ATE74752T1 - Biologisch erodierbares system mit gesteuerter freisetzung des arzneiwirkstoffes. - Google Patents

Biologisch erodierbares system mit gesteuerter freisetzung des arzneiwirkstoffes.

Info

Publication number
ATE74752T1
ATE74752T1 AT87305625T AT87305625T ATE74752T1 AT E74752 T1 ATE74752 T1 AT E74752T1 AT 87305625 T AT87305625 T AT 87305625T AT 87305625 T AT87305625 T AT 87305625T AT E74752 T1 ATE74752 T1 AT E74752T1
Authority
AT
Austria
Prior art keywords
fluids
pharmaceutical compound
body fluids
drug release
microparticles
Prior art date
Application number
AT87305625T
Other languages
German (de)
English (en)
Inventor
John Weldon Shell
Original Assignee
Iolab Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Iolab Inc filed Critical Iolab Inc
Application granted granted Critical
Publication of ATE74752T1 publication Critical patent/ATE74752T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts, ocular implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1658—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT87305625T 1986-06-25 1987-06-24 Biologisch erodierbares system mit gesteuerter freisetzung des arzneiwirkstoffes. ATE74752T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87827286A 1986-06-25 1986-06-25
EP87305625A EP0251680B1 (en) 1986-06-25 1987-06-24 Controlled release bioerodible drug delivery system

Publications (1)

Publication Number Publication Date
ATE74752T1 true ATE74752T1 (de) 1992-05-15

Family

ID=25371703

Family Applications (1)

Application Number Title Priority Date Filing Date
AT87305625T ATE74752T1 (de) 1986-06-25 1987-06-24 Biologisch erodierbares system mit gesteuerter freisetzung des arzneiwirkstoffes.

Country Status (8)

Country Link
EP (1) EP0251680B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPS6322516A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) ATE74752T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU606872B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1311686C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE3778223D1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES2037082T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GR (1) GR3004710T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4853224A (en) * 1987-12-22 1989-08-01 Visionex Biodegradable ocular implants
US4923699A (en) * 1988-06-03 1990-05-08 Kaufman Herbert E Eye treatment suspension
US5082667A (en) * 1988-06-07 1992-01-21 Abbott Laboratories Solid pharmaceutical dosage in tablet triturate form and method of producing same
DE68906461T2 (de) * 1988-06-07 1993-10-21 Abbott Lab Feste Arzneidosis in Form eines Tablettentriturats sowie Verfahren zu deren Herstellung.
US5007790A (en) * 1989-04-11 1991-04-16 Depomed Systems, Inc. Sustained-release oral drug dosage form
GB8917217D0 (en) * 1989-07-27 1989-09-13 Smith & Nephew Ophthalmic compositions
US5164188A (en) * 1989-11-22 1992-11-17 Visionex, Inc. Biodegradable ocular implants
JP3011752B2 (ja) * 1990-10-23 2000-02-21 フロイント産業株式会社 徐放性製剤およびその製造方法
FR2673843B1 (fr) * 1991-03-14 1995-01-13 Centre Nat Rech Scient Composition pharmaceutique implantable, bioresorbable a base de poly(acide lactique), destinee a mettre en óoeuvre une antibiotherapie interne locale.
US5912015A (en) * 1992-03-12 1999-06-15 Alkermes Controlled Therapeutics, Inc. Modulated release from biocompatible polymers
EP0762874A4 (en) * 1992-12-30 1997-08-06 Clover Cons Ltd BIOLOGICALLY ACTIVE SUBSTANCE PACKAGING SYSTEMS IN RECOVERABLE, BIOCOMPATIBLE AND CYTOPROTECTOR MACROCAPSULES
IE75744B1 (en) * 1995-04-03 1997-09-24 Elan Corp Plc Controlled release biodegradable micro- and nanospheres containing cyclosporin
AU710347B2 (en) * 1995-08-31 1999-09-16 Alkermes Controlled Therapeutics, Inc. Composition for sustained release of an agent
US6265389B1 (en) 1995-08-31 2001-07-24 Alkermes Controlled Therapeutics, Inc. Microencapsulation and sustained release of oligonucleotides
DE19756314C2 (de) * 1997-12-12 2000-06-29 Roland Bodmeier Zubereitung mit verlängerter Verweildauer am Applikationsort
US6264971B1 (en) 1999-11-04 2001-07-24 Btg International Limited Ocular insert
DE10133870A1 (de) * 2001-07-12 2003-02-06 Chris P Lohmann Ophthalmisches Mittel, Verwendung von EGF zur Behandlung von Dry Eye-Syndrom und Insert zur Verabreichung von EGF am Auge
JP2005525299A (ja) * 2001-09-14 2005-08-25 スコラー インコーポレイテッド アミノ酸調節性の長期放出投薬形態
DE10246900A1 (de) 2002-10-08 2004-04-22 Horstmann, Michael, Dr. Am Auge applizierbare Vorrichtung zur sicheren Dosierung systemischer und tropischer Medikation
US7976520B2 (en) 2004-01-12 2011-07-12 Nulens Ltd. Eye wall anchored fixtures
US8722097B2 (en) 2004-04-30 2014-05-13 Allergan, Inc. Oil-in-water method for making polymeric implants containing a hypotensive lipid
US7799336B2 (en) 2004-04-30 2010-09-21 Allergan, Inc. Hypotensive lipid-containing biodegradable intraocular implants and related methods
US8673341B2 (en) 2004-04-30 2014-03-18 Allergan, Inc. Intraocular pressure reduction with intracameral bimatoprost implants
US9498457B2 (en) 2004-04-30 2016-11-22 Allergan, Inc. Hypotensive prostamide-containing biodegradable intraocular implants and related implants
US7993634B2 (en) 2004-04-30 2011-08-09 Allergan, Inc. Oil-in-oil emulsified polymeric implants containing a hypotensive lipid and related methods
US8246569B1 (en) 2004-08-17 2012-08-21 California Institute Of Technology Implantable intraocular pressure drain
EP3381446A1 (en) * 2004-10-29 2018-10-03 The Regents of The University of California Porous photonic crystals for drug delivery to the eye
JP2006257080A (ja) * 2005-02-18 2006-09-28 Santen Pharmaceut Co Ltd ステロイド化合物の副作用軽減または回避方法
CA2833354C (en) 2006-03-14 2015-12-15 University Of Southern California Mems device and method for delivery of therapeutic agents
US8802128B2 (en) * 2006-06-23 2014-08-12 Allergan, Inc. Steroid-containing sustained release intraocular implants and related methods
WO2008002657A2 (en) * 2006-06-28 2008-01-03 Surmodics, Inc. Microparticles containing active agent dispersed in a polymer matrix as implant or as coating for medical devices
ITMI20061545A1 (it) * 2006-08-02 2008-02-03 Mediolanum Pharmaceuticals Ltd Particelle in grado di rilasciare il principio attivo per un periodo prolungato di tempo
WO2008143906A2 (en) * 2007-05-14 2008-11-27 Sustained Nano Systems Llc Hypercompressed particles for controlled release of ophthalmic medications
MX364408B (es) 2007-12-20 2019-04-25 Univ Southern California Aparatos y metodos para suministrar agentes terapeuticos.
PL2240220T3 (pl) 2008-01-03 2016-09-30 Wszczepialne urządzenia do podawania leków i aparaty do napełniania urządzeń
US9849238B2 (en) 2008-05-08 2017-12-26 Minipumps, Llc Drug-delivery pump with intelligent control
US8486278B2 (en) 2008-05-08 2013-07-16 Minipumps, Llc Drug-delivery pumps and methods of manufacture
MX2010012213A (es) 2008-05-08 2011-05-03 Minipumps Llc Bombas implantables y cánulas para las mismas.
JP2011519695A (ja) 2008-05-08 2011-07-14 リプレニッシュ パンプス， エルエルシー 植設可能な薬物送達デバイスおよびそのデバイスを充填する装置および方法
US9498431B2 (en) 2008-12-10 2016-11-22 Jianjian Xu Controlled releasing composition
USD629503S1 (en) 2009-05-08 2010-12-21 Sean Caffey Implantable drug-delivery pump
EP2437684B1 (en) * 2009-06-03 2022-06-15 ForSight Vision5, Inc. Anterior segment drug delivery
EP2467797B1 (en) 2009-08-18 2017-07-19 MiniPumps, LLC Electrolytic drug-delivery pump with adaptive control
US8469934B2 (en) 2010-01-27 2013-06-25 Alcon Research, Ltd. Pulsatile peri-corneal drug delivery device
JP2012025708A (ja) * 2010-07-27 2012-02-09 Sepa Sigma Inc 膜透過機構を異にする複数の徐放機構を利用した徐放化局所投与剤
US9603997B2 (en) 2011-03-14 2017-03-28 Minipumps, Llc Implantable drug pumps and refill devices therefor
US9919099B2 (en) 2011-03-14 2018-03-20 Minipumps, Llc Implantable drug pumps and refill devices therefor
US10286146B2 (en) 2011-03-14 2019-05-14 Minipumps, Llc Implantable drug pumps and refill devices therefor
MX2013008993A (es) 2013-08-02 2014-03-24 Raam De Sahuayo S A De C V Lab Sistema de liberacion modificada en tres fases de un antiinflamatorio no esteroide.
EP3351239B1 (en) 2013-10-31 2020-04-01 Allergan, Inc. Prostamide-containing intraocular implants and methods of use thereof
EP3302382A4 (en) * 2015-05-29 2019-02-20 Allergan, Inc. IMPLANT FOR THE TREATMENT OF OCULAR DISEASE
EP3108874A1 (en) * 2015-06-26 2016-12-28 TRB Chemedica AG Ophthalmologic pharmaceutical composition
TW201907907A (zh) * 2017-07-17 2019-03-01 新加坡商福溪生技有限公司 用於輸送活性劑的微粒調配物
CN115554460A (zh) * 2022-09-26 2023-01-03 山东万容生物科技有限公司 一种多功能湿性敷料及其制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3981303A (en) * 1971-09-09 1976-09-21 Alza Corporation Bioerodible ocular device
BE788575A (fr) * 1971-09-09 1973-01-02 Alza Corp Dispositif oculaire pour l'administration d'un
US4179497A (en) * 1973-12-17 1979-12-18 Merck & Co., Inc. Solid state ophthalmic medication
US4115544A (en) * 1976-08-18 1978-09-19 Alza Corporation Ocular system made of bioerodible esters having linear ether
IE50901B1 (en) * 1980-03-04 1986-08-06 Merck & Co Inc Ophthalmic compositions of carbonic anhydrase inhibitors for topical application in the treatment of elevated intraocular pressure
IE58110B1 (en) * 1984-10-30 1993-07-14 Elan Corp Plc Controlled release powder and process for its preparation

Also Published As

Publication number Publication date
JPS6322516A (ja) 1988-01-30
EP0251680A3 (en) 1988-02-24
ES2037082T3 (es) 1993-06-16
AU606872B2 (en) 1991-02-21
EP0251680B1 (en) 1992-04-15
CA1311686C (en) 1992-12-22
DE3778223D1 (de) 1992-05-21
GR3004710T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1993-04-28
EP0251680A2 (en) 1988-01-07
AU7465087A (en) 1988-01-07

Similar Documents

Publication Publication Date Title
ATE74752T1 (de) Biologisch erodierbares system mit gesteuerter freisetzung des arzneiwirkstoffes.
ES2051881T3 (es) Procedimiento de preparacion de un formulacion farmaceutica de liberacion prolongada.
DE59009495D1 (de) Oestrogenhaltiges Wirkstoffpflaster.
DE68907139D1 (de) Mikrokapsel mit verzoegerter freigabe fuer wasserloesliche arzneistoffe.
DE3872739D1 (de) Arzneimittel mit langsamer freisetzung.
ATE22535T1 (de) Pharmazeutische zusammensetzungen fuer die kontinuierliche freigabe des wirkstoffes.
ATE67407T1 (de) Pharmazeutische zubereitung mit abgabeeigenschaften.
DE3773468D1 (de) Hydromorphon-zusammensetzung mit gesteuerter wirkstofffreisetzung.
CO5130022A1 (es) Sistema de entrega controlado de droga administrado oralmente, que provee control temporal y espacial
DE60023520D1 (de) Flüssiges hochvisköses system mit gesteuerter freisetzung und medizinische oder chirurgische vorrichtung
BR9809453A (pt) Composição de suprimento de medicamento para a liberação controlada de um ingrediente ativo dentro do meio-ambiente do estÈmago, uso da mesma, formulação farmacêutica, processo para obter gastrorretenção, para o tratamento ou profilaxia de uma doença, para melhorar a absorção gastrointestinal de medicamentos, e para a preparação de uma composição, e, estojo de partes para uso no tratamento de infecção por h. pylori.
PT706401E (pt) Sistema para administracao de farmacos
PT93490A (pt) Sistema de libertacao de medicamentos administratos intra-oralmente
BR0210631A (pt) Composição farmacêutica de liberação prolongada
DK0994887T3 (da) Modificerede glycosider, præparater omfattet deraf og fremgangsmåder til anvendelse deraf
DE58906232D1 (de) Azelastin enthaltende Arzneimittel mit kontrollierter Wirkstoffabgabe.
ATE295157T1 (de) Mittel zur transdermalen verabreichung von arzneistoffen
ATE148340T1 (de) Naproxen-tabletten mit gesteuerter wirkstoffabgabe
DE69803670D1 (de) Tiagabinhaltige arzneizubereitungen mit gesteuerter wirkstoffverabreichung
ES2043567T1 (es) Una composicion farmaceutica de liberacion controlada para uso oral que contiene farmacos anti-inflamatorios no esteroideos.
DE68907091D1 (de) Scleroglucan und wirkstoff enthaltende pharmazeutische tabletten und kapselgranulate.
DE3688355D1 (de) Fester koerper mit ueberzogenem kern.
TH14574A (th) สารผสมทางเภสัชกรรม

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee