미티드 | 테리플루노미드의 신규한 제조 공정 |
JOP20190207A1 (ar) | 2017-03-14 | 2019-09-10 | Actelion Pharmaceuticals Ltd | تركيبة صيدلانية تشتمل على بونيسيمود |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2854439A1 (de) | 1978-12-16 | 1980-07-03 | Hoechst Ag | Ein isoxazolderivat, verfahren zu seiner herstellung, diese verbindung enthaltende mittel und verwendung |
GB8619432D0 (en) | 1986-08-08 | 1986-09-17 | Lilly Industries Ltd | Pharmaceutical compounds |
BR9008022A (pt) * | 1990-05-18 | 1993-04-06 | Hoechst Ag | Amida de acido isoxazol-4-carboxilico e amidas de acido hidroxialquilideno-cianoacetico,medicamentos contendo estes compostos e sua aplicacao |
ATE174218T1 (de) | 1993-01-08 | 1998-12-15 | Hoechst Ag | Verwendung von leflunomid zur hemmung von interleukin 1 beta |
US5610173A (en) | 1994-01-07 | 1997-03-11 | Sugen, Inc. | Formulations for lipophilic compounds |
EP0903345B1 (fr) * | 1997-08-08 | 2000-10-04 | Aventis Pharma Deutschland GmbH | Forme cristalline de N-(4-trifluorométhylphényl)-5-méthylisoxazole-4-carboxamid |
DE19908527C2 (de) * | 1999-02-26 | 2001-08-30 | Aventis Pharma Gmbh | Verfahren zur Kristallisation von N-(4-Trifluormethylphenyl)-5-methyl-isoxazol-4-carboxamid |
CA2397601A1 (fr) * | 1999-12-16 | 2001-06-21 | Teva Pharmaceutical Industries, Ltd. | Nouveaux procedes de preparation d'une nouvelle forme cristalline de leflunomide et nouvelle forme cristalline de leflunomide |
-
2001
- 2001-02-08 US US09/779,928 patent/US6723855B2/en not_active Expired - Fee Related
- 2001-02-08 AT AT01907127T patent/ATE292966T1/de not_active IP Right Cessation
- 2001-02-08 ES ES01907127T patent/ES2237553T3/es not_active Expired - Lifetime
- 2001-02-08 IL IL15119601A patent/IL151196A0/xx unknown
- 2001-02-08 JP JP2001559460A patent/JP2004500380A/ja active Pending
- 2001-02-08 WO PCT/US2001/004095 patent/WO2001060363A1/fr not_active Application Discontinuation
- 2001-02-08 YU YU61602A patent/YU61602A/sh unknown
- 2001-02-08 CA CA002400290A patent/CA2400290A1/fr not_active Abandoned
- 2001-02-08 AU AU2001234943A patent/AU2001234943A1/en not_active Abandoned
- 2001-02-08 KR KR1020027010595A patent/KR20020072312A/ko not_active Application Discontinuation
- 2001-02-08 HU HU0301865A patent/HUP0301865A3/hu unknown
- 2001-02-08 DE DE60110043T patent/DE60110043T2/de not_active Expired - Fee Related
- 2001-02-08 PL PL01366088A patent/PL366088A1/xx not_active Application Discontinuation
- 2001-02-08 EP EP01907127A patent/EP1257270B1/fr not_active Expired - Lifetime
- 2001-02-08 SK SK1299-2002A patent/SK12992002A3/sk unknown
- 2001-02-08 CZ CZ20023024A patent/CZ20023024A3/cs unknown
-
2002
- 2002-08-14 HR HRP20020671 patent/HRP20020671A2/hr not_active Application Discontinuation
- 2002-08-14 ZA ZA200206494A patent/ZA200206494B/en unknown
-
2003
- 2003-12-10 US US10/730,949 patent/US20040127532A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
HRP20020671A2 (en) | 2004-12-31 |
HUP0301865A3 (en) | 2005-12-28 |
YU61602A (sh) | 2006-01-16 |
CZ20023024A3 (cs) | 2003-05-14 |
DE60110043T2 (de) | 2006-03-02 |
JP2004500380A (ja) | 2004-01-08 |
WO2001060363A1 (fr) | 2001-08-23 |
EP1257270A4 (fr) | 2003-05-07 |
SK12992002A3 (sk) | 2003-05-02 |
CA2400290A1 (fr) | 2001-08-23 |
PL366088A1 (en) | 2005-01-24 |
HUP0301865A2 (hu) | 2003-09-29 |
US20040127532A1 (en) | 2004-07-01 |
IL151196A0 (en) | 2003-04-10 |
ZA200206494B (en) | 2003-08-20 |
US6723855B2 (en) | 2004-04-20 |
US20020022646A1 (en) | 2002-02-21 |
DE60110043D1 (de) | 2005-05-19 |
EP1257270B1 (fr) | 2005-04-13 |
ES2237553T3 (es) | 2005-08-01 |
ATE292966T1 (de) | 2005-04-15 |
EP1257270A1 (fr) | 2002-11-20 |
KR20020072312A (ko) | 2002-09-14 |
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