ATE65993T1 - Chinolinverbindung. - Google Patents

Chinolinverbindung.

Info

Publication number
ATE65993T1
ATE65993T1 AT87311275T AT87311275T ATE65993T1 AT E65993 T1 ATE65993 T1 AT E65993T1 AT 87311275 T AT87311275 T AT 87311275T AT 87311275 T AT87311275 T AT 87311275T AT E65993 T1 ATE65993 T1 AT E65993T1
Authority
AT
Austria
Prior art keywords
quinoline compound
compound
quinoline
concerned
chem
Prior art date
Application number
AT87311275T
Other languages
English (en)
Inventor
Arthur Page Phillips
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Found filed Critical Wellcome Found
Application granted granted Critical
Publication of ATE65993T1 publication Critical patent/ATE65993T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Quinoline Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)
  • Secondary Cells (AREA)
  • Carbon And Carbon Compounds (AREA)
AT87311275T 1986-12-23 1987-12-22 Chinolinverbindung. ATE65993T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB868630702A GB8630702D0 (en) 1986-12-23 1986-12-23 Quinoline compound
EP87311275A EP0272910B1 (de) 1986-12-23 1987-12-22 Chinolinverbindung

Publications (1)

Publication Number Publication Date
ATE65993T1 true ATE65993T1 (de) 1991-08-15

Family

ID=10609475

Family Applications (1)

Application Number Title Priority Date Filing Date
AT87311275T ATE65993T1 (de) 1986-12-23 1987-12-22 Chinolinverbindung.

Country Status (22)

Country Link
US (1) US4937248A (de)
EP (1) EP0272910B1 (de)
JP (1) JPS63166866A (de)
KR (1) KR880007514A (de)
AT (1) ATE65993T1 (de)
AU (1) AU594220B2 (de)
CA (1) CA1318671C (de)
DE (1) DE3772015D1 (de)
DK (1) DK163429C (de)
ES (1) ES2029842T3 (de)
FI (1) FI90768C (de)
GB (1) GB8630702D0 (de)
GR (1) GR3002445T3 (de)
HU (1) HU196991B (de)
IE (1) IE60619B1 (de)
IL (1) IL84917A (de)
MX (1) MX9203788A (de)
MY (1) MY102277A (de)
NZ (1) NZ223036A (de)
PH (1) PH23448A (de)
PT (1) PT86448B (de)
ZA (1) ZA879615B (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5166160A (en) * 1986-12-23 1992-11-24 Burroughs Wellcome Co. Quinoline compound
GB8820174D0 (en) * 1988-08-25 1988-09-28 Wellcome Found Quinoline compound
AU735729B2 (en) * 1997-09-24 2001-07-12 Orion Corporation Bisethers of 1-oxa, aza and thianaphthalen-2-ones as phospholamban inhibitors
DE60027443D1 (de) 1999-08-27 2006-05-24 Ligand Pharm Inc Androgenrezeptor-modulatorverbindungen und verfahren
US6667313B1 (en) 1999-08-27 2003-12-23 Ligand Pharmaceuticals Inc. 8-substituted-6-triflouromethyl-9-pyrido [3,2-G] quinoline compounds as androgen receptor modulators
US6566372B1 (en) 1999-08-27 2003-05-20 Ligand Pharmaceuticals Incorporated Bicyclic androgen and progesterone receptor modulator compounds and methods
CO5200852A1 (es) 1999-09-14 2002-09-27 Lilly Co Eli Moduladores rxr con mejorado perfil farmacologico ceptores x de los retinoides
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
US7816372B2 (en) 2003-08-22 2010-10-19 Ligand Pharmaceuticals Incorporated 6-cycloamino-2-quinolinone derivatives as androgen receptor modulator compounds
US8034782B2 (en) 2008-07-16 2011-10-11 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
WO2008151257A2 (en) 2007-06-04 2008-12-11 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
EP2810951B1 (de) 2008-06-04 2017-03-15 Synergy Pharmaceuticals Inc. Für die Behandlung von gastrointestinalen Erkrankungen, Entzündungen, Krebs und anderen Erkrankungen geeignete Agonisten von Guanylatcyclase
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CN107090016A (zh) 2011-03-01 2017-08-25 辛纳吉制药公司 制备鸟苷酸环化酶c激动剂的方法
US9545446B2 (en) 2013-02-25 2017-01-17 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
US9708367B2 (en) 2013-03-15 2017-07-18 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
AU2014235209B2 (en) 2013-03-15 2018-06-14 Bausch Health Ireland Limited Guanylate cyclase receptor agonists combined with other drugs
CN105764916B (zh) 2013-06-05 2021-05-18 博士医疗爱尔兰有限公司 鸟苷酸环化酶c的超纯激动剂、制备和使用所述激动剂的方法
CN114404588A (zh) 2013-08-09 2022-04-29 阿德利克斯公司 用于抑制磷酸盐转运的化合物和方法
EP3972599B1 (de) 2019-05-21 2025-10-22 Ardelyx, Inc. Kombination zur senkung des serum-phosphatspiegels bei einem patienten

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2616855A (en) * 1948-01-15 1952-11-04 Procter & Gamble Detergent composition
US4329347A (en) * 1978-02-17 1982-05-11 Boehringer Ingelheim Gmbh Cardiotonic and antithrombotic sulfur-containing derivatives of carbostyril
JPS5777676A (en) * 1980-10-31 1982-05-15 Otsuka Pharmaceut Co Ltd Carbostyril derivative
US4710507A (en) * 1983-12-22 1987-12-01 Pfizer Inc. Quinolone inotropic agents
ES8608874A1 (es) * 1984-05-29 1986-09-01 Pfizer Un procedimiento para la preparacion de una 2-(1h)-quinolona
US4760064A (en) * 1984-12-18 1988-07-26 Otsuka Pharmaceutical Co., Ltd. Carbostyril compounds, compositions containing same and processes for preparing same
US4845100A (en) * 1985-04-12 1989-07-04 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives and salts thereof, processes for preparing the same and cardiotonic composition containing the same
FR2580646A1 (fr) * 1985-04-19 1986-10-24 Synthelabo Derives de 2(1h)-quinolinone, leur preparation et leur application en therapeutique
GB8529362D0 (en) * 1985-11-28 1986-01-02 Pfizer Ltd Quinolone cardiac stimulants
DK111387A (da) * 1986-03-05 1987-09-06 Otsuka Pharma Co Ltd Carbostyrilderivater og salte deraf, laegemiddel indeholdende saadanne derivater samt fremgangsmaade til fremstilling af derivaterne
US4886809A (en) * 1986-07-31 1989-12-12 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives and salts thereof

Also Published As

Publication number Publication date
FI875666L (fi) 1988-06-24
AU594220B2 (en) 1990-03-01
GB8630702D0 (en) 1987-02-04
MY102277A (en) 1992-05-15
IL84917A0 (en) 1988-06-30
ZA879615B (en) 1989-08-30
GR3002445T3 (en) 1992-12-30
DK680887A (da) 1988-06-24
US4937248A (en) 1990-06-26
DK680887D0 (da) 1987-12-22
IL84917A (en) 1991-08-16
EP0272910B1 (de) 1991-08-07
MX9203788A (es) 1992-07-01
PT86448B (pt) 1990-11-20
AU8293387A (en) 1988-06-23
FI90768C (fi) 1994-03-25
ES2029842T3 (es) 1992-10-01
NZ223036A (en) 1990-11-27
EP0272910A1 (de) 1988-06-29
FI875666A0 (fi) 1987-12-22
HUT45984A (en) 1988-09-28
HU196991B (en) 1989-02-28
DK163429C (da) 1992-07-20
DE3772015D1 (de) 1991-09-12
IE873490L (en) 1988-06-23
DK163429B (da) 1992-03-02
PT86448A (en) 1988-01-01
PH23448A (en) 1989-08-07
IE60619B1 (en) 1994-07-27
JPS63166866A (ja) 1988-07-11
FI90768B (fi) 1993-12-15
KR880007514A (ko) 1988-08-27
CA1318671C (en) 1993-06-01

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