ATE556788T1 - Herstellung pharmazeutischer wirkstoffpartikel unter verwendung fokussierter akustischer energie - Google Patents

Herstellung pharmazeutischer wirkstoffpartikel unter verwendung fokussierter akustischer energie

Info

Publication number
ATE556788T1
ATE556788T1 AT02725473T AT02725473T ATE556788T1 AT E556788 T1 ATE556788 T1 AT E556788T1 AT 02725473 T AT02725473 T AT 02725473T AT 02725473 T AT02725473 T AT 02725473T AT E556788 T1 ATE556788 T1 AT E556788T1
Authority
AT
Austria
Prior art keywords
acoustic energy
focused acoustic
production
pharmaceutical active
active particles
Prior art date
Application number
AT02725473T
Other languages
German (de)
English (en)
Inventor
David Lee
Original Assignee
Picoliter Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Picoliter Inc filed Critical Picoliter Inc
Application granted granted Critical
Publication of ATE556788T1 publication Critical patent/ATE556788T1/de

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
    • B01J2/04—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a gaseous medium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient

Landscapes

  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
AT02725473T 2001-03-30 2002-04-01 Herstellung pharmazeutischer wirkstoffpartikel unter verwendung fokussierter akustischer energie ATE556788T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/823,899 US6596206B2 (en) 2001-03-30 2001-03-30 Generation of pharmaceutical agent particles using focused acoustic energy
PCT/US2002/010266 WO2002078863A1 (en) 2001-03-30 2002-04-01 Generation of pharmaceutical agent particles using focused acoustic energy

Publications (1)

Publication Number Publication Date
ATE556788T1 true ATE556788T1 (de) 2012-05-15

Family

ID=25240048

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02725473T ATE556788T1 (de) 2001-03-30 2002-04-01 Herstellung pharmazeutischer wirkstoffpartikel unter verwendung fokussierter akustischer energie

Country Status (5)

Country Link
US (1) US6596206B2 (https=)
EP (1) EP1379337B1 (https=)
JP (1) JP2004532102A (https=)
AT (1) ATE556788T1 (https=)
WO (1) WO2002078863A1 (https=)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6620351B2 (en) * 2000-05-24 2003-09-16 Auburn University Method of forming nanoparticles and microparticles of controllable size using supercritical fluids with enhanced mass transfer
US6642061B2 (en) * 2000-09-25 2003-11-04 Picoliter Inc. Use of immiscible fluids in droplet ejection through application of focused acoustic energy
US6869551B2 (en) * 2001-03-30 2005-03-22 Picoliter Inc. Precipitation of solid particles from droplets formed using focused acoustic energy
US20050260273A1 (en) * 2001-06-07 2005-11-24 Chinea Vanessa I Applicatin of a bioactive agent in a solvent composition to produce a target particle morphology
US7354141B2 (en) * 2001-12-04 2008-04-08 Labcyte Inc. Acoustic assessment of characteristics of a fluid relevant to acoustic ejection
US20050244508A1 (en) * 2002-06-12 2005-11-03 Messer Griesheim Anti-spasmodic comprising xenon
JP2005533062A (ja) * 2002-06-12 2005-11-04 メツサー グリースハイム ゲゼルシヤフト ミツト ベシユレンクテル ハフツング キセノン含有ガスによる脳保護
US7070260B2 (en) * 2003-01-09 2006-07-04 Labcyte Inc. Droplet dispensation from a reservoir with reduction in uncontrolled electrostatic charge
WO2004091571A2 (en) * 2003-04-08 2004-10-28 New Jersey Institute Of Technology (Njit) Polymer coating/encapsulation of nanoparticles using a supercritical antisolvent process
WO2005051511A1 (ja) * 2003-11-28 2005-06-09 Mitsubishi Chemical Corporation 有機化合物微粒子の製造方法
KR100603974B1 (ko) 2003-12-05 2006-07-25 김갑식 고체상 지질을 용매로 이용한 나노수준의 또는 비결정질입자의 제조 방법
CA2548281C (en) * 2003-12-09 2013-11-12 Medcrystalforms, Llc Method of preparation of mixed phase co-crystals with active agents
US20060210443A1 (en) 2005-03-14 2006-09-21 Stearns Richard G Avoidance of bouncing and splashing in droplet-based fluid transport
US20070120281A1 (en) * 2005-11-08 2007-05-31 Boris Khusid Manufacture of fine particles and nano particles and coating thereof
WO2007129829A1 (en) * 2006-05-04 2007-11-15 Bio-Synectics Inc. Method for preparing nano-scale particle of active material
WO2008030473A2 (en) * 2006-09-05 2008-03-13 University Of Wyoming Process for forming nanoparticles by micellization of blocky copolymers in subcritical and supercritical solvents
KR20090077066A (ko) * 2006-10-06 2009-07-14 뉴사우스 이노베이션즈 피티와이 리미티드 입자 형성
JP5307382B2 (ja) * 2007-11-14 2013-10-02 日機装株式会社 微粒子化方法
WO2011118960A2 (ko) 2010-03-22 2011-09-29 (주)바이오시네틱스 나노입자 제조방법
CN102058996A (zh) * 2010-10-29 2011-05-18 华侨大学 非溶剂法改进超临界抗溶剂过程制备药物超细微粒的方法
WO2014007771A2 (en) 2012-07-05 2014-01-09 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Inhalation compositions comprising muscarinic receptor antagonist
WO2014007772A2 (en) * 2012-07-05 2014-01-09 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Inhalation compositions comprising glucose anhydrous
WO2014078258A1 (en) * 2012-11-16 2014-05-22 Merck Sharp & Dohme Corp. Process for making agglomerates using acoustic mixing technology
GB201402556D0 (en) 2014-02-13 2014-04-02 Crystec Ltd Improvements relating to inhalable particles
US11344496B2 (en) 2017-08-25 2022-05-31 Merck Sharp & Dohme Corp. Methods for preparing stabilized amorphous drug formulations using acoustic fusion
JP7503781B2 (ja) * 2018-07-30 2024-06-21 株式会社リコー 粒子の製造方法、並びに、それにより製造された粒子及び医薬

