IL84917A - Quinolinone derivative,its preparation and pharmaceutical compositions containing it - Google Patents
Quinolinone derivative,its preparation and pharmaceutical compositions containing itInfo
- Publication number
- IL84917A IL84917A IL84917A IL8491787A IL84917A IL 84917 A IL84917 A IL 84917A IL 84917 A IL84917 A IL 84917A IL 8491787 A IL8491787 A IL 8491787A IL 84917 A IL84917 A IL 84917A
- Authority
- IL
- Israel
- Prior art keywords
- preparation
- pharmaceutical compositions
- compositions containing
- quinolinone derivative
- quinolinone
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- LISFMEBWQUVKPJ-UHFFFAOYSA-N quinolin-2-ol Chemical class C1=CC=C2NC(=O)C=CC2=C1 LISFMEBWQUVKPJ-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Secondary Cells (AREA)
- Carbon And Carbon Compounds (AREA)
- Superconductors And Manufacturing Methods Therefor (AREA)
- Quinoline Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB868630702A GB8630702D0 (en) | 1986-12-23 | 1986-12-23 | Quinoline compound |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL84917A0 IL84917A0 (en) | 1988-06-30 |
| IL84917A true IL84917A (en) | 1991-08-16 |
Family
ID=10609475
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL84917A IL84917A (en) | 1986-12-23 | 1987-12-22 | Quinolinone derivative,its preparation and pharmaceutical compositions containing it |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US4937248A (de) |
| EP (1) | EP0272910B1 (de) |
| JP (1) | JPS63166866A (de) |
| KR (1) | KR880007514A (de) |
| AT (1) | ATE65993T1 (de) |
| AU (1) | AU594220B2 (de) |
| CA (1) | CA1318671C (de) |
| DE (1) | DE3772015D1 (de) |
| DK (1) | DK163429C (de) |
| ES (1) | ES2029842T3 (de) |
| FI (1) | FI90768C (de) |
| GB (1) | GB8630702D0 (de) |
| GR (1) | GR3002445T3 (de) |
| HU (1) | HU196991B (de) |
| IE (1) | IE60619B1 (de) |
| IL (1) | IL84917A (de) |
| MX (1) | MX9203788A (de) |
| MY (1) | MY102277A (de) |
| NZ (1) | NZ223036A (de) |
| PH (1) | PH23448A (de) |
| PT (1) | PT86448B (de) |
| ZA (1) | ZA879615B (de) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5166160A (en) * | 1986-12-23 | 1992-11-24 | Burroughs Wellcome Co. | Quinoline compound |
| GB8820174D0 (en) * | 1988-08-25 | 1988-09-28 | Wellcome Found | Quinoline compound |
| JP2003525838A (ja) * | 1997-09-24 | 2003-09-02 | オリオン コーポレーション | ホスホランバン阻害剤としての１−オキサ、アザおよびチアナフタレン−２−オンのビスエーテル類 |
| US6566372B1 (en) | 1999-08-27 | 2003-05-20 | Ligand Pharmaceuticals Incorporated | Bicyclic androgen and progesterone receptor modulator compounds and methods |
| CZ2002711A3 (cs) | 1999-08-27 | 2003-11-12 | Ligand Pharmaceuticals Incorporated | Modulátory androgenních receptorů, způsoby jejich výroby a způsoby jejich použití |
| AU6941200A (en) | 1999-08-27 | 2001-03-26 | Ligand Pharmaceuticals Incorporated | 8-substituted-6-trifluoromethyl-9-pyrido(3,2-g)quinoline compounds as androgen receptor modulators |
| WO2001019770A2 (en) | 1999-09-14 | 2001-03-22 | Ligand Pharmaceuticals Incorporated | Rxr modulators with improved pharmacologic profile |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| EP1656142A4 (de) | 2003-08-22 | 2011-06-22 | Ligand Pharm Inc | 6-cycloamino-2-chinolinonderivative als androgenrezeptor-modulatorverbindungen |
| US20100120694A1 (en) | 2008-06-04 | 2010-05-13 | Synergy Pharmaceuticals, Inc. | Agonists of Guanylate Cyclase Useful for the Treatment of Gastrointestinal Disorders, Inflammation, Cancer and Other Disorders |
| CA3089569C (en) | 2007-06-04 | 2023-12-05 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| EP2321341B1 (de) | 2008-07-16 | 2017-02-22 | Synergy Pharmaceuticals Inc. | Zur behandlung von erkrankungen des magen-darm-trakts, entzündlichen erkrankungen, krebs und anderen erkrankungen geeignete agonisten von guanylatcyclase |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| CN108676076A (zh) | 2011-03-01 | 2018-10-19 | 辛纳吉制药公司 | 制备鸟苷酸环化酶c激动剂的方法 |
| JP6499591B2 (ja) | 2013-02-25 | 2019-04-10 | シナジー ファーマシューティカルズ インコーポレイテッド | 結腸洗浄において用いるためのグアニル酸シクラーゼ受容体アゴニスト |
| EP2970384A1 (de) | 2013-03-15 | 2016-01-20 | Synergy Pharmaceuticals Inc. | Agonisten der guanylatcyclase und deren verwendungen |
| JP2016514670A (ja) | 2013-03-15 | 2016-05-23 | シナジー ファーマシューティカルズ インコーポレイテッド | 他の薬物と組み合わせたグアニル酸シクラーゼ受容体アゴニスト |
| RS65632B1 (sr) | 2013-06-05 | 2024-07-31 | Bausch Health Ireland Ltd | Ultra-prečišćeni agonisti guanilat-ciklaze c, postupak njihove pripreme i upotrebe |
| WO2015021358A2 (en) | 2013-08-09 | 2015-02-12 | Dominique Charmot | Compounds and methods for inhibiting phosphate transport |
| JP2022533251A (ja) | 2019-05-21 | 2022-07-21 | アルデリックス， インコーポレイテッド | 患者において血清リン酸塩を低下させるための組み合わせ |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2616855A (en) * | 1948-01-15 | 1952-11-04 | Procter & Gamble | Detergent composition |
| US4329347A (en) * | 1978-02-17 | 1982-05-11 | Boehringer Ingelheim Gmbh | Cardiotonic and antithrombotic sulfur-containing derivatives of carbostyril |
| JPS5777676A (en) * | 1980-10-31 | 1982-05-15 | Otsuka Pharmaceut Co Ltd | Carbostyril derivative |
| PT79699B (en) * | 1983-12-22 | 1986-12-10 | Pfizer | Process for preparing quinolone inotropic agents |
| CA1292234C (en) * | 1984-05-29 | 1991-11-19 | Simon Fraser Campbell | Heterocyclic-substituted quinolone inotropic agents |
| US4760064A (en) * | 1984-12-18 | 1988-07-26 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril compounds, compositions containing same and processes for preparing same |
| US4845100A (en) * | 1985-04-12 | 1989-07-04 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivatives and salts thereof, processes for preparing the same and cardiotonic composition containing the same |
| FR2580646A1 (fr) * | 1985-04-19 | 1986-10-24 | Synthelabo | Derives de 2(1h)-quinolinone, leur preparation et leur application en therapeutique |
| GB8529362D0 (en) * | 1985-11-28 | 1986-01-02 | Pfizer Ltd | Quinolone cardiac stimulants |
| DK111387A (da) * | 1986-03-05 | 1987-09-06 | Otsuka Pharma Co Ltd | Carbostyrilderivater og salte deraf, laegemiddel indeholdende saadanne derivater samt fremgangsmaade til fremstilling af derivaterne |
| ES2053480T3 (es) * | 1986-07-31 | 1994-08-01 | Otsuka Pharma Co Ltd | Un procedimiento para preparar un derivado de carboestirilo. |
-
1986
- 1986-12-23 GB GB868630702A patent/GB8630702D0/en active Pending
-
1987
- 1987-12-21 MY MYPI87003231A patent/MY102277A/en unknown
- 1987-12-21 US US07/135,654 patent/US4937248A/en not_active Expired - Fee Related
- 1987-12-22 KR KR870014675A patent/KR880007514A/ko not_active Application Discontinuation
- 1987-12-22 NZ NZ223036A patent/NZ223036A/en unknown
- 1987-12-22 PT PT86448A patent/PT86448B/pt not_active IP Right Cessation
- 1987-12-22 CA CA000555175A patent/CA1318671C/en not_active Expired - Fee Related
- 1987-12-22 AT AT87311275T patent/ATE65993T1/de active
- 1987-12-22 ZA ZA879615A patent/ZA879615B/xx unknown
- 1987-12-22 AU AU82933/87A patent/AU594220B2/en not_active Ceased
- 1987-12-22 FI FI875666A patent/FI90768C/fi not_active IP Right Cessation
- 1987-12-22 DK DK680887A patent/DK163429C/da not_active IP Right Cessation
- 1987-12-22 EP EP87311275A patent/EP0272910B1/de not_active Expired - Lifetime
- 1987-12-22 ES ES198787311275T patent/ES2029842T3/es not_active Expired - Lifetime
- 1987-12-22 JP JP62325121A patent/JPS63166866A/ja active Pending
- 1987-12-22 HU HU875962A patent/HU196991B/hu not_active IP Right Cessation
- 1987-12-22 IE IE349087A patent/IE60619B1/en not_active IP Right Cessation
- 1987-12-22 DE DE8787311275T patent/DE3772015D1/de not_active Expired - Fee Related
- 1987-12-22 PH PH36289A patent/PH23448A/en unknown
- 1987-12-22 IL IL84917A patent/IL84917A/xx not_active IP Right Cessation
-
1991
- 1991-08-08 GR GR91401029T patent/GR3002445T3/el unknown
-
1992
- 1992-06-29 MX MX9203788A patent/MX9203788A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUT45984A (en) | 1988-09-28 |
| FI875666A (fi) | 1988-06-24 |
| NZ223036A (en) | 1990-11-27 |
| KR880007514A (ko) | 1988-08-27 |
| PT86448A (en) | 1988-01-01 |
| ES2029842T3 (es) | 1992-10-01 |
| EP0272910A1 (de) | 1988-06-29 |
| DK163429C (da) | 1992-07-20 |
| JPS63166866A (ja) | 1988-07-11 |
| DE3772015D1 (de) | 1991-09-12 |
| ATE65993T1 (de) | 1991-08-15 |
| AU8293387A (en) | 1988-06-23 |
| CA1318671C (en) | 1993-06-01 |
| FI90768C (fi) | 1994-03-25 |
| ZA879615B (en) | 1989-08-30 |
| IE873490L (en) | 1988-06-23 |
| FI875666A0 (fi) | 1987-12-22 |
| IE60619B1 (en) | 1994-07-27 |
| GR3002445T3 (en) | 1992-12-30 |
| MY102277A (en) | 1992-05-15 |
| US4937248A (en) | 1990-06-26 |
| FI90768B (fi) | 1993-12-15 |
| GB8630702D0 (en) | 1987-02-04 |
| MX9203788A (es) | 1992-07-01 |
| EP0272910B1 (de) | 1991-08-07 |
| HU196991B (en) | 1989-02-28 |
| DK680887A (da) | 1988-06-24 |
| PH23448A (en) | 1989-08-07 |
| AU594220B2 (en) | 1990-03-01 |
| IL84917A0 (en) | 1988-06-30 |
| PT86448B (pt) | 1990-11-20 |
| DK163429B (da) | 1992-03-02 |
| DK680887D0 (da) | 1987-12-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RH | Patent void |