ATE330002T1 - Verfahren zur herstellung von membranvesikeln - Google Patents
Verfahren zur herstellung von membranvesikelnInfo
- Publication number
- ATE330002T1 ATE330002T1 AT01943246T AT01943246T ATE330002T1 AT E330002 T1 ATE330002 T1 AT E330002T1 AT 01943246 T AT01943246 T AT 01943246T AT 01943246 T AT01943246 T AT 01943246T AT E330002 T1 ATE330002 T1 AT E330002T1
- Authority
- AT
- Austria
- Prior art keywords
- membrane vesicles
- preparations
- methods
- relates
- present
- Prior art date
Links
- 239000012528 membrane Substances 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 abstract 3
- 238000002360 preparation method Methods 0.000 abstract 3
- 210000001808 exosome Anatomy 0.000 abstract 2
- 241000282414 Homo sapiens Species 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 239000012620 biological material Substances 0.000 abstract 1
- 238000005119 centrifugation Methods 0.000 abstract 1
- 238000011026 diafiltration Methods 0.000 abstract 1
- 238000009169 immunotherapy Methods 0.000 abstract 1
- 210000004962 mammalian cell Anatomy 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 229940127557 pharmaceutical product Drugs 0.000 abstract 1
- 238000003908 quality control method Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
- C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
- C23C16/00—Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes
- C23C16/44—Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating
- C23C16/4401—Means for minimising impurities, e.g. dust, moisture or residual gas, in the reaction chamber
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/19—Dendritic cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
- A61K40/24—Antigen-presenting cells [APC]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0639—Dendritic cells, e.g. Langherhans cells in the epidermis
-
- C—CHEMISTRY; METALLURGY
- C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
- C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
- C23C16/00—Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes
- C23C16/44—Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating
- C23C16/50—Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating using electric discharges
- C23C16/505—Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating using electric discharges using radio frequency discharges
- C23C16/509—Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating using electric discharges using radio frequency discharges using internal electrodes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/5432—Liposomes or microcapsules
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J37/00—Discharge tubes with provision for introducing objects or material to be exposed to the discharge, e.g. for the purpose of examination or processing thereof
- H01J37/32—Gas-filled discharge tubes
- H01J37/32431—Constructional details of the reactor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/22—Colony stimulating factors (G-CSF, GM-CSF)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/24—Interferons [IFN]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Metallurgy (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Zoology (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Plasma & Fusion (AREA)
- Materials Engineering (AREA)
- Mechanical Engineering (AREA)
- Pulmonology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Rheumatology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/561,205 US6812023B1 (en) | 2000-04-27 | 2000-04-27 | Methods of producing membrane vesicles |
| US09/780,748 US20040241176A1 (en) | 2000-04-27 | 2001-02-09 | Method of producing membrane vesicles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE330002T1 true ATE330002T1 (de) | 2006-07-15 |
Family
ID=27072576
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01943246T ATE330002T1 (de) | 2000-04-27 | 2001-04-11 | Verfahren zur herstellung von membranvesikeln |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20040241176A1 (de) |
| EP (1) | EP1278825B1 (de) |
| JP (1) | JP2003531864A (de) |
| CN (1) | CN1426461A (de) |
| AT (1) | ATE330002T1 (de) |
| AU (1) | AU6587301A (de) |
| CA (1) | CA2407225A1 (de) |
| DE (1) | DE60120683D1 (de) |
| EA (1) | EA005425B1 (de) |
| IL (1) | IL152472A0 (de) |
| WO (1) | WO2001082958A2 (de) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1356291B1 (de) | 2000-12-06 | 2011-05-04 | Ecole Polytechnique Fédérale de Lausanne (EPFL) | Verfahren zur herstellung eines bioanalytischen reagenzes, nachweisverfahren beruhend auf der verwendung des bioanalytischen reagenz, sowie dessen verwendung |
| CA2454756C (en) | 2001-08-17 | 2014-02-18 | Anosys, Inc. | Methods and compounds for the targeting of protein to exosomes |
| DK1448229T3 (da) * | 2001-11-29 | 2010-03-08 | Dandrit Biotech As | Farmaceutisk sammensætning til at inducere et immunrespons hos et menneske eller et dyr |
| AU2003214566A1 (en) * | 2002-03-14 | 2003-09-22 | Anosys, Inc. | Functionalization of T cell derived vesicles and use thereof for the preparation of immunogenic pharmaceutical compositions |
| KR20030085659A (ko) * | 2002-04-30 | 2003-11-07 | 동부한농화학 주식회사 | 암 치료용 엑소좀 및 그를 이용한 암 백신 |
| KR100519384B1 (ko) * | 2002-08-13 | 2005-10-06 | (주)누백스 | 유전자 이입을 이용한 엑소좀의 제조방법 및 상기 엑소좀의 용도 |
| US7914792B2 (en) | 2003-02-14 | 2011-03-29 | Exothera L.L.C. | Methods and compounds for raising antibodies and for screening antibody repertoires |
| FR2852393B1 (fr) * | 2003-03-14 | 2007-04-13 | Univ Aix Marseille Ii | Methode de detection et d'analyse d'organelle immobilises sur biopuce et leurs applications |
| GB0316560D0 (en) * | 2003-07-15 | 2003-08-20 | Chiron Srl | Vesicle filtration |
| US20080268429A1 (en) * | 2004-06-02 | 2008-10-30 | Sourcepharm, Inc. | Rna - Containing Microvesicles and Methods Therefor |
| US7901921B2 (en) * | 2004-10-22 | 2011-03-08 | Oncolytics Biotech Inc. | Viral purification methods |
| CA2504279A1 (en) * | 2005-04-15 | 2006-10-15 | University Of Saskatchewan | Materials and method of modulating the immune response using t helper-antigen presenting cells |
| US9599611B2 (en) | 2005-04-25 | 2017-03-21 | Trustees Of Boston University | Structured substrates for optical surface profiling |
| WO2008092153A2 (en) * | 2007-01-26 | 2008-07-31 | University Of Louisville Research Foundation, Inc. | Modification of exosomal components for use as a vaccine |
| US20100255514A1 (en) | 2007-08-16 | 2010-10-07 | The Royal Institution For The Advancement Of Learning/Mcgill University | Tumor cell-derived microvesicles |
| EP2696203A3 (de) | 2007-08-16 | 2014-05-28 | The Royal Institution for the Advancement of Learning/McGill University | Tumorzellen-abgeleitete Mikrovesikel |
| US8617806B2 (en) * | 2008-01-25 | 2013-12-31 | Hansabiomed Ou | Method to measure and characterize microvesicles in the human body fluids |
| US10545149B2 (en) * | 2008-10-06 | 2020-01-28 | Morehouse School Of Medicine | Detection of HIV-related proteins in urine |
| US9487837B2 (en) | 2008-10-06 | 2016-11-08 | Morehouse School Of Medicine | Exosome-mediated diagnosis of hepatitis virus infections and diseases |
| CN102308004A (zh) | 2008-10-30 | 2012-01-04 | 卡里斯生命科学卢森堡控股有限责任公司 | 评价rna图案的方法 |
| CA2743211A1 (en) | 2008-11-12 | 2010-05-20 | Caris Life Sciences Luxembourg Holdings, S.A.R.L. | Methods and systems of using exosomes for determining phenotypes |
| WO2010065968A1 (en) * | 2008-12-05 | 2010-06-10 | Myriad Genetics, Inc. | Cancer detection markers |
| US9835618B1 (en) * | 2009-02-06 | 2017-12-05 | Los Alamos National Security, Llc | Discovery, detection and use of biomarkers |
| EP2419144B1 (de) | 2009-04-17 | 2019-08-07 | Oxford University Innovation Limited | Zusammensetzung zur abgabe eines genetischen materials |
| JP5667180B2 (ja) | 2009-07-01 | 2015-02-12 | イオン メディックス インコーポレイテッド | 哺乳類の有核細胞に由来するマイクロベシクル及びその用途 |
| KR20120081972A (ko) | 2009-07-02 | 2012-07-20 | 아이티에이치 임뮨 세라피 홀딩스 에이비 | 엑소좀에 기초한 암의 치료 |
| IN2012DN00866A (de) * | 2009-07-16 | 2015-07-10 | Gen Hospital Corp | |
| WO2011031892A1 (en) | 2009-09-09 | 2011-03-17 | The General Hospital Corporation | Use of microvesicles in analyzing kras mutations |
| WO2011031877A1 (en) | 2009-09-09 | 2011-03-17 | The General Hospital Corporation | Use of microvesicles in analyzing nucleic acid profiles |
| US9128101B2 (en) | 2010-03-01 | 2015-09-08 | Caris Life Sciences Switzerland Holdings Gmbh | Biomarkers for theranostics |
| WO2011127219A1 (en) | 2010-04-06 | 2011-10-13 | Caris Life Sciences Luxembourg Holdings | Circulating biomarkers for disease |
| EP2578236B1 (de) | 2010-05-26 | 2016-03-30 | Micromedmark Biotech Co., Ltd | Herstellung von mikrovesikel-si-rna-komplexen und ihre verwendung bei der behandlung von aids |
| US9376679B2 (en) | 2010-05-26 | 2016-06-28 | Micromedmark Biotech Co. Ltd. | Microvesicles carrying small interfering RNAs, preparation methods and uses thereof |
| WO2012031008A2 (en) | 2010-08-31 | 2012-03-08 | The General Hospital Corporation | Cancer-related biological materials in microvesicles |
| EP2638057B1 (de) | 2010-11-10 | 2019-03-06 | Exosome Diagnostics, Inc. | Verfahren zur isolierung von nukleinsäure enthaltenden partikeln und extraktion von nukleinsäuren daraus |
| SG183579A1 (en) | 2011-02-11 | 2012-09-27 | Agency Science Tech & Res | Methods of detecting therapeutic exosomes |
| ITNA20110012A1 (it) * | 2011-03-14 | 2012-09-15 | Amal Raj Delfin Albert | Procedura di isolamento e di purificazione degli esosomi urinari per la ricerca di biomarcatori proteici |
| HK1199754A1 (en) * | 2011-09-22 | 2015-07-17 | Universidad De Los Andes | Method for monitoring, diagnosis and/or prognosis of acute kidney injury in early stage |
| GB201121070D0 (en) | 2011-12-07 | 2012-01-18 | Isis Innovation | composition for delivery of biotherapeutics |
| WO2013109713A1 (en) | 2012-01-18 | 2013-07-25 | The General Hospital Corporation | Targeting rnas to microvesicles |
| CN103479682B (zh) * | 2012-06-14 | 2015-03-11 | 苏州恒宇生物科技有限公司 | 一种植物来源活性成分-纳米级膜性囊泡的制备方法 |
| WO2014028763A1 (en) | 2012-08-15 | 2014-02-20 | The University Of Chicago | Exosome-based therapeutics against neurodegenerative disorders |
| US20140186293A1 (en) * | 2012-12-31 | 2014-07-03 | University Of Louisville Research Foundation, Inc. | Immunoglobulin-bound extracellular vesicles and uses thereof |
| SG11201508433TA (en) | 2013-04-12 | 2015-11-27 | Andaloussi Samir El | Therapeutic delivery vesicles |
| CN104274828B (zh) * | 2013-07-04 | 2017-11-17 | 复旦大学 | IFN‑α处理细胞所分泌外体在制备抑制肝炎病毒的药物中的应用 |
| JP6547625B2 (ja) | 2013-10-25 | 2019-07-24 | 凸版印刷株式会社 | 膜小胞回収デバイス、膜小胞回収方法、及び膜小胞分析方法 |
