ATE88723T1 - Heparinderivate, verfahren zu deren herstellung und verwendung fuer pharmazeutische zwecke. - Google Patents

Heparinderivate, verfahren zu deren herstellung und verwendung fuer pharmazeutische zwecke.

Info

Publication number
ATE88723T1
ATE88723T1 AT88850184T AT88850184T ATE88723T1 AT E88723 T1 ATE88723 T1 AT E88723T1 AT 88850184 T AT88850184 T AT 88850184T AT 88850184 T AT88850184 T AT 88850184T AT E88723 T1 ATE88723 T1 AT E88723T1
Authority
AT
Austria
Prior art keywords
heparin
heparan sulfate
processes
production
pharmaceutical purposes
Prior art date
Application number
AT88850184T
Other languages
English (en)
Inventor
Karin Helena Louise Bergendal
Rolf Arne Johansson
Carl Magnus Erik Svahn
Original Assignee
Kabi Pharmacia Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kabi Pharmacia Ab filed Critical Kabi Pharmacia Ab
Application granted granted Critical
Publication of ATE88723T1 publication Critical patent/ATE88723T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Saccharide Compounds (AREA)
AT88850184T 1987-05-29 1988-05-26 Heparinderivate, verfahren zu deren herstellung und verwendung fuer pharmazeutische zwecke. ATE88723T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE8702254A SE8702254D0 (sv) 1987-05-29 1987-05-29 Novel heparin derivatives
EP88850184A EP0302034B1 (de) 1987-05-29 1988-05-26 Heparinderivate, Verfahren zu deren Herstellung und Verwendung für pharmazeutische Zwecke

Publications (1)

Publication Number Publication Date
ATE88723T1 true ATE88723T1 (de) 1993-05-15

Family

ID=20368699

Family Applications (1)

Application Number Title Priority Date Filing Date
AT88850184T ATE88723T1 (de) 1987-05-29 1988-05-26 Heparinderivate, verfahren zu deren herstellung und verwendung fuer pharmazeutische zwecke.

Country Status (11)

Country Link
US (1) US5039529A (de)
EP (2) EP0302034B1 (de)
JP (1) JPH01503548A (de)
AT (1) ATE88723T1 (de)
AU (1) AU1936988A (de)
DE (1) DE3880577T2 (de)
DK (1) DK21989D0 (de)
ES (1) ES2054875T3 (de)
FI (1) FI890340A (de)
SE (1) SE8702254D0 (de)
WO (1) WO1988009347A1 (de)

