ES2054052T3 - Procedimiento de preparacion de sistemas coloidales dispersables de una proteina en forma de nanoparticulas. - Google Patents
Procedimiento de preparacion de sistemas coloidales dispersables de una proteina en forma de nanoparticulas.Info
- Publication number
- ES2054052T3 ES2054052T3 ES89401856T ES89401856T ES2054052T3 ES 2054052 T3 ES2054052 T3 ES 2054052T3 ES 89401856 T ES89401856 T ES 89401856T ES 89401856 T ES89401856 T ES 89401856T ES 2054052 T3 ES2054052 T3 ES 2054052T3
- Authority
- ES
- Spain
- Prior art keywords
- protein
- nanoparticles
- added
- active substance
- biologically active
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5169—Proteins, e.g. albumin, gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0241—Containing particulates characterized by their shape and/or structure
- A61K8/025—Explicitly spheroidal or spherical shape
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5192—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/12—Powdering or granulating
- C08J3/14—Powdering or granulating by precipitation from solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/413—Nanosized, i.e. having sizes below 100 nm
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/56—Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Nanotechnology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Optics & Photonics (AREA)
- Biomedical Technology (AREA)
- Birds (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Polymers & Plastics (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
- Colloid Chemistry (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
EL PROCEDIMIENTO SEGUN LA INVENCION SE CARACTERIZA PORQUE: (1) SE PREPARA UNA FASE LIQUIDA CONSTITUIDA ESENCIALMENTE POR UNA DISOLUCION DE LA PROTEINA Y, EVENTUALMENTE, DE UNA SUSTANCIA BIOLOGICAMENTE ACTIVA EN AGUA O EN UNA MEZCLA ACUOSA A UNA TEMPERATURA INFERIOR A LA DE COAGULACION DE LA PROTEINA, Y PUDIENDO AÑADIRLE UNO O VARIOS TENSIOACTIVOS, (2) SE PREPARA UNA SEGUNDA FASE LIQUIDA CONSTITUIDA ESENCIALMENTE POR AGUA O UNA MEZCLA ACUOSA A UNA TEMPERATURA SUPERIOR A LA DE COAGULACION DE LA PROTEINA, PUDIENDO CONTENER UNA SUSTANCIA BIOLOGICAMENTE ACTIVA, Y PUDIENDO AÑADIRLE UNO O VARIOS TENSIOACTIVOS, (3) SE AÑADE, CON AGITACION MODERADA, UNA DE LAS FASES LIQUIDAS OBTENIDA EN (1) O (2) A LA OTRA EN CONDICONES DE PH ALEJADO DEL PUNTO ISOELECTRICO DE LA PROTEINA, DE MANERA QUE SE OBTIENE DE MODO PRACTICAMENTE INSTANTANEO UNA SUSPENSION COLOIDAL DE NANOPARTICULAS DE LA PROTEINA Y, EVENTUALMENTE, DE LA SUSTANCIA BIOLOGICAMENTE ACTIVA, Y (4), SI SE DESEA, SE ELIMINA TODA O PARTE DEL AGUA ODE LA MEZCLA ACUOSA, PARA OBTENER UNA SUSPENSION COLOIDAL DE CONCENTRACION DESEADA EN NANOPARTICULAS O PARA OBTENER UN POLVO DE NANOPARTICULAS. APLICACIONES: BIOQUIMICA, FARMACIA MEDICINA, COSMETICA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR888808871A FR2634397B2 (fr) | 1986-12-31 | 1988-06-30 | Procede de preparation de systemes colloidaux dispersibles d'une proteine sous forme de nanoparticules |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2054052T3 true ES2054052T3 (es) | 1994-08-01 |
Family
ID=9367939
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES89401856T Expired - Lifetime ES2054052T3 (es) | 1988-06-30 | 1989-06-28 | Procedimiento de preparacion de sistemas coloidales dispersables de una proteina en forma de nanoparticulas. |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP0349428B1 (es) |
JP (1) | JPH062224B2 (es) |
KR (1) | KR960014870B1 (es) |
AT (1) | ATE84710T1 (es) |
DE (1) | DE68904483T2 (es) |
ES (1) | ES2054052T3 (es) |
GR (1) | GR3007248T3 (es) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0449592B1 (en) * | 1990-03-27 | 1994-11-30 | Bioelastics Research, Ltd. | Bioelastomeric drug delivery system |
DE4140194C2 (de) * | 1991-12-05 | 1998-02-19 | Alfatec Pharma Gmbh | Ein Dihydropyridinderivat in Nanosolform enthaltendes Arzneimittel und seine Herstellung |
