DE3778223D1 - Biologisch erodierbares system mit gesteuerter freisetzung des arzneiwirkstoffes. - Google Patents
Biologisch erodierbares system mit gesteuerter freisetzung des arzneiwirkstoffes.Info
- Publication number
- DE3778223D1 DE3778223D1 DE8787305625T DE3778223T DE3778223D1 DE 3778223 D1 DE3778223 D1 DE 3778223D1 DE 8787305625 T DE8787305625 T DE 8787305625T DE 3778223 T DE3778223 T DE 3778223T DE 3778223 D1 DE3778223 D1 DE 3778223D1
- Authority
- DE
- Germany
- Prior art keywords
- controlled release
- fluids
- bioderodible
- pharmaceutical compound
- active substance
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A61K9/0051—Ocular inserts, ocular implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
- A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1658—Proteins, e.g. albumin, gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US87827286A | 1986-06-25 | 1986-06-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
DE3778223D1 true DE3778223D1 (de) | 1992-05-21 |
Family
ID=25371703
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8787305625T Expired - Lifetime DE3778223D1 (de) | 1986-06-25 | 1987-06-24 | Biologisch erodierbares system mit gesteuerter freisetzung des arzneiwirkstoffes. |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0251680B1 (de) |
JP (1) | JPS6322516A (de) |
AT (1) | ATE74752T1 (de) |
AU (1) | AU606872B2 (de) |
CA (1) | CA1311686C (de) |
DE (1) | DE3778223D1 (de) |
ES (1) | ES2037082T3 (de) |
GR (1) | GR3004710T3 (de) |
Families Citing this family (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4853224A (en) * | 1987-12-22 | 1989-08-01 | Visionex | Biodegradable ocular implants |
US4923699A (en) * | 1988-06-03 | 1990-05-08 | Kaufman Herbert E | Eye treatment suspension |
DE68906461T2 (de) * | 1988-06-07 | 1993-10-21 | Abbott Lab | Feste Arzneidosis in Form eines Tablettentriturats sowie Verfahren zu deren Herstellung. |
US5082667A (en) * | 1988-06-07 | 1992-01-21 | Abbott Laboratories | Solid pharmaceutical dosage in tablet triturate form and method of producing same |
US5007790A (en) * | 1989-04-11 | 1991-04-16 | Depomed Systems, Inc. | Sustained-release oral drug dosage form |
GB8917217D0 (en) * | 1989-07-27 | 1989-09-13 | Smith & Nephew | Ophthalmic compositions |
US5164188A (en) * | 1989-11-22 | 1992-11-17 | Visionex, Inc. | Biodegradable ocular implants |
JP3011752B2 (ja) * | 1990-10-23 | 2000-02-21 | フロイント産業株式会社 | 徐放性製剤およびその製造方法 |
FR2673843B1 (fr) * | 1991-03-14 | 1995-01-13 | Centre Nat Rech Scient | Composition pharmaceutique implantable, bioresorbable a base de poly(acide lactique), destinee a mettre en óoeuvre une antibiotherapie interne locale. |
US5912015A (en) * | 1992-03-12 | 1999-06-15 | Alkermes Controlled Therapeutics, Inc. | Modulated release from biocompatible polymers |
JPH08507747A (ja) * | 1992-12-30 | 1996-08-20 | クローバー コンソリデイテッド,リミテッド | 生物学的活性物質用の細包を保護し生体に適合する、再利用可能なマクロカプセル封入システム |
IE75744B1 (en) * | 1995-04-03 | 1997-09-24 | Elan Corp Plc | Controlled release biodegradable micro- and nanospheres containing cyclosporin |
US6265389B1 (en) | 1995-08-31 | 2001-07-24 | Alkermes Controlled Therapeutics, Inc. | Microencapsulation and sustained release of oligonucleotides |
CA2230494A1 (en) * | 1995-08-31 | 1997-03-06 | Alkermes Controlled Therapeutics Inc. | Composition for sustained release of an agent |
DE19756314C2 (de) * | 1997-12-12 | 2000-06-29 | Roland Bodmeier | Zubereitung mit verlängerter Verweildauer am Applikationsort |
US6264971B1 (en) | 1999-11-04 | 2001-07-24 | Btg International Limited | Ocular insert |
DE10133870A1 (de) * | 2001-07-12 | 2003-02-06 | Chris P Lohmann | Ophthalmisches Mittel, Verwendung von EGF zur Behandlung von Dry Eye-Syndrom und Insert zur Verabreichung von EGF am Auge |
JP2005525299A (ja) * | 2001-09-14 | 2005-08-25 | スコラー インコーポレイテッド | アミノ酸調節性の長期放出投薬形態 |
DE10246900A1 (de) | 2002-10-08 | 2004-04-22 | Horstmann, Michael, Dr. | Am Auge applizierbare Vorrichtung zur sicheren Dosierung systemischer und tropischer Medikation |
US7976520B2 (en) | 2004-01-12 | 2011-07-12 | Nulens Ltd. | Eye wall anchored fixtures |
US8673341B2 (en) | 2004-04-30 | 2014-03-18 | Allergan, Inc. | Intraocular pressure reduction with intracameral bimatoprost implants |
US8722097B2 (en) | 2004-04-30 | 2014-05-13 | Allergan, Inc. | Oil-in-water method for making polymeric implants containing a hypotensive lipid |
US7993634B2 (en) | 2004-04-30 | 2011-08-09 | Allergan, Inc. | Oil-in-oil emulsified polymeric implants containing a hypotensive lipid and related methods |
US7799336B2 (en) | 2004-04-30 | 2010-09-21 | Allergan, Inc. | Hypotensive lipid-containing biodegradable intraocular implants and related methods |
US9498457B2 (en) | 2004-04-30 | 2016-11-22 | Allergan, Inc. | Hypotensive prostamide-containing biodegradable intraocular implants and related implants |
US8246569B1 (en) | 2004-08-17 | 2012-08-21 | California Institute Of Technology | Implantable intraocular pressure drain |
ES2669585T3 (es) * | 2004-10-29 | 2018-05-28 | The Regents Of The University Of California | Micropartículas porosas de silicio para la entrega de fármaco para el ojo |
JP2006257080A (ja) * | 2005-02-18 | 2006-09-28 | Santen Pharmaceut Co Ltd | ステロイド化合物の副作用軽減または回避方法 |
DE602007012417D1 (de) | 2006-03-14 | 2011-03-24 | Univ Southern California | Mems-Vorrichtung zur Wirkstofffreisetzung |
US8802128B2 (en) * | 2006-06-23 | 2014-08-12 | Allergan, Inc. | Steroid-containing sustained release intraocular implants and related methods |
JP2009542671A (ja) * | 2006-06-28 | 2009-12-03 | サーモディクス,インコーポレイティド | 微粒子を含む活性剤溶出マトリックス |
ITMI20061545A1 (it) * | 2006-08-02 | 2008-02-03 | Mediolanum Pharmaceuticals Ltd | Particelle in grado di rilasciare il principio attivo per un periodo prolungato di tempo |
AU2008254989B2 (en) * | 2007-05-14 | 2013-06-06 | Sustained Nano Systems Llc | Hypercompressed particles for controlled release of ophthalmic medications |
MX2010006840A (es) | 2007-12-20 | 2010-08-12 | Univ Southern California | Aparato y métodos para suministrar agentes terapeuticos. |
US20090192493A1 (en) | 2008-01-03 | 2009-07-30 | University Of Southern California | Implantable drug-delivery devices, and apparatus and methods for refilling the devices |
JP5719767B2 (ja) | 2008-05-08 | 2015-05-20 | ミニパンプス, エルエルシー | 埋込型ポンプおよびそのためのカニューレ |
US9849238B2 (en) | 2008-05-08 | 2017-12-26 | Minipumps, Llc | Drug-delivery pump with intelligent control |
WO2009137777A2 (en) | 2008-05-08 | 2009-11-12 | Replenish Pumps, Llc | Implantable drug-delivery devices, and apparatus and methods for filling the devices |
WO2009137785A2 (en) | 2008-05-08 | 2009-11-12 | Replenish Pumps, Llc | Drug-delivery pumps and methods of manufacture |
JP2012511519A (ja) * | 2008-12-10 | 2012-05-24 | アンフイ ジョンレン テクノロジー コーポレイション,リミテッド | 制御放出組成物 |
EP4108216A1 (de) * | 2009-06-03 | 2022-12-28 | Forsight Vision5, Inc. | Wirkstofffreisetzung im vorderen augensegment |
AU2010284216B2 (en) | 2009-08-18 | 2015-10-15 | Minipumps, Llc | Electrolytic drug-delivery pump with adaptive control |
US8469934B2 (en) | 2010-01-27 | 2013-06-25 | Alcon Research, Ltd. | Pulsatile peri-corneal drug delivery device |
JP2012025708A (ja) * | 2010-07-27 | 2012-02-09 | Sepa Sigma Inc | 膜透過機構を異にする複数の徐放機構を利用した徐放化局所投与剤 |
US10286146B2 (en) | 2011-03-14 | 2019-05-14 | Minipumps, Llc | Implantable drug pumps and refill devices therefor |
US9603997B2 (en) | 2011-03-14 | 2017-03-28 | Minipumps, Llc | Implantable drug pumps and refill devices therefor |
US9919099B2 (en) | 2011-03-14 | 2018-03-20 | Minipumps, Llc | Implantable drug pumps and refill devices therefor |
MX2013008993A (es) | 2013-08-02 | 2014-03-24 | Raam De Sahuayo S A De C V Lab | Sistema de liberacion modificada en tres fases de un antiinflamatorio no esteroide. |
CN110302138B (zh) | 2013-10-31 | 2022-09-30 | 阿勒根公司 | 含前列腺酰胺的眼内植入物及其使用方法 |
EP3302382A4 (de) * | 2015-05-29 | 2019-02-20 | Allergan, Inc. | Implantat zur behandlung eines augenleidens |
EP3108874A1 (de) * | 2015-06-26 | 2016-12-28 | TRB Chemedica AG | Pharmazeutische zubereitung zur anwendung am auge |
WO2019016686A1 (en) * | 2017-07-17 | 2019-01-24 | Wolfcreek Biotech Pte Ltd | MICROPARTICLE FORMULATIONS FOR THE ADMINISTRATION OF ACTIVE AGENTS |
CN115554460A (zh) * | 2022-09-26 | 2023-01-03 | 山东万容生物科技有限公司 | 一种多功能湿性敷料及其制备方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3981303A (en) * | 1971-09-09 | 1976-09-21 | Alza Corporation | Bioerodible ocular device |
BE788575A (fr) * | 1971-09-09 | 1973-01-02 | Alza Corp | Dispositif oculaire pour l'administration d'un |
US4179497A (en) * | 1973-12-17 | 1979-12-18 | Merck & Co., Inc. | Solid state ophthalmic medication |
US4115544A (en) * | 1976-08-18 | 1978-09-19 | Alza Corporation | Ocular system made of bioerodible esters having linear ether |
IE50901B1 (en) * | 1980-03-04 | 1986-08-06 | Merck & Co Inc | Ophthalmic compositions of carbonic anhydrase inhibitors for topical application in the treatment of elevated intraocular pressure |
IE58110B1 (en) * | 1984-10-30 | 1993-07-14 | Elan Corp Plc | Controlled release powder and process for its preparation |
-
1987
- 1987-06-23 CA CA000540361A patent/CA1311686C/en not_active Expired - Lifetime
- 1987-06-24 AT AT87305625T patent/ATE74752T1/de not_active IP Right Cessation
- 1987-06-24 ES ES198787305625T patent/ES2037082T3/es not_active Expired - Lifetime
- 1987-06-24 AU AU74650/87A patent/AU606872B2/en not_active Expired - Fee Related
- 1987-06-24 JP JP62155622A patent/JPS6322516A/ja active Pending
- 1987-06-24 DE DE8787305625T patent/DE3778223D1/de not_active Expired - Lifetime
- 1987-06-24 EP EP87305625A patent/EP0251680B1/de not_active Expired - Lifetime
-
1992
- 1992-05-26 GR GR920401046T patent/GR3004710T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
AU606872B2 (en) | 1991-02-21 |
GR3004710T3 (de) | 1993-04-28 |
JPS6322516A (ja) | 1988-01-30 |
CA1311686C (en) | 1992-12-22 |
AU7465087A (en) | 1988-01-07 |
ATE74752T1 (de) | 1992-05-15 |
EP0251680A3 (en) | 1988-02-24 |
EP0251680A2 (de) | 1988-01-07 |
EP0251680B1 (de) | 1992-04-15 |
ES2037082T3 (es) | 1993-06-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: CIBA-GEIGY AG, BASEL, CH |
|
8328 | Change in the person/name/address of the agent |
Free format text: ZUMSTEIN & KLINGSEISEN, 80331 MUENCHEN |
|
8327 | Change in the person/name/address of the patent owner |
Owner name: NOVARTIS AG, BASEL, CH |
|
8339 | Ceased/non-payment of the annual fee |