Families Citing this family (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5707604A (en) * 1986-11-18 1998-01-13 Access Pharmaceuticals, Inc. Vivo agents comprising metal-ion chelates with acidic saccharides and glycosaminoglycans, giving improved site-selective localization, uptake mechanism, sensitivity and kinetic-spatial profiles
US5672334A (en) * 1991-01-16 1997-09-30 Access Pharmaceuticals, Inc. Invivo agents comprising cationic metal chelators with acidic saccharides and glycosaminoglycans
US5145841A (en) * 1987-03-19 1992-09-08 Arthropharm Pty. Limited Anti-inflammatory compounds and compositions
NL8900119A (nl) * 1989-01-19 1990-08-16 Akzo Nv Werkwijze voor het afsplitsen van (delta)4-onverzadigd uronzuur in glycosaminoglycaan fragmenten.
IT1243300B (it) * 1990-12-20 1994-05-26 Fidia Spa Derivati dell'eparina
SE9101155D0 (sv) * 1991-04-18 1991-04-18 Kabi Pharmacia Ab Novel heparin derivatives
HUT67136A (en) * 1991-05-02 1995-02-28 Yeda Res & Dev Compositions for the prevention and/or treatment of pathological processes
US6515009B1 (en) 1991-09-27 2003-02-04 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5811447A (en) 1993-01-28 1998-09-22 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
HUT72993A (en) * 1992-08-19 1996-06-28 Merrell Dow Pharma Process to prepare phatmaceutical compns. contg antiangiogenic oligomers
US5958883A (en) * 1992-09-23 1999-09-28 Board Of Regents Of The University Of Washington Office Of Technology Animal models of human amyloidoses
US6251920B1 (en) 1993-05-13 2001-06-26 Neorx Corporation Prevention and treatment of cardiovascular pathologies
US5336620A (en) * 1993-01-27 1994-08-09 American Home Products Corporation Process for the production of an anticoagulant composition
US6491938B2 (en) 1993-05-13 2002-12-10 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
ES2123133T3 (es) * 1993-03-10 1999-01-01 Magainin Pharma Derivados esteroidianos, composiciones farmaceuticas que contienen estos derivados esteroidianos y utilizacion de estos ultimos como antibioticos o desinfectantes.
US20020055710A1 (en) 1998-04-30 2002-05-09 Ronald J. Tuch Medical device for delivering a therapeutic agent and method of preparation
DE69435137D1 (de) 1993-05-13 2008-10-16 Poniard Pharmaceuticals Inc Prävention und behandlung von pathologien, die mit einer abnormalen proliferationglatter muskelzellen verbunden sind
AU1831195A (en) * 1994-01-13 1995-08-01 Research Foundation For Mental Hygiene, Inc. Methods and compositions for treatment and diagnosis of alzheimer disease and other disorders
US5783568A (en) * 1994-06-10 1998-07-21 Sugen, Inc. Methods for treating cancer and other cell proliferative diseases
US5840740A (en) * 1995-06-07 1998-11-24 Magainin Pharmaceuticals Inc. Aminosterol compounds and a method of treating infection using the aminosterol compounds
US5856535A (en) * 1994-08-18 1999-01-05 Magainin Pharmaceuticals, Inc. Aminosterol ester compounds
DE4429660B4 (de) 1994-08-20 2004-02-12 Dade Behring Marburg Gmbh Zusatzmittel für diagnostische Tests zur Bestimmung der Gerinnungsfähigkeit des Blutes, Verfahren zur Reduzierung der Beeinflussung von diagnostischen Tests durch Heparin und Verwendung von Metallsalzen zu diesen Zwecken
US7404967B2 (en) 1994-12-21 2008-07-29 Cosmederm, Inc. Topical product formulations containing strontium for reducing skin irritation
US5763427A (en) * 1995-03-31 1998-06-09 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
US6001820A (en) * 1995-03-31 1999-12-14 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
US6143738A (en) * 1995-06-07 2000-11-07 Magainin Pharmaceuticals, Inc. Therapeutic uses for an aminosterol compound
