ES2054052T3 - Procedimiento de preparacion de sistemas coloidales dispersables de una proteina en forma de nanoparticulas. - Google Patents

Procedimiento de preparacion de sistemas coloidales dispersables de una proteina en forma de nanoparticulas.

Info

Publication number
ES2054052T3
ES2054052T3 ES89401856T ES89401856T ES2054052T3 ES 2054052 T3 ES2054052 T3 ES 2054052T3 ES 89401856 T ES89401856 T ES 89401856T ES 89401856 T ES89401856 T ES 89401856T ES 2054052 T3 ES2054052 T3 ES 2054052T3
Authority
ES
Spain
Prior art keywords
protein
nanoparticles
added
active substance
biologically active
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89401856T
Other languages
English (en)
Inventor
Serge Stainmesse
Hatem Fessi
Jean-Philippe Devissaguet
Francis Puisieux
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Original Assignee
Centre National de la Recherche Scientifique CNRS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR888808871A external-priority patent/FR2634397B2/fr
Application filed by Centre National de la Recherche Scientifique CNRS filed Critical Centre National de la Recherche Scientifique CNRS
Application granted granted Critical
Publication of ES2054052T3 publication Critical patent/ES2054052T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5169—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0241—Containing particulates characterized by their shape and/or structure
    • A61K8/025—Explicitly spheroidal or spherical shape
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5192—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/12—Powdering or granulating
    • C08J3/14—Powdering or granulating by precipitation from solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/41—Particular ingredients further characterized by their size
    • A61K2800/413—Nanosized, i.e. having sizes below 100 nm
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/56—Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nanotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Birds (AREA)
  • Optics & Photonics (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Medical Informatics (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Polymers & Plastics (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)
  • Colloid Chemistry (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

EL PROCEDIMIENTO SEGUN LA INVENCION SE CARACTERIZA PORQUE: (1) SE PREPARA UNA FASE LIQUIDA CONSTITUIDA ESENCIALMENTE POR UNA DISOLUCION DE LA PROTEINA Y, EVENTUALMENTE, DE UNA SUSTANCIA BIOLOGICAMENTE ACTIVA EN AGUA O EN UNA MEZCLA ACUOSA A UNA TEMPERATURA INFERIOR A LA DE COAGULACION DE LA PROTEINA, Y PUDIENDO AÑADIRLE UNO O VARIOS TENSIOACTIVOS, (2) SE PREPARA UNA SEGUNDA FASE LIQUIDA CONSTITUIDA ESENCIALMENTE POR AGUA O UNA MEZCLA ACUOSA A UNA TEMPERATURA SUPERIOR A LA DE COAGULACION DE LA PROTEINA, PUDIENDO CONTENER UNA SUSTANCIA BIOLOGICAMENTE ACTIVA, Y PUDIENDO AÑADIRLE UNO O VARIOS TENSIOACTIVOS, (3) SE AÑADE, CON AGITACION MODERADA, UNA DE LAS FASES LIQUIDAS OBTENIDA EN (1) O (2) A LA OTRA EN CONDICONES DE PH ALEJADO DEL PUNTO ISOELECTRICO DE LA PROTEINA, DE MANERA QUE SE OBTIENE DE MODO PRACTICAMENTE INSTANTANEO UNA SUSPENSION COLOIDAL DE NANOPARTICULAS DE LA PROTEINA Y, EVENTUALMENTE, DE LA SUSTANCIA BIOLOGICAMENTE ACTIVA, Y (4), SI SE DESEA, SE ELIMINA TODA O PARTE DEL AGUA ODE LA MEZCLA ACUOSA, PARA OBTENER UNA SUSPENSION COLOIDAL DE CONCENTRACION DESEADA EN NANOPARTICULAS O PARA OBTENER UN POLVO DE NANOPARTICULAS. APLICACIONES: BIOQUIMICA, FARMACIA MEDICINA, COSMETICA.
ES89401856T 1988-06-30 1989-06-28 Procedimiento de preparacion de sistemas coloidales dispersables de una proteina en forma de nanoparticulas. Expired - Lifetime ES2054052T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR888808871A FR2634397B2 (fr) 1986-12-31 1988-06-30 Procede de preparation de systemes colloidaux dispersibles d'une proteine sous forme de nanoparticules

Publications (1)

Publication Number Publication Date
ES2054052T3 true ES2054052T3 (es) 1994-08-01

Family

ID=9367939

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89401856T Expired - Lifetime ES2054052T3 (es) 1988-06-30 1989-06-28 Procedimiento de preparacion de sistemas coloidales dispersables de una proteina en forma de nanoparticulas.

Country Status (7)

Country Link
EP (1) EP0349428B1 (es)
JP (1) JPH062224B2 (es)
KR (1) KR960014870B1 (es)
AT (1) ATE84710T1 (es)
DE (1) DE68904483T2 (es)
ES (1) ES2054052T3 (es)
GR (1) GR3007248T3 (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0449592B1 (en) * 1990-03-27 1994-11-30 Bioelastics Research, Ltd. Bioelastomeric drug delivery system
DE4140179C2 (de) * 1991-12-05 1995-12-21 Alfatec Pharma Gmbh Akutform für ein Ibuprofen enthaltendes Arzneimittel
DE4140194C2 (de) * 1991-12-05 1998-02-19 Alfatec Pharma Gmbh Ein Dihydropyridinderivat in Nanosolform enthaltendes Arzneimittel und seine Herstellung
DK0615445T3 (da) * 1991-12-05 1996-06-03 Alfatec Pharma Gmbh Farmaceutisk administrerbar nanosol og fremgangsmåde til fremstilling deraf
EP1683517A1 (en) 1996-08-19 2006-07-26 American Bioscience, Inc. Methods for the production of protein particles useful for delivery of pharmacological agents
AU5860798A (en) * 1997-12-29 1999-07-19 Universite De Geneve Method for producing an aqueous colloidal dispersion of nanoparticles
US8067032B2 (en) 2000-12-22 2011-11-29 Baxter International Inc. Method for preparing submicron particles of antineoplastic agents
US20050048126A1 (en) 2000-12-22 2005-03-03 Barrett Rabinow Formulation to render an antimicrobial drug potent against organisms normally considered to be resistant to the drug
US9700866B2 (en) 2000-12-22 2017-07-11 Baxter International Inc. Surfactant systems for delivery of organic compounds
EP1429749A2 (en) 2001-09-26 2004-06-23 Baxter International Inc. Preparation of submicron sized nanoparticles via dispersion and solvent or liquid phase removal
US20060003012A9 (en) 2001-09-26 2006-01-05 Sean Brynjelsen Preparation of submicron solid particle suspensions by sonication of multiphase systems
JP4290381B2 (ja) * 2002-04-11 2009-07-01 学校法人 聖マリアンナ医科大学 ピリドンカルボン酸化合物含有エマルション
AU2003299590B8 (en) 2002-12-09 2010-04-08 Abraxis Bioscience, Llc Compositions and methods of delivery of pharmacological agents
US8426467B2 (en) 2007-05-22 2013-04-23 Baxter International Inc. Colored esmolol concentrate
US8722736B2 (en) 2007-05-22 2014-05-13 Baxter International Inc. Multi-dose concentrate esmolol with benzyl alcohol
DE102011002295B3 (de) 2011-04-27 2012-08-30 Mekra Lang Gmbh & Co. Kg Längenverstellbare Außenspiegelanordnung
DE202011000988U1 (de) 2011-04-27 2011-07-01 MEKRA Lang GmbH & Co. KG, 90765 Längenverstellbare Außenspiegelanordnung
DE102013022096B4 (de) * 2013-12-20 2020-10-29 Nanoval Gmbh & Co. Kg Vorrichtung und Verfahren zum tiegelfreien Schmelzen eines Materials und zum Zerstäuben des geschmolzenen Materials zum Herstellen von Pulver

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3137631A (en) * 1959-12-01 1964-06-16 Faberge Inc Encapsulation in natural products
US3406119A (en) * 1965-03-05 1968-10-15 Keuffel & Esser Co Encapsulation
FR2608942B1 (fr) * 1986-12-31 1991-01-11 Centre Nat Rech Scient Procede de preparation de systemes colloidaux dispersibles d'une substance, sous forme de nanocapsules
FR2608988B1 (fr) * 1986-12-31 1991-01-11 Centre Nat Rech Scient Procede de preparation de systemes colloidaux dispersibles d'une substance, sous forme de nanoparticules

Also Published As

Publication number Publication date
KR910000128A (ko) 1991-01-29
KR960014870B1 (ko) 1996-10-21
GR3007248T3 (es) 1993-07-30
ATE84710T1 (de) 1993-02-15
DE68904483D1 (de) 1993-03-04
JPH062224B2 (ja) 1994-01-12
EP0349428A1 (fr) 1990-01-03
DE68904483T2 (de) 1993-05-19
JPH02149334A (ja) 1990-06-07
EP0349428B1 (fr) 1993-01-20

Similar Documents

Publication Publication Date Title
ES2054052T3 (es) Procedimiento de preparacion de sistemas coloidales dispersables de una proteina en forma de nanoparticulas.
FR2634397B2 (fr) Procede de preparation de systemes colloidaux dispersibles d'une proteine sous forme de nanoparticules
FR2608988B1 (fr) Procede de preparation de systemes colloidaux dispersibles d'une substance, sous forme de nanoparticules
RU94026279A (ru) Катионокомплексные полисахариды
DK653688D0 (da) Stabiliserede laegemiddelaktive forbindelser, fremgangsmaade til deres frmstilling samt stabile laegemiddelpraeparater
DE69023682D1 (de) Gefriergetrocknete Polymerdispersionen und ihre Anwendung zur Darstellung von Arzneimittelzubereitungen mit protrahierter Wirkstoffabgabe.
IE43809L (en) Low fat spread
NO865162L (no) Fremgangsmaate for fremstilling av en ekstemporaer homogen mikrokapselsuspensjon.
CA2092346A1 (en) Protein stabilised oil-in-water emulsions
DE336200T1 (de) Piroxicam in waessrigen loesungen enthaltende arzneizubereitungen und verfahren zu deren herstellung.
ATE173276T1 (de) Verfahren zur herstellung von iodierten biopolymeren mit desinfizierender und vernarbungsfördernder wirkung und darnach hergestellte iodierte biopolymeren
DE59102701D1 (de) Arzneimittelzubereitung zur systemischen Behandlung von Zier- und Nutzfischen.
ATE85888T1 (de) Verfahren zur herstellung dispergierbarer kolloidaler systeme aus amphiphilen lipiden in form von liposomen in submikrongroesse.
JP3497932B2 (ja) 含水化粧料の変臭・変色防止方法
ATE92075T1 (de) Verfahren zur gewinnung aktiver proteine aus einer biologisch inaktiven form.
WO1999006011A3 (de) Schellackhaltiges kosmetisches produkt
EA200200294A1 (ru) Сферические агломераты телитромицина, способ их получения и их применение для приготовления лекарственных форм
ATA77095A (de) Stabiles präparat zur behandlung von blutgerinnungsstörungen, enthaltend eine aktive gerinnungsfördernde stubstanz
JPS6097043A (ja) 乳化組成物
FI935725A (fi) Aktiivisia maitoproteiinikomponentteja sisältäviä komponentteja ja menetelmä niiden valmistamiseksi
NZ235297A (en) Aqueous solution containing a protein and anionic polymer or salt and method of increasing the protein concentration of an aqueous solution
ATE103803T1 (de) Verfahren zur herstellung waessriger mischmicelloesungen.
HU215435B (hu) Eljárás sejtkultúrák tenyésztésére alkalmas biológiai hordozó és bőrszövet-helyettesítő előállítására
SU1517173A1 (ru) Антисептическое средство
DE69423623D1 (de) Aminosäureergänzung

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 349428

Country of ref document: ES