| CN106573220B (zh) | 2014-07-24 | 2019-08-16 | 凸版印刷株式会社 | 脂质膜结构体、脂质膜结构体固定化载体、及胞体的融合方法 |
| US10329323B2 (en) * | 2014-07-25 | 2019-06-25 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Method for purifying antibodies using PBS |
| EP3353528B1 (de) | 2015-09-22 | 2023-11-29 | Trustees of Boston University | Multiplexierte phänotypisierung von nanovesikeln |
| CA3001065A1 (en) * | 2015-10-14 | 2017-04-20 | Xiaoxi WEI | Compositions and methods for reducing ice crystal formation |
| EP3411713B1 (de) | 2016-02-05 | 2021-06-30 | NanoView Biosciences, Inc. | Detektion von exosomen mit oberflächenmarkierungen |
| WO2017204187A1 (ja) | 2016-05-24 | 2017-11-30 | 公益財団法人がん研究会 | 細胞外小胞回収方法及び細胞外小胞用容器 |
| GB2552473A (en) * | 2016-07-21 | 2018-01-31 | Evox Therapeutics Ltd | Surface decoration of extracellular vesicles |
| US20200046766A1 (en) * | 2016-10-13 | 2020-02-13 | Vbc Holdings Llc | Cancer stem cell exosomes |
| CN110073195B (zh) * | 2016-11-23 | 2022-03-29 | 阿曼·沙马 | 提取外泌体以及与之结合的生物大分子的方法以及试剂盒 |
| CN107907689A (zh) * | 2017-10-10 | 2018-04-13 | 北京大学 | 外泌体蛋白cd5l的检测方法 |
| NL2019814B1 (en) * | 2017-10-26 | 2019-05-06 | Stichting Het Nederlands Kanker Inst Antoni Van Leeuwenhoek Ziekenhuis | Methods for producing a MHC multimer. |
| CA3094577A1 (en) | 2018-03-30 | 2019-10-03 | Exosomics S.p.A. | Use of hollow fibers to obtain blood or a blood derivative impoverished from blood cells and platelets derived extracellular vesicles |
| US12510462B2 (en) | 2018-06-01 | 2025-12-30 | Unchained Labs | Compositions, systems, and methods for enhanced label-free and fluorescence-based detection of nanoparticles |
| JP7376887B2 (ja) * | 2019-08-20 | 2023-11-09 | Jfeエンジニアリング株式会社 | 動物細胞の増殖促進方法、連続培養方法及び連続培養装置 |
| JP7513869B2 (ja) | 2020-03-23 | 2024-07-10 | 澁谷工業株式会社 | エクソソーム抽出装置およびエクソソームの抽出方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2766205B1 (fr) * | 1997-07-16 | 2002-08-30 | Inst Nat Sante Rech Med | Nouveau procede de sensibilisation de cellules presentatrices d'antigene et nouveaux moyens pour la mise en oeuvre du procede |
| FR2785543B1 (fr) * | 1998-11-05 | 2003-02-28 | Inst Nat Sante Rech Med | Exosomes modifies et utilisations |
-
2001
- 2001-02-09 US US09/780,748 patent/US20040241176A1/en not_active Abandoned
- 2001-04-11 WO PCT/EP2001/004173 patent/WO2001082958A2/en not_active Ceased
- 2001-04-11 CN CN01808615A patent/CN1426461A/zh active Pending
- 2001-04-11 EP EP01943246A patent/EP1278825B1/de not_active Expired - Lifetime
- 2001-04-11 AT AT01943246T patent/ATE330002T1/de not_active IP Right Cessation
- 2001-04-11 AU AU65873/01A patent/AU6587301A/en not_active Abandoned
- 2001-04-11 CA CA002407225A patent/CA2407225A1/en not_active Abandoned
- 2001-04-11 IL IL15247201A patent/IL152472A0/xx unknown
- 2001-04-11 DE DE60120683T patent/DE60120683D1/de not_active Expired - Lifetime
- 2001-04-11 JP JP2001579831A patent/JP2003531864A/ja active Pending
- 2001-04-11 EA EA200201150A patent/EA005425B1/ru not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| US20040241176A1 (en) | 2004-12-02 |
| EA005425B1 (ru) | 2005-02-24 |
| DE60120683D1 (de) | 2006-07-27 |
| WO2001082958A2 (en) | 2001-11-08 |
| EA200201150A1 (ru) | 2003-04-24 |
| EP1278825A2 (de) | 2003-01-29 |
| IL152472A0 (en) | 2003-05-29 |
| EP1278825B1 (de) | 2006-06-14 |
| CN1426461A (zh) | 2003-06-25 |
| JP2003531864A (ja) | 2003-10-28 |
| WO2001082958A3 (en) | 2002-04-18 |
| AU6587301A (en) | 2001-11-12 |
| CA2407225A1 (en) | 2001-11-08 |
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