US5763430A (en) * 1995-06-07 1998-06-09 Magainin Pharmaceuticals Inc. Method of treating a viral infection by administering a steroid compound
US5795885A (en) * 1995-06-07 1998-08-18 Magainin Pharmaceuticals Inc. Method of inhibiting profileration of cells by administering an aminosterol compound
US5874597A (en) * 1995-06-07 1999-02-23 Magainin Pharmaceuticals, Inc. Certain aminosterol compounds and pharmaceutical compositions including these compounds
US5847172A (en) * 1995-06-07 1998-12-08 Magainin Pharmaceuticals Inc. Certain aminosterol compounds and pharmaceutical compositions including these compounds
US5792635A (en) * 1995-06-07 1998-08-11 Magainin Pharmaceuticals, Inc. Method of inhibiting the sodium/proton exchanger NHE3 and method of inhibiting growth by administering squalamine
US5994336A (en) * 1995-06-07 1999-11-30 Magainin Pharmaceuticals Inc. Method of inhibiting proliferation of cells by administering an aminosterol compound
US5840936A (en) * 1995-06-07 1998-11-24 Magainin Pharmaceuticals Inc. Aminosterol compounds useful as inhibitors of the sodium/proton exchanger (NHE)
US6106866A (en) * 1995-07-31 2000-08-22 Access Pharmaceuticals, Inc. In vivo agents comprising cationic drugs, peptides and metal chelators with acidic saccharides and glycosaminoglycans, giving improved site-selective localization, uptake mechanism, sensitivity and kinetic-spatial profiles, including tumor sites
CA2235223A1 (en) 1995-10-30 1997-05-09 Massachusetts Institute Of Technology Rationally designed polysaccharide lyases derived from heparinase i
CA2252584C (en) * 1996-04-26 2008-06-10 Magainin Pharmaceuticals Inc. Treatment of carcinomas using squalamine in combination with other anti-cancer agents
US6596712B2 (en) 1996-04-26 2003-07-22 Genaera Corporation Treatment of carcinomas using squalamine in combination with other anti-cancer agents or modalities
US5767269A (en) * 1996-10-01 1998-06-16 Hamilton Civic Hospitals Research Development Inc. Processes for the preparation of low-affinity, low molecular weight heparins useful as antithrombotics
US6262283B1 (en) 1996-12-06 2001-07-17 Magainin Pharmaceuticals Inc. Stereoselective synthesis of 24-hydroxylated compounds useful for the preparation of aminosterols, vitamin D analogs, and other compounds
WO1998046588A2 (en) 1997-04-11 1998-10-22 Neorx Corporation Compounds and therapies for the prevention of vascular and non-vascular pathologies
US6203536B1 (en) * 1997-06-17 2001-03-20 Medtronic, Inc. Medical device for delivering a therapeutic substance and method therefor
US6106454A (en) * 1997-06-17 2000-08-22 Medtronic, Inc. Medical device for delivering localized radiation
US6013099A (en) 1998-04-29 2000-01-11 Medtronic, Inc. Medical device for delivering a water-insoluble therapeutic salt or substance
JP2003527822A (ja) * 1998-08-27 2003-09-24 マサチューセッツ インスティテュート オブ テクノロジー ヘパリナーゼｉおよびｉｉ由来の合理的に設計されたヘパリナーゼ
US7056504B1 (en) 1998-08-27 2006-06-06 Massachusetts Institute Of Technology Rationally designed heparinases derived from heparinase I and II
CA2370539C (en) 1999-04-23 2009-01-06 Massachusetts Institute Of Technology System and method for notating polymers
CA2402160C (en) 2000-03-08 2012-02-14 Massachusetts Institute Of Technology Heparinase iii and uses thereof
CA2406847C (en) * 2000-04-12 2009-11-17 Genaera Corporation Regioselective and stereoselective oxidation of fused ring systems useful for the preparation of aminosterols
DE10028204A1 (de) * 2000-06-09 2002-01-03 Aventis Pharma Gmbh Verfahren zur Auffindung von medizinisch wertvollen Wirkstoffen
JP4911865B2 (ja) 2000-09-12 2012-04-04 マサチューセッツ インスティテュート オブ テクノロジー 低分子量ヘパリンに関連する方法および生成物
JP2004523479A (ja) * 2000-10-18 2004-08-05 マサチューセッツ　インスティテュート　オブ　テクノロジー 多糖の肺送達に関する方法および産物
