ATE63456T1 - Verfahren zur herstellung kleiner vesikel durch mikroemulgierung. - Google Patents

Verfahren zur herstellung kleiner vesikel durch mikroemulgierung.

Info

Publication number
ATE63456T1
ATE63456T1 AT86300641T AT86300641T ATE63456T1 AT E63456 T1 ATE63456 T1 AT E63456T1 AT 86300641 T AT86300641 T AT 86300641T AT 86300641 T AT86300641 T AT 86300641T AT E63456 T1 ATE63456 T1 AT E63456T1
Authority
AT
Austria
Prior art keywords
microemulgation
procedure
production
vesicles
small vesicles
Prior art date
Application number
AT86300641T
Other languages
English (en)
Inventor
Ronald Carl Gamble
Original Assignee
Vestar Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vestar Inc filed Critical Vestar Inc
Application granted granted Critical
Publication of ATE63456T1 publication Critical patent/ATE63456T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1277—Processes for preparing; Proliposomes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/829—Liposomes, e.g. encapsulation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Colloid Chemistry (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
AT86300641T 1985-01-31 1986-01-30 Verfahren zur herstellung kleiner vesikel durch mikroemulgierung. ATE63456T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/696,727 US4753788A (en) 1985-01-31 1985-01-31 Method for preparing small vesicles using microemulsification
EP86300641A EP0190050B1 (de) 1985-01-31 1986-01-30 Verfahren zur Herstellung kleiner Vesikel durch Mikroemulgierung

Publications (1)

Publication Number Publication Date
ATE63456T1 true ATE63456T1 (de) 1991-06-15

Family

ID=24798285

Family Applications (1)

Application Number Title Priority Date Filing Date
AT86300641T ATE63456T1 (de) 1985-01-31 1986-01-30 Verfahren zur herstellung kleiner vesikel durch mikroemulgierung.

Country Status (7)

Country Link
US (1) US4753788A (de)
EP (1) EP0190050B1 (de)
JP (1) JPH0776170B2 (de)
AT (1) ATE63456T1 (de)
CA (1) CA1282699C (de)
DE (1) DE3679204D1 (de)
IE (1) IE57225B1 (de)

Families Citing this family (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE60901B1 (en) * 1986-08-21 1994-08-24 Vestar Inc Improved treatment of systemic fungal infections with phospholipid particles encapsulating polyene antifungal antibiotics
US4783220A (en) * 1986-12-18 1988-11-08 Xerox Corporation Vesicle ink compositions
FR2634375B3 (fr) * 1988-06-30 1991-07-05 Centre Nat Rech Scient Procede de preparation de systemes colloidaux dispersibles de lipide amphiphiles sous forme de liposomes submicroniques
US5023086A (en) * 1987-03-13 1991-06-11 Micro-Pak, Inc. Encapsulated ionophore growth factors
US5271881A (en) * 1987-09-28 1993-12-21 Redding Bruce K Apparatus and method for making microcapsules
WO1992011083A1 (en) * 1987-09-28 1992-07-09 Redding Bruce K Jr Apparatus and method for making microcapsules
IL88076A (en) * 1987-10-28 1993-01-14 Nippon Shinyaku Co Ltd Fat emulsions as drug carriers
US5013497A (en) * 1988-03-03 1991-05-07 Micro-Pak, Inc. Method and apparatus for producing lipid vesicles
US4895452A (en) * 1988-03-03 1990-01-23 Micro-Pak, Inc. Method and apparatus for producing lipid vesicles
MX9203504A (es) * 1988-04-20 1992-07-01 Liposome Co Inc Complejo agente: lipido activo de alta proporcion.
JPH03504382A (ja) * 1988-05-20 1991-09-26 ザ　リポソーム　カンパニー，インコーポレイテッド 高比率活性剤：脂質複合体
US4935171A (en) * 1989-01-27 1990-06-19 Vestar, Inc. Method for vesicle formation
EP0469082B1 (de) * 1989-04-18 1995-04-05 Vestar, Inc. Markierung mit liposomen von ischämischen geweben
FR2649335B1 (fr) * 1989-07-05 1991-09-20 Texinfine Sa Procede et dispositif de production directe de liposomes
WO1991001367A1 (en) * 1989-07-20 1991-02-07 Bioeng, Inc. Supercritical fluid disruption of and extraction from microbial cells
US5123414A (en) * 1989-12-22 1992-06-23 Unger Evan C Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same
US5776429A (en) * 1989-12-22 1998-07-07 Imarx Pharmaceutical Corp. Method of preparing gas-filled microspheres using a lyophilized lipids
US5820848A (en) * 1990-01-12 1998-10-13 The Liposome Company, Inc. Methods of preparing interdigitation-fusion liposomes and gels which encapsulate a bioactive agent
GB9000705D0 (en) * 1990-01-12 1990-03-14 Royal Postgrad Med School Improvements in or relating to radiotherapeutic agents
ATE127018T1 (de) * 1992-03-06 1995-09-15 Fiutowski Zdzislaw Pharmazeutische zusammensetzung mit antiviraler und antibakterieller wirkung.
ES2041597B1 (es) * 1992-05-05 1994-06-01 Bazaco Joan Freixas Nuevo procedimiento para la preparacion de liposomas que encapsulan productos farmaceuticos y cosmeticos.
WO1994008565A1 (en) * 1992-10-14 1994-04-28 The Liposome Company, Inc. Interdigitation-fusion liposomes and gels
US5958449A (en) 1992-12-02 1999-09-28 Nexstar Pharmaceuticals, Inc. Antibiotic formulation and use for bacterial infections
AU3244393A (en) * 1992-12-02 1994-06-22 Vestar, Inc. Antibiotic formulation and process
US5650156A (en) * 1993-02-22 1997-07-22 Vivorx Pharmaceuticals, Inc. Methods for in vivo delivery of nutriceuticals and compositions useful therefor
US5916596A (en) * 1993-02-22 1999-06-29 Vivorx Pharmaceuticals, Inc. Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof
US5439686A (en) * 1993-02-22 1995-08-08 Vivorx Pharmaceuticals, Inc. Methods for in vivo delivery of substantially water insoluble pharmacologically active agents and compositions useful therefor
US6753006B1 (en) 1993-02-22 2004-06-22 American Bioscience, Inc. Paclitaxel-containing formulations
US5997904A (en) * 1993-02-22 1999-12-07 American Bioscience, Inc. Total nutrient admixtures as stable multicomponent liquids or dry powders and methods for the preparation thereof
DK0693924T4 (da) * 1993-02-22 2008-08-04 Abraxis Bioscience Inc Fremgangsmåde til (in vivo) levering af biologiske materialer og sammensætninger, der er egnede dertil
US5665382A (en) * 1993-02-22 1997-09-09 Vivorx Pharmaceuticals, Inc. Methods for the preparation of pharmaceutically active agents for in vivo delivery
US6528067B1 (en) 1993-02-22 2003-03-04 American Bioscience, Inc. Total nutrient admixtures as stable multicomponent liquids or dry powders and methods for the preparation thereof
US5759571A (en) * 1993-05-11 1998-06-02 Nexstar Pharmaceuticals, Inc. Antibiotic formulation and use for drug resistant infections
DE69407292T2 (de) * 1993-06-30 1998-06-25 Genentech Inc Verfahren zur herstellung von liposomen
US6004534A (en) * 1993-07-23 1999-12-21 Massachusetts Institute Of Technology Targeted polymerized liposomes for improved drug delivery
WO1995003035A1 (en) * 1993-07-23 1995-02-02 Massachusetts Institute Of Technology Polymerized liposomes with enhanced stability for oral delivery
NZ275054A (en) * 1993-11-08 1997-04-24 Peptide Delivery Systems Pty L Diagnosing atherosclerosis or coronary artery disease using labelled composition which mimics essential features of an exogenous lipoprotein
US5468499A (en) * 1993-11-15 1995-11-21 Ohio State University Liposomes containing the salt of phosphoramide mustard and related compounds
US5589189A (en) * 1994-09-14 1996-12-31 Nexstar Pharmaceuticals, Inc. Liposome dispersion
US5662929A (en) * 1994-12-23 1997-09-02 Universite De Montreal Therapeutic liposomal formulation
DE69638099D1 (de) 1995-05-04 2010-01-28 Gilead Sciences Inc Nukleinsäureligand-komplexe
DE19639811A1 (de) * 1996-09-27 1998-04-02 Artur Herzog Dr Mesmer Verwendung einer Liposomenlösung zur Verstärkung der Wirksamkeit und/oder Verminderung der Toxizität von Arzneimitteln
US6060082A (en) * 1997-04-18 2000-05-09 Massachusetts Institute Of Technology Polymerized liposomes targeted to M cells and useful for oral or mucosal drug delivery
AUPP032097A0 (en) * 1997-11-11 1997-12-04 Peptide Delivery Systems Pty Ltd Improved labelled diagnostic compositions and methods of their use
US20010003580A1 (en) 1998-01-14 2001-06-14 Poh K. Hui Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
US6727079B1 (en) * 1998-02-25 2004-04-27 The United States Of America As Represented By The Department Of Health And Human Services cDNA encoding a gene BOG (B5T Over-expressed Gene) and its protein product
US6171652B1 (en) * 1998-05-26 2001-01-09 Brij P. Singh Method for modifying surfaces with ultra thin films
US6613352B2 (en) 1999-04-13 2003-09-02 Universite De Montreal Low-rigidity liposomal formulation
WO2001058238A2 (en) * 2000-01-31 2001-08-16 Collaborative Technologies, Inc. Method and system for producing customized cosmetic and pharmaceutical formulations on demand
DE60124080T2 (de) * 2000-03-23 2007-03-01 Elan Pharmaceuticals, Inc., San Francisco Verbindungen und verfahren zur behandlung der alzheimerschen krankheit
US6992081B2 (en) 2000-03-23 2006-01-31 Elan Pharmaceuticals, Inc. Compounds to treat Alzheimer's disease
PL360470A1 (en) 2000-06-09 2004-09-06 Osi Pharmaceuticals, Inc. Liposomal benzoquinazoline thymidylate synthase inhibitor formulations
US20030096864A1 (en) * 2000-06-30 2003-05-22 Fang Lawrence Y. Compounds to treat alzheimer's disease
EP1299352B1 (de) 2000-06-30 2005-12-28 Elan Pharmaceuticals, Inc. Verbindungen zur behandlung der alzheimerischen krankheit
PE20020276A1 (es) 2000-06-30 2002-04-06 Elan Pharm Inc COMPUESTOS DE AMINA SUSTITUIDA COMO INHIBIDORES DE ß-SECRETASA PARA EL TRATAMIENTO DE ALZHEIMER
US6846813B2 (en) * 2000-06-30 2005-01-25 Pharmacia & Upjohn Company Compounds to treat alzheimer's disease
US20020150566A1 (en) * 2001-03-23 2002-10-17 Kun-Liang Guan Method of inhibiting cancerous cell proliferation using Ras mutants of GDP-bound conformation
US6984395B2 (en) * 2001-04-11 2006-01-10 Qlt, Inc. Drug delivery system for hydrophobic drugs
WO2003002122A1 (en) * 2001-06-27 2003-01-09 Elan Pharmaceuticals, Inc. Beta-hydroxyamine derivatives useful in treatment of alzheimer's disease
EA200200925A1 (ru) * 2002-07-18 2003-04-24 Ооо "Био-3" Способ получения вододисперсионных препаратов жирорастворимых витаминов и антиоксидантов
AU2003293140A1 (en) * 2002-11-26 2004-06-18 Gilead Sciences, Inc. Method of drug loading in liposomes by gradient
US7459529B2 (en) 2004-11-24 2008-12-02 Seoul National University Industry Foundation AIMP2-DX2 and its uses
US9944713B2 (en) 2004-11-24 2018-04-17 Medicinal Bioconvergence Research Center Antibody specific to the AIMP2-DX2
WO2006071659A1 (en) * 2004-12-29 2006-07-06 Trustees Of Boston University Delivery of h2 antagonists
WO2007120818A2 (en) * 2006-04-12 2007-10-25 Massachusetts Institute Of Technology Compositions and methods for inhibiting adhesions
WO2009128950A2 (en) 2008-04-18 2009-10-22 Vaxinnate Corporation Deletion mutants of flagellin and methods of use
KR20140092226A (ko) * 2010-12-14 2014-07-23 테크니칼 유니버시티 오브 덴마크 나노입자 조성물에서 방사성 핵종의 포집
JP6143740B2 (ja) 2011-04-07 2017-06-07 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 持続性ペプチド類似体
GB201204384D0 (en) 2012-03-13 2012-04-25 Univ Dundee Anti-flammatory agents
KR20150095809A (ko) 2012-12-12 2015-08-21 템플 유니버시티-오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 암 치료용 조성물 및 방법
KR101638156B1 (ko) 2013-10-29 2016-07-08 가톨릭대학교 산학협력단 C형 간염 바이러스 감염 질환의 예방 또는 치료용 약학 조성물
EP3234141A4 (de) 2014-12-18 2018-06-20 Alnylam Pharmaceuticals, Inc. Reversir-tm-verbindungen
EP3615545B1 (de) 2017-04-24 2021-09-01 Cocrystal Pharma, Inc. Pyrrolopyrimidinderivate als inhibitoren der influenza-virus-replikation
CN112638477B (zh) 2018-07-27 2024-01-26 共晶制药公司 作为流感病毒复制的抑制剂的吡咯并[2,3-b]吡啶衍生物
EP3849978B1 (de) 2018-09-10 2022-11-02 Cocrystal Pharma, Inc. Pyridopyrazin- und pyridotriazininhibitoren der influenzavirusreplikation
MX2021004215A (es) 2018-10-17 2021-07-15 Cocrystal Pharma Inc Combinaciones de inhibidores de la replicación del virus de la gripe.
WO2020112716A1 (en) 2018-11-26 2020-06-04 Cocrystal Pharma, Inc. Inhibitors of influenza virus replication
WO2021188620A1 (en) 2020-03-17 2021-09-23 Cocrystal Pharma Inc. Peptidomimetic n5-methyl-n2-(nonanoyl-l-leucyl)-l-glutaminate derivatives, triazaspiro[4.14]nonadecane derivatives and similar compounds as inhibitors of norovirus and coronavirus replication
TW202204318A (zh) 2020-04-10 2022-02-01 美商共結晶製藥公司 諾羅病毒及冠狀病毒複製之抑制劑
KR20240055745A (ko) 2021-08-03 2024-04-29 코크리스탈 파마, 아이엔씨. 코로나바이러스 억제제
WO2024168010A2 (en) 2023-02-09 2024-08-15 Alnylam Pharmaceuticals, Inc. Reversir molecules and methods of use thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5186117A (en) * 1975-01-27 1976-07-28 Tanabe Seiyaku Co Johoseibiryushiseizainoseiho
US4263428A (en) * 1978-03-24 1981-04-21 The Regents Of The University Of California Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same
US4310506A (en) * 1979-02-22 1982-01-12 California Institute Of Technology Means of preparation and applications of liposomes containing high concentrations of entrapped ionic species
CA1173360A (en) * 1979-06-22 1984-08-28 Jurg Schrank Pharmaceutical preparations
US4310505A (en) * 1979-11-08 1982-01-12 California Institute Of Technology Lipid vesicles bearing carbohydrate surfaces as lymphatic directed vehicles for therapeutic and diagnostic substances
US4485054A (en) * 1982-10-04 1984-11-27 Lipoderm Pharmaceuticals Limited Method of encapsulating biologically active materials in multilamellar lipid vesicles (MLV)
FR2534487B1 (fr) * 1982-10-15 1988-06-10 Dior Christian Parfums Procede d'homogeneisation de dispersions de phases lamellaires lipidiques hydratees, et suspensions obtenues par ce procede
US4544545A (en) * 1983-06-20 1985-10-01 Trustees University Of Massachusetts Liposomes containing modified cholesterol for organ targeting

Also Published As

Publication number Publication date
CA1282699C (en) 1991-04-09
DE3679204D1 (de) 1991-06-20
IE860273L (en) 1986-07-31
EP0190050B1 (de) 1991-05-15
US4753788A (en) 1988-06-28
EP0190050A2 (de) 1986-08-06
EP0190050A3 (en) 1987-09-30
IE57225B1 (en) 1992-06-03
JPH0776170B2 (ja) 1995-08-16
JPS61218515A (ja) 1986-09-29

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EEIH Change in the person of patent owner
EELA Cancelled due to lapse of time