ATE64849T1 - Formulierung mit langsamer freisetzung. - Google Patents
Formulierung mit langsamer freisetzung.Info
- Publication number
- ATE64849T1 ATE64849T1 AT87301231T AT87301231T ATE64849T1 AT E64849 T1 ATE64849 T1 AT E64849T1 AT 87301231 T AT87301231 T AT 87301231T AT 87301231 T AT87301231 T AT 87301231T AT E64849 T1 ATE64849 T1 AT E64849T1
- Authority
- AT
- Austria
- Prior art keywords
- slow release
- granules
- matrix
- dispersible
- water soluble
- Prior art date
Links
- 238000009472 formulation Methods 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 3
- 239000008187 granular material Substances 0.000 abstract 4
- 239000000463 material Substances 0.000 abstract 4
- 239000011159 matrix material Substances 0.000 abstract 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 4
- 239000004480 active ingredient Substances 0.000 abstract 2
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 abstract 1
- 241000220479 Acacia Species 0.000 abstract 1
- 239000001828 Gelatine Substances 0.000 abstract 1
- 235000010643 Leucaena leucocephala Nutrition 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 229940072056 alginate Drugs 0.000 abstract 1
- 235000010443 alginic acid Nutrition 0.000 abstract 1
- 229920000615 alginic acid Polymers 0.000 abstract 1
- 239000011230 binding agent Substances 0.000 abstract 1
- 229920000159 gelatin Polymers 0.000 abstract 1
- 235000019322 gelatine Nutrition 0.000 abstract 1
- 150000004676 glycans Chemical class 0.000 abstract 1
- 229920000609 methyl cellulose Polymers 0.000 abstract 1
- 239000001923 methylcellulose Substances 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 229920001282 polysaccharide Polymers 0.000 abstract 1
- 239000005017 polysaccharide Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
Landscapes
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB08603523A GB2186485B (en) | 1986-02-13 | 1986-02-13 | Slow release formulation |
| EP87301231A EP0235986B2 (de) | 1986-02-13 | 1987-02-12 | Formulierung mit langsamer Freisetzung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE64849T1 true ATE64849T1 (de) | 1991-07-15 |
Family
ID=10592976
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT87301231T ATE64849T1 (de) | 1986-02-13 | 1987-02-12 | Formulierung mit langsamer freisetzung. |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US4880830A (de) |
| EP (1) | EP0235986B2 (de) |
| JP (1) | JPH0655669B2 (de) |
| AT (1) | ATE64849T1 (de) |
| DE (1) | DE3771091D1 (de) |
| DK (1) | DK175055B1 (de) |
| ES (1) | ES2029269T5 (de) |
| FI (1) | FI91482C (de) |
| GB (1) | GB2186485B (de) |
| GR (2) | GR3002822T3 (de) |
| IE (1) | IE59451B1 (de) |
| NO (1) | NO175240C (de) |
| PH (1) | PH25347A (de) |
| ZA (1) | ZA871030B (de) |
Families Citing this family (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0418596A3 (en) * | 1989-09-21 | 1991-10-23 | American Cyanamid Company | Controlled release pharmaceutical compositions from spherical granules in tabletted oral dosage unit form |
| IL96311A (en) † | 1989-12-01 | 1995-05-26 | Abbott Lab | Medications with delayed release |
| JP3011752B2 (ja) * | 1990-10-23 | 2000-02-21 | フロイント産業株式会社 | 徐放性製剤およびその製造方法 |
| US5380535A (en) * | 1991-05-28 | 1995-01-10 | Geyer; Robert P. | Chewable drug-delivery compositions and methods for preparing the same |
| ATE245023T1 (de) * | 1991-05-28 | 2003-08-15 | Mcneil Ppc Inc | Kaubare zusammensetzung zur arzneimittelfreisetzung |
| DE4119306C2 (de) * | 1991-06-12 | 1996-05-30 | Wheli Inter Ag | Organische Rohstoffe, Zwischen- und Endprodukte für die Ernährung und zur Verwendung für technische Zwecke, die Vitalstoffe enthalten |
| DE4122591C1 (en) * | 1991-07-08 | 1993-02-18 | Roland 8012 Ottobrunn De Bodmeier | Producing microcapsules of water insoluble polymer and active agent - includes dissolving or dispersing active agent in aq. polymer contg. gellable assistants |
| US5356629A (en) * | 1991-07-12 | 1994-10-18 | United States Surgical Corporation | Composition for effecting bone repair |
| US5478577A (en) * | 1993-11-23 | 1995-12-26 | Euroceltique, S.A. | Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level |
| US5968551A (en) | 1991-12-24 | 1999-10-19 | Purdue Pharma L.P. | Orally administrable opioid formulations having extended duration of effect |
| US5958459A (en) * | 1991-12-24 | 1999-09-28 | Purdue Pharma L.P. | Opioid formulations having extended controlled released |
| NZ260408A (en) | 1993-05-10 | 1996-05-28 | Euro Celtique Sa | Controlled release preparation comprising tramadol |
| IL110014A (en) * | 1993-07-01 | 1999-11-30 | Euro Celtique Sa | Solid controlled-release oral dosage forms of opioid analgesics |
| US7740881B1 (en) | 1993-07-01 | 2010-06-22 | Purdue Pharma Lp | Method of treating humans with opioid formulations having extended controlled release |
| AU7966694A (en) * | 1993-07-21 | 1996-05-02 | University Of Kentucky Research Foundation, The | A multicompartment hard capsule with control release properties |
| US5879705A (en) * | 1993-07-27 | 1999-03-09 | Euro-Celtique S.A. | Sustained release compositions of morphine and a method of preparing pharmaceutical compositions |
| US5891471A (en) * | 1993-11-23 | 1999-04-06 | Euro-Celtique, S.A. | Pharmaceutical multiparticulates |
| KR100354702B1 (ko) * | 1993-11-23 | 2002-12-28 | 유로-셀티크 소시에떼 아노뉨 | 약학조성물의제조방법및서방형조성물 |
| US5458887A (en) * | 1994-03-02 | 1995-10-17 | Andrx Pharmaceuticals, Inc. | Controlled release tablet formulation |
| US5843480A (en) * | 1994-03-14 | 1998-12-01 | Euro-Celtique, S.A. | Controlled release diamorphine formulation |
| US5938990A (en) * | 1994-07-01 | 1999-08-17 | Roche Vitamins Inc. | Encapsulation of oleophilic substances and compositions produced thereby |
| DE4426396A1 (de) * | 1994-07-26 | 1996-02-01 | Ulrich Prof Dr Zimmermann | Verfahren zur Herstellung konzentrierter Lösungen von mikroverkapselten Zellen oder von suspendierten Wirkstoffen in mikroverkapselter Form |
| GB9422154D0 (en) * | 1994-11-03 | 1994-12-21 | Euro Celtique Sa | Pharmaceutical compositions and method of producing the same |
| US5965161A (en) | 1994-11-04 | 1999-10-12 | Euro-Celtique, S.A. | Extruded multi-particulates |
| US6166024A (en) | 1995-03-30 | 2000-12-26 | Mayo Foundation For Medical Education And Research | Use of topical azathioprine and thioguanine to treat colorectal adenomas |
| JP3628809B2 (ja) * | 1996-06-10 | 2005-03-16 | アルケア株式会社 | 薬剤徐放性医療用配合物及びその製造方法 |
| US20030100532A1 (en) * | 1997-02-14 | 2003-05-29 | Gary S. Jacob | Use of n-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy for treating hepatitis virus infections |
| US6656508B2 (en) * | 1997-04-17 | 2003-12-02 | Amgen Inc. | Sustained-release alginate gels |
| IN186245B (de) | 1997-09-19 | 2001-07-14 | Ranbaxy Lab Ltd | |
| ES2216327T3 (es) | 1997-11-10 | 2004-10-16 | G.D. SEARLE & CO. | Uso de iminoazucares alquilados para tratar la resistencia a multiples a farmacos. |
| ID27290A (id) | 1998-02-12 | 2001-03-22 | Searle & Co | Penggunaan senyawa 1,5-dideoksi-1,5-imino-d-glusitol tersubstitusi-n pada pengobatan infeksi virus hepatitis |
| US6689759B1 (en) | 1998-02-12 | 2004-02-10 | G. D. Searle & Co. | Methods of Treating hepatitis virus infections with N-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy |
| US6806294B2 (en) | 1998-10-15 | 2004-10-19 | Euro-Celtique S.A. | Opioid analgesic |
| WO2000033818A1 (en) | 1998-12-11 | 2000-06-15 | Nostrum Pharmaceuticals, Inc. | Sustained release tablet containing hydrocolloid and cellulose ether |
| US6673367B1 (en) * | 1998-12-17 | 2004-01-06 | Euro-Celtique, S.A. | Controlled/modified release oral methylphenidate formulations |
| US6419960B1 (en) | 1998-12-17 | 2002-07-16 | Euro-Celtique S.A. | Controlled release formulations having rapid onset and rapid decline of effective plasma drug concentrations |
| AU3858600A (en) | 1999-02-12 | 2001-02-19 | G.D. Searle & Co. | Glucamine compounds for treating hepatitis virus infections |
| ATE402701T1 (de) * | 1999-02-12 | 2008-08-15 | United Therapeutics Corp | N-(8,8,8-trifluorooctyl)-1,5-dideoxy-1,5-imino- - glucitol zur behandlung von hepatitis-virus- infektionen |
| DE19918325A1 (de) | 1999-04-22 | 2000-10-26 | Euro Celtique Sa | Verfahren zur Herstellung von Arzneiformen mit regulierter Wirkstofffreisetzung mittels Extrusion |
| US6555139B2 (en) | 1999-06-28 | 2003-04-29 | Wockhardt Europe Limited | Preparation of micron-size pharmaceutical particles by microfluidization |
| NZ517466A (en) | 1999-09-02 | 2003-11-28 | Nostrum Pharmaceuticals Inc | Controlled release oral dosage suitable for oral administration |
| US7235258B1 (en) | 1999-10-19 | 2007-06-26 | Nps Pharmaceuticals, Inc. | Sustained-release formulations for treating CNS-mediated disorders |
| KR100889069B1 (ko) | 1999-10-29 | 2009-03-17 | 유로-셀티크 소시에떼 아노뉨 | 서방성 하이드로코돈 제형 |
| US10179130B2 (en) | 1999-10-29 | 2019-01-15 | Purdue Pharma L.P. | Controlled release hydrocodone formulations |
| GB2356346A (en) * | 1999-11-19 | 2001-05-23 | Mars Uk Ltd | Food product for oral delivery of a pharmaceutical agent to a non-human animal comprising encapsulated particles of said agent distributed within the product |
| AU2001236938A1 (en) * | 2000-02-14 | 2001-08-27 | Pharmacia Corporation | Use of n-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds for treating hepatitis virus infections |
| BR0115382A (pt) | 2000-10-30 | 2003-09-16 | Euro Celtique Sa | Formulações para liberação controlada de hidrocodona, método de produzir analgesia efetiva, processo de preparação de uma forma farmacêutica de um sólido oral de liberação controlada, liberação controlada da forma farmacêutica oral e uso da forma farmacêutica |
| UA81224C2 (uk) | 2001-05-02 | 2007-12-25 | Euro Celtic S A | Дозована форма оксикодону та її застосування |
| US20110104214A1 (en) | 2004-04-15 | 2011-05-05 | Purdue Pharma L.P. | Once-a-day oxycodone formulations |
| KR100540035B1 (ko) * | 2002-02-01 | 2005-12-29 | 주식회사 태평양 | 다단계 경구 약물 방출 제어 시스템 |
| CA2578224A1 (en) * | 2004-08-25 | 2006-03-09 | Essentialis, Inc. | Pharmaceutical formulations of potassium atp channel openers and uses thereof |
| US20060128794A1 (en) | 2004-12-13 | 2006-06-15 | Indevus Pharmaceuticals, Inc. | Treatment of interstitial cystitis using (6aR,10aR)-delta8-tetrahydrocannabinol-11-OIC acids |
| WO2006065792A2 (en) * | 2004-12-13 | 2006-06-22 | Indevus Pharmaceuticals, Inc. | Treatment of interstitial cystitis using cannabinoid analogs |
| US9757384B2 (en) | 2005-04-06 | 2017-09-12 | Essentialis, Inc. | Methods for treating subjects with Prader-Willi syndrome or Smith-Magenis syndrome |
| EP1968601B1 (de) | 2006-01-05 | 2011-10-19 | Essentialis, Inc. | Salze von kalium-atp-kanal-öffnern und ihre verwendungen |
| US20080075768A1 (en) * | 2006-07-21 | 2008-03-27 | Vaughn Jason M | Hydrophobic opioid abuse deterrent delivery system using opioid antagonists |
| EP2170341A4 (de) * | 2007-07-02 | 2010-12-01 | Essentialis Inc | Salze von kalium-atp-kanal-öffnern und ihre verwendungen |
| WO2012048045A1 (en) * | 2010-10-05 | 2012-04-12 | Jb Therapeutics, Inc. | Compositions, dosages, and methods of using tetrahydrocannabinol derivatives |
| EP2819675A4 (de) | 2012-02-27 | 2015-07-22 | Essentialis Inc | Salze von kalium-atp-kanalöffnern und verwendungen davon |
| JP6689078B2 (ja) | 2013-02-12 | 2020-04-28 | コーバス ファーマシューティカルズ インク. | 超高純度なテトラヒドロカンナビノール−11−酸 |
| CA3018328A1 (en) | 2014-10-31 | 2016-04-30 | Purdue Pharma | Methods and compositions particularly for treatment of attention deficit disorder |
| HUE050895T2 (hu) | 2014-11-14 | 2021-01-28 | Essentialis Inc | Módszerek prader-willi szindrómával vagy smith-magenis szindrómával kezelt betegek kezelésére |
| US10722473B2 (en) | 2018-11-19 | 2020-07-28 | Purdue Pharma L.P. | Methods and compositions particularly for treatment of attention deficit disorder |
| NL2022614B1 (en) | 2019-02-21 | 2020-08-31 | Patrick Alexander Unger | Pharmaceutical, phyto-cannabinoid based compositions |
| NL2022616B1 (en) | 2019-02-21 | 2020-09-18 | Patrick Alexander Unger | Cannabigerol and pharmaceutical compositions comprising cannabigerol for use in the treatment of insomnia |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2809917A (en) * | 1955-10-17 | 1957-10-15 | Victor M Hermelin | Sustained release pharmaceutical tablets |
| US2809916A (en) * | 1955-10-17 | 1957-10-15 | Victor M Hermelin | Sustained release pharmaceutical preparations |
| US3402240A (en) * | 1957-06-25 | 1968-09-17 | Pfizer & Co C | Medicinal tablet and process of making same |
| US3148124A (en) * | 1962-06-12 | 1964-09-08 | William E Gaunt | Method of preparing sustained release pharmaceutical tablets |
| GB1021924A (en) * | 1962-06-22 | 1966-03-09 | Smith Kline French Lab | Improvements in or relating to method of preparing sustained release tablets |
| US3279998A (en) * | 1962-06-22 | 1966-10-18 | Smith Kline French Lab | Method of preparing sustained release tablets |
| GB1033484A (en) * | 1963-06-28 | 1966-06-22 | Mead Johnson & Co | Process for preparing tablets containing chloral betaine |
| US3400197A (en) * | 1965-01-26 | 1968-09-03 | Robins Co Inc A H | Compressible sustained release pharmaceutical tablet lipid-colloidal silica gel matrix fragment granules |
| GB1137379A (en) * | 1967-10-26 | 1968-12-18 | Dow Chemical Co | Pharmaceutical preparation |
| US3870790A (en) * | 1970-01-22 | 1975-03-11 | Forest Laboratories | Solid pharmaceutical formulations containing hydroxypropyl methyl cellulose |
| GB1333576A (en) * | 1970-10-21 | 1973-10-10 | Alza Corp | Sustained release drug dosage device |
| GB1405088A (en) * | 1971-06-03 | 1975-09-03 | Mundipharma Ag | Slow release formulation |
| US3962414A (en) * | 1972-04-27 | 1976-06-08 | Alza Corporation | Structured bioerodible drug delivery device |
| FR2250793B1 (de) * | 1973-11-09 | 1978-12-29 | Commissariat Energie Atomique | |
| US3946110A (en) * | 1974-05-30 | 1976-03-23 | Peter, Strong Research And Development Company, Inc. | Medicinal compositions and methods of preparing the same |
| EP0013131A3 (de) * | 1978-12-27 | 1981-01-07 | Mundipharma A.G. | Pharmazeutische Zusammensetzung in fester Verabreichungsform und Verfahren zu ihrer Herstellung |
| FI63335B (fi) * | 1979-02-02 | 1983-02-28 | Orion Yhtymae Oy | Foerfarande foer framstaellning av tabletter med foerdroejd loslighet av effektaemne |
| US4369172A (en) * | 1981-12-18 | 1983-01-18 | Forest Laboratories Inc. | Prolonged release therapeutic compositions based on hydroxypropylmethylcellulose |
| DE3218150C2 (de) * | 1982-05-14 | 1986-09-25 | Akzo Gmbh, 5600 Wuppertal | Wirkstoff enthaltender Körper für die Langzeitabgabe sowie Verfahren zu dessen Herstellung |
| US4443428A (en) * | 1982-06-21 | 1984-04-17 | Euroceltique, S.A. | Extended action controlled release compositions |
| SE457505B (sv) * | 1984-01-10 | 1989-01-09 | Lejus Medical Ab | Laminatbelagd oral farmaceutisk komposition och foerfarande foer dess framstaellning |
| US4540566A (en) * | 1984-04-02 | 1985-09-10 | Forest Laboratories, Inc. | Prolonged release drug dosage forms based on modified low viscosity grade hydroxypropylmethylcellulose |
| US4590062A (en) * | 1984-04-16 | 1986-05-20 | Tech Trade Corp. | Dry direct compression compositions for controlled release dosage forms |
| JPS6124516A (ja) * | 1984-07-12 | 1986-02-03 | Fujisawa Pharmaceut Co Ltd | 持続性錠剤 |
-
1986
- 1986-02-13 GB GB08603523A patent/GB2186485B/en not_active Expired
-
1987
- 1987-02-09 IE IE33287A patent/IE59451B1/en not_active IP Right Cessation
- 1987-02-09 US US07/012,026 patent/US4880830A/en not_active Expired - Lifetime
- 1987-02-11 PH PH34843A patent/PH25347A/en unknown
- 1987-02-12 ZA ZA871030A patent/ZA871030B/xx unknown
- 1987-02-12 DE DE8787301231T patent/DE3771091D1/de not_active Expired - Lifetime
- 1987-02-12 AT AT87301231T patent/ATE64849T1/de not_active IP Right Cessation
- 1987-02-12 FI FI870588A patent/FI91482C/fi not_active IP Right Cessation
- 1987-02-12 ES ES87301231T patent/ES2029269T5/es not_active Expired - Lifetime
- 1987-02-12 NO NO870558A patent/NO175240C/no unknown
- 1987-02-12 EP EP87301231A patent/EP0235986B2/de not_active Expired - Lifetime
- 1987-02-13 DK DK198700741A patent/DK175055B1/da not_active IP Right Cessation
- 1987-02-13 JP JP62029969A patent/JPH0655669B2/ja not_active Expired - Lifetime
-
1991
- 1991-09-30 GR GR91401457T patent/GR3002822T3/el unknown
-
1999
- 1999-07-07 GR GR990401789T patent/GR3030706T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0235986B2 (de) | 1999-04-21 |
| NO175240C (no) | 1998-02-10 |
| FI91482B (fi) | 1994-03-31 |
| FI870588A7 (fi) | 1987-08-14 |
| GB2186485A (en) | 1987-08-19 |
| ES2029269T3 (es) | 1992-08-01 |
| DK74187A (da) | 1987-08-14 |
| DE3771091D1 (de) | 1991-08-08 |
| ES2029269T5 (es) | 1999-07-01 |
| GB8603523D0 (en) | 1986-03-19 |
| NO870558L (no) | 1987-08-14 |
| PH25347A (en) | 1991-05-13 |
| IE59451B1 (en) | 1994-02-23 |
| NO870558D0 (no) | 1987-02-12 |
| ZA871030B (en) | 1988-04-27 |
| GB2186485B (en) | 1988-09-07 |
| IE870332L (en) | 1987-08-13 |
| DK175055B1 (da) | 2004-05-10 |
| FI91482C (fi) | 1997-05-27 |
| NO175240B (no) | 1994-06-13 |
| FI870588A0 (fi) | 1987-02-12 |
| GR3002822T3 (en) | 1993-01-25 |
| EP0235986A1 (de) | 1987-09-09 |
| JPH0655669B2 (ja) | 1994-07-27 |
| GR3030706T3 (en) | 1999-11-30 |
| EP0235986B1 (de) | 1991-07-03 |
| AU6877687A (en) | 1987-08-20 |
| DK74187D0 (da) | 1987-02-13 |
| JPS62215519A (ja) | 1987-09-22 |
| US4880830A (en) | 1989-11-14 |
| AU589254B2 (en) | 1989-10-05 |
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