CA2458651C (en) * 2001-08-31 2011-11-29 Ivax Research, Inc. Saccharide sulfation methods
US6932978B2 (en) 2001-10-18 2005-08-23 James Benjamin Huntley Double-headed, closed-mouth cough suppressant and cold relief device
SE521676C2 (sv) 2002-01-02 2003-11-25 Dilafor Ab Användning av glykosaminoglykaner för prevention och behandling av värksvaghet vid fullgången graviditet
EP2284535A1 (de) 2002-03-11 2011-02-16 Momenta Pharmaceuticals, Inc. Heparine mit niedrigem Molekulargewicht
US20040265943A1 (en) * 2002-09-23 2004-12-30 Aventis Pharma S.A. Method for quantitatively determining specific groups constituting heparins or low molecular weight heparins
FR2844808B1 (fr) * 2002-09-23 2005-02-25 Aventis Pharma Sa Methode de determination de groupements specifiques constituant les heparines ou les heparines de bas poids moleculaire
US20040171819A1 (en) 2002-10-10 2004-09-02 Aventis Pharma S.A. Mixtures of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them
CN1234371C (zh) * 2003-01-28 2006-01-04 马驷 纳米铜粉作为制备预防治疗骨质疏松、骨折药物的应用
US20050186679A1 (en) * 2004-02-24 2005-08-25 Christian Viskov Method for determining specific groups constituting heparins or low molecular weight heparins
CN102908361A (zh) * 2004-07-09 2013-02-06 罗伯特·萨宾 治疗哺乳动物疾病的组合物及使用方法
FR2880951B1 (fr) * 2005-01-19 2015-09-18 Aventis Pharma Sa Methode d'analyse d'oligosaccharides a partir de plasma sanguin
US7608246B2 (en) * 2005-09-02 2009-10-27 The Brigham And Women's Hospital, Inc. Apolipoprotein E as an adjuvant for lipid antigens
US9139876B1 (en) 2007-05-03 2015-09-22 Momenta Pharmacueticals, Inc. Method of analyzing a preparation of a low molecular weight heparin
US20090130017A1 (en) * 2007-11-19 2009-05-21 Searete Llc Targeted short-lived drug delivery
US8435795B2 (en) * 2010-01-19 2013-05-07 Momenta Pharmaceuticals, Inc. Evaluating heparin preparations
FR2956322A1 (fr) * 2010-02-17 2011-08-19 Urgo Lab Utilisation d'oligosaccharides polysulfates synthetiques comme agents de detersion d'une plaie.
WO2012115952A1 (en) 2011-02-21 2012-08-30 Momenta Pharmaceuticals, Inc. Evaluating heparin preparations
US9315587B2 (en) 2011-03-10 2016-04-19 Victoria Link Limited Oligosaccharide compounds
CN104672344B (zh) * 2015-03-25 2017-03-29 福建农林大学 一种浒苔功能性寡糖锌及其制备方法
US11471497B1 (en) 2019-03-13 2022-10-18 David Gordon Bermudes Copper chelation therapeutics
CN112079942A (zh) * 2019-06-14 2020-12-15 苏州融析生物科技有限公司 一种甲基化肝素化合物及其制备和应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE890622C (de) * 1941-10-21 1953-09-21 Joseph Elliott Kennedy Vorrichtung zum Behandeln von Schuettgut mit Gasen
CH387007A (fr) * 1958-12-15 1965-01-31 Fo We Forschungs Und Verwertun Procédé de préparation d'un complexe à action thérapeutique
FR6853M (de) * 1967-12-08 1969-04-08
CA1042001A (en) * 1973-04-13 1978-11-07 Choay S.A. Mixed heparin salts
FR2400036A1 (fr) * 1977-08-08 1979-03-09 Choay Sa Heparines purifiees et leur preparation
IT1141263B (it) * 1980-02-29 1986-10-01 Italfarmaco Spa Metodo per la preparazione di eparinato di calcio
HU193769B (en) * 1985-06-04 1987-11-30 Richter Gedeon Vegyeszet Sodium-exchanging process for producing pharmaceutically acceptable heparinates applicable even for injections

Also Published As

Publication number Publication date
ES2054875T3 (es) 1994-08-16
DK21989A (da) 1989-01-19
DE3880577T2 (de) 1993-08-26
EP0302034B1 (de) 1993-04-28
DE3880577D1 (de) 1993-06-03
SE8702254D0 (sv) 1987-05-29
AU1936988A (en) 1988-12-21
JPH01503548A (ja) 1989-11-30
DK21989D0 (da) 1989-01-19
EP0319559A1 (de) 1989-06-14
FI890340A0 (fi) 1989-01-24
EP0302034A1 (de) 1989-02-01
FI890340A (fi) 1989-01-24
US5039529A (en) 1991-08-13
WO1988009347A1 (en) 1988-12-01

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee