ATE88723T1 - Heparinderivate, verfahren zu deren herstellung und verwendung fuer pharmazeutische zwecke. - Google Patents

Heparinderivate, verfahren zu deren herstellung und verwendung fuer pharmazeutische zwecke.

Info

Publication number
ATE88723T1
ATE88723T1 AT88850184T AT88850184T ATE88723T1 AT E88723 T1 ATE88723 T1 AT E88723T1 AT 88850184 T AT88850184 T AT 88850184T AT 88850184 T AT88850184 T AT 88850184T AT E88723 T1 ATE88723 T1 AT E88723T1
Authority
AT
Austria
Prior art keywords
heparin
heparan sulfate
processes
production
pharmaceutical purposes
Prior art date
Application number
AT88850184T
Other languages
English (en)
Inventor
Karin Helena Louise Bergendal
Rolf Arne Johansson
Carl Magnus Erik Svahn
Original Assignee
Kabi Pharmacia Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kabi Pharmacia Ab filed Critical Kabi Pharmacia Ab
Application granted granted Critical
Publication of ATE88723T1 publication Critical patent/ATE88723T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Saccharide Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
AT88850184T 1987-05-29 1988-05-26 Heparinderivate, verfahren zu deren herstellung und verwendung fuer pharmazeutische zwecke. ATE88723T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE8702254A SE8702254D0 (sv) 1987-05-29 1987-05-29 Novel heparin derivatives
EP88850184A EP0302034B1 (de) 1987-05-29 1988-05-26 Heparinderivate, Verfahren zu deren Herstellung und Verwendung für pharmazeutische Zwecke

Publications (1)

Publication Number Publication Date
ATE88723T1 true ATE88723T1 (de) 1993-05-15

Family

ID=20368699

Family Applications (1)

Application Number Title Priority Date Filing Date
AT88850184T ATE88723T1 (de) 1987-05-29 1988-05-26 Heparinderivate, verfahren zu deren herstellung und verwendung fuer pharmazeutische zwecke.

Country Status (11)

Country Link
US (1) US5039529A (de)
EP (2) EP0302034B1 (de)
JP (1) JPH01503548A (de)
AT (1) ATE88723T1 (de)
AU (1) AU1936988A (de)
DE (1) DE3880577T2 (de)
DK (1) DK21989A (de)
ES (1) ES2054875T3 (de)
FI (1) FI890340A (de)
SE (1) SE8702254D0 (de)
WO (1) WO1988009347A1 (de)