US5932245A (en) * | 1991-12-05 | 1999-08-03 | Alfatec Pharma Gmbh | Gelatin or collagen hydrolysate containing drug formulation that provides for immediate release of nanoparticle drug compounds |
DE4140179C2 (de) * | 1991-12-05 | 1995-12-21 | Alfatec Pharma Gmbh | Akutform für ein Ibuprofen enthaltendes Arzneimittel |
EP1683517A1 (en) | 1996-08-19 | 2006-07-26 | American Bioscience, Inc. | Methods for the production of protein particles useful for delivery of pharmacological agents |
AU5860798A (en) * | 1997-12-29 | 1999-07-19 | Universite De Geneve | Method for producing an aqueous colloidal dispersion of nanoparticles |
US8067032B2 (en) | 2000-12-22 | 2011-11-29 | Baxter International Inc. | Method for preparing submicron particles of antineoplastic agents |
US9700866B2 (en) | 2000-12-22 | 2017-07-11 | Baxter International Inc. | Surfactant systems for delivery of organic compounds |
US20050048126A1 (en) | 2000-12-22 | 2005-03-03 | Barrett Rabinow | Formulation to render an antimicrobial drug potent against organisms normally considered to be resistant to the drug |
US20060003012A9 (en) | 2001-09-26 | 2006-01-05 | Sean Brynjelsen | Preparation of submicron solid particle suspensions by sonication of multiphase systems |
AU2002337692B2 (en) | 2001-09-26 | 2007-09-13 | Baxter International Inc. | Preparation of submicron sized nanoparticles via dispersion and solvent or liquid phase removal |
JP4290381B2 (ja) * | 2002-04-11 | 2009-07-01 | 学校法人 聖マリアンナ医科大学 | ピリドンカルボン酸化合物含有エマルション |
CN103405405A (zh) * | 2002-12-09 | 2013-11-27 | 阿布拉西斯生物科学有限责任公司 | 组合物和传递药剂的方法 |
US8426467B2 (en) | 2007-05-22 | 2013-04-23 | Baxter International Inc. | Colored esmolol concentrate |
US8722736B2 (en) | 2007-05-22 | 2014-05-13 | Baxter International Inc. | Multi-dose concentrate esmolol with benzyl alcohol |
DE102011002295B3 (de) | 2011-04-27 | 2012-08-30 | Mekra Lang Gmbh & Co. Kg | Längenverstellbare Außenspiegelanordnung |
DE202011000988U1 (de) | 2011-04-27 | 2011-07-01 | MEKRA Lang GmbH & Co. KG, 90765 | Längenverstellbare Außenspiegelanordnung |
DE102013022096B4 (de) * | 2013-12-20 | 2020-10-29 | Nanoval Gmbh & Co. Kg | Vorrichtung und Verfahren zum tiegelfreien Schmelzen eines Materials und zum Zerstäuben des geschmolzenen Materials zum Herstellen von Pulver |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3137631A (en) * | 1959-12-01 | 1964-06-16 | Faberge Inc | Encapsulation in natural products |
US3406119A (en) * | 1965-03-05 | 1968-10-15 | Keuffel & Esser Co | Encapsulation |
FR2608988B1 (fr) * | 1986-12-31 | 1991-01-11 | Centre Nat Rech Scient | Procede de preparation de systemes colloidaux dispersibles d'une substance, sous forme de nanoparticules |
FR2608942B1 (fr) * | 1986-12-31 | 1991-01-11 | Centre Nat Rech Scient | Procede de preparation de systemes colloidaux dispersibles d'une substance, sous forme de nanocapsules |
-
1989
- 1989-06-28 EP EP89401856A patent/EP0349428B1/fr not_active Expired - Lifetime
- 1989-06-28 DE DE8989401856T patent/DE68904483T2/de not_active Expired - Lifetime
- 1989-06-28 AT AT89401856T patent/ATE84710T1/de not_active IP Right Cessation
- 1989-06-28 ES ES89401856T patent/ES2054052T3/es not_active Expired - Lifetime
- 1989-06-29 KR KR1019890009022A patent/KR960014870B1/ko not_active IP Right Cessation
- 1989-06-30 JP JP1169743A patent/JPH062224B2/ja not_active Expired - Lifetime
-
1993
- 1993-03-05 GR GR930400469T patent/GR3007248T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
GR3007248T3 (es) | 1993-07-30 |
DE68904483D1 (de) | 1993-03-04 |
ATE84710T1 (de) | 1993-02-15 |
JPH062224B2 (ja) | 1994-01-12 |
DE68904483T2 (de) | 1993-05-19 |
KR910000128A (ko) | 1991-01-29 |
EP0349428A1 (fr) | 1990-01-03 |
EP0349428B1 (fr) | 1993-01-20 |
KR960014870B1 (ko) | 1996-10-21 |
JPH02149334A (ja) | 1990-06-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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