DK163429C - Carbostyrilderivat og farmaceutisk acceptable salte deraf, saadanne forbindelser til anvendelse som positive inotropiske midler, anvendelse af forbindelserne til fremstilling af farmaceutiske praeparater, farmaceutiske praeparater indeholdende en saadan forbindelse, samt fremgangsmaade til forbindelsernes fremstilling - Google Patents
Carbostyrilderivat og farmaceutisk acceptable salte deraf, saadanne forbindelser til anvendelse som positive inotropiske midler, anvendelse af forbindelserne til fremstilling af farmaceutiske praeparater, farmaceutiske praeparater indeholdende en saadan forbindelse, samt fremgangsmaade til forbindelsernes fremstillingInfo
- Publication number
- DK163429C DK163429C DK680887A DK680887A DK163429C DK 163429 C DK163429 C DK 163429C DK 680887 A DK680887 A DK 680887A DK 680887 A DK680887 A DK 680887A DK 163429 C DK163429 C DK 163429C
- Authority
- DK
- Denmark
- Prior art keywords
- carbonly
- carrially
- carbostyle
- car
- division
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 title abstract 2
- 230000000297 inotrophic effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Superconductors And Manufacturing Methods Therefor (AREA)
- Secondary Cells (AREA)
- Carbon And Carbon Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Quinoline Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8630702 | 1986-12-23 | ||
| GB868630702A GB8630702D0 (en) | 1986-12-23 | 1986-12-23 | Quinoline compound |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| DK680887D0 DK680887D0 (da) | 1987-12-22 |
| DK680887A DK680887A (da) | 1988-06-24 |
| DK163429B DK163429B (da) | 1992-03-02 |
| DK163429C true DK163429C (da) | 1992-07-20 |
Family
ID=10609475
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK680887A DK163429C (da) | 1986-12-23 | 1987-12-22 | Carbostyrilderivat og farmaceutisk acceptable salte deraf, saadanne forbindelser til anvendelse som positive inotropiske midler, anvendelse af forbindelserne til fremstilling af farmaceutiske praeparater, farmaceutiske praeparater indeholdende en saadan forbindelse, samt fremgangsmaade til forbindelsernes fremstilling |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US4937248A (da) |
| EP (1) | EP0272910B1 (da) |
| JP (1) | JPS63166866A (da) |
| KR (1) | KR880007514A (da) |
| AT (1) | ATE65993T1 (da) |
| AU (1) | AU594220B2 (da) |
| CA (1) | CA1318671C (da) |
| DE (1) | DE3772015D1 (da) |
| DK (1) | DK163429C (da) |
| ES (1) | ES2029842T3 (da) |
| FI (1) | FI90768C (da) |
| GB (1) | GB8630702D0 (da) |
| GR (1) | GR3002445T3 (da) |
| HU (1) | HU196991B (da) |
| IE (1) | IE60619B1 (da) |
| IL (1) | IL84917A (da) |
| MX (1) | MX9203788A (da) |
| MY (1) | MY102277A (da) |
| NZ (1) | NZ223036A (da) |
| PH (1) | PH23448A (da) |
| PT (1) | PT86448B (da) |
| ZA (1) | ZA879615B (da) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5166160A (en) * | 1986-12-23 | 1992-11-24 | Burroughs Wellcome Co. | Quinoline compound |
| GB8820174D0 (en) * | 1988-08-25 | 1988-09-28 | Wellcome Found | Quinoline compound |
| BR9813216A (pt) * | 1997-09-24 | 2000-08-29 | Orion Corp | Biésteres de 1-oxa, aza e tianaftalen-2-onas como inibidores de fosfolamban |
| MXPA02002032A (es) | 1999-08-27 | 2003-05-19 | Ligand Pharm Inc | Compuestos moduladores del receptor de androgeno y metodos. |
| US6566372B1 (en) | 1999-08-27 | 2003-05-20 | Ligand Pharmaceuticals Incorporated | Bicyclic androgen and progesterone receptor modulator compounds and methods |
| EP1212322A2 (en) | 1999-08-27 | 2002-06-12 | Ligand Pharmaceuticals Incorporated | 8-substituted-6-trifluoromethyl-9-pyrido[3,2-g]quinoline compounds as androgen receptor modulators |
| EP1216221A2 (en) | 1999-09-14 | 2002-06-26 | Ligand Pharmaceuticals Incorporated | Rxr modulators with improved pharmacologic profile |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| AU2004266160A1 (en) | 2003-08-22 | 2005-03-03 | Ligand Pharmaceuticals Incorporated | 6-cycloamino-2-quinolinone derivatives as androgen receptor modulator compounds |
| MX354786B (es) | 2007-06-04 | 2018-03-21 | Synergy Pharmaceuticals Inc | Agonistas de guanilato ciclasa utiles para el tratamiento de trastornos gastrointestinales, inflamacion, cancer y otros trastornos. |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| CA2726917C (en) | 2008-06-04 | 2018-06-26 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| EP2321341B1 (en) | 2008-07-16 | 2017-02-22 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| EA201391254A1 (ru) | 2011-03-01 | 2014-02-28 | Синерджи Фармасьютикалз Инк. | Способ получения агонистов гуанилатциклазы c |
| JP6499591B2 (ja) | 2013-02-25 | 2019-04-10 | シナジー ファーマシューティカルズ インコーポレイテッド | 結腸洗浄において用いるためのグアニル酸シクラーゼ受容体アゴニスト |
| WO2014151200A2 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
| JP2016514671A (ja) | 2013-03-15 | 2016-05-23 | シナジー ファーマシューティカルズ インコーポレイテッド | グアニル酸シクラーゼのアゴニストおよびその使用 |
| CN105764916B (zh) | 2013-06-05 | 2021-05-18 | 博士医疗爱尔兰有限公司 | 鸟苷酸环化酶c的超纯激动剂、制备和使用所述激动剂的方法 |
| EP3492106B1 (en) | 2013-08-09 | 2021-02-17 | Ardelyx, Inc. | Compounds and methods for inhibiting phosphate transport |
| EP3972599B1 (en) | 2019-05-21 | 2025-10-22 | Ardelyx, Inc. | Combination for lowering serum phosphate in a patient |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2616855A (en) * | 1948-01-15 | 1952-11-04 | Procter & Gamble | Detergent composition |
| US4329347A (en) * | 1978-02-17 | 1982-05-11 | Boehringer Ingelheim Gmbh | Cardiotonic and antithrombotic sulfur-containing derivatives of carbostyril |
| JPS5777676A (en) * | 1980-10-31 | 1982-05-15 | Otsuka Pharmaceut Co Ltd | Carbostyril derivative |
| PT79699B (en) * | 1983-12-22 | 1986-12-10 | Pfizer | Process for preparing quinolone inotropic agents |
| GR851296B (da) * | 1984-05-29 | 1985-11-25 | Pfizer | |
| US4760064A (en) * | 1984-12-18 | 1988-07-26 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril compounds, compositions containing same and processes for preparing same |
| US4845100A (en) * | 1985-04-12 | 1989-07-04 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivatives and salts thereof, processes for preparing the same and cardiotonic composition containing the same |
| FR2580646A1 (fr) * | 1985-04-19 | 1986-10-24 | Synthelabo | Derives de 2(1h)-quinolinone, leur preparation et leur application en therapeutique |
| GB8529362D0 (en) * | 1985-11-28 | 1986-01-02 | Pfizer Ltd | Quinolone cardiac stimulants |
| DK111387A (da) * | 1986-03-05 | 1987-09-06 | Otsuka Pharma Co Ltd | Carbostyrilderivater og salte deraf, laegemiddel indeholdende saadanne derivater samt fremgangsmaade til fremstilling af derivaterne |
| EP0255134B1 (en) * | 1986-07-31 | 1993-03-03 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivatives and salts thereof, process for preparing them, and cardiotonic composition containing same |
-
1986
- 1986-12-23 GB GB868630702A patent/GB8630702D0/en active Pending
-
1987
- 1987-12-21 MY MYPI87003231A patent/MY102277A/en unknown
- 1987-12-21 US US07/135,654 patent/US4937248A/en not_active Expired - Fee Related
- 1987-12-22 EP EP87311275A patent/EP0272910B1/en not_active Expired - Lifetime
- 1987-12-22 KR KR870014675A patent/KR880007514A/ko not_active Ceased
- 1987-12-22 PH PH36289A patent/PH23448A/en unknown
- 1987-12-22 HU HU875962A patent/HU196991B/hu not_active IP Right Cessation
- 1987-12-22 IE IE349087A patent/IE60619B1/en not_active IP Right Cessation
- 1987-12-22 CA CA000555175A patent/CA1318671C/en not_active Expired - Fee Related
- 1987-12-22 AT AT87311275T patent/ATE65993T1/de active
- 1987-12-22 ZA ZA879615A patent/ZA879615B/xx unknown
- 1987-12-22 DE DE8787311275T patent/DE3772015D1/de not_active Expired - Fee Related
- 1987-12-22 FI FI875666A patent/FI90768C/fi not_active IP Right Cessation
- 1987-12-22 DK DK680887A patent/DK163429C/da not_active IP Right Cessation
- 1987-12-22 AU AU82933/87A patent/AU594220B2/en not_active Ceased
- 1987-12-22 PT PT86448A patent/PT86448B/pt not_active IP Right Cessation
- 1987-12-22 IL IL84917A patent/IL84917A/xx not_active IP Right Cessation
- 1987-12-22 JP JP62325121A patent/JPS63166866A/ja active Pending
- 1987-12-22 ES ES198787311275T patent/ES2029842T3/es not_active Expired - Lifetime
- 1987-12-22 NZ NZ223036A patent/NZ223036A/en unknown
-
1991
- 1991-08-08 GR GR91401029T patent/GR3002445T3/el unknown
-
1992
- 1992-06-29 MX MX9203788A patent/MX9203788A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FI90768C (fi) | 1994-03-25 |
| DK680887A (da) | 1988-06-24 |
| HU196991B (en) | 1989-02-28 |
| FI875666A0 (fi) | 1987-12-22 |
| EP0272910B1 (en) | 1991-08-07 |
| PH23448A (en) | 1989-08-07 |
| CA1318671C (en) | 1993-06-01 |
| PT86448A (en) | 1988-01-01 |
| ES2029842T3 (es) | 1992-10-01 |
| PT86448B (pt) | 1990-11-20 |
| JPS63166866A (ja) | 1988-07-11 |
| FI90768B (fi) | 1993-12-15 |
| EP0272910A1 (en) | 1988-06-29 |
| DK163429B (da) | 1992-03-02 |
| KR880007514A (ko) | 1988-08-27 |
| IL84917A0 (en) | 1988-06-30 |
| IE873490L (en) | 1988-06-23 |
| FI875666L (fi) | 1988-06-24 |
| DE3772015D1 (de) | 1991-09-12 |
| AU8293387A (en) | 1988-06-23 |
| US4937248A (en) | 1990-06-26 |
| HUT45984A (en) | 1988-09-28 |
| DK680887D0 (da) | 1987-12-22 |
| NZ223036A (en) | 1990-11-27 |
| GB8630702D0 (en) | 1987-02-04 |
| ZA879615B (en) | 1989-08-30 |
| MX9203788A (es) | 1992-07-01 |
| IE60619B1 (en) | 1994-07-27 |
| GR3002445T3 (en) | 1992-12-30 |
| IL84917A (en) | 1991-08-16 |
| ATE65993T1 (de) | 1991-08-15 |
| AU594220B2 (en) | 1990-03-01 |
| MY102277A (en) | 1992-05-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PBP | Patent lapsed |