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4308547A (en) 1978-04-13 1981-12-29 Recognition Equipment Incorporated Liquid drop emitter
US5041849A (en) 1989-12-26 1991-08-20 Xerox Corporation Multi-discrete-phase Fresnel acoustic lenses and their application to acoustic ink printing
US6063910A (en) 1991-11-14 2000-05-16 The Trustees Of Princeton University Preparation of protein microparticles by supercritical fluid precipitation
DK0863202T3 (da) * 1995-11-01 2010-09-27 Dnavec Research Inc Rekombinant Sendai-virus
EP0885038B1 (en) * 1996-03-01 2011-06-15 The University Of Kansas Methods and apparatus for particle precipitation and coating using near-critical and supercritical antisolvents
US5874029A (en) 1996-10-09 1999-02-23 The University Of Kansas Methods for particle micronization and nanonization by recrystallization from organic solutions sprayed into a compressed antisolvent
GB9828204D0 (en) 1998-12-21 1999-02-17 Smithkline Beecham Plc Process
DK1173265T3 (da) 1999-01-29 2006-04-10 Bristol Myers Squibb Co Apparat og fremgangsmåde til krystallisation med ultralydstråler
US6620351B2 (en) 2000-05-24 2003-09-16 Auburn University Method of forming nanoparticles and microparticles of controllable size using supercritical fluids with enhanced mass transfer
GB0016002D0 (en) 2000-06-29 2000-08-23 Glaxo Group Ltd Novel process for preparing crystalline particles
US7121275B2 (en) 2000-12-18 2006-10-17 Xerox Corporation Method of using focused acoustic waves to deliver a pharmaceutical product
US6622720B2 (en) 2000-12-18 2003-09-23 Xerox Corporation Using capillary wave driven droplets to deliver a pharmaceutical product
US8122880B2 (en) 2000-12-18 2012-02-28 Palo Alto Research Center Incorporated Inhaler that uses focused acoustic waves to deliver a pharmaceutical product
JPWO2003029475A1 (ja) * 2001-09-28 2005-01-20 株式会社ディナベック研究所 エピトープ結合β２ｍをコードする哺乳動物細胞感染性ウイルスベクターおよびその利用

Also Published As

Publication number Publication date
US6596206B2 (en) 2003-07-22
EP1379337B1 (en) 2012-05-09
JP2004532102A (ja) 2004-10-21
US20020142049A1 (en) 2002-10-03
WO2002078863A1 (en) 2002-10-10
EP1379337A1 (en) 2004-01-14

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