ATE84710T1 - Verfahren zur herstellung von kolloidalen dispergierbaren proteinsystemen, wie nanopartikeln. - Google Patents

Verfahren zur herstellung von kolloidalen dispergierbaren proteinsystemen, wie nanopartikeln.

Info

Publication number
ATE84710T1
ATE84710T1 AT89401856T AT89401856T ATE84710T1 AT E84710 T1 ATE84710 T1 AT E84710T1 AT 89401856 T AT89401856 T AT 89401856T AT 89401856 T AT89401856 T AT 89401856T AT E84710 T1 ATE84710 T1 AT E84710T1
Authority
AT
Austria
Prior art keywords
protein
nanoparticles
added
active substance
biologically active
Prior art date
Application number
AT89401856T
Other languages
German (de)
English (en)
Inventor
Serge Stainmesse
Hatem Fessi
Jean-Philippe Devissaguet
Francis Puisieux
Original Assignee
Centre Nat Rech Scient
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR888808871A external-priority patent/FR2634397B2/fr
Application filed by Centre Nat Rech Scient filed Critical Centre Nat Rech Scient
Application granted granted Critical
Publication of ATE84710T1 publication Critical patent/ATE84710T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5169—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0241—Containing particulates characterized by their shape and/or structure
    • A61K8/025—Explicitly spheroidal or spherical shape
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5192—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/12—Powdering or granulating
    • C08J3/14—Powdering or granulating by precipitation from solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/41—Particular ingredients further characterized by their size
    • A61K2800/413—Nanosized, i.e. having sizes below 100 nm
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/56—Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nanotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Birds (AREA)
  • Optics & Photonics (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
  • Biotechnology (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)
  • Colloid Chemistry (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
AT89401856T 1988-06-30 1989-06-28 Verfahren zur herstellung von kolloidalen dispergierbaren proteinsystemen, wie nanopartikeln. ATE84710T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR888808871A FR2634397B2 (fr) 1986-12-31 1988-06-30 Procede de preparation de systemes colloidaux dispersibles d'une proteine sous forme de nanoparticules
EP89401856A EP0349428B1 (fr) 1988-06-30 1989-06-28 Procédé de préparation de systèmes colloidaux dispersibles d'une protéine, sous forme de nanoparticules

Publications (1)

Publication Number Publication Date
ATE84710T1 true ATE84710T1 (de) 1993-02-15

Family

ID=9367939

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89401856T ATE84710T1 (de) 1988-06-30 1989-06-28 Verfahren zur herstellung von kolloidalen dispergierbaren proteinsystemen, wie nanopartikeln.

Country Status (7)

Country Link
EP (1) EP0349428B1 (enExample)
JP (1) JPH062224B2 (enExample)
KR (1) KR960014870B1 (enExample)
AT (1) ATE84710T1 (enExample)
DE (1) DE68904483T2 (enExample)
ES (1) ES2054052T3 (enExample)
GR (1) GR3007248T3 (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0449592B1 (en) 1990-03-27 1994-11-30 Bioelastics Research, Ltd. Bioelastomeric drug delivery system
DE4140179C2 (de) * 1991-12-05 1995-12-21 Alfatec Pharma Gmbh Akutform für ein Ibuprofen enthaltendes Arzneimittel
CA2125282C (en) * 1991-12-05 1999-08-31 Jens-Christian Wunderlich Pharmaceutically applicable nanosol and process for preparing the same
DE4140194C2 (de) * 1991-12-05 1998-02-19 Alfatec Pharma Gmbh Ein Dihydropyridinderivat in Nanosolform enthaltendes Arzneimittel und seine Herstellung
EP1683517A1 (en) 1996-08-19 2006-07-26 American Bioscience, Inc. Methods for the production of protein particles useful for delivery of pharmacological agents
WO1999033558A1 (en) * 1997-12-29 1999-07-08 Universite De Geneve Method for producing an aqueous colloidal dispersion of nanoparticles
US9700866B2 (en) 2000-12-22 2017-07-11 Baxter International Inc. Surfactant systems for delivery of organic compounds
US7193084B2 (en) 2000-12-22 2007-03-20 Baxter International Inc. Polymorphic form of itraconazole
US6884436B2 (en) 2000-12-22 2005-04-26 Baxter International Inc. Method for preparing submicron particle suspensions
US6977085B2 (en) 2000-12-22 2005-12-20 Baxter International Inc. Method for preparing submicron suspensions with polymorph control
US6607784B2 (en) 2000-12-22 2003-08-19 Baxter International Inc. Microprecipitation method for preparing submicron suspensions
US8067032B2 (en) 2000-12-22 2011-11-29 Baxter International Inc. Method for preparing submicron particles of antineoplastic agents
US20050048126A1 (en) 2000-12-22 2005-03-03 Barrett Rabinow Formulation to render an antimicrobial drug potent against organisms normally considered to be resistant to the drug
AU2002337692B2 (en) 2001-09-26 2007-09-13 Baxter International Inc. Preparation of submicron sized nanoparticles via dispersion and solvent or liquid phase removal
US20060003012A9 (en) 2001-09-26 2006-01-05 Sean Brynjelsen Preparation of submicron solid particle suspensions by sonication of multiphase systems
US7112340B2 (en) 2001-10-19 2006-09-26 Baxter International Inc. Compositions of and method for preparing stable particles in a frozen aqueous matrix
JP4290381B2 (ja) * 2002-04-11 2009-07-01 学校法人 聖マリアンナ医科大学 ピリドンカルボン酸化合物含有エマルション
EP1585548B1 (en) * 2002-12-09 2018-06-27 Abraxis BioScience, LLC Compositions and methods of delivery of pharmacological agents
US8722736B2 (en) 2007-05-22 2014-05-13 Baxter International Inc. Multi-dose concentrate esmolol with benzyl alcohol
US8426467B2 (en) 2007-05-22 2013-04-23 Baxter International Inc. Colored esmolol concentrate
DE202011000988U1 (de) 2011-04-27 2011-07-01 MEKRA Lang GmbH & Co. KG, 90765 Längenverstellbare Außenspiegelanordnung
DE102011002295B3 (de) 2011-04-27 2012-08-30 Mekra Lang Gmbh & Co. Kg Längenverstellbare Außenspiegelanordnung
DE102013022096B4 (de) * 2013-12-20 2020-10-29 Nanoval Gmbh & Co. Kg Vorrichtung und Verfahren zum tiegelfreien Schmelzen eines Materials und zum Zerstäuben des geschmolzenen Materials zum Herstellen von Pulver
ES2983813B2 (es) 2023-03-21 2025-08-11 E Grau Active Cosmetics S L U Combinación ternaria antimanchas para aclarar la piel

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3137631A (en) * 1959-12-01 1964-06-16 Faberge Inc Encapsulation in natural products
US3406119A (en) * 1965-03-05 1968-10-15 Keuffel & Esser Co Encapsulation
FR2608942B1 (fr) * 1986-12-31 1991-01-11 Centre Nat Rech Scient Procede de preparation de systemes colloidaux dispersibles d'une substance, sous forme de nanocapsules
FR2608988B1 (fr) * 1986-12-31 1991-01-11 Centre Nat Rech Scient Procede de preparation de systemes colloidaux dispersibles d'une substance, sous forme de nanoparticules

Also Published As

Publication number Publication date
JPH062224B2 (ja) 1994-01-12
EP0349428B1 (fr) 1993-01-20
ES2054052T3 (es) 1994-08-01
KR910000128A (ko) 1991-01-29
EP0349428A1 (fr) 1990-01-03
DE68904483D1 (de) 1993-03-04
JPH02149334A (ja) 1990-06-07
KR960014870B1 (ko) 1996-10-21
DE68904483T2 (de) 1993-05-19
GR3007248T3 (enExample) 1993-07-30

Similar Documents

Publication Publication Date Title
DE68904483D1 (de) Verfahren zur herstellung von kolloidalen dispergierbaren proteinsystemen, wie nanopartikeln.
ATE59402T1 (de) Verfahren zur abtrennung von cholesterin aus fettsubstanzen tierischen ursprungs und cholesterinarme fettsubstanzen.
ATE150642T1 (de) Verfahren zur kontinuierlichen herstellung von dispersen kolloide-systemen in form von nanokapseln oder nanopartikeln
ATE295745T1 (de) Hyaluronsäure-gel, verfahren zur dessen herstellung und hyaluronsäure-gel enthaltendes medizinisches material
DE3762630D1 (de) Verfahren zur herstellung von diperoxidodecandionsaeure enthaltenden agglomeraten und die verwendung derselben in bleichmitteln.
DE3752045D1 (de) Verwendung von Hydroxycarbonsäuren und Derivaten zur Herstellung topischer dermatologischer Zubereitungen zur Behandlung von Falten
DE59607548D1 (de) Verfahren zur herstellung von morphologisch einheitlichen mikrokapseln sowie nach diesem verfahren hergestellte mikrokapseln
ES2018923A6 (es) Un metodo para producir microparticulas dispersables en agua de proteina insoluble en agua.
DE69106827D1 (de) Verfahren zur Herstellung von Mikrokapseln und Gegenstände, welche eingekapseltes Material enthalten.
ATE322919T1 (de) Vorrichtung zur aufbereitung einer medizinischen flüssigkeit
FR2608988B1 (fr) Procede de preparation de systemes colloidaux dispersibles d'une substance, sous forme de nanoparticules
ZA878772B (en) Edible dispersion
ATE96167T1 (de) Verfahren zur kristallisation von enzymen.
ATE159186T1 (de) Verfahren zur erhöhung der stabilität von nanokapseln während deren lagerung
ATE147586T1 (de) Verfahren zur spontanen thermischen gelierung einer lösung eines proteins, das beim isoelektrischen ph koagulierbar ist, wie z.b. kasein, durch modifizierung des gehaltes an alkaliionen, auf diese weise erhaltene koagulate, und deren verwendung insbesondere zur herstellung von nahrungsmitteln
ATE92075T1 (de) Verfahren zur gewinnung aktiver proteine aus einer biologisch inaktiven form.
DE68924011D1 (de) Verfahren zur Herstellung von Pyrazolkarbonsäure und Derivaten.
FR2506616A1 (fr) Preparation de gamma-globuline pour injectio n intraveineuse et procede de fabrication, et agent therapeutique ainsi produit
ZA823339B (en) Purification or enrichment of biologically active proteins and agent therefor
ATE121419T1 (de) Protein l und ihre untereinheiten, mit immunglobulinbindender aktivität, verfahren zur herstellung, reagenssatz, pharmazeutische zubereitung und ein peptococcus-magnus-stamm.
DE68911836D1 (de) Benztriazolderivate und daraus abgeleitete Reagenzien zur Herstellung von chiralen Derivaten von Carbonsäuren.
ATE152432T1 (de) Herstellung von geförmten zirkoniumoxid-teilchen
DE3779063D1 (de) Verfahren zur stabilisierung von waesserigen phosphoenolbrenztraubensaeureloesungen und container dafuer.
PT90961A (pt) Processo para a obtencao de liquidos para o condicionamento de substancias dentarias ou osseas contendo acidos fosfonocarboxilicos
DE69603956D1 (de) Verfahren zur reduktion der infektiosität von potentiell infektiösem material

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time