ATE73499T1 - Anti-protein c monoklonaler antikoerper, seine herstellung und verwendung. - Google Patents
Anti-protein c monoklonaler antikoerper, seine herstellung und verwendung.Info
- Publication number
- ATE73499T1 ATE73499T1 AT84112453T AT84112453T ATE73499T1 AT E73499 T1 ATE73499 T1 AT E73499T1 AT 84112453 T AT84112453 T AT 84112453T AT 84112453 T AT84112453 T AT 84112453T AT E73499 T1 ATE73499 T1 AT E73499T1
- Authority
- AT
- Austria
- Prior art keywords
- protein
- antibody
- production
- monoclonal antibody
- monoclonal anti
- Prior art date
Links
- 229960000856 protein c Drugs 0.000 abstract 5
- 101800004937 Protein C Proteins 0.000 abstract 2
- 102100036546 Salivary acidic proline-rich phosphoprotein 1/2 Human genes 0.000 abstract 2
- 101800001700 Saposin-D Proteins 0.000 abstract 2
- 238000000746 purification Methods 0.000 abstract 2
- 238000002965 ELISA Methods 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 210000004408 hybridoma Anatomy 0.000 abstract 1
- 238000005259 measurement Methods 0.000 abstract 1
- 230000003248 secreting effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/948—Microorganisms using viruses or cell lines
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/815—Test for named compound or class of compounds
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hematology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB838327860A GB8327860D0 (en) | 1983-10-18 | 1983-10-18 | Monoclonal antiprotein c antibody |
EP84112453A EP0138222B1 (de) | 1983-10-18 | 1984-10-16 | Herstellung von anti-Protein C monoklonalen Antikörpern |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE73499T1 true ATE73499T1 (de) | 1992-03-15 |
Family
ID=10550386
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT84112453T ATE73499T1 (de) | 1983-10-18 | 1984-10-16 | Anti-protein c monoklonaler antikoerper, seine herstellung und verwendung. |
Country Status (6)
Country | Link |
---|---|
US (1) | US4696895A (de) |
EP (1) | EP0138222B1 (de) |
JP (2) | JPS60120825A (de) |
AT (1) | ATE73499T1 (de) |
DE (1) | DE3485559D1 (de) |
GB (1) | GB8327860D0 (de) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS61134399A (ja) * | 1984-12-03 | 1986-06-21 | Teijin Ltd | モノクローナル抗体及びその製造方法 |
US4902614A (en) * | 1984-12-03 | 1990-02-20 | Teijin Limited | Monoclonal antibody to human protein C |
JPH0619352B2 (ja) * | 1985-06-10 | 1994-03-16 | 帝人株式会社 | ヒト・プロテインcの測定方法 |
FR2582103B1 (fr) * | 1985-03-19 | 1989-05-05 | Canavaggio Michel | Procede de determination d'une substance biologique dans un echantillon |
DE3688900T3 (de) * | 1985-06-27 | 1998-06-10 | Univ Washington | Expression von Protein C. |
US4968626A (en) * | 1985-08-15 | 1990-11-06 | Board Of Reagents Of The University Of Washington | DNA sequence coding for protein C |
US5516650A (en) * | 1985-06-27 | 1996-05-14 | Zymogenetics, Inc. | Production of activated protein C |
US4959318A (en) * | 1985-06-27 | 1990-09-25 | Zymogenetics, Inc. | Expression of protein C |
USRE38981E1 (en) * | 1985-08-15 | 2006-02-14 | Board Of Regents Of The University Of Washington | DNA sequence coding for protein C |
AT399095B (de) * | 1986-03-27 | 1995-03-27 | Vukovich Thomas Dr | Verfahren zur auftrennung von proteinen mittels gradientenelution und vorrichtung zur durchführung des verfahrens |
IL98886A (en) * | 1986-04-09 | 1992-12-01 | Lilly Co Eli | Method for producing a functional polypeptide in a eukaryotic cell |
USH1148H (en) | 1987-04-17 | 1993-03-02 | Method of separating activated human protein C | |
JPS6485091A (en) * | 1987-04-17 | 1989-03-30 | Teijin Ltd | Isolation and purification of activated human protein c using antibody |
DE3882411T2 (de) * | 1987-04-17 | 1993-12-16 | Teijin Ltd | Verfahren zur Trennung von aktiviertem menschlichem Protein C. |
US4992373A (en) * | 1987-12-04 | 1991-02-12 | Eli Lilly And Company | Vectors and compounds for direct expression of activated human protein C |
US5374533A (en) * | 1988-05-10 | 1994-12-20 | Tetjin Limited | Method for determining chondrocalcin |
DE68923833T2 (de) * | 1988-06-20 | 1996-06-13 | Mitsubishi Electric Corp | Optischer Kopf mit Kippkorrekturservomechanismus. |
US5288612A (en) * | 1991-07-03 | 1994-02-22 | The Scripps Research Institute | Assay methods for detecting serum proteases, particularly activated protein C |
WO2001098782A1 (fr) * | 2000-06-22 | 2001-12-27 | Mochida Pharmaceutical Co., Ltd | Kit de determination du pouvoir de coagulation du sang |
TW200407335A (en) | 2002-07-22 | 2004-05-16 | Chugai Pharmaceutical Co Ltd | Non-neutralizing antibody to inhibit the inactivation of activated protein C |
WO2015041310A1 (ja) * | 2013-09-20 | 2015-03-26 | 中外製薬株式会社 | 抗プロテインc抗体による出血性疾患の治療 |
TW201906868A (zh) * | 2017-07-07 | 2019-02-16 | 日商第一三共股份有限公司 | 抗蛋白c抗體 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4486530A (en) * | 1980-08-04 | 1984-12-04 | Hybritech Incorporated | Immunometric assays using monoclonal antibodies |
EP0118256B1 (de) * | 1983-03-04 | 1992-05-13 | Scripps Clinic And Research Foundation | Immunoadsorbens und Verfahren zur Zurückgewinnung von Vitamin-K-abhängigen Proteinen mittels dieses Adsorbens |
JPS61500226A (ja) * | 1983-10-28 | 1986-02-06 | ニュ−・イングランド・メディカル・センタ−・ホスピタルズ・インコ−ポレ−テッド | コンホメ−ション特異性抗体を用いる血液凝固タンパク質の精製および単離法 |
-
1983
- 1983-10-18 GB GB838327860A patent/GB8327860D0/en active Pending
-
1984
- 1984-10-08 JP JP59212341A patent/JPS60120825A/ja active Pending
- 1984-10-09 US US06/658,560 patent/US4696895A/en not_active Expired - Fee Related
- 1984-10-16 AT AT84112453T patent/ATE73499T1/de active
- 1984-10-16 EP EP84112453A patent/EP0138222B1/de not_active Expired - Lifetime
- 1984-10-16 DE DE8484112453T patent/DE3485559D1/de not_active Revoked
-
1992
- 1992-04-13 JP JP4092745A patent/JPH0638743A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
DE3485559D1 (de) | 1992-04-16 |
EP0138222A2 (de) | 1985-04-24 |
JPS60120825A (ja) | 1985-06-28 |
EP0138222B1 (de) | 1992-03-11 |
JPH0638743A (ja) | 1994-02-15 |
US4696895A (en) | 1987-09-29 |
EP0138222A3 (en) | 1987-11-04 |
GB8327860D0 (en) | 1983-11-16 |
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