JPS6322516A - 制御放出性医薬組成物 - Google Patents
制御放出性医薬組成物Info
- Publication number
- JPS6322516A JPS6322516A JP62155622A JP15562287A JPS6322516A JP S6322516 A JPS6322516 A JP S6322516A JP 62155622 A JP62155622 A JP 62155622A JP 15562287 A JP15562287 A JP 15562287A JP S6322516 A JPS6322516 A JP S6322516A
- Authority
- JP
- Japan
- Prior art keywords
- drug
- dosage form
- microparticles
- matrix
- eye
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- 239000010813 municipal solid waste Substances 0.000 description 1
- 229950006780 n-acetylglucosamine Drugs 0.000 description 1
- 229960005016 naphazoline Drugs 0.000 description 1
- 231100000344 non-irritating Toxicity 0.000 description 1
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 description 1
- 239000012074 organic phase Substances 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 229960000625 oxytetracycline Drugs 0.000 description 1
- IWVCMVBTMGNXQD-PXOLEDIWSA-N oxytetracycline Chemical compound C1=CC=C2[C@](O)(C)[C@H]3[C@H](O)[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-PXOLEDIWSA-N 0.000 description 1
- 235000019366 oxytetracycline Nutrition 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- HZOTZTANVBDFOF-PBCQUBLHSA-N physostigmine salicylate Chemical compound OC(=O)C1=CC=CC=C1O.C12=CC(OC(=O)NC)=CC=C2N(C)[C@@H]2[C@@]1(C)CCN2C HZOTZTANVBDFOF-PBCQUBLHSA-N 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 229920000729 poly(L-lysine) polymer Polymers 0.000 description 1
- 229920001308 poly(aminoacid) Polymers 0.000 description 1
- 229920001610 polycaprolactone Polymers 0.000 description 1
- 239000004632 polycaprolactone Substances 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 description 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 1
- 239000004810 polytetrafluoroethylene Substances 0.000 description 1
- 235000011056 potassium acetate Nutrition 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 229960002800 prednisolone acetate Drugs 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 239000012460 protein solution Substances 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000004080 punching Methods 0.000 description 1
- 210000001747 pupil Anatomy 0.000 description 1
- LISFMEBWQUVKPJ-UHFFFAOYSA-N quinolin-2-ol Chemical compound C1=CC=C2NC(=O)C=CC2=C1 LISFMEBWQUVKPJ-UHFFFAOYSA-N 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 229930002330 retinoic acid Natural products 0.000 description 1
- 210000003705 ribosome Anatomy 0.000 description 1
- 239000011435 rock Substances 0.000 description 1
- 239000012047 saturated solution Substances 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 229960002901 sodium glycerophosphate Drugs 0.000 description 1
- 229960004025 sodium salicylate Drugs 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 229940074404 sodium succinate Drugs 0.000 description 1
- ZDQYSKICYIVCPN-UHFFFAOYSA-L sodium succinate (anhydrous) Chemical compound [Na+].[Na+].[O-]C(=O)CCC([O-])=O ZDQYSKICYIVCPN-UHFFFAOYSA-L 0.000 description 1
- 235000010339 sodium tetraborate Nutrition 0.000 description 1
- REULQIKBNNDNDX-UHFFFAOYSA-M sodium;2,3-dihydroxypropyl hydrogen phosphate Chemical compound [Na+].OCC(O)COP(O)([O-])=O REULQIKBNNDNDX-UHFFFAOYSA-M 0.000 description 1
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
- 239000011343 solid material Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 229940124530 sulfonamide Drugs 0.000 description 1
- 150000003456 sulfonamides Chemical class 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 239000002344 surface layer Substances 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 229940127230 sympathomimetic drug Drugs 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 229920003002 synthetic resin Polymers 0.000 description 1
- IWVCMVBTMGNXQD-UHFFFAOYSA-N terramycin dehydrate Natural products C1=CC=C2C(O)(C)C3C(O)C4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-UHFFFAOYSA-N 0.000 description 1
- 229960002180 tetracycline Drugs 0.000 description 1
- 235000019364 tetracycline Nutrition 0.000 description 1
- 229930101283 tetracycline Natural products 0.000 description 1
- 150000003522 tetracyclines Chemical class 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 238000011269 treatment regimen Methods 0.000 description 1
- VSQQQLOSPVPRAZ-RRKCRQDMSA-N trifluridine Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(C(F)(F)F)=C1 VSQQQLOSPVPRAZ-RRKCRQDMSA-N 0.000 description 1
- 229960003962 trifluridine Drugs 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
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- 230000000007 visual effect Effects 0.000 description 1
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- 239000011719 vitamin A Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A61K9/0051—Ocular inserts, ocular implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
- A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1658—Proteins, e.g. albumin, gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Ophthalmology & Optometry (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87827286A | 1986-06-25 | 1986-06-25 | |
| US878272 | 1986-06-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS6322516A true JPS6322516A (ja) | 1988-01-30 |
Family
ID=25371703
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP62155622A Pending JPS6322516A (ja) | 1986-06-25 | 1987-06-24 | 制御放出性医薬組成物 |
Country Status (8)
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH02702A (ja) * | 1987-12-22 | 1990-01-05 | Vernon G Wong | 生物分解性眼移植物 |
| JPH08507747A (ja) * | 1992-12-30 | 1996-08-20 | クローバー コンソリデイテッド，リミテッド | 生物学的活性物質用の細包を保護し生体に適合する、再利用可能なマクロカプセル封入システム |
| JP2005525299A (ja) * | 2001-09-14 | 2005-08-25 | スコラー インコーポレイテッド | アミノ酸調節性の長期放出投薬形態 |
| JP2006257080A (ja) * | 2005-02-18 | 2006-09-28 | Santen Pharmaceut Co Ltd | ステロイド化合物の副作用軽減または回避方法 |
| JP2007535537A (ja) * | 2004-04-30 | 2007-12-06 | アラーガン、インコーポレイテッド | プロスタミド含有生分解性眼内インプラント |
| JP2009542671A (ja) * | 2006-06-28 | 2009-12-03 | サーモディクス，インコーポレイティド | 微粒子を含む活性剤溶出マトリックス |
| JP2009545564A (ja) * | 2006-08-02 | 2009-12-24 | メディオラヌム ファルマチェウティカルズ リミテッド | 長時間にわたって活性本体を放出する皮下移植物 |
| JP2012025708A (ja) * | 2010-07-27 | 2012-02-09 | Sepa Sigma Inc | 膜透過機構を異にする複数の徐放機構を利用した徐放化局所投与剤 |
| JP2012511519A (ja) * | 2008-12-10 | 2012-05-24 | アンフイ ジョンレン テクノロジー コーポレイション，リミテッド | 制御放出組成物 |
| JP2018518514A (ja) * | 2015-06-26 | 2018-07-12 | コンティプロ アクチオヴァ スポレチノスト | 眼科医薬組成物 |
| JP2020527591A (ja) * | 2017-07-17 | 2020-09-10 | ウルフクリーク バイオテック プライベート リミテッド | 活性薬剤送達のための微粒子製剤 |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4923699A (en) * | 1988-06-03 | 1990-05-08 | Kaufman Herbert E | Eye treatment suspension |
| US5082667A (en) * | 1988-06-07 | 1992-01-21 | Abbott Laboratories | Solid pharmaceutical dosage in tablet triturate form and method of producing same |
| ES2057021T3 (es) * | 1988-06-07 | 1994-10-16 | Abbott Lab | Un metodo de manufactura de una dosificacion farmaceutica solida en forma de triturado en tableta. |
| US5007790A (en) * | 1989-04-11 | 1991-04-16 | Depomed Systems, Inc. | Sustained-release oral drug dosage form |
| GB8917217D0 (en) * | 1989-07-27 | 1989-09-13 | Smith & Nephew | Ophthalmic compositions |
| US5164188A (en) * | 1989-11-22 | 1992-11-17 | Visionex, Inc. | Biodegradable ocular implants |
| JP3011752B2 (ja) * | 1990-10-23 | 2000-02-21 | フロイント産業株式会社 | 徐放性製剤およびその製造方法 |
| FR2673843B1 (fr) * | 1991-03-14 | 1995-01-13 | Centre Nat Rech Scient | Composition pharmaceutique implantable, bioresorbable a base de poly(acide lactique), destinee a mettre en óoeuvre une antibiotherapie interne locale. |
| US5912015A (en) | 1992-03-12 | 1999-06-15 | Alkermes Controlled Therapeutics, Inc. | Modulated release from biocompatible polymers |
| IE75744B1 (en) * | 1995-04-03 | 1997-09-24 | Elan Corp Plc | Controlled release biodegradable micro- and nanospheres containing cyclosporin |
| US6265389B1 (en) | 1995-08-31 | 2001-07-24 | Alkermes Controlled Therapeutics, Inc. | Microencapsulation and sustained release of oligonucleotides |
| EP0850051A2 (en) * | 1995-08-31 | 1998-07-01 | Alkermes Controlled Therapeutics, Inc. | Composition for sustained release of an agent |
| DE19756314C2 (de) * | 1997-12-12 | 2000-06-29 | Roland Bodmeier | Zubereitung mit verlängerter Verweildauer am Applikationsort |
| US6264971B1 (en) | 1999-11-04 | 2001-07-24 | Btg International Limited | Ocular insert |
| DE10133870A1 (de) * | 2001-07-12 | 2003-02-06 | Chris P Lohmann | Ophthalmisches Mittel, Verwendung von EGF zur Behandlung von Dry Eye-Syndrom und Insert zur Verabreichung von EGF am Auge |
| DE10246900A1 (de) | 2002-10-08 | 2004-04-22 | Horstmann, Michael, Dr. | Am Auge applizierbare Vorrichtung zur sicheren Dosierung systemischer und tropischer Medikation |
| US7976520B2 (en) | 2004-01-12 | 2011-07-12 | Nulens Ltd. | Eye wall anchored fixtures |
| US9498457B2 (en) | 2004-04-30 | 2016-11-22 | Allergan, Inc. | Hypotensive prostamide-containing biodegradable intraocular implants and related implants |
| US8673341B2 (en) | 2004-04-30 | 2014-03-18 | Allergan, Inc. | Intraocular pressure reduction with intracameral bimatoprost implants |
| US7993634B2 (en) | 2004-04-30 | 2011-08-09 | Allergan, Inc. | Oil-in-oil emulsified polymeric implants containing a hypotensive lipid and related methods |
| US8722097B2 (en) | 2004-04-30 | 2014-05-13 | Allergan, Inc. | Oil-in-water method for making polymeric implants containing a hypotensive lipid |
| US8246569B1 (en) | 2004-08-17 | 2012-08-21 | California Institute Of Technology | Implantable intraocular pressure drain |
| US20090208556A1 (en) | 2004-10-29 | 2009-08-20 | Regents Of The University Of California, The | Porous photonic crystals for drug delivery to the eye |
| EP1998829B1 (en) | 2006-03-14 | 2011-02-09 | University Of Southern California | Mems device for delivery of therapeutic agents |
| US8802128B2 (en) * | 2006-06-23 | 2014-08-12 | Allergan, Inc. | Steroid-containing sustained release intraocular implants and related methods |
| CA2704111C (en) * | 2007-05-14 | 2017-06-20 | Sustained Nano Systems Llc | Hypercompressed particles for controlled release of ophthalmic medications |
| EP2242464B2 (en) | 2007-12-20 | 2017-03-01 | University Of Southern California | Apparatus for delivering therapeutic agents |
| MX2010007382A (es) | 2008-01-03 | 2010-12-20 | Univ Southern California | Dispositivos implantables para suministro de farmacos, y aparato y metodos para recargar los dispositivos. |
| WO2009137780A2 (en) | 2008-05-08 | 2009-11-12 | Replenish Pumps, Llc | Implantable pumps and cannulas therefor |
| US8348897B2 (en) | 2008-05-08 | 2013-01-08 | Minipumps, Llc | Implantable drug-delivery devices, and apparatus and methods for filling the devices |
| US8231609B2 (en) | 2008-05-08 | 2012-07-31 | Minipumps, Llc | Drug-delivery pumps and methods of manufacture |
| US9333297B2 (en) | 2008-05-08 | 2016-05-10 | Minipumps, Llc | Drug-delivery pump with intelligent control |
| USD629503S1 (en) | 2009-05-08 | 2010-12-21 | Sean Caffey | Implantable drug-delivery pump |
| CN102596097B (zh) * | 2009-06-03 | 2015-05-20 | 弗赛特实验室有限责任公司 | 一种眼插入件 |
| MX2012002063A (es) | 2009-08-18 | 2012-08-01 | Minipumps Llc | Bomba electrolitica para la administracion de farmacos con control adaptativo. |
| WO2011094170A1 (en) | 2010-01-27 | 2011-08-04 | Alcon Research, Ltd. | Pulsatile peri-corneal drug delivery device |
| US9919099B2 (en) | 2011-03-14 | 2018-03-20 | Minipumps, Llc | Implantable drug pumps and refill devices therefor |
| US9603997B2 (en) | 2011-03-14 | 2017-03-28 | Minipumps, Llc | Implantable drug pumps and refill devices therefor |
| US10286146B2 (en) | 2011-03-14 | 2019-05-14 | Minipumps, Llc | Implantable drug pumps and refill devices therefor |
| MX2013008993A (es) | 2013-08-02 | 2014-03-24 | Raam De Sahuayo S A De C V Lab | Sistema de liberacion modificada en tres fases de un antiinflamatorio no esteroide. |
| DK3351239T3 (da) | 2013-10-31 | 2020-06-29 | Allergan Inc | Prostamid-indeholdende intraokulære implantater og fremgangsmåder til anvendelse deraf |
| EP4566638A3 (en) * | 2015-05-29 | 2025-08-27 | Allergan, Inc. | Implant for treatment of an ocular condition |
| CN115554460A (zh) * | 2022-09-26 | 2023-01-03 | 山东万容生物科技有限公司 | 一种多功能湿性敷料及其制备方法 |
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| JPS4836993A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1971-09-09 | 1973-05-31 | ||
| JPS61109711A (ja) * | 1984-10-30 | 1986-05-28 | エラン コーポレーシヨン ピー エル シー | 制御放出パウダー及びその製法 |
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| US3981303A (en) * | 1971-09-09 | 1976-09-21 | Alza Corporation | Bioerodible ocular device |
| US4179497A (en) * | 1973-12-17 | 1979-12-18 | Merck & Co., Inc. | Solid state ophthalmic medication |
| US4115544A (en) * | 1976-08-18 | 1978-09-19 | Alza Corporation | Ocular system made of bioerodible esters having linear ether |
| IE50901B1 (en) * | 1980-03-04 | 1986-08-06 | Merck & Co Inc | Ophthalmic compositions of carbonic anhydrase inhibitors for topical application in the treatment of elevated intraocular pressure |
-
1987
- 1987-06-23 CA CA000540361A patent/CA1311686C/en not_active Expired - Lifetime
- 1987-06-24 DE DE8787305625T patent/DE3778223D1/de not_active Expired - Lifetime
- 1987-06-24 JP JP62155622A patent/JPS6322516A/ja active Pending
- 1987-06-24 EP EP87305625A patent/EP0251680B1/en not_active Expired - Lifetime
- 1987-06-24 ES ES198787305625T patent/ES2037082T3/es not_active Expired - Lifetime
- 1987-06-24 AU AU74650/87A patent/AU606872B2/en not_active Expired - Fee Related
- 1987-06-24 AT AT87305625T patent/ATE74752T1/de not_active IP Right Cessation
-
1992
- 1992-05-26 GR GR920401046T patent/GR3004710T3/el unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4836993A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1971-09-09 | 1973-05-31 | ||
| JPS61109711A (ja) * | 1984-10-30 | 1986-05-28 | エラン コーポレーシヨン ピー エル シー | 制御放出パウダー及びその製法 |
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH02702A (ja) * | 1987-12-22 | 1990-01-05 | Vernon G Wong | 生物分解性眼移植物 |
| JPH08507747A (ja) * | 1992-12-30 | 1996-08-20 | クローバー コンソリデイテッド，リミテッド | 生物学的活性物質用の細包を保護し生体に適合する、再利用可能なマクロカプセル封入システム |
| JP2005525299A (ja) * | 2001-09-14 | 2005-08-25 | スコラー インコーポレイテッド | アミノ酸調節性の長期放出投薬形態 |
| JP2012121927A (ja) * | 2004-04-30 | 2012-06-28 | Allergan Inc | プロスタミド含有生分解性眼内インプラント |
| JP2007535537A (ja) * | 2004-04-30 | 2007-12-06 | アラーガン、インコーポレイテッド | プロスタミド含有生分解性眼内インプラント |
| JP2006257080A (ja) * | 2005-02-18 | 2006-09-28 | Santen Pharmaceut Co Ltd | ステロイド化合物の副作用軽減または回避方法 |
| JP2009542671A (ja) * | 2006-06-28 | 2009-12-03 | サーモディクス，インコーポレイティド | 微粒子を含む活性剤溶出マトリックス |
| JP2009545564A (ja) * | 2006-08-02 | 2009-12-24 | メディオラヌム ファルマチェウティカルズ リミテッド | 長時間にわたって活性本体を放出する皮下移植物 |
| JP2012511519A (ja) * | 2008-12-10 | 2012-05-24 | アンフイ ジョンレン テクノロジー コーポレイション，リミテッド | 制御放出組成物 |
| US9498431B2 (en) | 2008-12-10 | 2016-11-22 | Jianjian Xu | Controlled releasing composition |
| JP2012025708A (ja) * | 2010-07-27 | 2012-02-09 | Sepa Sigma Inc | 膜透過機構を異にする複数の徐放機構を利用した徐放化局所投与剤 |
| JP2018518514A (ja) * | 2015-06-26 | 2018-07-12 | コンティプロ アクチオヴァ スポレチノスト | 眼科医薬組成物 |
| JP2020527591A (ja) * | 2017-07-17 | 2020-09-10 | ウルフクリーク バイオテック プライベート リミテッド | 活性薬剤送達のための微粒子製剤 |
Also Published As
| Publication number | Publication date |
|---|---|
| GR3004710T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1993-04-28 |
| EP0251680A2 (en) | 1988-01-07 |
| EP0251680B1 (en) | 1992-04-15 |
| AU7465087A (en) | 1988-01-07 |
| ES2037082T3 (es) | 1993-06-16 |
| DE3778223D1 (de) | 1992-05-21 |
| AU606872B2 (en) | 1991-02-21 |
| EP0251680A3 (en) | 1988-02-24 |
| CA1311686C (en) | 1992-12-22 |
| ATE74752T1 (de) | 1992-05-15 |
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