DE69812645D1 - Verfahren zur herstellung von kontrastmitteln - Google Patents

Verfahren zur herstellung von kontrastmitteln

Info

Publication number
DE69812645D1
DE69812645D1 DE69812645T DE69812645T DE69812645D1 DE 69812645 D1 DE69812645 D1 DE 69812645D1 DE 69812645 T DE69812645 T DE 69812645T DE 69812645 T DE69812645 T DE 69812645T DE 69812645 D1 DE69812645 D1 DE 69812645D1
Authority
DE
Germany
Prior art keywords
gas
containing vesicles
aqueous dispersion
dispersion
liquid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69812645T
Other languages
English (en)
Other versions
DE69812645T2 (de
Inventor
Ingrid Henriksen
Vera Kasparkova
Arnfinn Andersen
Kjersti Fahlvik
Ingrid Odegardstuen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare AS
Original Assignee
Amersham Health AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amersham Health AS filed Critical Amersham Health AS
Publication of DE69812645D1 publication Critical patent/DE69812645D1/de
Application granted granted Critical
Publication of DE69812645T2 publication Critical patent/DE69812645T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Acoustics & Sound (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Glass Compositions (AREA)
  • Iron Core Of Rotating Electric Machines (AREA)
DE69812645T 1997-08-19 1998-08-19 Verfahren zur herstellung von kontrastmitteln Expired - Lifetime DE69812645T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9717542.6A GB9717542D0 (en) 1997-08-19 1997-08-19 Process
GB9717542 1997-08-19
PCT/GB1998/002490 WO1999008715A1 (en) 1997-08-19 1998-08-19 Process for preparing contrast agents

Publications (2)

Publication Number Publication Date
DE69812645D1 true DE69812645D1 (de) 2003-04-30
DE69812645T2 DE69812645T2 (de) 2004-03-04

Family

ID=10817701

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69812645T Expired - Lifetime DE69812645T2 (de) 1997-08-19 1998-08-19 Verfahren zur herstellung von kontrastmitteln

Country Status (10)

Country Link
US (1) US6509004B1 (de)
EP (1) EP1007102B1 (de)
JP (1) JP5047415B2 (de)
AT (1) ATE235259T1 (de)
AU (1) AU8816098A (de)
DE (1) DE69812645T2 (de)
GB (1) GB9717542D0 (de)
NO (1) NO20000621L (de)
WO (1) WO1999008715A1 (de)
ZA (1) ZA987480B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9810051D0 (en) * 1998-05-11 1998-07-08 Nycomed Imaging As Contrast media
GB0811856D0 (en) * 2008-06-27 2008-07-30 Ucl Business Plc Magnetic microbubbles, methods of preparing them and their uses
GB201405735D0 (en) * 2014-03-31 2014-05-14 Ge Healthcare As Ultrasound precursor preparation method
GB201411423D0 (en) * 2014-06-26 2014-08-13 Ge Healthcare As Lipid sterilisation method
CN113289034A (zh) 2014-12-31 2021-08-24 蓝瑟斯医学影像公司 脂质封装的气体微球组合物及相关方法
US9789210B1 (en) 2016-07-06 2017-10-17 Lantheus Medical Imaging, Inc. Methods for making ultrasound contrast agents

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4857319A (en) * 1985-01-11 1989-08-15 The Regents Of The University Of California Method for preserving liposomes
US4642903A (en) * 1985-03-26 1987-02-17 R. P. Scherer Corporation Freeze-dried foam dosage form
US5922304A (en) * 1989-12-22 1999-07-13 Imarx Pharmaceutical Corp. Gaseous precursor filled microspheres as magnetic resonance imaging contrast agents
US5445813A (en) * 1992-11-02 1995-08-29 Bracco International B.V. Stable microbubble suspensions as enhancement agents for ultrasound echography
WO1994001140A1 (de) * 1992-07-03 1994-01-20 Byk Gulden Lomberg Chemische Fabrik Gmbh Echokontrastmittelzubereitung
US5798091A (en) * 1993-07-30 1998-08-25 Alliance Pharmaceutical Corp. Stabilized gas emulsion containing phospholipid for ultrasound contrast enhancement
GB9423419D0 (en) * 1994-11-19 1995-01-11 Andaris Ltd Preparation of hollow microcapsules
DE19510690A1 (de) * 1995-03-14 1996-09-19 Schering Ag Polymere Nano- und/oder Mikropartikel, Verfahren zu deren Herstellung, sowie Verwendung in medizinischen Diagnostik und Therapie
US5997898A (en) * 1995-06-06 1999-12-07 Imarx Pharmaceutical Corp. Stabilized compositions of fluorinated amphiphiles for methods of therapeutic delivery
GB9511488D0 (en) * 1995-06-07 1995-08-02 Nycomed Imaging As Improvements in or relating to contrast agents
US5601085A (en) * 1995-10-02 1997-02-11 Nycomed Imaging As Ultrasound imaging
EP0885016B1 (de) * 1996-02-19 2003-04-16 Amersham Health AS Thermostabilisiertes kontrastmittel
WO1997029783A1 (en) * 1996-02-19 1997-08-21 Nycomed Imaging A/S Improvements in or relating to contrast agents
DE19611769A1 (de) * 1996-03-14 1997-09-18 Schering Ag Mikropartikel, Verfahren zu deren Herstellung, sowie deren Verwendung in der Ultraschall Diagnostik
US6120751A (en) * 1997-03-21 2000-09-19 Imarx Pharmaceutical Corp. Charged lipids and uses for the same

Also Published As

Publication number Publication date
NO20000621D0 (no) 2000-02-08
JP2001515054A (ja) 2001-09-18
US6509004B1 (en) 2003-01-21
ATE235259T1 (de) 2003-04-15
JP5047415B2 (ja) 2012-10-10
GB9717542D0 (en) 1997-10-22
AU8816098A (en) 1999-03-08
DE69812645T2 (de) 2004-03-04
EP1007102B1 (de) 2003-03-26
EP1007102A1 (de) 2000-06-14
NO20000621L (no) 2000-03-10
WO1999008715A1 (en) 1999-02-25
ZA987480B (en) 2000-02-21

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: GE HEALTHCARE AS, OSLO, NO

8328 Change in the person/name/address of the agent

Representative=s name: HAMMONDS LLP, LONDON, GB

R082 Change of representative

Ref document number: 1007102

Country of ref document: EP

Representative=s name: J D REYNOLDS & CO., GB