DK163429C - Carbostyrilderivat og farmaceutisk acceptable salte deraf, saadanne forbindelser til anvendelse som positive inotropiske midler, anvendelse af forbindelserne til fremstilling af farmaceutiske praeparater, farmaceutiske praeparater indeholdende en saadan forbindelse, samt fremgangsmaade til forbindelsernes fremstilling - Google Patents
Carbostyrilderivat og farmaceutisk acceptable salte deraf, saadanne forbindelser til anvendelse som positive inotropiske midler, anvendelse af forbindelserne til fremstilling af farmaceutiske praeparater, farmaceutiske praeparater indeholdende en saadan forbindelse, samt fremgangsmaade til forbindelsernes fremstillingInfo
- Publication number
- DK163429C DK163429C DK680887A DK680887A DK163429C DK 163429 C DK163429 C DK 163429C DK 680887 A DK680887 A DK 680887A DK 680887 A DK680887 A DK 680887A DK 163429 C DK163429 C DK 163429C
- Authority
- DK
- Denmark
- Prior art keywords
- carbonly
- carrially
- carbostyle
- car
- division
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 title abstract 2
- 230000000297 inotrophic effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
- Superconductors And Manufacturing Methods Therefor (AREA)
- Secondary Cells (AREA)
- Carbon And Carbon Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Quinoline Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB8630702 | 1986-12-23 | ||
GB868630702A GB8630702D0 (en) | 1986-12-23 | 1986-12-23 | Quinoline compound |
Publications (4)
Publication Number | Publication Date |
---|---|
DK680887D0 DK680887D0 (da) | 1987-12-22 |
DK680887A DK680887A (da) | 1988-06-24 |
DK163429B DK163429B (da) | 1992-03-02 |
DK163429C true DK163429C (da) | 1992-07-20 |
Family
ID=10609475
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK680887A DK163429C (da) | 1986-12-23 | 1987-12-22 | Carbostyrilderivat og farmaceutisk acceptable salte deraf, saadanne forbindelser til anvendelse som positive inotropiske midler, anvendelse af forbindelserne til fremstilling af farmaceutiske praeparater, farmaceutiske praeparater indeholdende en saadan forbindelse, samt fremgangsmaade til forbindelsernes fremstilling |
Country Status (22)
Country | Link |
---|---|
US (1) | US4937248A (da) |
EP (1) | EP0272910B1 (da) |
JP (1) | JPS63166866A (da) |
KR (1) | KR880007514A (da) |
AT (1) | ATE65993T1 (da) |
AU (1) | AU594220B2 (da) |
CA (1) | CA1318671C (da) |
DE (1) | DE3772015D1 (da) |
DK (1) | DK163429C (da) |
ES (1) | ES2029842T3 (da) |
FI (1) | FI90768C (da) |
GB (1) | GB8630702D0 (da) |
GR (1) | GR3002445T3 (da) |
HU (1) | HU196991B (da) |
IE (1) | IE60619B1 (da) |
IL (1) | IL84917A (da) |
MX (1) | MX9203788A (da) |
MY (1) | MY102277A (da) |
NZ (1) | NZ223036A (da) |
PH (1) | PH23448A (da) |
PT (1) | PT86448B (da) |
ZA (1) | ZA879615B (da) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5166160A (en) * | 1986-12-23 | 1992-11-24 | Burroughs Wellcome Co. | Quinoline compound |
GB8820174D0 (en) * | 1988-08-25 | 1988-09-28 | Wellcome Found | Quinoline compound |
IL134662A0 (en) * | 1997-09-24 | 2001-04-30 | Orion Corp | Bisethers of 1-oxa, aza and thianaphthalen-2- ones as phospholamban inhibitors |
US6566372B1 (en) | 1999-08-27 | 2003-05-20 | Ligand Pharmaceuticals Incorporated | Bicyclic androgen and progesterone receptor modulator compounds and methods |
AU6941200A (en) | 1999-08-27 | 2001-03-26 | Ligand Pharmaceuticals Incorporated | 8-substituted-6-trifluoromethyl-9-pyrido(3,2-g)quinoline compounds as androgen receptor modulators |
WO2001016139A1 (en) | 1999-08-27 | 2001-03-08 | Ligand Pharmaceuticals Incorporated | Androgen receptor modulator compounds and methods |
CO5200852A1 (es) | 1999-09-14 | 2002-09-27 | Lilly Co Eli | Moduladores rxr con mejorado perfil farmacologico ceptores x de los retinoides |
US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
CN1838956A (zh) | 2003-08-22 | 2006-09-27 | 配体药物公司 | 作为雄激素受体调节剂化合物的6-环氨基-2-喹啉酮衍生物 |
US20100120694A1 (en) | 2008-06-04 | 2010-05-13 | Synergy Pharmaceuticals, Inc. | Agonists of Guanylate Cyclase Useful for the Treatment of Gastrointestinal Disorders, Inflammation, Cancer and Other Disorders |
US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
US7879802B2 (en) | 2007-06-04 | 2011-02-01 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
EP2321341B1 (en) | 2008-07-16 | 2017-02-22 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
MX357121B (es) | 2011-03-01 | 2018-06-27 | Synergy Pharmaceuticals Inc Star | Proceso de preparacion de agonistas c de guanilato ciclasa. |
CA2902348C (en) | 2013-02-25 | 2021-11-30 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
EP2970384A1 (en) | 2013-03-15 | 2016-01-20 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
CA2905435A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
BR112015030326A2 (pt) | 2013-06-05 | 2017-08-29 | Synergy Pharmaceuticals Inc | Agonistas ultrapuros de guanilato ciclase c, método de fabricar e usar os mesmos |
WO2015021358A2 (en) | 2013-08-09 | 2015-02-12 | Dominique Charmot | Compounds and methods for inhibiting phosphate transport |
US20200368223A1 (en) | 2019-05-21 | 2020-11-26 | Ardelyx, Inc. | Methods for inhibiting phosphate transport |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2616855A (en) * | 1948-01-15 | 1952-11-04 | Procter & Gamble | Detergent composition |
US4329347A (en) * | 1978-02-17 | 1982-05-11 | Boehringer Ingelheim Gmbh | Cardiotonic and antithrombotic sulfur-containing derivatives of carbostyril |
JPS5777676A (en) * | 1980-10-31 | 1982-05-15 | Otsuka Pharmaceut Co Ltd | Carbostyril derivative |
PT79699B (en) * | 1983-12-22 | 1986-12-10 | Pfizer | Process for preparing quinolone inotropic agents |
NZ212209A (en) * | 1984-05-29 | 1988-08-30 | Pfizer | Quinolone derivatives and pharmaceutical compositions |
US4760064A (en) * | 1984-12-18 | 1988-07-26 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril compounds, compositions containing same and processes for preparing same |
US4845100A (en) * | 1985-04-12 | 1989-07-04 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivatives and salts thereof, processes for preparing the same and cardiotonic composition containing the same |
FR2580646A1 (fr) * | 1985-04-19 | 1986-10-24 | Synthelabo | Derives de 2(1h)-quinolinone, leur preparation et leur application en therapeutique |
GB8529362D0 (en) * | 1985-11-28 | 1986-01-02 | Pfizer Ltd | Quinolone cardiac stimulants |
DK111387A (da) * | 1986-03-05 | 1987-09-06 | Otsuka Pharma Co Ltd | Carbostyrilderivater og salte deraf, laegemiddel indeholdende saadanne derivater samt fremgangsmaade til fremstilling af derivaterne |
US4886809A (en) * | 1986-07-31 | 1989-12-12 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivatives and salts thereof |
-
1986
- 1986-12-23 GB GB868630702A patent/GB8630702D0/en active Pending
-
1987
- 1987-12-21 US US07/135,654 patent/US4937248A/en not_active Expired - Fee Related
- 1987-12-21 MY MYPI87003231A patent/MY102277A/en unknown
- 1987-12-22 AU AU82933/87A patent/AU594220B2/en not_active Ceased
- 1987-12-22 DK DK680887A patent/DK163429C/da not_active IP Right Cessation
- 1987-12-22 DE DE8787311275T patent/DE3772015D1/de not_active Expired - Fee Related
- 1987-12-22 IL IL84917A patent/IL84917A/xx not_active IP Right Cessation
- 1987-12-22 JP JP62325121A patent/JPS63166866A/ja active Pending
- 1987-12-22 FI FI875666A patent/FI90768C/fi not_active IP Right Cessation
- 1987-12-22 PT PT86448A patent/PT86448B/pt not_active IP Right Cessation
- 1987-12-22 KR KR870014675A patent/KR880007514A/ko not_active Application Discontinuation
- 1987-12-22 ES ES198787311275T patent/ES2029842T3/es not_active Expired - Lifetime
- 1987-12-22 ZA ZA879615A patent/ZA879615B/xx unknown
- 1987-12-22 IE IE349087A patent/IE60619B1/en not_active IP Right Cessation
- 1987-12-22 AT AT87311275T patent/ATE65993T1/de active
- 1987-12-22 HU HU875962A patent/HU196991B/hu not_active IP Right Cessation
- 1987-12-22 PH PH36289A patent/PH23448A/en unknown
- 1987-12-22 CA CA000555175A patent/CA1318671C/en not_active Expired - Fee Related
- 1987-12-22 EP EP87311275A patent/EP0272910B1/en not_active Expired - Lifetime
- 1987-12-22 NZ NZ223036A patent/NZ223036A/en unknown
-
1991
- 1991-08-08 GR GR91401029T patent/GR3002445T3/el unknown
-
1992
- 1992-06-29 MX MX9203788A patent/MX9203788A/es unknown
Also Published As
Publication number | Publication date |
---|---|
DK680887D0 (da) | 1987-12-22 |
US4937248A (en) | 1990-06-26 |
ES2029842T3 (es) | 1992-10-01 |
IE873490L (en) | 1988-06-23 |
HUT45984A (en) | 1988-09-28 |
GB8630702D0 (en) | 1987-02-04 |
IE60619B1 (en) | 1994-07-27 |
DK680887A (da) | 1988-06-24 |
PH23448A (en) | 1989-08-07 |
AU594220B2 (en) | 1990-03-01 |
GR3002445T3 (en) | 1992-12-30 |
FI875666A0 (fi) | 1987-12-22 |
ATE65993T1 (de) | 1991-08-15 |
PT86448B (pt) | 1990-11-20 |
ZA879615B (en) | 1989-08-30 |
FI90768C (fi) | 1994-03-25 |
FI90768B (fi) | 1993-12-15 |
PT86448A (en) | 1988-01-01 |
EP0272910B1 (en) | 1991-08-07 |
IL84917A (en) | 1991-08-16 |
MY102277A (en) | 1992-05-15 |
DK163429B (da) | 1992-03-02 |
AU8293387A (en) | 1988-06-23 |
EP0272910A1 (en) | 1988-06-29 |
NZ223036A (en) | 1990-11-27 |
MX9203788A (es) | 1992-07-01 |
CA1318671C (en) | 1993-06-01 |
HU196991B (en) | 1989-02-28 |
KR880007514A (ko) | 1988-08-27 |
JPS63166866A (ja) | 1988-07-11 |
IL84917A0 (en) | 1988-06-30 |
DE3772015D1 (de) | 1991-09-12 |
FI875666A (fi) | 1988-06-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PBP | Patent lapsed |