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US5336620A (en) * 1993-01-27 1994-08-09 American Home Products Corporation Process for the production of an anticoagulant composition
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AU1831195A (en) * 1994-01-13 1995-08-01 Research Foundation For Mental Hygiene, Inc. Methods and compositions for treatment and diagnosis of alzheimer disease and other disorders
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US5856535A (en) * 1994-08-18 1999-01-05 Magainin Pharmaceuticals, Inc. Aminosterol ester compounds
US5840740A (en) * 1995-06-07 1998-11-24 Magainin Pharmaceuticals Inc. Aminosterol compounds and a method of treating infection using the aminosterol compounds
DE4429660B4 (de) * 1994-08-20 2004-02-12 Dade Behring Marburg Gmbh Zusatzmittel für diagnostische Tests zur Bestimmung der Gerinnungsfähigkeit des Blutes, Verfahren zur Reduzierung der Beeinflussung von diagnostischen Tests durch Heparin und Verwendung von Metallsalzen zu diesen Zwecken
US7404967B2 (en) * 1994-12-21 2008-07-29 Cosmederm, Inc. Topical product formulations containing strontium for reducing skin irritation
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US5795885A (en) * 1995-06-07 1998-08-18 Magainin Pharmaceuticals Inc. Method of inhibiting profileration of cells by administering an aminosterol compound
US5840936A (en) * 1995-06-07 1998-11-24 Magainin Pharmaceuticals Inc. Aminosterol compounds useful as inhibitors of the sodium/proton exchanger (NHE)
US6143738A (en) * 1995-06-07 2000-11-07 Magainin Pharmaceuticals, Inc. Therapeutic uses for an aminosterol compound
US5994336A (en) * 1995-06-07 1999-11-30 Magainin Pharmaceuticals Inc. Method of inhibiting proliferation of cells by administering an aminosterol compound
US5763430A (en) * 1995-06-07 1998-06-09 Magainin Pharmaceuticals Inc. Method of treating a viral infection by administering a steroid compound
US5847172A (en) * 1995-06-07 1998-12-08 Magainin Pharmaceuticals Inc. Certain aminosterol compounds and pharmaceutical compositions including these compounds
US5792635A (en) * 1995-06-07 1998-08-11 Magainin Pharmaceuticals, Inc. Method of inhibiting the sodium/proton exchanger NHE3 and method of inhibiting growth by administering squalamine
US5874597A (en) * 1995-06-07 1999-02-23 Magainin Pharmaceuticals, Inc. Certain aminosterol compounds and pharmaceutical compositions including these compounds
US6106866A (en) * 1995-07-31 2000-08-22 Access Pharmaceuticals, Inc. In vivo agents comprising cationic drugs, peptides and metal chelators with acidic saccharides and glycosaminoglycans, giving improved site-selective localization, uptake mechanism, sensitivity and kinetic-spatial profiles, including tumor sites
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ATE242635T1 (de) * 1996-04-26 2003-06-15 Magainin Pharma Squalamin in kombination mit anderen antikrebs- mittelen zur behandlung von tumoren
US6596712B2 (en) 1996-04-26 2003-07-22 Genaera Corporation Treatment of carcinomas using squalamine in combination with other anti-cancer agents or modalities
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US6262283B1 (en) 1996-12-06 2001-07-17 Magainin Pharmaceuticals Inc. Stereoselective synthesis of 24-hydroxylated compounds useful for the preparation of aminosterols, vitamin D analogs, and other compounds
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US6013099A (en) 1998-04-29 2000-01-11 Medtronic, Inc. Medical device for delivering a water-insoluble therapeutic salt or substance
US7056504B1 (en) 1998-08-27 2006-06-06 Massachusetts Institute Of Technology Rationally designed heparinases derived from heparinase I and II
JP2003527822A (ja) * 1998-08-27 2003-09-24 マサチューセッツ インスティテュート オブ テクノロジー ヘパリナーゼiおよびii由来の合理的に設計されたヘパリナーゼ
WO2000065521A2 (en) * 1999-04-23 2000-11-02 Massachusetts Institute Of Technology System and method for polymer notation
WO2001066772A2 (en) * 2000-03-08 2001-09-13 Massachusetts Institute Of Technology Heparinase iii and uses thereof
DE60123939T2 (de) * 2000-04-12 2007-05-31 Genaera Corp. Ein verfahren zur herstellung von 7.alpha.-hydroxy 3-aminosubstituierten sterol-verbindungen, ohne schutz der 7.alpha.-hydroxy-gruppe
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CA2422059C (en) 2000-09-12 2012-05-15 Massachusetts Institute Of Technology Methods and products related to low molecular weight heparin
CA2423469A1 (en) * 2000-10-18 2002-04-25 Massachusetts Institute Of Technology Methods and products related to pulmonary delivery of polysaccharides
EP1421091A4 (de) * 2001-08-31 2008-02-20 Ivax Research Inc Verfahren zur sulfatierung von sacchariden
US6932978B2 (en) 2001-10-18 2005-08-23 James Benjamin Huntley Double-headed, closed-mouth cough suppressant and cold relief device
SE521676C2 (sv) 2002-01-02 2003-11-25 Dilafor Ab Användning av glykosaminoglykaner för prevention och behandling av värksvaghet vid fullgången graviditet
EP2402753A1 (de) * 2002-03-11 2012-01-04 Momenta Pharmaceuticals, Inc. Analyse von sulfatierten Polysacchariden
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US20040265943A1 (en) * 2002-09-23 2004-12-30 Aventis Pharma S.A. Method for quantitatively determining specific groups constituting heparins or low molecular weight heparins
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US20050186679A1 (en) * 2004-02-24 2005-08-25 Christian Viskov Method for determining specific groups constituting heparins or low molecular weight heparins
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Also Published As

Publication number Publication date
ES2054875T3 (es) 1994-08-16
US5039529A (en) 1991-08-13
SE8702254D0 (sv) 1987-05-29
WO1988009347A1 (en) 1988-12-01
EP0319559A1 (de) 1989-06-14
DK21989D0 (da) 1989-01-19
DE3880577D1 (de) 1993-06-03
FI890340A0 (fi) 1989-01-24
FI890340A (fi) 1989-01-24
DE3880577T2 (de) 1993-08-26
EP0302034B1 (de) 1993-04-28
JPH01503548A (ja) 1989-11-30
EP0302034A1 (de) 1989-02-01
DK21989A (da) 1989-01-19
AU1936988A (en) 1988-12-21

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee