KR910000128A - 나노입자형태 단백질의 분산성 교질상 시스템을 제조하는 방법 - Google Patents

나노입자형태 단백질의 분산성 교질상 시스템을 제조하는 방법 Download PDF

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KR910000128A
KR910000128A KR1019890009022A KR890009022A KR910000128A KR 910000128 A KR910000128 A KR 910000128A KR 1019890009022 A KR1019890009022 A KR 1019890009022A KR 890009022 A KR890009022 A KR 890009022A KR 910000128 A KR910000128 A KR 910000128A
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protein
biologically active
water
aqueous mixture
temperature
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KR1019890009022A
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KR960014870B1 (ko
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스탠메쓰 세르쥬
페씨 아탐
드비싸게 쟝-필립
퓌시외 프랑시스
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원본미기재
쌍트르 나시오날 드 라 르쉐르슈 씨앙띠피끄
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5169—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0241—Containing particulates characterized by their shape and/or structure
    • A61K8/025—Explicitly spheroidal or spherical shape
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5192—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/12—Powdering or granulating
    • C08J3/14—Powdering or granulating by precipitation from solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/41—Particular ingredients further characterized by their size
    • A61K2800/413—Nanosized, i.e. having sizes below 100 nm
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/56—Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms

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  • Colloid Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Peptides Or Proteins (AREA)

Abstract

내용 없음

Description

나노입자 형태 잔백질의 분산성 교질상 시스템을 제조하는 방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (12)

  1. (1) 필수적으로 단백질 용액 및 임의로 물 또는 수성 혼합물중의 생물학적 활성성분을 함유하며, 하나이상의 계면활성제가 첨가될 수 있는 액체상을 단백질의 응집온도보다 낮은 온도에서 제조하고, (2) 필수적으로 물 또는 수성 혼합물을 함유하고, 생물학적 활성물질을 함유할 수 있으며, 하나이상의 계면활성제가 첨가될 수 있는 제2액체상을 단백질의 응집 온도보다 높은 온도에서 제조한 후, (3) (1) 또는 (2)에서 수득된 액체상 중 하나를, 단백질의 동전점과는 다른 pH 조건하에서 서서히 교반하면서 다른하나에 가하여 단백질 및 임의의 생물학적 활성물질의 나노입자 교질상 현탁액을 거의 순간적으로 형성시키고, (4) 경우에 따라, 물 또는 수성 혼합물의 전부 또는 일부를 제거하여 목저하는 농도의 나노입자 교질상 현탁액을 생성시키거나 나노입자 분말을 형성시키는 단계로 이루어짐을 특징으로 하는, 매트릭스형태의 크기가 500㎚ 미만인 구형입자(나노입자 : nanoparticles)형태 단백질의 분산성 교질상 시스템의 제조방법.
  2. 제1항에 있어서, 단백질이 혈청알부민인 방법.
  3. 제1항에 있어서, 단백질이 엘라스틴인 방법.
  4. 제1항 내지 3항중 어느 한 항에 있어서, 생물학적 활성물질이 의학적 활성성분 또는 약제 전구체, 생물학적 시약 또는 화장품 성분인 방법.
  5. 제1항 내지 3항중 어느 한 항에 있어서, 생물학적 활성물질이 단계(3)에서 미리 생성시킨 단백질만의 나노입자와 결합되는 방법.
  6. 제1항 내지 5항중 어느 한 항에 있어서, 상(1)의 물 또는 수성 혼합물이 0℃ 내지 50℃의 온도를 지니는 방법.
  7. 제1항 내지 6항중 어느 한 항에 있어서, 상(2)의 물 또는 수성 혼합물이 80℃ 내지 100℃의 온도를 지니는 방법.
  8. 제1항 내지 7항중 어느 한 항에 있어서, 상 (1) 및 (2) 혼합물의 pH가 단백질의 동전점과 2 내지 3단위 차이나는 방법.
  9. 제1항 내지 8항중 어느 한 항에 있어서, 상(1)중의 단백질 농도가 0.1 내지 10%, 바람직하게는 0.5 내지 4%인 방법.
  10. 제1항 내지 9항중 어느 한 항에 있어서, 상(1), 상(2)의 용적비가 0.1 내지 1, 바람직하게는 0.1 내지 0.6인 방법.
  11. 제1항 내지 10항중 어느 한 항에 있어서, 물전체를 단계(4)의 동결건조법으로 제거하는 방법.
  12. 제1항 내지 11항중 어느 한 항에 있어서, 나노입자의 크기가 약 150 내지 300㎚이 방법.
    ※참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890009022A 1988-06-30 1989-06-29 나노 입자형 단백질의 분산성 교질상 시스템의 제조방법 KR960014870B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR888808871A FR2634397B2 (fr) 1986-12-31 1988-06-30 Procede de preparation de systemes colloidaux dispersibles d'une proteine sous forme de nanoparticules
FR8808871 1988-06-30

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KR910000128A true KR910000128A (ko) 1991-01-29
KR960014870B1 KR960014870B1 (ko) 1996-10-21

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EP (1) EP0349428B1 (ko)
JP (1) JPH062224B2 (ko)
KR (1) KR960014870B1 (ko)
AT (1) ATE84710T1 (ko)
DE (1) DE68904483T2 (ko)
ES (1) ES2054052T3 (ko)
GR (1) GR3007248T3 (ko)

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KR20160101004A (ko) * 2013-12-20 2016-08-24 나노발 게엠베하 운트 코. 카게 분말 제조를 위해 도가니 없이 재료를 용융하고 용융된 재료를 무화하기 위한 장치 및 방법

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DE69105323T2 (de) 1990-03-27 1995-06-01 Bioelastics Res Ltd Bioelastomeres Arzneimittelabgabesystem.
DE4140194C2 (de) * 1991-12-05 1998-02-19 Alfatec Pharma Gmbh Ein Dihydropyridinderivat in Nanosolform enthaltendes Arzneimittel und seine Herstellung
AU671965B2 (en) * 1991-12-05 1996-09-19 Alfatec-Pharma Gmbh Pharmaceutically Applicable Nanosol and Process for Preparing The Same
DE4140179C2 (de) * 1991-12-05 1995-12-21 Alfatec Pharma Gmbh Akutform für ein Ibuprofen enthaltendes Arzneimittel
EP1683517A1 (en) 1996-08-19 2006-07-26 American Bioscience, Inc. Methods for the production of protein particles useful for delivery of pharmacological agents
AU5860798A (en) * 1997-12-29 1999-07-19 Universite De Geneve Method for producing an aqueous colloidal dispersion of nanoparticles
US9700866B2 (en) 2000-12-22 2017-07-11 Baxter International Inc. Surfactant systems for delivery of organic compounds
US20050048126A1 (en) 2000-12-22 2005-03-03 Barrett Rabinow Formulation to render an antimicrobial drug potent against organisms normally considered to be resistant to the drug
US8067032B2 (en) 2000-12-22 2011-11-29 Baxter International Inc. Method for preparing submicron particles of antineoplastic agents
IL160570A0 (en) 2001-09-26 2004-07-25 Baxter Int Preparation of submicron sized nanoparticles via dispersion and solvent or liquid phase removal
US20060003012A9 (en) 2001-09-26 2006-01-05 Sean Brynjelsen Preparation of submicron solid particle suspensions by sonication of multiphase systems
JP4290381B2 (ja) * 2002-04-11 2009-07-01 学校法人 聖マリアンナ医科大学 ピリドンカルボン酸化合物含有エマルション
SI1585548T1 (sl) * 2002-12-09 2018-11-30 Abraxis Bioscience, Llc Sestave in metode odmerjanja farmakoloških sredstev
US8426467B2 (en) 2007-05-22 2013-04-23 Baxter International Inc. Colored esmolol concentrate
US8722736B2 (en) 2007-05-22 2014-05-13 Baxter International Inc. Multi-dose concentrate esmolol with benzyl alcohol
DE202011000988U1 (de) 2011-04-27 2011-07-01 MEKRA Lang GmbH & Co. KG, 90765 Längenverstellbare Außenspiegelanordnung
DE102011002295B3 (de) 2011-04-27 2012-08-30 Mekra Lang Gmbh & Co. Kg Längenverstellbare Außenspiegelanordnung

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US3137631A (en) * 1959-12-01 1964-06-16 Faberge Inc Encapsulation in natural products
US3406119A (en) * 1965-03-05 1968-10-15 Keuffel & Esser Co Encapsulation
FR2608988B1 (fr) * 1986-12-31 1991-01-11 Centre Nat Rech Scient Procede de preparation de systemes colloidaux dispersibles d'une substance, sous forme de nanoparticules
FR2608942B1 (fr) * 1986-12-31 1991-01-11 Centre Nat Rech Scient Procede de preparation de systemes colloidaux dispersibles d'une substance, sous forme de nanocapsules

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20160101004A (ko) * 2013-12-20 2016-08-24 나노발 게엠베하 운트 코. 카게 분말 제조를 위해 도가니 없이 재료를 용융하고 용융된 재료를 무화하기 위한 장치 및 방법

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ES2054052T3 (es) 1994-08-01
JPH062224B2 (ja) 1994-01-12
DE68904483T2 (de) 1993-05-19
ATE84710T1 (de) 1993-02-15
EP0349428A1 (fr) 1990-01-03
EP0349428B1 (fr) 1993-01-20
GR3007248T3 (ko) 1993-07-30
KR960014870B1 (ko) 1996-10-21
JPH02149334A (ja) 1990-06-07
DE68904483D1 (de) 1993-03-04

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